[Additional karyotypic abnormalities analysis in patients with hematological malignancies post-allogeneic hematopoietic stem cell transplantation].

Jia wei Zhao, Wei hua Zhai, Cheng wen Li, Qin Zhang, Fang yun Xu, Heng hua Chen, Jin ya Yue, Ming zhe Han

Research output: Contribution to journalArticle

Abstract

To analyze the karyotype stability in hematological malignancies patients before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its prognostic significance of monitoring. The karyotypes and clinical data of 21 patients with hematological malignancies at the initial diagnosis and at relapse after allo-HSCT were retrospectively reviewed. Chromosome analysis was performed by standard 24 h-cultured method and R banding. Karyotypes at the initial diagnosis and at relapse after allo-HSCT were different in 11 patients (52.38%), including chromosome 1, 3, 6, 12, 17, 21. Numberical abnormalities and structural chromosomal abnormalities always occurs together. The median survival time of relapse of the patients with karyotype changes was significantly shorter than that of patients without a karyotype change (79 d vs 522 d, P = 0.027), and that of the patients with trisomy 6 was also significantly shorter than that of the patients without trisomy 6 (9 d vs 275 d, P = 0.005). Karyotype changes after relapse are associated with the prognosis of allo-HSCT.

LanguageEnglish (US)
Pages619-622
Number of pages4
JournalZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Volume33
Issue number8
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Hematologic Neoplasms
Karyotype
Recurrence
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Trisomy
Chromosome Aberrations
Chromosomes
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

[Additional karyotypic abnormalities analysis in patients with hematological malignancies post-allogeneic hematopoietic stem cell transplantation]. / Zhao, Jia wei; Zhai, Wei hua; Li, Cheng wen; Zhang, Qin; Xu, Fang yun; Chen, Heng hua; Yue, Jin ya; Han, Ming zhe.

In: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, Vol. 33, No. 8, 08.2012, p. 619-622.

Research output: Contribution to journalArticle

Zhao, Jia wei ; Zhai, Wei hua ; Li, Cheng wen ; Zhang, Qin ; Xu, Fang yun ; Chen, Heng hua ; Yue, Jin ya ; Han, Ming zhe. / [Additional karyotypic abnormalities analysis in patients with hematological malignancies post-allogeneic hematopoietic stem cell transplantation].In: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2012 ; Vol. 33, No. 8. pp. 619-622
@article{398a3cbd422f47a18f0a7bb2b80d6255,
title = "[Additional karyotypic abnormalities analysis in patients with hematological malignancies post-allogeneic hematopoietic stem cell transplantation].",
abstract = "To analyze the karyotype stability in hematological malignancies patients before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its prognostic significance of monitoring. The karyotypes and clinical data of 21 patients with hematological malignancies at the initial diagnosis and at relapse after allo-HSCT were retrospectively reviewed. Chromosome analysis was performed by standard 24 h-cultured method and R banding. Karyotypes at the initial diagnosis and at relapse after allo-HSCT were different in 11 patients (52.38{\%}), including chromosome 1, 3, 6, 12, 17, 21. Numberical abnormalities and structural chromosomal abnormalities always occurs together. The median survival time of relapse of the patients with karyotype changes was significantly shorter than that of patients without a karyotype change (79 d vs 522 d, P = 0.027), and that of the patients with trisomy 6 was also significantly shorter than that of the patients without trisomy 6 (9 d vs 275 d, P = 0.005). Karyotype changes after relapse are associated with the prognosis of allo-HSCT.",
author = "Zhao, {Jia wei} and Zhai, {Wei hua} and Li, {Cheng wen} and Qin Zhang and Xu, {Fang yun} and Chen, {Heng hua} and Yue, {Jin ya} and Han, {Ming zhe}",
year = "2012",
month = "8",
language = "English (US)",
volume = "33",
pages = "619--622",
journal = "Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi",
issn = "0253-2727",
publisher = "Zhongguo Yixue Kexueyuan",
number = "8",

}

TY - JOUR

T1 - [Additional karyotypic abnormalities analysis in patients with hematological malignancies post-allogeneic hematopoietic stem cell transplantation].

AU - Zhao,Jia wei

AU - Zhai,Wei hua

AU - Li,Cheng wen

AU - Zhang,Qin

AU - Xu,Fang yun

AU - Chen,Heng hua

AU - Yue,Jin ya

AU - Han,Ming zhe

PY - 2012/8

Y1 - 2012/8

N2 - To analyze the karyotype stability in hematological malignancies patients before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its prognostic significance of monitoring. The karyotypes and clinical data of 21 patients with hematological malignancies at the initial diagnosis and at relapse after allo-HSCT were retrospectively reviewed. Chromosome analysis was performed by standard 24 h-cultured method and R banding. Karyotypes at the initial diagnosis and at relapse after allo-HSCT were different in 11 patients (52.38%), including chromosome 1, 3, 6, 12, 17, 21. Numberical abnormalities and structural chromosomal abnormalities always occurs together. The median survival time of relapse of the patients with karyotype changes was significantly shorter than that of patients without a karyotype change (79 d vs 522 d, P = 0.027), and that of the patients with trisomy 6 was also significantly shorter than that of the patients without trisomy 6 (9 d vs 275 d, P = 0.005). Karyotype changes after relapse are associated with the prognosis of allo-HSCT.

AB - To analyze the karyotype stability in hematological malignancies patients before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its prognostic significance of monitoring. The karyotypes and clinical data of 21 patients with hematological malignancies at the initial diagnosis and at relapse after allo-HSCT were retrospectively reviewed. Chromosome analysis was performed by standard 24 h-cultured method and R banding. Karyotypes at the initial diagnosis and at relapse after allo-HSCT were different in 11 patients (52.38%), including chromosome 1, 3, 6, 12, 17, 21. Numberical abnormalities and structural chromosomal abnormalities always occurs together. The median survival time of relapse of the patients with karyotype changes was significantly shorter than that of patients without a karyotype change (79 d vs 522 d, P = 0.027), and that of the patients with trisomy 6 was also significantly shorter than that of the patients without trisomy 6 (9 d vs 275 d, P = 0.005). Karyotype changes after relapse are associated with the prognosis of allo-HSCT.

UR - http://www.scopus.com/inward/record.url?scp=84885901047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885901047&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 619

EP - 622

JO - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

T2 - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

SN - 0253-2727

IS - 8

ER -