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2018

Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System

Srinivas, N., Maffuid, K. & Kashuba, A. D. M. Feb 20 2018 (Accepted/In press) In : Clinical Pharmacokinetics. p. 1-16 16 p.

Research output: Contribution to journalArticle

Central Nervous System Agents
Pharmacokinetics
Central Nervous System Diseases
Extracellular Fluid
Psychotic Disorders
1 Citations

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women

McKinnon, L. R., Liebenberg, L. J., Yende-Zuma, N., Archary, D., Ngcapu, S., Sivro, A., Nagelkerke, N., Lerma, J. G. G., Kashuba, A. D., Masson, L., Mansoor, L. E., Karim, Q. A., Karim, S. S. A. & Passmore, J. A. S. May 1 2018 In : Nature Medicine. 24, 4, p. 491-496 6 p.

Research output: Contribution to journalArticle

Tenofovir
Sulfur hexafluoride circuit breakers
Gels
HIV
Inflammation

The role of menopause in tenofovir diphosphate and emtricitabine triphosphate concentrations in cervical tissue

Nicol, M. R., Brewers, L. M., Kashuba, A. D. M. & Sykes, C. Jan 2 2018 In : AIDS. 32, 1, p. 11-15 5 p.

Research output: Contribution to journalArticle

Tenofovir
Menopause
Diphosphates
Biological Factors
Nucleosides
Tenofovir
Slip forming
Lamivudine
HIV
Blood Cells
2017
1 Citations

A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

Feder, A. F., Kline, C., Polacino, P., Cottrell, M., Kashuba, A. D. M., Keele, B. F., Hu, S. L., Petrov, D. A., Pennings, P. S. & Ambrose, Z. May 1 2017 In : PLoS pathogens. 13, 5, e1006358

Research output: Contribution to journalArticle

Simian Acquired Immunodeficiency Syndrome
Viral Drug Resistance
HIV Reverse Transcriptase
Mononuclear Leukocytes
Simian Immunodeficiency Virus

Darunavir for use in pregnant women with HIV

Pope, R. & Kashuba, A. Dec 2 2017 In : Expert Review of Clinical Pharmacology. 10, 12, p. 1317-1327 11 p.

Research output: Contribution to journalArticle

Infectious Pregnancy Complications
Drug Dose Response Relationship
Vertical Infectious Disease Transmission
Drug Administration Schedule
HIV Protease Inhibitors
1 Citations

HIV Persistence in Gut-Associated Lymphoid Tissues: Pharmacological Challenges and Opportunities

Thompson, C. G., Gay, C. L. & Kashuba, A. D. M. Jun 1 2017 In : AIDS Research and Human Retroviruses. 33, 6, p. 513-523 11 p.

Research output: Contribution to journalReview article

Lymphoid Tissue
HIV
Pharmacology
Clinical Pharmacology
Infection

Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

Shen, Z., Rodriguez-Garcia, M., Patel, M. V., Bodwell, J., Kashuba, A. D. M. & Wira, C. R. Dec 1 2017 In : Scientific Reports. 7, 1, 17697

Research output: Contribution to journalArticle

Tenofovir
Contraceptive Agents
HIV Infections
Medroxyprogesterone Acetate
T-Lymphocytes
9 Citations

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

Archin, N. M., Kirchherr, J. L., Sung, J. A. M., Clutton, G., Sholtis, K., Xu, Y., Allard, B., Stuelke, E., Kashuba, A. D., Kuruc, J. D., Eron, J., Gay, C. L., Goonetilleke, N. & Margolis, D. M. Aug 1 2017 In : Journal of Clinical Investigation. 127, 8, p. 3126-3135 10 p.

Research output: Contribution to journalArticle

1 Citations

Multimodal analysis of drug transporter expression in gastrointestinal tissue

Thompson, C. G., Fallon, J. K., Mathews, M., Charlins, P., Remling-Mulder, L., Kovarova, M., Adamson, L., Srinivas, N., Schauer, A., Sykes, C., Luciw, P., Garcia, J. V., Akkina, R., Smith, P. C. & Kashuba, A. D. M. Jul 31 2017 In : AIDS. 31, 12, p. 1669-1678 10 p.

Research output: Contribution to journalArticle

2 Citations

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact

Gonzalez, D., Rao, G. G., Bailey, S. C., Brouwer, K. L. R., Cao, Y., Crona, D. J., Kashuba, A. D. M., Lee, C. R., Morbitzer, K., Patterson, J. H., Wiltshire, T., Easter, J., Savage, S. W. & Powell, J. R. Nov 1 2017 In : Clinical and translational science. 10, 6, p. 443-454 12 p.

Research output: Contribution to journalReview article

Public Health
4 Citations

Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers

Asher, G. N., Xie, Y., Moaddel, R., Sanghvi, M., Dossou, K. S. S., Kashuba, A. D. M., Sandler, R. S. & Hawke, R. L. Jan 1 2017 In : Journal of clinical pharmacology. 57, 2, p. 185-193 9 p.

Research output: Contribution to journalArticle

Curcumin
Cross-Over Studies
Healthy Volunteers
Pharmacokinetics
Phosphatidylcholines
3 Citations

Single-dose pharmacokinetics of tenofovir alafenamide and its active metabolite in the mucosal tissues

Cottrell, M. L., Garrett, K. L., Prince, H. M. A., Sykes, C., Schauer, A., Emerson, C. W., Peery, A., Rooney, J. F., McCallister, S., Gay, C. & Kashuba, A. D. M. Jan 1 2017 In : Journal of Antimicrobial Chemotherapy. 72, 6, p. 1731-1740 10 p., dkx064

Research output: Contribution to journalArticle

Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy

Asmuth, D. M., Thompson, C. G., Chun, T. W., Ma, Z. M., Mann, S., Sainz, T., Serrano-Villar, S., Utay, N. S., Garcia, J. C., Troia-Cancio, P., Pollard, R. B., Miller, C. J., Landay, A. & Kashuba, A. D. Jan 1 2017 In : Journal of Infectious Diseases. 216, 7, p. 813-818 6 p.

Research output: Contribution to journalArticle

Cyclohexanes
Benzoxazines
Anti-HIV Agents
Triazoles
Viral DNA
2016
8 Citations

Analysis of Antiretrovirals in Single Hair Strands for Evaluation of Drug Adherence with Infrared-Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging

Rosen, E. P., Thompson, C. G., Bokhart, M. T., Prince, H. M. A., Sykes, C., Muddiman, D. C. & Kashuba, A. D. M. Jan 19 2016 In : Analytical chemistry. 88, 2, p. 1336-1344 9 p.

Research output: Contribution to journalArticle

Electrospray ionization
Mass spectrometry
Desorption
Infrared radiation
Imaging techniques
1 Citations

Antiretroviral activity and safety of once-daily etravirine in treatment-naive HIV-infected adults: 48-week results

Floris-Moore, M. A., Mollan, K., Wilkin, A. M., Johnson, M. A., Kashuba, A. D. M., Wohl, D. A., Patterson, K. B., Francis, O., Kronk, C. & Eron, J. J. Jan 1 2016 In : Antiviral therapy. 21, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

etravirine
HIV
Safety
HIV-1
Tenofovir
1 Citations

A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses

Khandelwal, P., Fukuda, T., Mizuno, K., Teusink-Cross, A., Mehta, P. A., Marsh, R. A., Kashuba, A. D. M., Vinks, A. A. & Davies, S. M. Oct 1 2016 In : Biology of Blood and Marrow Transplantation. 22, 10, p. 1829-1835 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Stem Cells
Pharmacokinetics
Pediatrics
Transplants
53 Citations
Tenofovir
Mucous Membrane
HIV
Pharmacology
Nucleotides
3 Citations

Cervicovaginal and rectal fluid as a surrogate marker of antiretroviral tissue concentration: Implications for clinical trial design

Cottrell, M. L., Prince, H. M. A., Allmon, A., Mollan, K. R., Hudgens, M. G., Sykes, C., White, N., Malone, S., Dellon, E. S., Madanick, R. D., Shaheen, N. J., Patterson, K. B. & Kashuba, A. D. M. Aug 15 2016 In : Journal of Acquired Immune Deficiency Syndromes. 72, 5, p. 498-506 9 p.

Research output: Contribution to journalArticle

Biomarkers
Clinical Trials
Tenofovir
Lower Gastrointestinal Tract
Pharmaceutical Preparations
27 Citations

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine after Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Hendrix, C. W. , Andrade, A. , Bumpus, N. N. , Kashuba, A. D. , Marzinke, M. A. , Moore, A. , Anderson, P. L. , Bushman, L. R. , Fuchs, E. J. , Wiggins, I. , Radebaugh, C. , Prince, H. A. , Bakshi, R. P. , Wang, R. , Richardson, P. , Shieh, E. , McKinstry, L. , Li, X. , Donnell, D. , Elharrar, V. & 2 others Mayer, K. H. & Patterson, K. B. Jan 1 2016 In : AIDS Research and Human Retroviruses. 32, 1, p. 32-43 12 p.

Research output: Contribution to journalArticle

Tenofovir
Benchmarking
Healthy Volunteers
Pharmacokinetics
Tablets
19 Citations

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Serrano-Villar, S., Sainz, T., Ma, Z. M., Utay, N. S., Wook-Chun, T., Mann, S., Kashuba, A. D., Siewe, B., Albanese, A., Troia-Cancio, P., Sinclair, E., Somasunderam, A., Yotter, T., Deeks, S. G., Landay, A., Pollard, R. B., Miller, C. J., Moreno, S. & Asmuth, D. M. Jan 1 2016 In : PLoS pathogens. 12, 1, e1005381

Research output: Contribution to journalArticle

Integrase Inhibitors
Mucosal Immunity
HIV
T-Lymphocytes
T-Lymphocyte Subsets
4 Citations

HIV-1-RNA decay and dolutegravir concentrations in semen of patients starting a first antiretroviral regimen

Imaz, A., Martinez-Picado, J., Niubó, J., Kashuba, A. D. M., Ferrer, E., Ouchi, D., Sykes, C., Rozas, N., Acerete, L., Curto, J., Vila, A. & Podzamczer, D. Nov 15 2016 In : Journal of Infectious Diseases. 214, 10, p. 1512-1519 8 p.

Research output: Contribution to journalArticle

RNA Stability
Semen
HIV-1
RNA
dolutegravir
3 Citations

Mucosal tissue pharmacokinetics of the integrase inhibitor raltegravir in a humanized mouse model: Implications for HIV pre-exposure prophylaxis

Veselinovic, M., Yang, K. H., Sykes, C., Remling-Mulder, L., Kashuba, A. D. M. & Akkina, R. Feb 1 2016 In : Virology. 489, p. 173-178 6 p.

Research output: Contribution to journalArticle

Integrase Inhibitors
Mucous Membrane
Pharmacokinetics
HIV
Pharmaceutical Preparations
Virus Diseases
Coinfection
Hepacivirus
Antiviral Agents
HIV
1 Citations

Plasma and Intracellular Concentrations in HIV-Infected Patients Requiring Hemodialysis Dosed with Tenofovir Disoproxil Fumarate and Emtricitabine

Slaven, J. E., Decker, B. S., Kashuba, A. D. M., Atta, M. G., Wyatt, C. M. & Gupta, S. K. Sep 1 2016 In : Journal of Acquired Immune Deficiency Syndromes. 73, 1, p. e8-e10

Research output: Contribution to journalLetter

2 Citations

Saquinavir Loaded Acetalated Dextran Microconfetti – a Long Acting Protease Inhibitor Injectable

Collier, M. A., Gallovic, M. D., Bachelder, E. M., Sykes, C. D., Kashuba, A. & Ainslie, K. M. Aug 1 2016 In : Pharmaceutical Research. 33, 8, p. 1998-2009 12 p.

Research output: Contribution to journalArticle

Saquinavir
Dextrans
Protease Inhibitors
Injections
Pharmaceutical Preparations

S-warfarin limited sampling models to estimate area under the concentration versus time curve for cytochrome P450 2C9 baseline activity and after induction

Chang, A. T., Bertino, J. S., Nafziger, A. N., Kashuba, A. D. M., Turpault, S., Lewis, L. D. & Ma, J. D. Jan 1 2016 In : Therapeutic Drug Monitoring. 38, 3, p. 383-387 5 p.

Research output: Contribution to journalArticle

Warfarin
Cytochrome P-450 Enzyme System
Area Under Curve
Neoplasms
Lopinavir
11 Citations

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

Clutton, G., Xu, Y., Baldoni, P. L., Mollan, K. R., Kirchherr, J., Newhard, W., Cox, K., Kuruc, J. D., Kashuba, A., Barnard, R., Archin, N., Gay, C. L., Hudgens, M. G., Margolis, D. M. & Goonetilleke, N. Aug 2 2016 In : Scientific Reports. 6, 30749

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Histone Deacetylase Inhibitors
Protein Kinase C
CD8 Antigens
2015
18 Citations

Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials

Agot, K., Taylor, D., Corneli, A. L., Wang, M., Ambia, J., Kashuba, A. D. M., Parker, C., Lemons, A., Malahleha, M., Lombaard, J. & Van Damme, L. May 1 2015 In : AIDS and behavior. 19, 5, p. 743-751 9 p.

Research output: Contribution to journalArticle

Tenofovir
Self Report
Clinical Trials
HIV
Pharmaceutical Preparations
58 Citations

Bottlenecks in HIV-1 transmission: Insights from the study of founder viruses

Joseph, S. B., Swanstrom, R., Kashuba, A. D. M. & Cohen, M. S. Jan 1 2015 In : Nature Reviews Microbiology. 13, 7, p. 414-425 12 p.

Research output: Contribution to journalReview article

HIV-1
Viruses
HIV Infections
Phenotype
10 Citations

Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue

Maher, J. R., Chuchuen, O., Henderson, M. H., Kim, S., Rinehart, M. T., Kashuba, A. D. M., Wax, A. & Katz, D. F. May 8 2015 In : Biomedical Optics Express. 6, 6, p. 2022-2035 14 p.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Optical Coherence Tomography
Tenofovir
Raman spectroscopy
tomography
1 Citations

Combined raman spectroscopy and optical coherence tomography for measuring analytes in targeted tissues

Maher, J. R., Chuchuen, O., Kashuba, A. D. M., Katz, D. F. & Wax, A. Apr 6 2015 Optical Molecular Probes, Imaging and Drug Delivery, OMP 2015. OSA - The Optical Society

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Raman Spectrum Analysis
Optical tomography
Optical Coherence Tomography
Anti-Infective Agents
Raman spectroscopy
11 Citations

Effect of cytomegalovirus infection on breastfeeding transmission of HIV and on the health of infants born to HIV-infected mothers

Chang, T. S. , Wiener, J. , Dollard, S. C. , Amin, M. M. , Ellington, S. , Chasela, C. , Kayira, D. , Tegha, G. , Kamwendo, D. , Jamieson, D. J. , Van Der Horst, C. , Kourtis, A. P. , Adair, L. , Ahmed, Y. , Ait-Khaled, M. , Albrecht, S. , Bangdiwala, S. , Bayer, R. , Bentley, M. , Bramson, B. & 104 others Bobrow, E., Boyle, N., Butera, S., Chavula, C., Chimerang'ambe, J., Chigwenembe, M., Chikasema, M., Chikhungu, N., Chilongozi, D., Chiudzu, G., Chome, L., Cole, A., Corbett, A., Corneli, A., Dow, A., Duerr, A., Eliya, H., Eron, J., Farr, S., Ferguson, Y. O., Fiscus, S., Flax, V., Fokar, A., Galvin, S., Guay, L., Heilig, C., Hoffman, I., Hooten, E., Hosseinipour, M., Hudgens, M., Hurst, S., Hyde, L., Joaki, G., Jones, D., Jordan-Bell, E., Kacheche, Z., Kamanga, E., Kamanga, G., Kampani, C., Kamthunzi, P., Kanyama, C., Kashuba, A., Kathyola, D., Kazembe, P., King, C. C., Knight, R., Krysiak, R., Kumwenda, J., Lee, H., Loeliger, E., Long, D., Luhanga, M., Madhlopa, V., Majawa, M., Maida, A., Marcus, C., Martinson, F., Thoofer, N., Matiki, C., Mayers, D., Mayuni, I., McDonough, M., Meme, J., Merry, C., Mita, K., Mkomawanthu, C., Mndala, G., Mndala, I., Moses, A., Msika, A., Msungama, W., Mtimuni, B., Muita, J., Mumba, N., Musis, B., Mwansambo, C., Mwapasa, G., Nkhoma, J., Parker, M., Pendame, R., Piwoz, E., Raines, B., Ramdas, Z., Rublein, J., Ryan, M., Sanne, I., Sellers, C., Shugars, D., Sichali, D., Snowden, W., Soko, A., Spensley, A., Steens, J. M., Tembo, M., Thomas, R., Tien, H. C., Tohill, B., Van Der Horst, C., Waalberg, E., Widen, E., Wilfert, C., Wiyo, P., Zgambo, I. & Zimba, C. Apr 24 2015 In : AIDS. 29, 7, p. 831-836 6 p.

Research output: Contribution to journalArticle

Cytomegalovirus Infections
Breast Feeding
Mothers
HIV
Cytomegalovirus
2 Citations

Effect of HIV infection and menopause status on raltegravir pharmacokinetics in the blood and genital tract

Cottrell, M. L., Patterson, K. B., Prince, H. M. A., Jones, A., White, N., Wang, R. & Kashuba, A. D. M. 2015 In : Antiviral Therapy. 20, 8, p. 795-803 9 p.

Research output: Contribution to journalArticle

Menopause
HIV Infections
Pharmacokinetics
HIV
Area Under Curve
31 Citations

Genital Tenofovir Concentrations Correlate with Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness

Kashuba, A. D. M., Gengiah, T. N., Werner, L., Yang, K. H., White, N. R., Karim, Q. A. & Abdool Karim, S. S. Jul 1 2015 In : Journal of Acquired Immune Deficiency Syndromes. 69, 3, p. 264-269 6 p.

Research output: Contribution to journalArticle

Tenofovir
Anti-Infective Agents
HIV Infections
HIV
Gels
1 Citations
HIV
Therapeutic Irrigation
Endometrium
Biomarkers
RNA
7 Citations

Interactions of the hepatitis C virus protease inhibitor faldaprevir with cytochrome P450 enzymes: In vitro and in vivo correlation

Sabo, J. P., Kort, J., Ballow, C., Kashuba, A. D. M., Haschke, M., Battegay, M., Girlich, B., Ting, N., Lang, B., Zhang, W., Cooper, C., O'Brien, D., Seibert, E., Chan, T. S., Tweedie, D. & Li, Y. Jan 1 2015 In : Journal of Clinical Pharmacology. 55, 4, p. 467-477 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Protease Inhibitors
Hepacivirus
Cytochrome P-450 Enzyme System
Area Under Curve
5 Citations

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation

Peterson, C. W., Haworth, K. G., Polacino, P., Huang, M. L., Sykes, C., Obenza, W. M., Repetto, A. C., Kashuba, A., Bumgarner, R., DeRosa, S. C., Woolfrey, A. E., Jerome, K. R., Mullins, J. I., Hu, S. L. & Kiem, H. P. Aug 24 2015 In : AIDS. 29, 13, p. 1597-1606 10 p.

Research output: Contribution to journalArticle

Macaca
Bone Marrow Transplantation
Mutation
Hematopoietic Stem Cell Transplantation
Viremia
2 Citations

Low frequency of drug-resistant variants selected by long-acting rilpivirine in macaques infected with simian immunodeficiency virus containing HIV-1 reverse transcriptase

Melody, K., McBeth, S., Kline, C., Kashuba, A. D. M., Mellors, J. W. & Ambrose, Z. Dec 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 12, p. 7762-7770 9 p.

Research output: Contribution to journalArticle

Rilpivirine
Simian Immunodeficiency Virus
Macaca
HIV-1
RNA-Directed DNA Polymerase
19 Citations

Mass spectrometry imaging reveals heterogeneous efavirenz distribution within putative HIV reservoirs

Thompson, C. G., Bokhart, M. T., Sykes, C., Adamson, L., Fedoriw, Y., Luciw, P. A., Muddiman, D. C., Kashuba, A. D. M. & Rosen, E. P. May 1 2015 In : Antimicrobial agents and chemotherapy. 59, 5, p. 2944-2948 5 p.

Research output: Contribution to journalArticle

efavirenz
Mass Spectrometry
HIV
Macaca
Pharmaceutical Preparations
10 Citations

Models for predicting effective HIV chemoprevention in women

Nicol, M. R., Emerson, C. W., Prince, H. M. A., Nelson, J. A. E., Fedoriw, Y., Sykes, C., Geller, E. J., Patterson, K. B., Cohen, M. S. & Kashuba, A. D. M. Apr 1 2015 In : Journal of Acquired Immune Deficiency Syndromes. 68, 4, p. 369-376 8 p.

Research output: Contribution to journalArticle

Tenofovir
Chemoprevention
HIV
HIV Infections
Protective Agents
1 Citations

Pharmacokinetic modeling of lamivudine and zidovudine triphosphates predicts differential pharmacokinetics in seminal mononuclear cells and peripheral blood mononuclear cells

Dumond, J. B., Yang, K. H., Kendrick, R., Reddy, Y. S., Kashuba, A. D. M., Troiani, L., Bridges, A. S., Fiscus, S. A., Forrest, A. & Cohen, M. S. Oct 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 10, p. 6395-6401 7 p.

Research output: Contribution to journalArticle

Blood Cells
Pharmacokinetics
Zidovudine
Semen
Lamivudine
15 Citations

Pharmacokinetics of antiretrovirals in mucosal tissue

Cottrell, M. L., Srinivas, N. & Kashuba, A. D. M. Jan 1 2015 In : Expert Opinion on Drug Metabolism and Toxicology. 11, 6, p. 893-905 13 p.

Research output: Contribution to journalReview article

Pharmacokinetics
Lower Gastrointestinal Tract
Mucous Membrane
HIV
Pharmaceutical Preparations
5 Citations
Micronutrients
Highly Active Antiretroviral Therapy
HIV
Lipids
Food
6 Citations

Proof-of-principle for immune control of global HIV-1 reactivation in vivo

Smith, N. M. G., Mlcochova, P., Watters, S. A., Aasa-Chapman, M. M. I., Rabin, N., Moore, S., Edwards, S. G., Garson, J. A., Grant, P. R., Ferns, R. B., Kashuba, A., Mayor, N. P., Schellekens, J., Marsh, S. G. E., McMichael, A. J., Perelson, A. S., Pillay, D., Goonetilleke, N. & Gupta, R. K. Jul 1 2015 In : Clinical Infectious Diseases. 61, 1, p. 120-128 9 p.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Vaccines
Staining and Labeling
Viruses
20 Citations

Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization

Bokhart, M. T., Rosen, E., Thompson, C., Sykes, C., Kashuba, A. D. M. & Muddiman, D. C. Mar 1 2015 In : Analytical and bioanalytical chemistry. 407, 8, p. 2073-2084 12 p.

Research output: Contribution to journalArticle

Papillomavirus Vaccines
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Slip forming
Diagnostic Imaging
Uterine Cervical Neoplasms

Significant decreases in both total and unbound lopinavir and amprenavir exposures during coadministration: ACTG protocol A5143/A5147s results

Dumond, J. B., Rigdon, J., Mollan, K., Tierney, C., Kashuba, A. D. M., Aweeka, F. & Collier, A. C. Jan 1 2015 In : Journal of Acquired Immune Deficiency Syndromes. 70, 5, p. 510-514 5 p.

Research output: Contribution to journalArticle

Lopinavir
Hepatitis C
Drug Interactions
Pharmaceutical Preparations
Pharmacokinetics
7 Citations

Sino-implant (II)® continuation and effect of concomitant tenofovir disoproxil fumarate-emtricitabine use on plasma levonorgestrel concentrations among women in Bondo, Kenya

Todd, C. S. , Deese, J. , Wang, M. , Hubacher, D. , Steiner, M. J. , Otunga, S. , Van Damme, L. , Abele, R. , Adagi, L. , Agingu, W. , Agot, K. , Ahmed, K. , Ambia, J. , Andreasen, A. , Asewe, J. , De Baetselier, I. , Bonyo, T. , Cates, W. , Chiduo, S. , Chilwane, M. C. & 70 others Corneli, A., Crucitti, T., Defechereux, P., Dorflinger, L., Fransen, K., Gaddiel, J., Grant, R., Headley, J., Kapiga, S., Kashuba, A., Kiernan, H., Kirkendale, S., Kiyanga, P., Lalbahadur, T., Lanham, M., Lemons, A., Liegler, T., Lombaard, J., Ma, Y. R., Maboa, R. M., Makanda, M., Makatu, S. E., Mak'Oketch, P., Malahleha, M., Malone, S., Mandala, J., Manongi, R., Masaki, M., Mastro, T., Mawere, F., McKenna, K., Mlay, A., Mohale, L. B., Monedi, M. C., Mueller, M., Mullins, S., Naicker, S., Nanda, K., Ndyetabura, T., Ogola, D., Ogola, R. B., Omondi, J., Omullo, P., Omungo, Z., Ogada, T., Ollotu, I., Onyango, J., Onuonga, E., Owino, F., Parker, C., Perry, B., Ratlhagana, M. J. M., Rammutla, E., Reblin, I., Sam, N., Saylor, L., Segoe, T., Siguntu, P., Skhosana, J. S., Taylor, D., Temu, L., Thole, T. T., Thulare, N. G., Troxler, A., Chetty-Tulsee, S., Veena, V., Venkatasubramanian, L., Wassonga, L., White, N. & Wong, C. Jan 1 2015 In : Contraception. 91, 3, p. 248-252 5 p.

Research output: Contribution to journalArticle

Tenofovir
Levonorgestrel
Kenya
Contraception
Placebos
32 Citations

Tenofovir gel for the prevention of herpes simplex virus type 2 infection

Karim, S. S. A., Karim, Q. A., Kharsany, A. B. M., Baxter, C., Grobler, A. C., Werner, L., Kashuba, A., Mansoor, L. E., Samsunder, N., Mindel, A. & Gengiah, T. N. Aug 6 2015 In : New England Journal of Medicine. 373, 6, p. 530-539 10 p.

Research output: Contribution to journalArticle

Tenofovir
Human Herpesvirus 2
Virus Diseases
Gels
Confidence Intervals
2014
4 Citations

Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

Davis, N. L. , Miller, W. C. , Hudgens, M. G. , Chasela, C. S. , Sichali, D. , Kayira, D. , Nelson, J. A. E. , Stringer, J. S. A. , Ellington, S. R. , Kourtis, A. P. , Jamieson, D. J. , Van Der Horst, C. , Adair, L. , Ahmed, Y. , Ait-Khaled, M. , Albrecht, S. , Bangdiwala, S. , Bayer, R. , Bentley, M. , Bramson, B. & 104 others Bobrow, E., Boyle, N., Butera, S., Chavula, C., Chimerang'ambe, J., Chigwenembe, M., Chikasema, M., Chikhungu, N., Chilongozi, D., Chiudzu, G., Chome, L., Cole, A., Corbett, A., Corneli, A., Dow, A., Duerr, A., Eliya, H., Eron, J., Farr, S., Ferguson, Y. O., Fiscus, S., Flax, V., Fokar, A., Galvin, S., Guay, L., Heilig, C., Hoffman, I., Hooten, E., Hosseinipour, M., Hurst, S., Hyde, L., Joaki, G., Jones, D., Jordan-Bell, E., Kacheche, Z., Kamanga, E., Kamanga, G., Kampani, C., Kamthunzi, P., Kamwendo, D., Kanyama, C., Kashuba, A., Kathyola, D., Kazembe, P., King, C. C., Knight, R., Krysiak, R., Kumwenda, J., Lee, H., Loeliger, E., Long, D., Luhanga, M., Madhlopa, V., Majawa, M., Maida, A., Marcus, C., Martinson, F., Thoofer, N., Matiki, C., Mayers, D., Mayuni, I., McDonough, M., Meme, J., Merry, C., Mita, K., Mkomawanthu, C., Mndala, G., Mndala, I., Moses, A., Msika, A., Msungama, W., Mtimuni, B., Muita, J., Mumba, N., Musis, B., Mwansambo, C., Mwapasa, G., Nkhoma, J., Parker, M., Pendame, R., Piwoz, E., Raines, B., Ramdas, Z., Rublein, J., Ryan, M., Sanne, I., Sellers, C., Shugars, D., Snowden, W., Soko, A., Spensley, A., Steens, J. M., Tegha, G., Tembo, M., Thomas, R., Tien, H. C., Tohill, B., Waalberg, E., Widen, E., Wiener, J., Wilfert, C., Wiyo, P., Zgambo, I. & Zimba, C. Jan 1 2014 In : AIDS. 28, 18, p. 2739-2749 11 p.

Research output: Contribution to journalArticle

Human Milk
Postpartum Period
HIV-1
Mothers
Breast Feeding