Acute stress modifies oscillatory indices of affective processing: Insight on the pathophysiology of schizophrenia spectrum disorders

Elizabeth Andersen, Alana Campbell, Susan S Girdler, Kelly Duffy, Aysenil Belger

Research output: Contribution to journalArticle

Abstract

Objective: The current study evaluated the differential impact of acute psychosocial stress exposure on oscillatory correlates of affective processing in control participants and patients with schizophrenia spectrum disorders (SCZ) to elucidate the stress-mediated pathway to psychopathology. Methods: EEG was recorded while 21 control participants and 21 patients with SCZ performed emotional framing tasks (assessing a key aspect of emotion regulation (ER)) before and after a laboratory stress challenge (Trier Social Stress Test). EEG spectral perturbations evoked in response to neutral and aversive stimuli (presented with positive or negative contextual cues) were extracted in theta (4–8 Hz) and beta (12–30 Hz) frequencies. Results: Patients demonstrated aberrant theta and beta oscillatory activity, with impaired frontal theta-mediated framing and beta-derived motivated attention processes relative to controls. Following stress exposure, controls exhibited impaired frontal theta-mediated emotional framing, similar to the oscillatory profile observed in patients before stress. Conclusions: The acute stress-induced oscillatory changes observed in controls were persistently present in patients, indicating an inefficiency of fronto-limbic adaptation to stress exposure. Significance: Results provide novel insight on the electrophysiological correlates of arousal and affect regulation, which are core homogeneous symptom dimensions shared across neuropsychiatric disorders, and shed light on putative mechanisms in the translation of stress into psychopathology.

LanguageEnglish (US)
Pages214-223
Number of pages10
JournalClinical Neurophysiology
Volume130
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Schizophrenia
Psychopathology
Electroencephalography
Arousal
Exercise Test
Cues
Emotions

Keywords

  • Emotion regulation
  • HPA reactivity
  • Psychosocial stress
  • Schizophrenia
  • Theta and beta oscillatory activity
  • Trier Social Stress Test (TSST)

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Acute stress modifies oscillatory indices of affective processing : Insight on the pathophysiology of schizophrenia spectrum disorders. / Andersen, Elizabeth; Campbell, Alana; Girdler, Susan S; Duffy, Kelly; Belger, Aysenil.

In: Clinical Neurophysiology, Vol. 130, No. 2, 01.02.2019, p. 214-223.

Research output: Contribution to journalArticle

@article{d1cdb5e9d89443249642913d27e8d33f,
title = "Acute stress modifies oscillatory indices of affective processing: Insight on the pathophysiology of schizophrenia spectrum disorders",
abstract = "Objective: The current study evaluated the differential impact of acute psychosocial stress exposure on oscillatory correlates of affective processing in control participants and patients with schizophrenia spectrum disorders (SCZ) to elucidate the stress-mediated pathway to psychopathology. Methods: EEG was recorded while 21 control participants and 21 patients with SCZ performed emotional framing tasks (assessing a key aspect of emotion regulation (ER)) before and after a laboratory stress challenge (Trier Social Stress Test). EEG spectral perturbations evoked in response to neutral and aversive stimuli (presented with positive or negative contextual cues) were extracted in theta (4–8 Hz) and beta (12–30 Hz) frequencies. Results: Patients demonstrated aberrant theta and beta oscillatory activity, with impaired frontal theta-mediated framing and beta-derived motivated attention processes relative to controls. Following stress exposure, controls exhibited impaired frontal theta-mediated emotional framing, similar to the oscillatory profile observed in patients before stress. Conclusions: The acute stress-induced oscillatory changes observed in controls were persistently present in patients, indicating an inefficiency of fronto-limbic adaptation to stress exposure. Significance: Results provide novel insight on the electrophysiological correlates of arousal and affect regulation, which are core homogeneous symptom dimensions shared across neuropsychiatric disorders, and shed light on putative mechanisms in the translation of stress into psychopathology.",
keywords = "Emotion regulation, HPA reactivity, Psychosocial stress, Schizophrenia, Theta and beta oscillatory activity, Trier Social Stress Test (TSST)",
author = "Elizabeth Andersen and Alana Campbell and Girdler, {Susan S} and Kelly Duffy and Aysenil Belger",
year = "2019",
month = "2",
day = "1",
doi = "10.1016/j.clinph.2018.10.019",
language = "English (US)",
volume = "130",
pages = "214--223",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Acute stress modifies oscillatory indices of affective processing

T2 - Clinical Neurophysiology

AU - Andersen, Elizabeth

AU - Campbell, Alana

AU - Girdler, Susan S

AU - Duffy, Kelly

AU - Belger, Aysenil

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Objective: The current study evaluated the differential impact of acute psychosocial stress exposure on oscillatory correlates of affective processing in control participants and patients with schizophrenia spectrum disorders (SCZ) to elucidate the stress-mediated pathway to psychopathology. Methods: EEG was recorded while 21 control participants and 21 patients with SCZ performed emotional framing tasks (assessing a key aspect of emotion regulation (ER)) before and after a laboratory stress challenge (Trier Social Stress Test). EEG spectral perturbations evoked in response to neutral and aversive stimuli (presented with positive or negative contextual cues) were extracted in theta (4–8 Hz) and beta (12–30 Hz) frequencies. Results: Patients demonstrated aberrant theta and beta oscillatory activity, with impaired frontal theta-mediated framing and beta-derived motivated attention processes relative to controls. Following stress exposure, controls exhibited impaired frontal theta-mediated emotional framing, similar to the oscillatory profile observed in patients before stress. Conclusions: The acute stress-induced oscillatory changes observed in controls were persistently present in patients, indicating an inefficiency of fronto-limbic adaptation to stress exposure. Significance: Results provide novel insight on the electrophysiological correlates of arousal and affect regulation, which are core homogeneous symptom dimensions shared across neuropsychiatric disorders, and shed light on putative mechanisms in the translation of stress into psychopathology.

AB - Objective: The current study evaluated the differential impact of acute psychosocial stress exposure on oscillatory correlates of affective processing in control participants and patients with schizophrenia spectrum disorders (SCZ) to elucidate the stress-mediated pathway to psychopathology. Methods: EEG was recorded while 21 control participants and 21 patients with SCZ performed emotional framing tasks (assessing a key aspect of emotion regulation (ER)) before and after a laboratory stress challenge (Trier Social Stress Test). EEG spectral perturbations evoked in response to neutral and aversive stimuli (presented with positive or negative contextual cues) were extracted in theta (4–8 Hz) and beta (12–30 Hz) frequencies. Results: Patients demonstrated aberrant theta and beta oscillatory activity, with impaired frontal theta-mediated framing and beta-derived motivated attention processes relative to controls. Following stress exposure, controls exhibited impaired frontal theta-mediated emotional framing, similar to the oscillatory profile observed in patients before stress. Conclusions: The acute stress-induced oscillatory changes observed in controls were persistently present in patients, indicating an inefficiency of fronto-limbic adaptation to stress exposure. Significance: Results provide novel insight on the electrophysiological correlates of arousal and affect regulation, which are core homogeneous symptom dimensions shared across neuropsychiatric disorders, and shed light on putative mechanisms in the translation of stress into psychopathology.

KW - Emotion regulation

KW - HPA reactivity

KW - Psychosocial stress

KW - Schizophrenia

KW - Theta and beta oscillatory activity

KW - Trier Social Stress Test (TSST)

UR - http://www.scopus.com/inward/record.url?scp=85058665681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058665681&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2018.10.019

DO - 10.1016/j.clinph.2018.10.019

M3 - Article

VL - 130

SP - 214

EP - 223

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 2

ER -