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2018

A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer

McRee, A. J., Marcom, P. K., Moore, D. T., Zamboni, W. C., Kornblum, Z. A., Hu, Z., Phipps, R., Anders, C. K., Reeder-Hayes, K., Carey, L. A., Weck, K. E., Perou, C. M. & Dees, E. C., Aug 1 2018, In : Clinical Breast Cancer. 18, 4, p. 289-297 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Breast Neoplasms
Maximum Tolerated Dose
Pharmacokinetics
Aspartate Aminotransferases
10 Citations

Asparagine bioavailability governs metastasis in a model of breast cancer

Knott, S. R. V., Wagenblast, E., Khan, S., Kim, S. Y., Soto, M., Wagner, M., Turgeon, M. O., Fish, L., Erard, N., Gable, A. L., MacEli, A. R., DIckopf, S., Papachristou, E. K., D'Santos, C. S., Carey, L. A., Wilkinson, J. E., Harrell, J. C., Perou, C. M., Goodarzi, H., Poulogiannis, G. & 1 othersHannon, G. J., Feb 15 2018, In : Nature. 554, 7692, p. 378-381 4 p.

Research output: Contribution to journalArticle

Asparagine
Aspartate-Ammonia Ligase
Biological Availability
Breast Neoplasms
Neoplasm Metastasis

Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast

An, Y., Adams, J. R., Hollern, D. P., Zhao, A., Chang, S. G., Gams, M. S., Chung, P. E. D., He, X., Jangra, R., Shah, J. S., Yang, J., Beck, L. A., Raghuram, N., Kozma, K. J., Loch, A. J., Wang, W., Fan, C., Done, S. J., Zacksenhaus, E., Guidos, C. J. & 2 othersPerou, C. M. & Egan, S. E., Oct 16 2018, In : Cell Reports. 25, 3, p. 702-714.e6

Research output: Contribution to journalArticle

Tumors
Transcription
Infiltration
Gene expression
Genes

Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer

Cejalvo, J. M., Pascual, T., Fernández-Martínez, A., Brasó-Maristany, F., Gomis, R. R., Perou, C. M., Muñoz, M. & Prat, A., Jun 1 2018, In : Cancer Treatment Reviews. 67, p. 63-70 8 p.

Research output: Contribution to journalReview article

Hormones
Breast Neoplasms
Gene Expression Profiling
Protein-Tyrosine Kinases
Estrogens
1 Citations

FGFR1-activated translation of WNT pathway components with structured 50 utrs is vulnerable to inhibition of EIF4A-dependent translation initiation

Nguyen, T. M., Kabotyanski, E. B., Dou, Y., Reineke, L. C., Zhang, P., Zhang, X. H. F., Malovannaya, A., Jung, S. Y., Mo, Q., Roarty, K. P., Chen, Y., Zhang, B., Neilson, J. R., Lloyd, R. E., Perou, C. M., Ellis, M. J. & Rosen, J. M., Aug 1 2018, In : Cancer Research. 78, 15, p. 4229-4240 12 p.

Research output: Contribution to journalArticle

RNA
Ribosomes
RNA Helicases
G-Quadruplexes
Genes

Frequency of breast cancer subtypes among African American women in the AMBER consortium: Breast Cancer Res

Allott, E. H., Geradts, J., Cohen, S. M., Khoury, T., Zirpoli, G. R., Bshara, W., Davis, W., Omilian, A., Nair, P., Ondracek, R. P., Cheng, T. D., Miller, C. R., Hwang, H., Thorne, L. B., O'Connor, S., Bethea, T. N., Bell, M. E., Hu, Z., Li, Y., Kirk, E. L. & 7 othersSun, X., Ruiz-Narvaez, E. A., Perou, C. M., Palmer, J. R., Olshan, A. F., Ambrosone, C. B. & Troester, M. A., Feb 8 2018, In : Breast cancer research : BCR. 20, 1

Research output: Contribution to journalArticle

African Americans
Epidemiology
Breast Neoplasms
Estrogen Receptors
Neoplasms
1 Citations

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

Takaku, M., Grimm, S. A., Roberts, J. D., Chrysovergis, K., Bennett, B. D., Myers, P., Perera, L., Tucker, C. J., Perou, C. M. & Wade, P. A., Dec 1 2018, In : Nature communications. 9, 1, 1059.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Zinc Fingers
mutations
breast
Zinc

Image analysis with deep learning to predict breast cancer grade, ER status, histologic subtype, and intrinsic subtype

Couture, H. D., Williams, L. A., Geradts, J., Nyante, S. J., Butler, E. N., Marron, J. S., Perou, C. M., Troester, M. A. & Niethammer, M., Dec 1 2018, In : npj Breast Cancer. 4, 1, 30.

Research output: Contribution to journalArticle

Learning
Breast Neoplasms
RNA
Neoplasms
Biomarkers

Integrated analysis of RNA and DNA from the phase III trial CALGB 40601 identifies predictors of response to trastuzumab-based neoadjuvant chemotherapy in HER2-positive breast cancer

Tanioka, M., Fan, C., Parker, J., Hoadley, K. A., Hu, Z., Li, Y., Hyslop, T. M., Pitcher, B. N., Soloway, M. G., Spears, P. A., Henry, L. N., Tolaney, S., Dang, C. T., Krop, I. E., Harris, L. N., Berry, D. A., Mardis, E. R., Winer, E. P., Hudis, C. A., Carey, L. A. & 1 othersPerou, C. M., Nov 1 2018, In : Clinical Cancer Research. 24, 21, p. 5292-5304 13 p.

Research output: Contribution to journalArticle

RNA
Breast Neoplasms
Drug Therapy
DNA
Paclitaxel

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer

Siegel, M. B., He, X., Hoadley, K. A., Hoyle, A., Pearce, J. B., Garrett, A. L., Kumar, S., Moylan, V. J., Brady, C. M., Van Swearingen, A. E. D., Marron, D., Gupta, G. P., Thorne, L. B., Kieran, N., Livasy, C., Mardis, E. R., Parker, J., Chen, M., Anders, C. K., Carey, L. A. & 1 othersPerou, C. M., Apr 2 2018, In : Journal of Clinical Investigation. 128, 4, p. 1371-1383 13 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
DNA Sequence Analysis
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Intrinsic molecular subtypes of breast cancers categorized as HER2-positive using an alternative chromosome 17 probe assay

Desai, N. V., Torous, V., Parker, J., Auman, J. T., Rosson, G. B., Cruz, C., Perou, C. M., Schnitt, S. J. & Tung, N., Jul 11 2018, In : Breast Cancer Research. 20, 1, 75.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 17
Breast Neoplasms
Fluorescence In Situ Hybridization
Estrogen Receptors
human ERBB2 protein
3 Citations

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy–results from two independent randomized trials

Laurberg, T., Tramm, T., Nielsen, T., Alsner, J., Nord, S., Myhre, S., Sørlie, T., Leung, S., Fan, C., Perou, C., Gelmon, K., Overgaard, J., Voduc, D., Prat, A. & Cheang, M. C. U., Jan 2 2018, In : Acta Oncologica. 57, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Radiotherapy
Breast Neoplasms
Adjuvant Radiotherapy
Radiation

Multiple instance learning for heterogeneous images: Training a CNN for histopathology

Couture, H. D., Marron, J. S., Perou, C. M., Troester, M. A. & Niethammer, M., Jan 1 2018, Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. Fichtinger, G., Davatzikos, C., Alberola-López, C., Frangi, A. F. & Schnabel, J. A. (eds.). Springer Verlag, p. 254-262 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 11071 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumors
Quantile Function
Histology
Image classification
Labels

PAM50 and risk of recurrence scores for interval breast cancers

Puvanesarajah, S., Nyante, S. J., Kuzmiak, C. M., Chen, M., Tse, C. K., Sun, X., Allott, E. H., Kirk, E. L., Carey, L. A., Perou, C. M., Olshan, A. F., Henderson, L. M. & Troester, M. A., Jun 1 2018, In : Cancer Prevention Research. 11, 6, p. 327-335 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Recurrence
Neoplasms
Confidence Intervals
Registries
2 Citations

Pathological response in a triple-negative breast cancer cohort treated with neoadjuvant carboplatin and docetaxel according to Lehmann's refined classification

Echavarria, I., Lopez-Tarruella, S., Picornell, A., García-Saenz, J. A., Jerez, Y., Hoadley, K., Gomez, H. L., Moreno, F., Monte-Millan, M. D., Marquez-Rodas, I., Alvarez, E., Ramos-Medina, R., Gayarre, J., Massarrah, T., Ocaña, I., Cebollero, M., Fuentes, H., Barnadas, A., Ballesteros, A. I., Bohn, U. & 2 othersPerou, C. M. & Martin, M., Apr 15 2018, In : Clinical Cancer Research. 24, 8, p. 1845-1852 8 p.

Research output: Contribution to journalArticle

docetaxel
Triple Negative Breast Neoplasms
Carboplatin
Drug Therapy
Germ-Line Mutation
6 Citations

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study

Troester, M. A., Sun, X., Allott, E. H., Geradts, J., Cohen, S. M., Tse, C. K., Kirk, E. L., Thorne, L. B., Mathews, M., Li, Y., Hu, Z., Robinson, W. R., Hoadley, K. A., Olopade, O. I., Reeder-Hayes, K. E., Earp, H. S., Olshan, A. F., Carey, L. A. & Perou, C. M., Feb 1 2018, In : Journal of the National Cancer Institute. 110, 2, djx135.

Research output: Contribution to journalArticle

Breast Neoplasms
Odds Ratio
Confidence Intervals
Neoplasms
Chi-Square Distribution

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

Williams, L. A., Nichols, H. B., Hoadley, K. A., Tse, C. K., Geradts, J., Bell, M. E., Perou, C. M., Love, M. I., Olshan, A. F. & Troester, M. A., Jan 1 2018, In : Cancer Causes and Control. 29, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Ductal Carcinoma
Breast Neoplasms
Odds Ratio
Confidence Intervals
1 Citations

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

Giraddi, R. R., Chung, C. Y., Heinz, R. E., Balcioglu, O., Novotny, M., Trejo, C. L., Dravis, C., Hagos, B. M., Mehrabad, E. M., Rodewald, L. W., Hwang, J. Y., Fan, C., Lasken, R., Varley, K. E., Perou, C. M., Wahl, G. M. & Spike, B. T., Aug 7 2018, In : Cell Reports. 24, 6, p. 1653-1666.e7

Research output: Contribution to journalArticle

Human Mammary Glands
Stem cells
Transcriptome
Breast
Stem Cells
2 Citations

The association between copy number aberration, DNA methylation and gene expression in tumor samples

Sun, W., Bunn, P., Jin, C., Little, P., Zhabotynsky, V., Perou, C. M., Hayes, D. N., Chen, M. & Lin, D. Y., Jan 1 2018, In : Nucleic acids research. 46, 6, p. 3009-3018 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Gene Expression
Neoplasms
Colonic Neoplasms
Breast Neoplasms

TP53 protein levels, RNA-based pathway assessment, and race among invasive breast cancer cases

Williams, L. A., Butler, E. N., Sun, X., Allott, E. H., Cohen, S. M., Fuller, A. M., Hoadley, K. A., Perou, C. M., Geradts, J., Olshan, A. F. & Troester, M. A., Dec 1 2018, In : npj Breast Cancer. 4, 1, 13.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
RNA
Breast Neoplasms
Immunohistochemistry
Neoplasms

Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

Thomas, A., Routh, E. D., Pullikuth, A., Jin, G., Su, J., Chou, J. W., Hoadley, K. A., Print, C., Knowlton, N., Black, M. A., Demaria, S., Wang, E., Bedognetti, D., Jones, W. D., Mehta, G. A., Gatza, M. L., Perou, C. M., Page, D. B., Triozzi, P. & Miller, L. D., Oct 3 2018, In : OncoImmunology. 7, 10, e1490854.

Research output: Contribution to journalArticle

Tumor Burden
Breast Neoplasms
Survival
Neoplasms
Atlases
2017

Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer

Mehta, G. A., Parker, J., Silva, G. O., Hoadley, K. A., Perou, C. M. & Gatza, M. L., Apr 1 2017, In : Breast Cancer Research and Treatment. 162, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Family Therapy
Genomic Instability
RNA Interference
3 Citations

A murine preclinical syngeneic transplantation model for breast cancer precision medicine

Federico, L., Chong, Z., Zhang, D., McGrail, D. J., Zhao, W., Jeong, K. J., Vellano, C. P., Ju, Z., Gagea, M., Liu, S., Mitra, S., Dennison, J. B., Lorenzi, P. L., Cardnell, R., Diao, L., Wang, J., Lu, Y., Byers, L. A., Perou, C. M., Lin, S. Y. & 1 othersMills, G. B., Apr 1 2017, In : Science Advances. 3, 4, e1600957.

Research output: Contribution to journalArticle

Experimental Mammary Neoplasms
Neoplasm Transplantation
Neoplasm Proteins
Phthalazines
Isogeneic Transplantation
5 Citations

A PAM50-based chemoendocrine score for hormone receptor-positive breast cancer with an intermediate risk of relapse

Prat, A., Lluch, A., Turnbull, A. K., Dunbier, A. K., Calvo, L., Albanell, J., De La Haba-Rodríguez, J., Arcusa, A., Chacón, J. I., Sánchez-Rovira, P., Plazaola, A., Muñoz, M., Paré, L., Parker, J., Ribelles, N., Jimenez, B., Bin Aiderus, A. A., Caballero, R., Adamo, B., Dowsett, M. & 5 othersCarrasco, E., Martín, M., Dixon, J. M., Perou, C. M. & Alba, E., Jun 15 2017, In : Clinical Cancer Research. 23, 12, p. 3035-3044 10 p.

Research output: Contribution to journalArticle

Hormones
Breast Neoplasms
Recurrence
Drug Therapy
Therapeutics
30 Citations

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Nolan, E., Savas, P., Policheni, A. N., Darcy, P. K., Vaillant, F., Mintoff, C. P., Dushyanthen, S., Mansour, M., Pang, J. M. B., Fox, S. B., Perou, C. M., Visvader, J. E., Gray, D. H. D., Loi, S. & Lindeman, G. J., Jun 7 2017, In : Science Translational Medicine. 9, 393, eaal4922.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasms
Cisplatin
CTLA-4 Antigen

Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas

Huo, D., Hu, H., Rhie, S. K., Gamazon, E. R., Cherniack, A. D., Liu, J., Yoshimatsu, T. F., Pitt, J. J., Hoadley, K. A., Troester, M. A., Ru, Y., Lichtenberg, T., Sturtz, L. A., Shelley, C. S., Benz, C. C., Mills, G. B., Laird, P. W., Shriver, C. D., Perou, C. M. & Olopade, O. I., Dec 1 2017, In : JAMA Oncology. 3, 12, p. 1654-1662 9 p.

Research output: Contribution to journalArticle

Atlases
Genome
Breast Neoplasms
Survival
Neoplasms
4 Citations

Docetaxel-loaded PLGA nanoparticles improve efficacy in taxane-resistant triple-negative breast cancer

Bowerman, C. J., Byrne, J. D., Chu, K. S., Schorzman, A. N., Keeler, A. W., Sherwood, C. A., Perry, J. L., Luft, J. C., Darr, D. B., Deal, A. M., Napier, M. E., Zamboni, W. C., Sharpless, N. E., Perou, C. M. & DeSimone, J. M., Jan 1 2017, In : Nano Letters. 17, 1, p. 242-248 7 p.

Research output: Contribution to journalArticle

docetaxel
breast
cancer
Nanoparticles
nanoparticles
26 Citations

Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

Zawistowski, J. S., Bevill, S. M., Goulet, D. R., Stuhlmiller, T. J., Beltran Lopez, A. S., Olivares-Quintero, J. F., Singh, D., Sciaky, N., Parker, J., Rashid, N. U., Chen, X., Duncan, J. S., Whittle, M. C., Angus, S. P., Velarde, S. H., Golitz, B. T., He, X., Santos, C., Darr, D. B., Gallagher, K. & 5 othersGraves, L. M., Perou, C. M., Carey, L. A., Earp, H. S. & Johnson, G. L., Mar 1 2017, In : Cancer Discovery. 7, 3, p. 302-321 20 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Mitogen-Activated Protein Kinase Kinases
Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Neoplasms
2 Citations

Gene expression signatures and immunohistochemical subtypes add prognostic value to each other in breast cancer cohorts

Lundberg, A., Lindstrom, L. S., Harrell, J. C., Falato, C., Carlson, J. W., Wright, P. K., Foukakis, T., Perou, C. M., Czene, K., Bergh, J. & Tobin, N. P., Jan 1 2017, In : Clinical Cancer Research. 23, 24, p. 7512-7520 9 p.

Research output: Contribution to journalArticle

Transcriptome
Breast Neoplasms
Recurrence
cdc Genes
Proportional Hazards Models
11 Citations

Intrinsic subtype and therapeutic response among HER2-positive breast tumors from the NCCTG (Alliance) N9831 trial

Perez, E. A., Ballman, K. V., Mashadi-Hossein, A., Tenner, K. S., Kachergus, J. M., Norton, N., Necela, B. M., Carr, J. M., Ferree, S., Perou, C. M., Baehner, F., Cheang, M. C. U. & Thompson, E. A., Jan 1 2017, In : Journal of the National Cancer Institute. 109, 2

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Therapeutics
Confidence Intervals
Recurrence
11 Citations

Lung Adenocarcinoma and Squamous Cell Carcinoma Gene Expression Subtypes Demonstrate Significant Differences in Tumor Immune Landscape

Faruki, H., Mayhew, G. M., Serody, J. S., Hayes, D. N., Perou, C. M. & Lai-Goldman, M., Jun 1 2017, In : Journal of Thoracic Oncology. 12, 6, p. 943-953 11 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Gene Expression
Adenocarcinoma
Neoplasms
Major Histocompatibility Complex
4 Citations

Nuclear localized LSR: A novel regulator of breast cancer behavior and tumorigenesis

Reaves, D. K., Hoadley, K. A., Fagan-Solis, K. D., Jima, D. D., Bereman, M., Thorpe, L., Hicks, J., McDonald, D., Troester, M. A., Perou, C. M. & Fleming, J. M., Feb 1 2017, In : Molecular Cancer Research. 15, 2, p. 165-178 14 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Carcinogenesis
Breast Neoplasms
Neoplasms
Post Translational Protein Processing
2 Citations

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

Kechele, D. O., Blue, R. E., Zwarycz, B., Espenschied, S. T., Mah, A. T., Siegel, M. B., Perou, C. M., Ding, S., Magness, S. T., Lund, P. K. & Caron, K. M., Feb 1 2017, In : Journal of Clinical Investigation. 127, 2, p. 593-607 15 p.

Research output: Contribution to journalArticle

Orphaned Children
Adenoma
Regeneration
Stem Cells
Organoids

PAM50 provides prognostic information when applied to the lymph node metastases of advanced breast cancer patients

TEX Trialists Group, Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7225-7231 7 p.

Research output: Contribution to journalArticle

Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
Recurrence
Survival
4 Citations

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

Bower, J. J., Vance, L. D., Psioda, M., Smith-Roe, S. L., Simpson, D. A., Ibrahim, J. G., Hoadley, K. A., Perou, C. M. & Kaufmann, W. K., Dec 1 2017, In : npj Breast Cancer. 3, 1, 0009.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Breast Neoplasms
M Phase Cell Cycle Checkpoints
Cell Line
Genomic Instability
4 Citations

Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers

Thomas, C., Henry, W., Cuiffo, B. G., Collmann, A. Y., Marangoni, E., Benhamo, V., Bhasin, M. K., Fan, C., Fuhrmann, L., Baldwin, A. S., Perou, C., Vincent-Salomon, A., Toker, A. & Karnoub, A. E., Feb 21 2017, In : Science Signaling. 10, 467, eaah4674.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Stem cells
Phosphotransferases
Stem Cells
5 Citations

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness

Rojas, P. A., May, M., Sequeira, G. R., Elia, A., Alvarez, M., Martínez, P., Gonzalez, P., Hewitt, S., He, X., Perou, C. M., Molinolo, A., Gibbons, L., Abba, M. C., Gass, H. & Lanari, C., Jul 1 2017, In : Journal of the National Cancer Institute. 109, 7, djw317.

Research output: Contribution to journalArticle

Progesterone Receptors
Protein Isoforms
Breast Neoplasms
Neoplasms
Mifepristone
1 Citations

Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study

Parada, H., Sun, X., Fleming, J. M., Williams-DeVane, C. L. R., Kirk, E. L., Olsson, L. T., Perou, C. M., Olshan, A. F. & Troester, M. A., Dec 11 2017, In : Breast Cancer Research. 19, 1, 131.

Research output: Contribution to journalArticle

Confidence Intervals
Breast Neoplasms
Recurrence
Gene Expression
Genes
5 Citations

Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression

Roarty, K., Pfefferle, A. D., Creighton, C. J., Perou, C. M. & Rosen, J. M., Oct 26 2017, In : Oncogene. 36, 43, p. 5958-5968 11 p.

Research output: Contribution to journalArticle

Cell Adhesion
Breast Neoplasms
beta Catenin
Neoplasms
Wnt Signaling Pathway
4 Citations

SynthEx: A synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Silva, G. O., Siegel, M. B., Mose, L. E., Parker, J., Sun, W., Perou, C. M. & Chen, M., Apr 8 2017, In : Genome biology. 18, 1, 66.

Research output: Contribution to journalArticle

DNA Sequence Analysis
tumor
sequence analysis
Exome
DNA
13 Citations

Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer

Taylor, N. A., Vick, S. C., Iglesia, M. D., Brickey, W. J., Midkiff, B. R., Mckinnon, K. P., Reisdorf, S., Anders, C. K., Carey, L. A., Parker, J., Perou, C. M., Vincent, B. G. & Serody, J. S., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3472-3483 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Tumor Microenvironment
Neoplasms
TNF-Related Apoptosis-Inducing Ligand Receptors
Tumor-Infiltrating Lymphocytes
2016
36 Citations

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

He, Z., Wan, X., Schulz, A., Bludau, H., Dobrovolskaia, M. A., Stern, S. T., Montgomery, S. A., Yuan, H., Li, Z., Alakhova, D., Sokolsky, M., Darr, D. B., Perou, C. M., Jordan, R., Luxenhofer, R. & Kabanov, A. V., Sep 1 2016, In : Biomaterials. 101, p. 296-309 14 p.

Research output: Contribution to journalArticle

Drug therapy
Micelles
Paclitaxel
Tumors
Solubility
10 Citations

Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V'DJer

Mose, L. E., Selitsky, S. R., Bixby, L. M., Marron, D. L., Iglesia, M. D., Serody, J. S., Perou, C. M., Vincent, B. G. & Parker, J., Dec 15 2016, In : Bioinformatics (Oxford, England). 32, 24, p. 3729-3734 6 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
B Cells
RNA
Receptor
Sequencing
3 Citations

Collective Wisdom: Lobular Carcinoma of the Breast

Sledge, G. W., Chagpar, A. & Perou, C., Jan 1 2016, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting. 35, p. 18-21 4 p.

Research output: Contribution to journalArticle

Hormone-Dependent Neoplasms
ErbB-2 Receptor
Lobular Carcinoma
Genetic Heterogeneity
Estrogen Receptor alpha
48 Citations
B-Lymphocytes
Confidence Intervals
Neoplasms
Melanoma
Survival
6 Citations

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

Pfefferle, A. D., Agrawal, Y. N., Koboldt, D. C., Kanchi, K. L., Herschkowitz, J. I., Mardis, E. R., Rosen, J. M. & Perou, C. M., Jul 1 2016, In : DMM Disease Models and Mechanisms. 9, 7, p. 749-757 9 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Pharmaceutical Preparations
Neoplasms
Triple Negative Breast Neoplasms
9 Citations

High intratumoral stromal content defines reactive breast cancer as a low-risk breast cancer subtype

Dennison, J. B., Shahmoradgoli, M., Liu, W., Ju, Z., Meric-Bernstam, F., Perou, C. M., Sahin, A. A., Welm, A., Oesterreich, S., Sikora, M. J., Brown, R. E. & Mills, G. B., Oct 15 2016, In : Clinical Cancer Research. 22, 20, p. 5068-5078 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogen Receptors
Protein Array Analysis
Neoplasms
Proteins
3 Citations

Identification of mRNA isoform switching in breast cancer

Zhao, W., Hoadley, K. A., Parker, J. & Perou, C. M., Jan 1 2016, In : BMC genomics. 17, 1, 181.

Research output: Contribution to journalArticle

RNA Isoforms
Protein Isoforms
Breast Neoplasms
Genes
Neoplasms
7 Citations

Insulin receptor substrate adaptor proteins mediate prognostic gene expression profiles in breast cancer

Becker, M. A., Ibrahim, Y. H., Oh, A. S., Fagan, D. H., Byron, S. A., Sarver, A. L., Lee, A. V., Shaw, L. M., Fan, C., Perou, C. M. & Yee, D., Mar 1 2016, In : PloS one. 11, 3, e0150564.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin Receptor
Transcriptome
Gene expression
breast neoplasms
95 Citations

Molecular heterogeneity and response to neoadjuvant human epidermal growth factor receptor 2 targeting in CALGB 40601, a randomized phase III trial of paclitaxel plus trastuzumab with or without lapatinib

Carey, L. A., Berry, D. A., Cirrincione, C. T., Barry, W. T., Pitcher, B. N., Harris, L. N., Ollila, D. W., Krop, I. E., Henry, N. L., Weckstein, D. J., Anders, C. K., Singh, B., Hoadley, K. A., Iglesia, M., Cheang, M. C. U., Perou, C. M., Winer, E. P. & Hudis, C. A., Feb 20 2016, In : Journal of Clinical Oncology. 34, 6, p. 542-549 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Tumor Microenvironment
Gene Expression
Arm
Hormones