Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers

S. Ghazaleh Dashti, Daniel D. Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Finlay A. MacRae, Graham G. Giles, Susan Parry, Graham Casey, Robert W. Haile, Steven Gallinger, Loc Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper & 2 others Mark A. Jenkins, Aung Ko Win

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Abstract

Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer. Results: Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09-2.07 and 1.69; 95% CI, 1.07-2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27-2.49 and 1.94; 95% CI, 1.19-3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk. Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.

LanguageEnglish (US)
Pages366-375
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2017

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DNA Mismatch Repair
Alcohol Drinking
Colorectal Neoplasms
Mutation
Genes
Confidence Intervals
Colonic Neoplasms
Alcoholic Beverages
Rectal Neoplasms
Ethanol
Odds Ratio
Germ-Line Mutation
Wine
Proportional Hazards Models
Registries
Life Style
Alcohols

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Ghazaleh Dashti, S., Buchanan, D. D., Jayasekara, H., Ouakrim, D. A., Clendenning, M., Rosty, C., ... Win, A. K. (2017). Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers. Cancer Epidemiology Biomarkers and Prevention, 26(3), 366-375. https://doi.org/10.1158/1055-9965.EPI-16-0496

Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers. / Ghazaleh Dashti, S.; Buchanan, Daniel D.; Jayasekara, Harindra; Ouakrim, Driss Ait; Clendenning, Mark; Rosty, Christophe; Winship, Ingrid M.; MacRae, Finlay A.; Giles, Graham G.; Parry, Susan; Casey, Graham; Haile, Robert W.; Gallinger, Steven; Le Marchand, Loc; Thibodeau, Stephen N.; Lindor, Noralane M.; Newcomb, Polly A.; Potter, John D.; Baron, John A.; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 26, No. 3, 01.03.2017, p. 366-375.

Research output: Contribution to journalArticle

Ghazaleh Dashti, S, Buchanan, DD, Jayasekara, H, Ouakrim, DA, Clendenning, M, Rosty, C, Winship, IM, MacRae, FA, Giles, GG, Parry, S, Casey, G, Haile, RW, Gallinger, S, Le Marchand, L, Thibodeau, SN, Lindor, NM, Newcomb, PA, Potter, JD, Baron, JA, Hopper, JL, Jenkins, MA & Win, AK 2017, 'Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers' Cancer Epidemiology Biomarkers and Prevention, vol. 26, no. 3, pp. 366-375. https://doi.org/10.1158/1055-9965.EPI-16-0496
Ghazaleh Dashti, S. ; Buchanan, Daniel D. ; Jayasekara, Harindra ; Ouakrim, Driss Ait ; Clendenning, Mark ; Rosty, Christophe ; Winship, Ingrid M. ; MacRae, Finlay A. ; Giles, Graham G. ; Parry, Susan ; Casey, Graham ; Haile, Robert W. ; Gallinger, Steven ; Le Marchand, Loc ; Thibodeau, Stephen N. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Potter, John D. ; Baron, John A. ; Hopper, John L. ; Jenkins, Mark A. ; Win, Aung Ko. / Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers. In: Cancer Epidemiology Biomarkers and Prevention. 2017 ; Vol. 26, No. 3. pp. 366-375.
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abstract = "Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95{\%} confidence intervals (CI) for the association between alcohol consumption and colorectal cancer. Results: Colorectal cancer was diagnosed in 769 carriers (40{\%}) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95{\%} CI, 1.09-2.07 and 1.69; 95{\%} CI, 1.07-2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95{\%} CI, 1.27-2.49 and 1.94; 95{\%} CI, 1.19-3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk. Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.",
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T1 - Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers

AU - Ghazaleh Dashti, S.

AU - Buchanan, Daniel D.

AU - Jayasekara, Harindra

AU - Ouakrim, Driss Ait

AU - Clendenning, Mark

AU - Rosty, Christophe

AU - Winship, Ingrid M.

AU - MacRae, Finlay A.

AU - Giles, Graham G.

AU - Parry, Susan

AU - Casey, Graham

AU - Haile, Robert W.

AU - Gallinger, Steven

AU - Le Marchand, Loc

AU - Thibodeau, Stephen N.

AU - Lindor, Noralane M.

AU - Newcomb, Polly A.

AU - Potter, John D.

AU - Baron, John A.

AU - Hopper, John L.

AU - Jenkins, Mark A.

AU - Win, Aung Ko

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer. Results: Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09-2.07 and 1.69; 95% CI, 1.07-2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27-2.49 and 1.94; 95% CI, 1.19-3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk. Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.

AB - Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer. Results: Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09-2.07 and 1.69; 95% CI, 1.07-2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27-2.49 and 1.94; 95% CI, 1.19-3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk. Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.

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