Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer

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Abstract

Background: Heterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported. Methods: Four previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking. Results: While some quantitative variation was evident, distinct molecular subtype schemes showed considerable consistency in the association with the risk factors. Generally, compared to patients with luminal-like tumors, patients with basal-like subtypes were more likely to be older (OR75 + yrs vs. <60 years range = 1.32–2.89), obese (ORobese vs. normal range = 1.30–3.05), and to start smoking at early age (OR<18 years vs. 25+ years range = 1.11–4.57). Conclusions: Different molecular subtypes of MIBC may have distinct risk profiles. Large population-based studies with detailed information on bladder cancer risk factors are needed to further define etiologic heterogeneity for bladder cancer.

LanguageEnglish (US)
Pages539-544
Number of pages6
JournalCancer Causes and Control
Volume28
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Urinary Bladder Neoplasms
Obesity
Smoking
Muscles
Genome
Neoplasms
Atlases
Reference Values
Logistic Models
Demography
RNA
Gene Expression
Messenger RNA
Population

Keywords

  • Age
  • Molecular subtype
  • Muscle-invasive bladder cancer
  • Obesity
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer",
abstract = "Background: Heterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported. Methods: Four previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking. Results: While some quantitative variation was evident, distinct molecular subtype schemes showed considerable consistency in the association with the risk factors. Generally, compared to patients with luminal-like tumors, patients with basal-like subtypes were more likely to be older (OR75 + yrs vs. <60 years range = 1.32–2.89), obese (ORobese vs. normal range = 1.30–3.05), and to start smoking at early age (OR<18 years vs. 25+ years range = 1.11–4.57). Conclusions: Different molecular subtypes of MIBC may have distinct risk profiles. Large population-based studies with detailed information on bladder cancer risk factors are needed to further define etiologic heterogeneity for bladder cancer.",
keywords = "Age, Molecular subtype, Muscle-invasive bladder cancer, Obesity, Smoking",
author = "Xuezheng Sun and Hoadley, {Katherine A.} and Kim, {William Y.} and Helena Furberg and Olshan, {Andrew F.} and Troester, {Melissa A.}",
year = "2017",
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doi = "10.1007/s10552-017-0885-z",
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T1 - Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer

AU - Sun,Xuezheng

AU - Hoadley,Katherine A.

AU - Kim,William Y.

AU - Furberg,Helena

AU - Olshan,Andrew F.

AU - Troester,Melissa A.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Heterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported. Methods: Four previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking. Results: While some quantitative variation was evident, distinct molecular subtype schemes showed considerable consistency in the association with the risk factors. Generally, compared to patients with luminal-like tumors, patients with basal-like subtypes were more likely to be older (OR75 + yrs vs. <60 years range = 1.32–2.89), obese (ORobese vs. normal range = 1.30–3.05), and to start smoking at early age (OR<18 years vs. 25+ years range = 1.11–4.57). Conclusions: Different molecular subtypes of MIBC may have distinct risk profiles. Large population-based studies with detailed information on bladder cancer risk factors are needed to further define etiologic heterogeneity for bladder cancer.

AB - Background: Heterogeneity of muscle-invasive bladder cancer (MIBC) has been characterized using whole-genome mRNA expression data, showing distinct molecular and clinicopathological characteristics by subtypes. However, associations between risk factors and molecular subtypes have not been reported. Methods: Four previously published schemes were used to categorize molecular subtypes in 372 MIBC patients from the Cancer Genome Atlas (TCGA). Data on gene expression (RNA-seq), demographic, and clinicopathological characteristics were retrieved through TCGA data portal. Polytomous logistic regression was used to estimate the associations of subtypes by different schemes with age at diagnosis, obesity, and smoking. Results: While some quantitative variation was evident, distinct molecular subtype schemes showed considerable consistency in the association with the risk factors. Generally, compared to patients with luminal-like tumors, patients with basal-like subtypes were more likely to be older (OR75 + yrs vs. <60 years range = 1.32–2.89), obese (ORobese vs. normal range = 1.30–3.05), and to start smoking at early age (OR<18 years vs. 25+ years range = 1.11–4.57). Conclusions: Different molecular subtypes of MIBC may have distinct risk profiles. Large population-based studies with detailed information on bladder cancer risk factors are needed to further define etiologic heterogeneity for bladder cancer.

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