Airway compliance measured by anatomic optical coherence tomography

Ruofei Bu, Santosh Balakrishnan, Nicusor Iftimia, Hillel Price, Carlton Zdanski, Amy L. Oldenburg

Research output: Research - peer-reviewArticle

Abstract

Quantification of airway compliance can aid in the diagnosis and treatment of obstructive airway disorders by detecting regions vulnerable to collapse. Here we evaluate the ability of a swept-source anatomic optical coherence tomography (SSaOCT) system to quantify airway cross-sectional compliance (CC) by measuring changes in the luminal cross-sectional area (CSA) under physiologically relevant pressures of 10–40 cmH2O. The accuracy and precision of CC measurements are determined using simulations of non-uniform rotation distortion (NURD) endemic to endoscopic scanning, and experiments performed in a simplified tube phantom and ex vivo porcine tracheas. NURD simulations show that CC measurements are typically more accurate than that of the CSAs from which they are derived. Phantom measurements of CSA versus pressure exhibit high linearity (R2>0.99), validating the dynamic range of the SSaOCT system. Tracheas also exhibited high linearity (R2 = 0.98) suggestive of linear elasticity, while CC measurements were obtained with typically ± 12% standard error.

LanguageEnglish (US)
Article number#283463
Pages2195-2209
Number of pages15
JournalBiomedical Optics Express
Volume8
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

tomography
Optical Coherence Tomography
Compliance
trachea
linearity
simulation
Trachea
Pressure
dynamic range
modulus of elasticity
disorders
tubes
scanning
Elasticity
Swine

Keywords

  • Endoscopic imaging
  • Medical and biological imaging
  • Medical optics instrumentation
  • Optical coherence tomography

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Airway compliance measured by anatomic optical coherence tomography. / Bu, Ruofei; Balakrishnan, Santosh; Iftimia, Nicusor; Price, Hillel; Zdanski, Carlton; Oldenburg, Amy L.

In: Biomedical Optics Express, Vol. 8, No. 4, #283463, 01.04.2017, p. 2195-2209.

Research output: Research - peer-reviewArticle

Bu, R, Balakrishnan, S, Iftimia, N, Price, H, Zdanski, C & Oldenburg, AL 2017, 'Airway compliance measured by anatomic optical coherence tomography' Biomedical Optics Express, vol 8, no. 4, #283463, pp. 2195-2209. DOI: 10.1364/BOE.8.002195
Bu R, Balakrishnan S, Iftimia N, Price H, Zdanski C, Oldenburg AL. Airway compliance measured by anatomic optical coherence tomography. Biomedical Optics Express. 2017 Apr 1;8(4):2195-2209. #283463. Available from, DOI: 10.1364/BOE.8.002195
Bu, Ruofei ; Balakrishnan, Santosh ; Iftimia, Nicusor ; Price, Hillel ; Zdanski, Carlton ; Oldenburg, Amy L./ Airway compliance measured by anatomic optical coherence tomography. In: Biomedical Optics Express. 2017 ; Vol. 8, No. 4. pp. 2195-2209
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