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2018

Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species

Srinivas, N., Rosen, E. P., Gilliland, W. M., Kovarova, M., Remling-Mulder, L., De La Cruz, G., White, N., Adamson, L., Schauer, A. P., Sykes, C., Luciw, P., Garcia-Martinez, J. V., Akkina, R. & Kashuba, A. D., Jan 1 2018, (Accepted/In press) In : Xenobiotica.

Research output: Contribution to journalArticle

efavirenz
Cerebrospinal fluid
Protein Binding
Cerebrospinal Fluid
Brain
2 Citations

Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System

Srinivas, N., Maffuid, K. & Kashuba, A. D. M., Sep 1 2018, In : Clinical Pharmacokinetics. 57, 9, p. 1059-1074 16 p.

Research output: Contribution to journalReview article

Central Nervous System Agents
Pharmacokinetics
Central Nervous System Diseases
Extracellular Fluid
Psychotic Disorders

Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair

Sykes, C., Blake, K., White, N., Schauer, A. P., Guzman, B. B., Cottrell, M. L., Tamraz, B. & Kashuba, A. D., Nov 1 2018, In : Analytical and bioanalytical chemistry. 410, 29, p. 7773-7781 9 p.

Research output: Contribution to journalArticle

Hair
Assays
formic acid
Solvent extraction
Degradation

Evaluation of Digital Image Recognition Methods for Mass Spectrometry Imaging Data Analysis

Ekelöf, M., Garrard, K. P., Judd, R., Rosen, E. P., Xie, D. Y., Kashuba, A. D. & Muddiman, D. C., Dec 1 2018, In : Journal of the American Society for Mass Spectrometry. 29, 12, p. 2467-2470 4 p.

Research output: Contribution to journalArticle

Image recognition
Mass spectrometry
Mass Spectrometry
Imaging techniques
Artemisia annua
7 Citations

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women

McKinnon, L. R., Liebenberg, L. J., Yende-Zuma, N., Archary, D., Ngcapu, S., Sivro, A., Nagelkerke, N., Lerma, J. G. G., Kashuba, A. D., Masson, L., Mansoor, L. E., Karim, Q. A., Karim, S. S. A. & Passmore, J. A. S., May 1 2018, In : Nature Medicine. 24, 4, p. 491-496 6 p.

Research output: Contribution to journalArticle

Tenofovir
Gels
HIV
Inflammation
Confidence Intervals

Injectable long-acting human immunodeficiency virus antiretroviral prodrugs with improved pharmacokinetic profiles

Krovi, S. A., Gallovic, M. D., Keller, A. M., Bhat, M., Tiet, P., Chen, N., Collier, M. A., Gurysh, E. G., Pino, E. N., Johnson, M. M., Shamim Hasan Zahid, M., Cottrell, M. L., Pirone, J. R., Kashuba, A. D., Kwiek, J. J., Bachelder, E. & Ainslie, K. M., Dec 1 2018, In : International Journal of Pharmaceutics. 552, 1-2, p. 371-377 7 p.

Research output: Contribution to journalArticle

Prodrugs
Pharmacokinetics
HIV
Injections
Pharmaceutical Preparations

Marginal effects of systemic CCR5 blockade with maraviroc on oral simian immunodeficiency virus transmission to infant macaques

Brocca-Cofano, E., Xu, C., Wetzel, K. S., Cottrell, M. L., Policicchio, B. B., Raehtz, K. D., Ma, D., Dunsmore, T., Haret-Richter, G. S., Musaitif, K., Keele, B. F., Kashuba, A. D., Collman, R. G., Pandrea, I. & Apetrei, C., Sep 1 2018, In : Journal of Virology. 92, 17, e00576-18.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
virus transmission
Macaca
Macaca mulatta

Rilpivirine Plasma and Cervicovaginal Concentrations in Women During Pregnancy and Postpartum

IMPAACT P1026s Protocol Team, Jul 1 2018, In : Journal of acquired immune deficiency syndromes (1999). 78, 3, p. 308-313 6 p.

Research output: Contribution to journalArticle

Rilpivirine
Postpartum Period
Pregnancy
Third Pregnancy Trimester
Clinical Protocols

Simian immunodeficiency virus persistence in cellular and anatomic reservoirs in antiretroviral therapy-suppressed infant rhesus macaques

Mavigner, M., Habib, J., Deleage, C., Rosen, E., Mattingly, C., Bricker, K., Kashuba, A. D., Amblard, F., Schinazi, R. F., Jean, S., Cohen, J., McGary, C., Paiardini, M., Wood, M. P., Sodora, D. L., Silvestri, G., Estes, J. & Chahroudi, A., Sep 1 2018, In : Journal of Virology. 92, 18, e00562.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Macaca mulatta
Human immunodeficiency virus
therapeutics

Smartphone-based contingency management intervention to improve pre-exposure prophylaxis adherence: Pilot trial

Mitchell, J. T., LeGrand, S., Hightow-Weidman, L. B., McKellar, M. S., Kashuba, A. D., Cottrell, M., McLaurin, T., Satapathy, G. & Joseph McClernon, F., Sep 1 2018, In : Journal of medical Internet research. 20, 9, e10456.

Research output: Contribution to journalArticle

Smartphone
Pre-Exposure Prophylaxis
Medication Adherence
Motivation
Biomarkers
1 Citations

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue

Nicol, M. R., Brewers, L. M., Kashuba, A. D. & Sykes, C., Jan 2 2018, In : AIDS. 32, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

Tenofovir
Menopause
Diphosphates
Biological Factors
Nucleosides
1 Citations

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Kovarova, M., Benhabbour, S. R., Massud, I., Spagnuolo, R. A., Skinner, B., Baker, C. E., Sykes, C., Mollan, K. R., Kashuba, A. D., García-Lerma, J. G., Mumper, R. J. & Garcia-Martinez, J. V., Dec 1 2018, In : Nature Communications. 9, 1, 4156.

Research output: Contribution to journalArticle

Thymus
human immunodeficiency virus
Drug Delivery Systems
Drug delivery
Liver
1 Citations
Tenofovir
Lamivudine
Metabolites
Assays
Blood

Virological and immunological responses to raltegravir and dolutegravir in the gut-associated lymphoid tissue of HIV-infected men and women

Weber, M. D., Andrews, E., Prince, H. A., Sykes, C., Rosen, E. P., Bay, C., Shaheen, N. J., Madanick, R. D., Dellon, E. S., De Paris, K., Nelson, J. A., Gay, C. L. & Kashuba, A. D., Jan 1 2018, In : Antiviral Therapy. 23, 6, p. 495-504 10 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV
RNA
Tenofovir
T-Lymphocytes
2017
3 Citations

A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

Feder, A. F., Kline, C., Polacino, P., Cottrell, M., Kashuba, A. D. M., Keele, B. F., Hu, S. L., Petrov, D. A., Pennings, P. S. & Ambrose, Z., May 1 2017, In : PLoS pathogens. 13, 5, e1006358.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
HIV-1
HIV
Lymph Nodes
RNA-Directed DNA Polymerase

Darunavir for use in pregnant women with HIV

Pope, R. & Kashuba, A. D., Dec 2 2017, In : Expert Review of Clinical Pharmacology. 10, 12, p. 1317-1327 11 p.

Research output: Contribution to journalArticle

Pregnant Women
HIV
Pregnancy
Protease Inhibitors
United States Dept. of Health and Human Services
3 Citations

HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities

Thompson, C. G., Gay, C. L. & Kashuba, A. D. M., Jun 1 2017, In : AIDS Research and Human Retroviruses. 33, 6, p. 513-523 11 p.

Research output: Contribution to journalReview article

Lymphoid Tissue
HIV
Pharmacology
Clinical Pharmacology
Infection
1 Citations

Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

Shen, Z., Rodriguez-Garcia, M., Patel, M. V., Bodwell, J., Kashuba, A. D. M. & Wira, C. R., Dec 1 2017, In : Scientific Reports. 7, 1, 17697.

Research output: Contribution to journalArticle

Tenofovir
Contraceptive Agents
HIV Infections
Medroxyprogesterone Acetate
T-Lymphocytes
19 Citations

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

Archin, N. M., Kirchherr, J. L., Sung, J. A. M., Clutton, G., Sholtis, K., Xu, Y., Allard, B., Stuelke, E., Kashuba, A. D., Kuruc, J. D., Eron, J., Gay, C. L., Goonetilleke, N. & Margolis, D. M., Aug 1 2017, In : Journal of Clinical Investigation. 127, 8, p. 3126-3135 10 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
HIV
T-Lymphocytes
RNA
Infection
2 Citations

Multimodal analysis of drug transporter expression in gastrointestinal tissue

Thompson, C. G., Fallon, J. K., Mathews, M., Charlins, P., Remling-Mulder, L., Kovarova, M., Adamson, L., Srinivas, N., Schauer, A., Sykes, C., Luciw, P., Garcia, J. V., Akkina, R., Smith, P. C. & Kashuba, A. D. M., Jul 31 2017, In : AIDS. 31, 12, p. 1669-1678 10 p.

Research output: Contribution to journalArticle

Proteomics
Cell- and Tissue-Based Therapy
Primates
Pharmaceutical Preparations
Proteins
5 Citations

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact

Gonzalez, D., Rao, G. G., Bailey, S. C., Brouwer, K. L. R., Cao, Y., Crona, D. J., Kashuba, A. D., Lee, C. R., Morbitzer, K., Patterson, J. H., Wiltshire, T. J., Easter, J., Savage, S. W. & Powell, J. R., Nov 1 2017, In : Clinical and translational science. 10, 6, p. 443-454 12 p.

Research output: Contribution to journalReview article

Public Health
6 Citations

Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers

Asher, G. N., Xie, Y., Moaddel, R., Sanghvi, M., Dossou, K. S. S., Kashuba, A. D. M., Sandler, R. S. & Hawke, R. L., Jan 1 2017, In : Journal of clinical pharmacology. 57, 2, p. 185-193 9 p.

Research output: Contribution to journalArticle

Curcumin
Cross-Over Studies
Healthy Volunteers
Pharmacokinetics
Phosphatidylcholines
7 Citations

Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues

Cottrell, M. L., Garrett, K. L., Prince, H. M. A., Sykes, C., Schauer, A., Emerson, C. W., Peery, A., Rooney, J. F., McCallister, S., Gay, C. & Kashuba, A. D. M., Jan 1 2017, In : Journal of Antimicrobial Chemotherapy. 72, 6, p. 1731-1740 10 p., dkx064.

Research output: Contribution to journalArticle

Tenofovir
Mucous Membrane
Pharmacokinetics
Gastrointestinal Tract
Epithelial Cells

Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

Asmuth, D. M., Thompson, C. G., Chun, T. W., Ma, Z. M., Mann, S., Sainz, T., Serrano-Villar, S., Utay, N. S., Garcia, J. C., Troia-Cancio, P., Pollard, R. B., Miller, C. J., Landay, A. & Kashuba, A. D., Jan 1 2017, In : Journal of Infectious Diseases. 216, 7, p. 813-818 6 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV
RNA
Pharmaceutical Preparations
Mucosal Immunity
2016
11 Citations

Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging

Rosen, E. P., Thompson, C. G., Bokhart, M. T., Prince, H. M. A., Sykes, C., Muddiman, D. C. & Kashuba, A. D. M., Jan 19 2016, In : Analytical Chemistry. 88, 2, p. 1336-1344 9 p.

Research output: Contribution to journalArticle

Electrospray ionization
Mass spectrometry
Desorption
Infrared radiation
Imaging techniques
1 Citations

Antiretroviral activity and safety of once-daily etravirine in treatment-naive HIV-infected adults: 48-week results

Floris-Moore, M. A., Mollan, K., Wilkin, A. M., Johnson, M. A., Kashuba, A. D. M., Wohl, D. A., Patterson, K. B., Francis, O., Kronk, C. & Eron, J. J., Jan 1 2016, In : Antiviral Therapy. 21, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

etravirine
HIV
Safety
HIV-1
Tenofovir
2 Citations

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses

Khandelwal, P., Fukuda, T., Mizuno, K., Teusink-Cross, A., Mehta, P. A., Marsh, R. A., Kashuba, A. D. M., Vinks, A. A. & Davies, S. M., Oct 1 2016, In : Biology of Blood and Marrow Transplantation. 22, 10, p. 1829-1835 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Stem Cells
Pharmacokinetics
Pediatrics
Transplants
62 Citations
Tenofovir
Mucous Membrane
HIV
Pharmacology
Nucleotides
5 Citations

Cervicovaginal and rectal fluid as a surrogate marker of antiretroviral tissue concentration: Implications for clinical trial design

Cottrell, M. L., Prince, H. M. A., Allmon, A., Mollan, K. R., Hudgens, M. G., Sykes, C., White, N., Malone, S., Dellon, E. S., Madanick, R. D., Shaheen, N. J., Patterson, K. B. & Kashuba, A. D. M., Aug 15 2016, In : Journal of Acquired Immune Deficiency Syndromes. 72, 5, p. 498-506 9 p.

Research output: Contribution to journalArticle

Biomarkers
Clinical Trials
Tenofovir
Lower Gastrointestinal Tract
Pharmaceutical Preparations
40 Citations

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Hendrix, C. W., Andrade, A., Bumpus, N. N., Kashuba, A. D., Marzinke, M. A., Moore, A., Anderson, P. L., Bushman, L. R., Fuchs, E. J., Wiggins, I., Radebaugh, C., Prince, H. A., Bakshi, R. P., Wang, R., Richardson, P., Shieh, E., McKinstry, L., Li, X., Donnell, D., Elharrar, V. & 2 othersMayer, K. H. & Patterson, K. B., Jan 1 2016, In : AIDS Research and Human Retroviruses. 32, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle

Tenofovir
Benchmarking
Healthy Volunteers
Pharmacokinetics
Tablets
23 Citations

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Serrano-Villar, S., Sainz, T., Ma, Z. M., Utay, N. S., Wook-Chun, T., Mann, S., Kashuba, A. D., Siewe, B., Albanese, A., Troia-Cancio, P., Sinclair, E., Somasunderam, A., Yotter, T., Deeks, S. G., Landay, A., Pollard, R. B., Miller, C. J., Moreno, S. & Asmuth, D. M., Jan 1 2016, In : PLoS pathogens. 12, 1, e1005381.

Research output: Contribution to journalArticle

Integrase Inhibitors
Mucosal Immunity
HIV
T-Lymphocytes
T-Lymphocyte Subsets
6 Citations

HIV-1-RNA decay and dolutegravir concentrations in semen of patients starting a first antiretroviral regimen

Imaz, A., Martinez-Picado, J., Niubó, J., Kashuba, A. D., Ferrer, E., Ouchi, D., Sykes, C., Rozas, N., Acerete, L., Curto, J., Vila, A. & Podzamczer, D., Nov 15 2016, In : Journal of Infectious Diseases. 214, 10, p. 1512-1519 8 p.

Research output: Contribution to journalArticle

RNA Stability
Semen
HIV-1
RNA
dolutegravir
4 Citations

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis

Veselinovic, M., Yang, K. H., Sykes, C., Remling-Mulder, L., Kashuba, A. D. M. & Akkina, R., Feb 1 2016, In : Virology. 489, p. 173-178 6 p.

Research output: Contribution to journalArticle

Integrase Inhibitors
Mucous Membrane
Pharmacokinetics
HIV
Pharmaceutical Preparations
Virus Diseases
Coinfection
Hepacivirus
Antiviral Agents
HIV
1 Citations

Plasma and Intracellular Concentrations in HIV-Infected Patients Requiring Hemodialysis Dosed with Tenofovir Disoproxil Fumarate and Emtricitabine

Slaven, J. E., Decker, B. S., Kashuba, A. D. M., Atta, M. G., Wyatt, C. M. & Gupta, S. K., Sep 1 2016, In : Journal of Acquired Immune Deficiency Syndromes. 73, 1, p. e8-e10

Research output: Contribution to journalLetter

4 Citations

Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable

Collier, M. A., Gallovic, M. D., Bachelder, E. M., Sykes, C. D., Kashuba, A. & Ainslie, K. M., Aug 1 2016, In : Pharmaceutical research. 33, 8, p. 1998-2009 12 p.

Research output: Contribution to journalArticle

Saquinavir
Dextrans
Protease Inhibitors
Injections
Pharmaceutical Preparations

S-warfarin limited sampling models to estimate area under the concentration versus time curve for cytochrome P450 2C9 baseline activity and after induction

Chang, A. T., Bertino, J. S., Nafziger, A. N., Kashuba, A. D. M., Turpault, S., Lewis, L. D. & Ma, J. D., Jan 1 2016, In : Therapeutic Drug Monitoring. 38, 3, p. 383-387 5 p.

Research output: Contribution to journalArticle

Warfarin
Cytochrome P-450 Enzyme System
Area Under Curve
Neoplasms
Lopinavir
16 Citations

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

Clutton, G., Xu, Y., Baldoni, P. L., Mollan, K. R., Kirchherr, J., Newhard, W., Cox, K., Kuruc, J. D., Kashuba, A. D., Barnard, R., Archin, N. M., Gay, C. L., Hudgens, M. G., Margolis, D. M. & Goonetilleke, N. P., Aug 2 2016, In : Scientific Reports. 6, 30749.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Histone Deacetylase Inhibitors
Protein Kinase C
CD8 Antigens
2015
21 Citations

Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials

Agot, K., Taylor, D., Corneli, A. L., Wang, M., Ambia, J., Kashuba, A. D., Parker, C., Lemons, A., Malahleha, M., Lombaard, J. & Van Damme, L., May 1 2015, In : AIDS and behavior. 19, 5, p. 743-751 9 p.

Research output: Contribution to journalArticle

Tenofovir
Self Report
Clinical Trials
HIV
Pharmaceutical Preparations
65 Citations

Bottlenecks in HIV-1 transmission: Insights from the study of founder viruses

Joseph, S. B., Swanstrom, R., Kashuba, A. D. M. & Cohen, M. S., Jan 1 2015, In : Nature Reviews Microbiology. 13, 7, p. 414-425 12 p.

Research output: Contribution to journalReview article

HIV-1
Viruses
HIV Infections
Phenotype
11 Citations

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

Maher, J. R., Chuchuen, O., Henderson, M. H., Kim, S., Rinehart, M. T., Kashuba, A. D. M., Wax, A. & Katz, D. F., May 8 2015, In : Biomedical Optics Express. 6, 6, p. 2022-2035 14 p.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Optical Coherence Tomography
Tenofovir
Raman spectroscopy
tomography
1 Citations

Combined raman spectroscopy and optical coherence tomography for measuring analytes in targeted tissues

Maher, J. R., Chuchuen, O., Kashuba, A. D. M., Katz, D. F. & Wax, A., Apr 6 2015, Optical Molecular Probes, Imaging and Drug Delivery, OMP 2015. OSA - The Optical Society

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Raman Spectrum Analysis
Optical tomography
Optical Coherence Tomography
Anti-Infective Agents
Raman spectroscopy
11 Citations

Effect of cytomegalovirus infection on breastfeeding transmission of HIV and on the health of infants born to HIV-infected mothers

Chang, T. S., Wiener, J., Dollard, S. C., Amin, M. M., Ellington, S., Chasela, C., Kayira, D., Tegha, G., Kamwendo, D., Jamieson, D. J., Van Der Horst, C., Kourtis, A. P., Adair, L., Ahmed, Y., Ait-Khaled, M., Albrecht, S., Bangdiwala, S., Bayer, R., Bentley, M., Bramson, B. & 104 othersBobrow, E., Boyle, N., Butera, S., Chavula, C., Chimerang'ambe, J., Chigwenembe, M., Chikasema, M., Chikhungu, N., Chilongozi, D., Chiudzu, G., Chome, L., Cole, A., Corbett, A., Corneli, A., Dow, A., Duerr, A., Eliya, H., Eron, J., Farr, S., Ferguson, Y. O., Fiscus, S., Flax, V., Fokar, A., Galvin, S., Guay, L., Heilig, C., Hoffman, I., Hooten, E., Hosseinipour, M., Hudgens, M., Hurst, S., Hyde, L., Joaki, G., Jones, D., Jordan-Bell, E., Kacheche, Z., Kamanga, E., Kamanga, G., Kampani, C., Kamthunzi, P., Kanyama, C., Kashuba, A., Kathyola, D., Kazembe, P., King, C. C., Knight, R., Krysiak, R., Kumwenda, J., Lee, H., Loeliger, E., Long, D., Luhanga, M., Madhlopa, V., Majawa, M., Maida, A., Marcus, C., Martinson, F., Thoofer, N., Matiki, C., Mayers, D., Mayuni, I., McDonough, M., Meme, J., Merry, C., Mita, K., Mkomawanthu, C., Mndala, G., Mndala, I., Moses, A., Msika, A., Msungama, W., Mtimuni, B., Muita, J., Mumba, N., Musis, B., Mwansambo, C., Mwapasa, G., Nkhoma, J., Parker, M., Pendame, R., Piwoz, E., Raines, B., Ramdas, Z., Rublein, J., Ryan, M., Sanne, I., Sellers, C., Shugars, D., Sichali, D., Snowden, W., Soko, A., Spensley, A., Steens, J. M., Tembo, M., Thomas, R., Tien, H. C., Tohill, B., Van Der Horst, C., Waalberg, E., Widen, E., Wilfert, C., Wiyo, P., Zgambo, I. & Zimba, C., Apr 24 2015, In : AIDS. 29, 7, p. 831-836 6 p.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Breast Feeding
Mothers
HIV
Cytomegalovirus
2 Citations

Effect of HIV infection and menopause status on raltegravir pharmacokinetics in the blood and genital tract

Cottrell, M. L., Patterson, K. B., Prince, H. M. A., Jones, A., White, N., Wang, R. & Kashuba, A. D. M., Jan 1 2015, In : Antiviral Therapy. 20, 8, p. 795-803 9 p.

Research output: Contribution to journalArticle

Menopause
HIV Infections
Pharmacokinetics
HIV
Raltegravir Potassium
38 Citations

Genital Tenofovir Concentrations Correlate with Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Kashuba, A. D., Gengiah, T. N., Werner, L., Yang, K-H., White, N. R., Karim, Q. A. & Abdool Karim, S. S., Jul 1 2015, In : Journal of Acquired Immune Deficiency Syndromes. 69, 3, p. 264-269 6 p.

Research output: Contribution to journalArticle

Tenofovir
Anti-Infective Agents
HIV Infections
HIV
Gels
3 Citations
HIV
Therapeutic Irrigation
Endometrium
Biomarkers
RNA
8 Citations

Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation

Sabo, J. P., Kort, J., Ballow, C., Kashuba, A. D., Haschke, M., Battegay, M., Girlich, B., Ting, N., Lang, B., Zhang, W., Cooper, C., O'Brien, D., Seibert, E., Chan, T. S., Tweedie, D. & Li, Y., Jan 1 2015, In : Journal of clinical pharmacology. 55, 4, p. 467-477 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Protease Inhibitors
Hepacivirus
Cytochrome P-450 Enzyme System
Midazolam
6 Citations

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation

Peterson, C. W., Haworth, K. G., Polacino, P., Huang, M. L., Sykes, C., Obenza, W. M., Repetto, A. C., Kashuba, A., Bumgarner, R., DeRosa, S. C., Woolfrey, A. E., Jerome, K. R., Mullins, J. I., Hu, S. L. & Kiem, H. P., Aug 24 2015, In : AIDS. 29, 13, p. 1597-1606 10 p.

Research output: Contribution to journalArticle

Macaca
Bone Marrow Transplantation
Mutation
Hematopoietic Stem Cell Transplantation
Viremia
4 Citations

Low frequency of drug-resistant variants selected by long-acting rilpivirine in macaques infected with simian immunodeficiency virus containing HIV-1 reverse transcriptase

Melody, K., McBeth, S., Kline, C., Kashuba, A. D., Mellors, J. W. & Ambrose, Z., Dec 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7762-7770 9 p.

Research output: Contribution to journalArticle

Rilpivirine
Simian Immunodeficiency Virus
Macaca
HIV-1
RNA-Directed DNA Polymerase
22 Citations

Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs

Thompson, C. G., Bokhart, M. T., Sykes, C., Adamson, L., Fedoriw, G., Luciw, P. A., Muddiman, D. C., Kashuba, A. D. & Rosen, E. P., May 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 5, p. 2944-2948 5 p.

Research output: Contribution to journalArticle

efavirenz
Mass Spectrometry
HIV
Macaca
Pharmaceutical Preparations