Abstract
Nucleotide excision repair is the major pathway for removing damage from DNA. (A)BC excinuclease is the nuclease activity which initiates nucleotide excision repair in Escherichia coli. In this review, we focus on current understanding of the structure-function of the enzyme and the reaction mechanism of the repair pathway. In addition, recent biochemical studies on preferential repair of actively transcribed genes in E. coli are summarized.
| Language | English (US) |
|---|---|
| Pages | 2219-2224 |
| Number of pages | 6 |
| Journal | Molecular Microbiology |
| Volume | 6 |
| Issue number | 16 |
| State | Published - Aug 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Microbiology
Cite this
(A)BC excinuclease : The Escherichia coli nucleotide excision repair enzyme. / Lin, Jing Jer; Sancar, Aziz.
In: Molecular Microbiology, Vol. 6, No. 16, 08.1992, p. 2219-2224.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - (A)BC excinuclease
T2 - Molecular Microbiology
AU - Lin,Jing Jer
AU - Sancar,Aziz
PY - 1992/8
Y1 - 1992/8
N2 - Nucleotide excision repair is the major pathway for removing damage from DNA. (A)BC excinuclease is the nuclease activity which initiates nucleotide excision repair in Escherichia coli. In this review, we focus on current understanding of the structure-function of the enzyme and the reaction mechanism of the repair pathway. In addition, recent biochemical studies on preferential repair of actively transcribed genes in E. coli are summarized.
AB - Nucleotide excision repair is the major pathway for removing damage from DNA. (A)BC excinuclease is the nuclease activity which initiates nucleotide excision repair in Escherichia coli. In this review, we focus on current understanding of the structure-function of the enzyme and the reaction mechanism of the repair pathway. In addition, recent biochemical studies on preferential repair of actively transcribed genes in E. coli are summarized.
UR - http://www.scopus.com/inward/record.url?scp=0026754657&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026754657&partnerID=8YFLogxK
M3 - Review article
VL - 6
SP - 2219
EP - 2224
JO - Molecular Microbiology
JF - Molecular Microbiology
SN - 0950-382X
IS - 16
ER -