A case-control analysis of smoking and breast cancer in African American women: Findings from the AMBER Consortium

Song Yi Park, Julie R. Palmer, Lynn Rosenberg, Christopher A. Haiman, Elisa V. Bandera, Traci N. Bethea, Melissa A. Troester, Emma Viscidi, Laurence N. Kolonel, Andrew F. Olshan, Christine B. Ambrosone

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Abstract

Recent population studies suggest a role of smoking in the etiology of breast cancer, but few have been conducted among African American women. In a collaborative project of four large studies, we examined associations between smoking measures and breast cancer risk by menopause and hormone receptor status [estrogen receptor-positive (ER+), ER-negative (ER-) and triple-negative (ER-, PR-, HER2-)]. The study included 5791 African American women with breast cancer and 17 376 African American controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in multivariable logistic regression analysis with adjustment for study and risk factors. Results differed by menopausal status. Among postmenopausal women, positive associations were observed for long duration and greater pack-years of smoking: relative to never smoking, fully adjusted ORs were 1.14 (95% CI: 1.03-1.26) for duration ≥20 years and 1.16 (95% CI: 1.01-1.33) for ≥20 pack-years. By contrast, inverse associations were observed among premenopausal women, with ORs of 0.80 (95% CI: 0.68- 95) for current smoking and 0.81 (95% CI: 0.69-0.96) for former smoking, without trends by duration. Associations among postmenopausal women were somewhat stronger for ER+ breast cancer. The findings suggest that the relation of cigarette smoking to breast cancer risk in African American women may vary by menopausal status and breast cancer subtype.

LanguageEnglish (US)
Article numberbgw040
Pages607-615
Number of pages9
JournalCarcinogenesis
Volume37
Issue number6
DOIs
StatePublished - Jun 4 2016

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African Americans
Smoking
Breast Neoplasms
Confidence Intervals
Odds Ratio
Menopause
Estrogen Receptors
Logistic Models
Regression Analysis
Hormones
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

Park, S. Y., Palmer, J. R., Rosenberg, L., Haiman, C. A., Bandera, E. V., Bethea, T. N., ... Ambrosone, C. B. (2016). A case-control analysis of smoking and breast cancer in African American women: Findings from the AMBER Consortium. Carcinogenesis, 37(6), 607-615. [bgw040]. DOI: 10.1093/carcin/bgw040

A case-control analysis of smoking and breast cancer in African American women : Findings from the AMBER Consortium. / Park, Song Yi; Palmer, Julie R.; Rosenberg, Lynn; Haiman, Christopher A.; Bandera, Elisa V.; Bethea, Traci N.; Troester, Melissa A.; Viscidi, Emma; Kolonel, Laurence N.; Olshan, Andrew F.; Ambrosone, Christine B.

In: Carcinogenesis, Vol. 37, No. 6, bgw040, 04.06.2016, p. 607-615.

Research output: Contribution to journalArticle

Park, SY, Palmer, JR, Rosenberg, L, Haiman, CA, Bandera, EV, Bethea, TN, Troester, MA, Viscidi, E, Kolonel, LN, Olshan, AF & Ambrosone, CB 2016, 'A case-control analysis of smoking and breast cancer in African American women: Findings from the AMBER Consortium' Carcinogenesis, vol 37, no. 6, bgw040, pp. 607-615. DOI: 10.1093/carcin/bgw040
Park SY, Palmer JR, Rosenberg L, Haiman CA, Bandera EV, Bethea TN et al. A case-control analysis of smoking and breast cancer in African American women: Findings from the AMBER Consortium. Carcinogenesis. 2016 Jun 4;37(6):607-615. bgw040. Available from, DOI: 10.1093/carcin/bgw040
Park, Song Yi ; Palmer, Julie R. ; Rosenberg, Lynn ; Haiman, Christopher A. ; Bandera, Elisa V. ; Bethea, Traci N. ; Troester, Melissa A. ; Viscidi, Emma ; Kolonel, Laurence N. ; Olshan, Andrew F. ; Ambrosone, Christine B./ A case-control analysis of smoking and breast cancer in African American women : Findings from the AMBER Consortium. In: Carcinogenesis. 2016 ; Vol. 37, No. 6. pp. 607-615
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