Animal Model for chronic obstrutive pulmonary disease and cystic fibrosis

Richard C Boucher (Inventor), Richard C. Jr. (Inventor), Wanda O'Neal (Inventor), Barbara Grubb (Inventor), Marcus Mall (Inventor)

Research output: Patent

Abstract

A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel .beta. subunit, wherein said promoter construct directs expression of the epithelial sodium channel .beta. subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.
LanguageEnglish
Patent number7772458
IPCG01N 33/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); A01K 67/033 (20060101)
StatePublished - 1800

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Cystic Fibrosis
Lung Diseases
Epithelial Sodium Channels
Mammals
Animal Models
Lung
Mucus
Chronic Obstructive Pulmonary Disease
Epithelial Cells
Genome
DNA

Cite this

Boucher, R. C., Jr., R. C., O'Neal, W., Grubb, B., & Mall, M. (1800). IPC No. G01N 33/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); A01K 67/033 (20060101). Animal Model for chronic obstrutive pulmonary disease and cystic fibrosis (Patent No. 7772458.)

Animal Model for chronic obstrutive pulmonary disease and cystic fibrosis. / Boucher, Richard C (Inventor); Jr., Richard C. (Inventor); O'Neal, Wanda (Inventor); Grubb, Barbara (Inventor); Mall, Marcus (Inventor).

IPC No.: G01N 33/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); A01K 67/033 (20060101). Patent No.: 7772458.

Research output: Patent

Boucher, RC, Jr., RC, O'Neal, W, Grubb, B & Mall, M 1800, Animal Model for chronic obstrutive pulmonary disease and cystic fibrosis, Patent No. 7772458, IPC No. G01N 33/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); A01K 67/033 (20060101).
Boucher RC, Jr. RC, O'Neal W, Grubb B, Mall M, inventors. Animal Model for chronic obstrutive pulmonary disease and cystic fibrosis. G01N 33/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); A01K 67/033 (20060101). 1800
Boucher, Richard C (Inventor) ; Jr., Richard C. (Inventor) ; O'Neal, Wanda (Inventor) ; Grubb, Barbara (Inventor) ; Mall, Marcus (Inventor). / Animal Model for chronic obstrutive pulmonary disease and cystic fibrosis. IPC No.: G01N 33/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); A01K 67/033 (20060101). Patent No.: 7772458.
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abstract = "A nonhuman transgenic mammal is described whose genome comprises a promoter construct operably linked to a heterologous DNA encoding an epithelial sodium channel .beta. subunit, wherein said promoter construct directs expression of the epithelial sodium channel .beta. subunit in lung epithelial cells of said animal, and wherein said transgenic mammal has increased lung mucus retention as compared to the corresponding wild-type mammal. The animal is useful in screening compounds for activity in treating lung diseases such as cystic fibrosis and chronic obstructive pulmonary disease.",
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