Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain

Tony W. Wilson, Amy L. Proskovec, Elizabeth Heinrichs-Graham, Jennifer O'Neill, Kevin R. Robertson, Howard S. Fox, Susan Swindells

Research output: Research - peer-reviewArticle

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Abstract

Impairments in working memory are among the most prevalent features of HIV-associated neurocognitive disorders (HAND), yet their origins are unknown, with some studies arguing that encoding operations are disturbed and others supporting deficits in memory maintenance. The current investigation directly addresses this issue by using a dynamic mapping approach to identify when and where processing in working memory circuits degrades. HIV-infected older adults and a demographically-matched group of uninfected controls performed a verbal working memory task during magnetoencephalography (MEG). Significant oscillatory neural responses were imaged using a beamforming approach to illuminate the spatiotemporal dynamics of neuronal activity. HIV-infected patients were significantly less accurate on the working memory task and their neuronal dynamics indicated that encoding operations were preserved, while memory maintenance processes were abnormal. Specifically, no group differences were detected during the encoding period, yet dysfunction in occipital, fronto-temporal, hippocampal, and cerebellar cortices emerged during memory maintenance. In addition, task performance in the controls covaried with occipital alpha synchronization and activity in right prefrontal cortices. In conclusion, working memory impairments are common and significantly impact the daily functioning and independence of HIV-infected patients. These impairments likely reflect deficits in the maintenance of memory representations, not failures to adequately encode stimuli.

LanguageEnglish (US)
Article number41568
JournalScientific Reports
Volume7
DOIs
StatePublished - Feb 3 2017

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Short-Term Memory
HIV
Brain
Maintenance
Magnetoencephalography
Cerebellar Cortex
Memory Disorders
Task Performance and Analysis
Temporal Lobe
Prefrontal Cortex
Research Design
Neurocognitive Disorders

ASJC Scopus subject areas

  • General

Cite this

Wilson, T. W., Proskovec, A. L., Heinrichs-Graham, E., O'Neill, J., Robertson, K. R., Fox, H. S., & Swindells, S. (2017). Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain. Scientific Reports, 7, [41568]. DOI: 10.1038/srep41568

Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain. / Wilson, Tony W.; Proskovec, Amy L.; Heinrichs-Graham, Elizabeth; O'Neill, Jennifer; Robertson, Kevin R.; Fox, Howard S.; Swindells, Susan.

In: Scientific Reports, Vol. 7, 41568, 03.02.2017.

Research output: Research - peer-reviewArticle

Wilson, TW, Proskovec, AL, Heinrichs-Graham, E, O'Neill, J, Robertson, KR, Fox, HS & Swindells, S 2017, 'Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain' Scientific Reports, vol 7, 41568. DOI: 10.1038/srep41568
Wilson TW, Proskovec AL, Heinrichs-Graham E, O'Neill J, Robertson KR, Fox HS et al. Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain. Scientific Reports. 2017 Feb 3;7. 41568. Available from, DOI: 10.1038/srep41568
Wilson, Tony W. ; Proskovec, Amy L. ; Heinrichs-Graham, Elizabeth ; O'Neill, Jennifer ; Robertson, Kevin R. ; Fox, Howard S. ; Swindells, Susan. / Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain. In: Scientific Reports. 2017 ; Vol. 7.
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