[A comparative cytogenetic analysis in large scale between adult and childhood patients with acute lymphoblastic leukemia].

Xu Ping Liu, Xiao Fan Zhu, Jian Xiang Wang, Ying Chang Mi, Yao Zou, Yu Mei Chen, Cheng Wen Li, Yun Dai, Shuang Qin, Ji Gang Xiao, Fang Yun Xu, Jin Ying Gong, Si Ping Wang, Cheng Long Yu, Jing Fan

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Abstract

This study was purposed to comparatively analyze the cytogenetic characteristics between 566 cases of adult acute lymphoblastic leukemia (aALL) and 586 cases of childhood acute lymphoblastic leukemia (cALL). The cytogenetic analysis of all the patients was performed, and the FISH detection for partial patients was carried out. The result showed that the difference of chromosome abnormality between cALL and aALL was statistically significant. The percentage of abnormal karyotypes in aALL was 62.0%, including mainly t(9;22)(q34;q11), hypodiploidy, hyperdiploidy (47 - 50), abn(6q), abn(9p) and -7, most of which conferring an unfavorable prognosis. The percentage of abnormal karyotypes in cALL was 39.2%, composed mainly of high hyperdiploidy, hypodiploidy, TEL/AML1(+), +8, hyperdiploidy (47 - 50) and +21, etc, most of which conferring a favorable prognosis. The incidences of abnormal karyotypes, total hypodiploidy, total hyperdiploidy (47 - 50), t(9;22)(q34;q11), -7, abn(7q), abn(14q32) and +Ph in aALL were significantly higher than those of cALL (p < 0.05), whereas the incidences of normal karyotype (N), high hyperdiploidy, +8, +21*2 and TEL/AML1(+) in cALL were significantly higher than those of aALL (p < 0.05). 20.5% of aALL were Ph+ aALL, with 63.8% of which being with additional abnormalities, composed mainly of +Ph, -7, i (9q+), 9p-, +8, +21, +X, 6q-, abn(14q32) and +14. In contrast, only 4.4% of cALL were Ph+ aALL, with 42.3% of which being with additional abnormalities, including mainly abn(9p), abn(7p), -7, 17p- and +21. It is concluded that almost every chromosome is involved in the numerical and structural abnormalities and complex karyotypes are common. The significant difference of chromosome abnormality exists between aALL and cALL.

LanguageEnglish (US)
Pages1399-1404
Number of pages6
JournalZhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
Volume17
Issue number6
StatePublished - Dec 2009
Externally publishedYes

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Cytogenetic Analysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polyploidy
Abnormal Karyotype
Karyotype
Chromosome Aberrations
Incidence

ASJC Scopus subject areas

  • Medicine(all)

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[A comparative cytogenetic analysis in large scale between adult and childhood patients with acute lymphoblastic leukemia]. / Liu, Xu Ping; Zhu, Xiao Fan; Wang, Jian Xiang; Mi, Ying Chang; Zou, Yao; Chen, Yu Mei; Li, Cheng Wen; Dai, Yun; Qin, Shuang; Xiao, Ji Gang; Xu, Fang Yun; Gong, Jin Ying; Wang, Si Ping; Yu, Cheng Long; Fan, Jing.

In: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 17, No. 6, 12.2009, p. 1399-1404.

Research output: Contribution to journalArticle

Liu, Xu Ping ; Zhu, Xiao Fan ; Wang, Jian Xiang ; Mi, Ying Chang ; Zou, Yao ; Chen, Yu Mei ; Li, Cheng Wen ; Dai, Yun ; Qin, Shuang ; Xiao, Ji Gang ; Xu, Fang Yun ; Gong, Jin Ying ; Wang, Si Ping ; Yu, Cheng Long ; Fan, Jing. / [A comparative cytogenetic analysis in large scale between adult and childhood patients with acute lymphoblastic leukemia].In: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology. 2009 ; Vol. 17, No. 6. pp. 1399-1404
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title = "[A comparative cytogenetic analysis in large scale between adult and childhood patients with acute lymphoblastic leukemia].",
abstract = "This study was purposed to comparatively analyze the cytogenetic characteristics between 566 cases of adult acute lymphoblastic leukemia (aALL) and 586 cases of childhood acute lymphoblastic leukemia (cALL). The cytogenetic analysis of all the patients was performed, and the FISH detection for partial patients was carried out. The result showed that the difference of chromosome abnormality between cALL and aALL was statistically significant. The percentage of abnormal karyotypes in aALL was 62.0{\%}, including mainly t(9;22)(q34;q11), hypodiploidy, hyperdiploidy (47 - 50), abn(6q), abn(9p) and -7, most of which conferring an unfavorable prognosis. The percentage of abnormal karyotypes in cALL was 39.2{\%}, composed mainly of high hyperdiploidy, hypodiploidy, TEL/AML1(+), +8, hyperdiploidy (47 - 50) and +21, etc, most of which conferring a favorable prognosis. The incidences of abnormal karyotypes, total hypodiploidy, total hyperdiploidy (47 - 50), t(9;22)(q34;q11), -7, abn(7q), abn(14q32) and +Ph in aALL were significantly higher than those of cALL (p < 0.05), whereas the incidences of normal karyotype (N), high hyperdiploidy, +8, +21*2 and TEL/AML1(+) in cALL were significantly higher than those of aALL (p < 0.05). 20.5{\%} of aALL were Ph+ aALL, with 63.8{\%} of which being with additional abnormalities, composed mainly of +Ph, -7, i (9q+), 9p-, +8, +21, +X, 6q-, abn(14q32) and +14. In contrast, only 4.4{\%} of cALL were Ph+ aALL, with 42.3{\%} of which being with additional abnormalities, including mainly abn(9p), abn(7p), -7, 17p- and +21. It is concluded that almost every chromosome is involved in the numerical and structural abnormalities and complex karyotypes are common. The significant difference of chromosome abnormality exists between aALL and cALL.",
author = "Liu, {Xu Ping} and Zhu, {Xiao Fan} and Wang, {Jian Xiang} and Mi, {Ying Chang} and Yao Zou and Chen, {Yu Mei} and Li, {Cheng Wen} and Yun Dai and Shuang Qin and Xiao, {Ji Gang} and Xu, {Fang Yun} and Gong, {Jin Ying} and Wang, {Si Ping} and Yu, {Cheng Long} and Jing Fan",
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T1 - [A comparative cytogenetic analysis in large scale between adult and childhood patients with acute lymphoblastic leukemia].

AU - Liu,Xu Ping

AU - Zhu,Xiao Fan

AU - Wang,Jian Xiang

AU - Mi,Ying Chang

AU - Zou,Yao

AU - Chen,Yu Mei

AU - Li,Cheng Wen

AU - Dai,Yun

AU - Qin,Shuang

AU - Xiao,Ji Gang

AU - Xu,Fang Yun

AU - Gong,Jin Ying

AU - Wang,Si Ping

AU - Yu,Cheng Long

AU - Fan,Jing

PY - 2009/12

Y1 - 2009/12

N2 - This study was purposed to comparatively analyze the cytogenetic characteristics between 566 cases of adult acute lymphoblastic leukemia (aALL) and 586 cases of childhood acute lymphoblastic leukemia (cALL). The cytogenetic analysis of all the patients was performed, and the FISH detection for partial patients was carried out. The result showed that the difference of chromosome abnormality between cALL and aALL was statistically significant. The percentage of abnormal karyotypes in aALL was 62.0%, including mainly t(9;22)(q34;q11), hypodiploidy, hyperdiploidy (47 - 50), abn(6q), abn(9p) and -7, most of which conferring an unfavorable prognosis. The percentage of abnormal karyotypes in cALL was 39.2%, composed mainly of high hyperdiploidy, hypodiploidy, TEL/AML1(+), +8, hyperdiploidy (47 - 50) and +21, etc, most of which conferring a favorable prognosis. The incidences of abnormal karyotypes, total hypodiploidy, total hyperdiploidy (47 - 50), t(9;22)(q34;q11), -7, abn(7q), abn(14q32) and +Ph in aALL were significantly higher than those of cALL (p < 0.05), whereas the incidences of normal karyotype (N), high hyperdiploidy, +8, +21*2 and TEL/AML1(+) in cALL were significantly higher than those of aALL (p < 0.05). 20.5% of aALL were Ph+ aALL, with 63.8% of which being with additional abnormalities, composed mainly of +Ph, -7, i (9q+), 9p-, +8, +21, +X, 6q-, abn(14q32) and +14. In contrast, only 4.4% of cALL were Ph+ aALL, with 42.3% of which being with additional abnormalities, including mainly abn(9p), abn(7p), -7, 17p- and +21. It is concluded that almost every chromosome is involved in the numerical and structural abnormalities and complex karyotypes are common. The significant difference of chromosome abnormality exists between aALL and cALL.

AB - This study was purposed to comparatively analyze the cytogenetic characteristics between 566 cases of adult acute lymphoblastic leukemia (aALL) and 586 cases of childhood acute lymphoblastic leukemia (cALL). The cytogenetic analysis of all the patients was performed, and the FISH detection for partial patients was carried out. The result showed that the difference of chromosome abnormality between cALL and aALL was statistically significant. The percentage of abnormal karyotypes in aALL was 62.0%, including mainly t(9;22)(q34;q11), hypodiploidy, hyperdiploidy (47 - 50), abn(6q), abn(9p) and -7, most of which conferring an unfavorable prognosis. The percentage of abnormal karyotypes in cALL was 39.2%, composed mainly of high hyperdiploidy, hypodiploidy, TEL/AML1(+), +8, hyperdiploidy (47 - 50) and +21, etc, most of which conferring a favorable prognosis. The incidences of abnormal karyotypes, total hypodiploidy, total hyperdiploidy (47 - 50), t(9;22)(q34;q11), -7, abn(7q), abn(14q32) and +Ph in aALL were significantly higher than those of cALL (p < 0.05), whereas the incidences of normal karyotype (N), high hyperdiploidy, +8, +21*2 and TEL/AML1(+) in cALL were significantly higher than those of aALL (p < 0.05). 20.5% of aALL were Ph+ aALL, with 63.8% of which being with additional abnormalities, composed mainly of +Ph, -7, i (9q+), 9p-, +8, +21, +X, 6q-, abn(14q32) and +14. In contrast, only 4.4% of cALL were Ph+ aALL, with 42.3% of which being with additional abnormalities, including mainly abn(9p), abn(7p), -7, 17p- and +21. It is concluded that almost every chromosome is involved in the numerical and structural abnormalities and complex karyotypes are common. The significant difference of chromosome abnormality exists between aALL and cALL.

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