A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans

Jerod M. Rasmussen, Frithjof Kruggel, John H. Gilmore, Martin Styner, Sonja Entringer, Kirsten N.Z. Consing, Steven G. Potkin, Pathik D. Wadhwa, Claudia Buss

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

Human birth presents an abrupt transition from intrauterine to extrauterine life. Here we introduce a novel Maturation Index (MI) that considers the relative importance of gestational age at birth and postnatal age at scan in a General Linear Model. The MI is then applied to Diffusion Tensor Imaging (DTI) in newborns for characterizing typical white matter development in neonates. DTI was performed cross-sectionally in 47 neonates (gestational age at birth = 39.1 ± 1.6 weeks [GA], postnatal age at scan = 25.5 ± 12.2 days [SA]). Radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) along 27 white matter fiber tracts were considered. The MI was used to characterize inflection in maturation at the time of birth using GLM estimated rates of change before and after birth. It is proposed that the sign (positive versus negative) of MI reflects the period of greatest maturation rate. Two general patterns emerged from the MI analysis. First, RD and AD (but not FA) had positive MI on average across the whole brain (average MIAD = 0.31 ± 0.42, average MIRD = 0.22 ± 0.34). Second, significant regions of negative MI in RD and FA (but not AD) were observed in the inferior corticospinal regions, areas known to myelinate early. Observations using the proposed method are consistent with proposed models of the white matter maturation process in which pre-myelination is described by changes in AD and RD due to oligodendrocyte proliferation while true myelination is characterized by changes in RD and FA due to myelin formation.

LanguageEnglish (US)
Pages42-51
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Volume56
DOIs
StatePublished - Feb 1 2017

Fingerprint

Diffusion Tensor Imaging
Human Development
Parturition
White Matter
Anisotropy
Gestational Age
Oligodendroglia
Myelin Sheath
Linear Models
Brain

Keywords

  • Age
  • Birth
  • DTI
  • Gestational
  • Myelination
  • Non-linear
  • Ontology
  • Postnatal

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Cite this

A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans. / Rasmussen, Jerod M.; Kruggel, Frithjof; Gilmore, John H.; Styner, Martin; Entringer, Sonja; Consing, Kirsten N.Z.; Potkin, Steven G.; Wadhwa, Pathik D.; Buss, Claudia.

In: International Journal of Developmental Neuroscience, Vol. 56, 01.02.2017, p. 42-51.

Research output: Research - peer-reviewArticle

Rasmussen, Jerod M. ; Kruggel, Frithjof ; Gilmore, John H. ; Styner, Martin ; Entringer, Sonja ; Consing, Kirsten N.Z. ; Potkin, Steven G. ; Wadhwa, Pathik D. ; Buss, Claudia. / A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans. In: International Journal of Developmental Neuroscience. 2017 ; Vol. 56. pp. 42-51
@article{6cacd5e2e908403494e1f9559592a766,
title = "A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans",
abstract = "Human birth presents an abrupt transition from intrauterine to extrauterine life. Here we introduce a novel Maturation Index (MI) that considers the relative importance of gestational age at birth and postnatal age at scan in a General Linear Model. The MI is then applied to Diffusion Tensor Imaging (DTI) in newborns for characterizing typical white matter development in neonates. DTI was performed cross-sectionally in 47 neonates (gestational age at birth = 39.1 ± 1.6 weeks [GA], postnatal age at scan = 25.5 ± 12.2 days [SA]). Radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) along 27 white matter fiber tracts were considered. The MI was used to characterize inflection in maturation at the time of birth using GLM estimated rates of change before and after birth. It is proposed that the sign (positive versus negative) of MI reflects the period of greatest maturation rate. Two general patterns emerged from the MI analysis. First, RD and AD (but not FA) had positive MI on average across the whole brain (average MIAD = 0.31 ± 0.42, average MIRD = 0.22 ± 0.34). Second, significant regions of negative MI in RD and FA (but not AD) were observed in the inferior corticospinal regions, areas known to myelinate early. Observations using the proposed method are consistent with proposed models of the white matter maturation process in which pre-myelination is described by changes in AD and RD due to oligodendrocyte proliferation while true myelination is characterized by changes in RD and FA due to myelin formation.",
keywords = "Age, Birth, DTI, Gestational, Myelination, Non-linear, Ontology, Postnatal",
author = "Rasmussen, {Jerod M.} and Frithjof Kruggel and Gilmore, {John H.} and Martin Styner and Sonja Entringer and Consing, {Kirsten N.Z.} and Potkin, {Steven G.} and Wadhwa, {Pathik D.} and Claudia Buss",
year = "2017",
month = "2",
doi = "10.1016/j.ijdevneu.2016.12.004",
volume = "56",
pages = "42--51",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans

AU - Rasmussen,Jerod M.

AU - Kruggel,Frithjof

AU - Gilmore,John H.

AU - Styner,Martin

AU - Entringer,Sonja

AU - Consing,Kirsten N.Z.

AU - Potkin,Steven G.

AU - Wadhwa,Pathik D.

AU - Buss,Claudia

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Human birth presents an abrupt transition from intrauterine to extrauterine life. Here we introduce a novel Maturation Index (MI) that considers the relative importance of gestational age at birth and postnatal age at scan in a General Linear Model. The MI is then applied to Diffusion Tensor Imaging (DTI) in newborns for characterizing typical white matter development in neonates. DTI was performed cross-sectionally in 47 neonates (gestational age at birth = 39.1 ± 1.6 weeks [GA], postnatal age at scan = 25.5 ± 12.2 days [SA]). Radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) along 27 white matter fiber tracts were considered. The MI was used to characterize inflection in maturation at the time of birth using GLM estimated rates of change before and after birth. It is proposed that the sign (positive versus negative) of MI reflects the period of greatest maturation rate. Two general patterns emerged from the MI analysis. First, RD and AD (but not FA) had positive MI on average across the whole brain (average MIAD = 0.31 ± 0.42, average MIRD = 0.22 ± 0.34). Second, significant regions of negative MI in RD and FA (but not AD) were observed in the inferior corticospinal regions, areas known to myelinate early. Observations using the proposed method are consistent with proposed models of the white matter maturation process in which pre-myelination is described by changes in AD and RD due to oligodendrocyte proliferation while true myelination is characterized by changes in RD and FA due to myelin formation.

AB - Human birth presents an abrupt transition from intrauterine to extrauterine life. Here we introduce a novel Maturation Index (MI) that considers the relative importance of gestational age at birth and postnatal age at scan in a General Linear Model. The MI is then applied to Diffusion Tensor Imaging (DTI) in newborns for characterizing typical white matter development in neonates. DTI was performed cross-sectionally in 47 neonates (gestational age at birth = 39.1 ± 1.6 weeks [GA], postnatal age at scan = 25.5 ± 12.2 days [SA]). Radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) along 27 white matter fiber tracts were considered. The MI was used to characterize inflection in maturation at the time of birth using GLM estimated rates of change before and after birth. It is proposed that the sign (positive versus negative) of MI reflects the period of greatest maturation rate. Two general patterns emerged from the MI analysis. First, RD and AD (but not FA) had positive MI on average across the whole brain (average MIAD = 0.31 ± 0.42, average MIRD = 0.22 ± 0.34). Second, significant regions of negative MI in RD and FA (but not AD) were observed in the inferior corticospinal regions, areas known to myelinate early. Observations using the proposed method are consistent with proposed models of the white matter maturation process in which pre-myelination is described by changes in AD and RD due to oligodendrocyte proliferation while true myelination is characterized by changes in RD and FA due to myelin formation.

KW - Age

KW - Birth

KW - DTI

KW - Gestational

KW - Myelination

KW - Non-linear

KW - Ontology

KW - Postnatal

UR - http://www.scopus.com/inward/record.url?scp=85007318459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007318459&partnerID=8YFLogxK

U2 - 10.1016/j.ijdevneu.2016.12.004

DO - 10.1016/j.ijdevneu.2016.12.004

M3 - Article

VL - 56

SP - 42

EP - 51

JO - International Journal of Developmental Neuroscience

T2 - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

ER -