A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart

Junnan Tang, Adam Vandergriff, Zegen Wang, Michael Taylor Hensley, Jhon Cores, Tyler A. Allen, Phuong Uyen Dinh, Jinying Zhang, Thomas George Caranasos, Ke Cheng

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction (MI). However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic, therefore prevents the translation of this strategy into the clinic. We sought to device a way to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure. To prove the concept, we used platelet fibrin gel as the "paint" material in a mouse model of MI. The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue. The spray treatment promoted cardiac repair and attenuated cardiac dysfunction after MI.

LanguageEnglish (US)
Pages146-155
Number of pages10
JournalTissue Engineering - Part C: Methods
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Paintings
Biocompatible Materials
Paint spraying
Biomaterials
Myocardial Infarction
Paint
Fibrin
Adhesives
Sutures
Polymers
Thorax
Blood Platelets
Gels
Equipment and Supplies
Glues
Spraying
Platelets
Scaffolds
Surgery
Repair

Keywords

  • Cardiac patch
  • Myocardial infarction
  • Platelet fibrin gel
  • Regeneration

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Tang, J., Vandergriff, A., Wang, Z., Hensley, M. T., Cores, J., Allen, T. A., ... Cheng, K. (2017). A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Engineering - Part C: Methods, 23(3), 146-155. DOI: 10.1089/ten.tec.2016.0492

A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. / Tang, Junnan; Vandergriff, Adam; Wang, Zegen; Hensley, Michael Taylor; Cores, Jhon; Allen, Tyler A.; Dinh, Phuong Uyen; Zhang, Jinying; Caranasos, Thomas George; Cheng, Ke.

In: Tissue Engineering - Part C: Methods, Vol. 23, No. 3, 01.03.2017, p. 146-155.

Research output: Research - peer-reviewArticle

Tang, J, Vandergriff, A, Wang, Z, Hensley, MT, Cores, J, Allen, TA, Dinh, PU, Zhang, J, Caranasos, TG & Cheng, K 2017, 'A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart' Tissue Engineering - Part C: Methods, vol 23, no. 3, pp. 146-155. DOI: 10.1089/ten.tec.2016.0492
Tang J, Vandergriff A, Wang Z, Hensley MT, Cores J, Allen TA et al. A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Engineering - Part C: Methods. 2017 Mar 1;23(3):146-155. Available from, DOI: 10.1089/ten.tec.2016.0492
Tang, Junnan ; Vandergriff, Adam ; Wang, Zegen ; Hensley, Michael Taylor ; Cores, Jhon ; Allen, Tyler A. ; Dinh, Phuong Uyen ; Zhang, Jinying ; Caranasos, Thomas George ; Cheng, Ke. / A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. In: Tissue Engineering - Part C: Methods. 2017 ; Vol. 23, No. 3. pp. 146-155
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