A design thinking approach to primary ovarian insufficiency

Lisa Arndt Martin, Alison Gatewood Porter, Vincent A. Pelligrini, Peter F. Schnatz, Xuezhi Jiang, Nicole Kleinstreuer, Janet E. Hall, Sarah Verbiest, Jill Olmstead, Ryan Fair, Alberto Falorni, Luca Persani, Aleksandar Rajkovic, Khanjan Mehta, Lawrence M. Nelson, Rachel's Well Primary Ovarian Insufficiency Community of Practice Group

Research output: Research - peer-reviewReview article

Abstract

Most clinicians are not prepared to provide integrated personal care to address all the clinical needs of women with primary ovarian insufficiency. Design thinking is an engineering methodology used to develop and evaluate novel concepts for systems operation. Here we articulate the need for a seamlessly integrated mobile health system to support genomic research as well as patient care. We also review the pathophysiology and management of primary ovarian insufficiency. Molecular understanding regarding the pathogenesis is essential to developing strategies for prevention, earlier diagnosis, and appropriate management of the disorder. The syndrome is a chronic disorder characterized by oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 years. There may be significant morbidity due to: 1) depression and anxiety related to the loss of reproductive hormones and infertility; 2) associated autoimmune adrenal insufficiency or hypothyroidism; and 3) reduced bone mineral density and increased risk of cardiovascular disease related to estrogen deficiency. Approximately 5% to 10% of women with primary ovarian insufficiency conceive and have a child. Women who develop primary ovarian insufficiency related to a premutation in FMR1 are at risk of having a child with fragile X syndrome, the most common cause of inherited intellectual disability. In most cases of spontaneous primary ovarian insufficiency no environmental exposure or genetic mechanism can be identified. As a rare disease, the diagnosis of primary ovarian insufficiency presents special challenges. Connecting patients and community health providers in real time with investigators who have the requisite knowledge and expertise would help solve this dilemma.

LanguageEnglish (US)
Pages15-32
Number of pages18
JournalPanminerva Medica
Volume59
Issue number1
DOIs
StatePublished - Mar 1 2017

Fingerprint

Primary Ovarian Insufficiency
Thinking
Fragile X Syndrome
Adrenal Insufficiency
Hypogonadism
Telemedicine
Amenorrhea
Environmental Exposure
Rare Diseases
Hypothyroidism
Intellectual Disability
Bone Density
Infertility
Early Diagnosis
Patient Care
Estrogens
Cardiovascular Diseases
Anxiety
Research Personnel
Hormones

Keywords

  • Menopause, premature
  • Primary ovarian insufficiency
  • Primary ovarian insufficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Martin, L. A., Porter, A. G., Pelligrini, V. A., Schnatz, P. F., Jiang, X., Kleinstreuer, N., ... Rachel's Well Primary Ovarian Insufficiency Community of Practice Group (2017). A design thinking approach to primary ovarian insufficiency. Panminerva Medica, 59(1), 15-32. DOI: 10.23736/S0031-0808.16.03259-6

A design thinking approach to primary ovarian insufficiency. / Martin, Lisa Arndt; Porter, Alison Gatewood; Pelligrini, Vincent A.; Schnatz, Peter F.; Jiang, Xuezhi; Kleinstreuer, Nicole; Hall, Janet E.; Verbiest, Sarah; Olmstead, Jill; Fair, Ryan; Falorni, Alberto; Persani, Luca; Rajkovic, Aleksandar; Mehta, Khanjan; Nelson, Lawrence M.; Rachel's Well Primary Ovarian Insufficiency Community of Practice Group.

In: Panminerva Medica, Vol. 59, No. 1, 01.03.2017, p. 15-32.

Research output: Research - peer-reviewReview article

Martin, LA, Porter, AG, Pelligrini, VA, Schnatz, PF, Jiang, X, Kleinstreuer, N, Hall, JE, Verbiest, S, Olmstead, J, Fair, R, Falorni, A, Persani, L, Rajkovic, A, Mehta, K, Nelson, LM & Rachel's Well Primary Ovarian Insufficiency Community of Practice Group 2017, 'A design thinking approach to primary ovarian insufficiency' Panminerva Medica, vol 59, no. 1, pp. 15-32. DOI: 10.23736/S0031-0808.16.03259-6
Martin LA, Porter AG, Pelligrini VA, Schnatz PF, Jiang X, Kleinstreuer N et al. A design thinking approach to primary ovarian insufficiency. Panminerva Medica. 2017 Mar 1;59(1):15-32. Available from, DOI: 10.23736/S0031-0808.16.03259-6
Martin, Lisa Arndt ; Porter, Alison Gatewood ; Pelligrini, Vincent A. ; Schnatz, Peter F. ; Jiang, Xuezhi ; Kleinstreuer, Nicole ; Hall, Janet E. ; Verbiest, Sarah ; Olmstead, Jill ; Fair, Ryan ; Falorni, Alberto ; Persani, Luca ; Rajkovic, Aleksandar ; Mehta, Khanjan ; Nelson, Lawrence M. ; Rachel's Well Primary Ovarian Insufficiency Community of Practice Group. / A design thinking approach to primary ovarian insufficiency. In: Panminerva Medica. 2017 ; Vol. 59, No. 1. pp. 15-32
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