Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs

Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Esperanza Ontiveros, Gilberto Gómez-Garza, Gerardo Barragán-Mejía, James Broadway, Susan Chapman, Gildardo Valencia-Salazar, Valerie Jewells, Robert R. Maronpot, Carlos Henríquez-Roldán, Beatriz Pérez-Guillé, Ricardo Torres-Jardón, Lou Herrit, Diane Brooks, Norma Osnaya-Brizuela, Maria E. Monroy, Angelica González-Maciel, Rafael Reynoso-Robles, Rafael Villarreal-Calderon & 2 others Anna C. Solt, Randall W. Engle

Research output: Contribution to journalArticle

  • 184 Citations

Abstract

Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 β in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow-Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children.

LanguageEnglish (US)
Pages117-127
Number of pages11
JournalBrain and Cognition
Volume68
Issue number2
DOIs
StatePublished - Nov 1 2008

Fingerprint

Air Pollution
Mexico
Dogs
Brain
Cyclooxygenase 1
Environmental Pollution
Songbirds
Gliosis
Particulate Matter
Cyclooxygenase 2
Dog
Prefrontal Cortex
Interleukin-1beta
Psychometrics
Cognition
Blood Vessels
Mexico City
Magnetic Resonance Imaging
Pathology
Messenger RNA

Keywords

  • Air pollution
  • Brain MRI
  • Children
  • Dogs
  • Endothelial pathology
  • Fluid cognition
  • Neuroinflammation
  • Particulate matter PM
  • Ultrafine PM
  • White matter hyperintense lesions WML

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Cite this

Calderón-Garcidueñas, L., Mora-Tiscareño, A., Ontiveros, E., Gómez-Garza, G., Barragán-Mejía, G., Broadway, J., ... Engle, R. W. (2008). Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs. Brain and Cognition, 68(2), 117-127. https://doi.org/10.1016/j.bandc.2008.04.008

Air pollution, cognitive deficits and brain abnormalities : A pilot study with children and dogs. / Calderón-Garcidueñas, Lilian; Mora-Tiscareño, Antonieta; Ontiveros, Esperanza; Gómez-Garza, Gilberto; Barragán-Mejía, Gerardo; Broadway, James; Chapman, Susan; Valencia-Salazar, Gildardo; Jewells, Valerie; Maronpot, Robert R.; Henríquez-Roldán, Carlos; Pérez-Guillé, Beatriz; Torres-Jardón, Ricardo; Herrit, Lou; Brooks, Diane; Osnaya-Brizuela, Norma; Monroy, Maria E.; González-Maciel, Angelica; Reynoso-Robles, Rafael; Villarreal-Calderon, Rafael; Solt, Anna C.; Engle, Randall W.

In: Brain and Cognition, Vol. 68, No. 2, 01.11.2008, p. 117-127.

Research output: Contribution to journalArticle

Calderón-Garcidueñas, L, Mora-Tiscareño, A, Ontiveros, E, Gómez-Garza, G, Barragán-Mejía, G, Broadway, J, Chapman, S, Valencia-Salazar, G, Jewells, V, Maronpot, RR, Henríquez-Roldán, C, Pérez-Guillé, B, Torres-Jardón, R, Herrit, L, Brooks, D, Osnaya-Brizuela, N, Monroy, ME, González-Maciel, A, Reynoso-Robles, R, Villarreal-Calderon, R, Solt, AC & Engle, RW 2008, 'Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs', Brain and Cognition, vol. 68, no. 2, pp. 117-127. https://doi.org/10.1016/j.bandc.2008.04.008
Calderón-Garcidueñas L, Mora-Tiscareño A, Ontiveros E, Gómez-Garza G, Barragán-Mejía G, Broadway J et al. Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs. Brain and Cognition. 2008 Nov 1;68(2):117-127. https://doi.org/10.1016/j.bandc.2008.04.008
Calderón-Garcidueñas, Lilian ; Mora-Tiscareño, Antonieta ; Ontiveros, Esperanza ; Gómez-Garza, Gilberto ; Barragán-Mejía, Gerardo ; Broadway, James ; Chapman, Susan ; Valencia-Salazar, Gildardo ; Jewells, Valerie ; Maronpot, Robert R. ; Henríquez-Roldán, Carlos ; Pérez-Guillé, Beatriz ; Torres-Jardón, Ricardo ; Herrit, Lou ; Brooks, Diane ; Osnaya-Brizuela, Norma ; Monroy, Maria E. ; González-Maciel, Angelica ; Reynoso-Robles, Rafael ; Villarreal-Calderon, Rafael ; Solt, Anna C. ; Engle, Randall W. / Air pollution, cognitive deficits and brain abnormalities : A pilot study with children and dogs. In: Brain and Cognition. 2008 ; Vol. 68, No. 2. pp. 117-127.
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