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2018
2 Citations

Asparagine bioavailability governs metastasis in a model of breast cancer

Knott, S. R. V. , Wagenblast, E. , Khan, S. , Kim, S. Y. , Soto, M. , Wagner, M. , Turgeon, M. O. , Fish, L. , Erard, N. , Gable, A. L. , MacEli, A. R. , DIckopf, S. , Papachristou, E. K. , D'Santos, C. S. , Carey, L. A. , Wilkinson, J. E. , Harrell, J. C. , Perou, C. M. , Goodarzi, H. , Poulogiannis, G. & 1 others Hannon, G. J. Feb 15 2018 In : Nature. 554, 7692, p. 378-381 4 p.

Research output: Contribution to journalArticle

genetic analysis
tumor
bioavailability
gene expression
cancer

Frequency of breast cancer subtypes among African American women in the AMBER consortium: Breast Cancer Res

Allott, E. H. , Geradts, J. , Cohen, S. M. , Khoury, T. , Zirpoli, G. R. , Bshara, W. , Davis, W. , Omilian, A. , Nair, P. , Ondracek, R. P. , Cheng, T. D. , Miller, C. R. , Hwang, H. , Thorne, L. B. , O'Connor, S. , Bethea, T. N. , Bell, M. E. , Hu, Z. , Li, Y. , Kirk, E. L. & 7 others Sun, X., Ruiz-Narvaez, E. A., Perou, C. M., Palmer, J. R., Olshan, A. F., Ambrosone, C. B. & Troester, M. A. Feb 8 2018 In : Breast cancer research : BCR. 20, 1

Research output: Contribution to journalArticle

African Americans
Epidemiology
Breast Neoplasms
Estrogen Receptors
Neoplasms

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

Takaku, M., Grimm, S. A., Roberts, J. D., Chrysovergis, K., Bennett, B. D., Myers, P., Perera, L., Tucker, C. J., Perou, C. M. & Wade, P. A. Dec 1 2018 In : Nature Communications. 9, 1, 1059

Research output: Contribution to journalArticle

Gene Regulatory Networks
Zinc Fingers
mutations
breast
mutation

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer

Siegel, M. B. , He, X. , Hoadley, K. A. , Hoyle, A. , Pearce, J. B. , Garrett, A. L. , Kumar, S. , Moylan, V. J. , Brady, C. M. , Van Swearingen, A. E. D. , Marron, D. , Gupta, G. P. , Thorne, L. B. , Kieran, N. , Livasy, C. , Mardis, E. R. , Parker, J. S. , Chen, M. , Anders, C. K. , Carey, L. A. & 1 others Perou, C. M. Apr 2 2018 In : Journal of Clinical Investigation. 128, 4, p. 1371-1383 13 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
DNA Sequence Analysis
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
1 Citations

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy–results from two independent randomized trials

Laurberg, T., Tramm, T., Nielsen, T., Alsner, J., Nord, S., Myhre, S., Sørlie, T., Leung, S., Fan, C., Perou, C., Gelmon, K., Overgaard, J., Voduc, D., Prat, A. & Cheang, M. C. U. Jan 2 2018 In : Acta Oncologica. 57, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

Local Neoplasm Recurrences
Premenopause
ErbB-2 Receptor
Dose Fractionation
Carcinoma, Ductal, Breast

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study

Troester, M. A., Sun, X., Allott, E. H., Geradts, J., Cohen, S. M., Tse, C. K., Kirk, E. L., Thorne, L. B., Mathews, M., Li, Y., Hu, Z., Robinson, W. R., Hoadley, K. A., Olopade, O. I., Reeder-Hayes, K. E., Earp, H. S., Olshan, A. F., Carey, L. A. & Perou, C. M. Feb 1 2018 In : Journal of the National Cancer Institute. 110, 2, djx135

Research output: Contribution to journalArticle

Neoplasm RNA
ErbB-2 Receptor
Progesterone Receptors
Tumor Burden
Estrogen Receptors

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

Williams, L. A., Nichols, H. B., Hoadley, K. A., Tse, C. K., Geradts, J., Bell, M. E., Perou, C. M., Love, M. I., Olshan, A. F. & Troester, M. A. Jan 1 2018 In : Cancer Causes and Control. 29, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Ductal Carcinoma
Histology
Breast Neoplasms
Odds Ratio
2017

Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer

Mehta, G. A., Parker, J. S., Silva, G. O., Hoadley, K. A., Perou, C. M. & Gatza, M. L. Apr 1 2017 In : Breast Cancer Research and Treatment. 162, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Family Therapy
Genomic Instability
RNA Interference
3 Citations

A murine preclinical syngeneic transplantation model for breast cancer precision medicine

Federico, L. , Chong, Z. , Zhang, D. , McGrail, D. J. , Zhao, W. , Jeong, K. J. , Vellano, C. P. , Ju, Z. , Gagea, M. , Liu, S. , Mitra, S. , Dennison, J. B. , Lorenzi, P. L. , Cardnell, R. , Diao, L. , Wang, J. , Lu, Y. , Byers, L. A. , Perou, C. M. , Lin, S. Y. & 1 others Mills, G. B. Apr 1 2017 In : Science Advances. 3, 4, e1600957

Research output: Contribution to journalArticle

Isogeneic Transplantation
Transplantation (surgical)
Precision Medicine
Transplants
Medicine
4 Citations

A PAM50-based chemoendocrine score for hormone receptor-positive breast cancer with an intermediate risk of relapse

Prat, A. , Lluch, A. , Turnbull, A. K. , Dunbier, A. K. , Calvo, L. , Albanell, J. , De La Haba-Rodríguez, J. , Arcusa, A. , Chacón, J. I. , Sánchez-Rovira, P. , Plazaola, A. , Muñoz, M. , Paré, L. , Parker, J. S. , Ribelles, N. , Jimenez, B. , Bin Aiderus, A. A. , Caballero, R. , Adamo, B. , Dowsett, M. & 5 others Carrasco, E., Martín, M., Dixon, J. M., Perou, C. M. & Alba, E. Jun 15 2017 In : Clinical Cancer Research. 23, 12, p. 3035-3044 10 p.

Research output: Contribution to journalArticle

A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer

McRee, A. J., Marcom, P. K., Moore, D. T., Zamboni, W. C., Kornblum, Z. A., Hu, Z., Phipps, R., Anders, C. K., Reeder-Hayes, K., Carey, L. A., Weck, K. E., Perou, C. M. & Dees, E. C. Jan 1 2017 (Accepted/In press) In : Clinical Breast Cancer.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Phosphotransferases
Breast Neoplasms
Maximum Tolerated Dose
Aspartate Aminotransferases
15 Citations

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Nolan, E., Savas, P., Policheni, A. N., Darcy, P. K., Vaillant, F., Mintoff, C. P., Dushyanthen, S., Mansour, M., Pang, J. M. B., Fox, S. B., Perou, C. M., Visvader, J. E., Gray, D. H. D., Loi, S. & Lindeman, G. J. Jun 7 2017 In : Science translational medicine. 9, 393, eaal4922

Research output: Contribution to journalArticle

1 Citations

Docetaxel-loaded PLGA nanoparticles improve efficacy in taxane-resistant triple-negative breast cancer

Bowerman, C. J., Byrne, J. D., Chu, K. S., Schorzman, A. N., Keeler, A. W., Sherwood, C. A., Perry, J. L., Luft, J. C., Darr, D. B., Deal, A. M., Napier, M. E., Zamboni, W. C., Sharpless, N. E., Perou, C. M. & DeSimone, J. M. 2017 In : Nano Letters. 17, 1, p. 242-248 7 p.

Research output: Contribution to journalArticle

docetaxel
breast
cancer
Nanoparticles
nanoparticles
18 Citations

Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

Zawistowski, J. S. , Bevill, S. M. , Goulet, D. R. , Stuhlmiller, T. J. , Beltran, A. S. , Olivares-Quintero, J. F. , Singh, D. , Sciaky, N. , Parker, J. S. , Rashid, N. U. , Chen, X. , Duncan, J. S. , Whittle, M. C. , Angus, S. P. , Velarde, S. H. , Golitz, B. T. , He, X. , Santos, C. , Darr, D. B. , Gallagher, K. & 5 others Graves, L. M., Perou, C. M., Carey, L. A., Shelton Earp, H. & Johnson, G. L. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 302-321 20 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Mitogen-Activated Protein Kinase Kinases
Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Neoplasms
1 Citations

Gene expression signatures and immunohistochemical subtypes add prognostic value to each other in breast cancer cohorts

Lundberg, A., Lindstrom, L. S., Harrell, J. C., Falato, C., Carlson, J. W., Wright, P. K., Foukakis, T., Perou, C. M., Czene, K., Bergh, J. & Tobin, N. P. Jan 1 2017 In : Clinical Cancer Research. 23, 24, p. 7512-7520 9 p.

Research output: Contribution to journalArticle

Transcriptome
Breast Neoplasms
Recurrence
cdc Genes
Proportional Hazards Models
9 Citations

Intrinsic subtype and therapeutic response among HER2-positive breast tumors from the NCCTG (Alliance) N9831 trial

Perez, E. A., Ballman, K. V., Mashadi-Hossein, A., Tenner, K. S., Kachergus, J. M., Norton, N., Necela, B. M., Carr, J. M., Ferree, S., Perou, C. M., Baehner, F., Cheang, M. C. U. & Thompson, E. A. Jan 1 2017 In : Journal of the National Cancer Institute. 109, 2

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
ErbB-2 Receptor
Adjuvant Chemotherapy
Paclitaxel
Tumor Burden
6 Citations

Lung Adenocarcinoma and Squamous Cell Carcinoma Gene Expression Subtypes Demonstrate Significant Differences in Tumor Immune Landscape

Faruki, H., Mayhew, G. M., Serody, J. S., Hayes, D. N., Perou, C. M. & Lai-Goldman, M. Jun 1 2017 In : Journal of Thoracic Oncology. 12, 6, p. 943-953 11 p.

Research output: Contribution to journalArticle

3 Citations

Nuclear localized LSR: A novel regulator of breast cancer behavior and tumorigenesis

Reaves, D. K., Hoadley, K. A., Fagan-Solis, K. D., Jima, D. D., Bereman, M., Thorpe, L., Hicks, J., McDonald, D., Troester, M. A., Perou, C. M. & Fleming, J. M. Feb 1 2017 In : Molecular Cancer Research. 15, 2, p. 165-178 14 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Carcinogenesis
Breast Neoplasms
Neoplasms
Post Translational Protein Processing
1 Citations

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

Kechele, D. O., Blue, R. E., Zwarycz, B., Espenschied, S. T., Mah, A. T., Siegel, M. B., Perou, C. M., Ding, S., Magness, S. T., Lund, P. K. & Caron, K. M. Feb 1 2017 In : Journal of Clinical Investigation. 127, 2, p. 593-607 15 p.

Research output: Contribution to journalArticle

Orphaned Children
Adenoma
Regeneration
Stem Cells
Organoids

PAM50 provides prognostic information when applied to the lymph node metastases of advanced breast cancer patients

TEX Trialists Group Dec 1 2017 In : Clinical Cancer Research. 23, 23, p. 7225-7231 7 p.

Research output: Contribution to journalArticle

Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
Recurrence
Survival
3 Citations

Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers

Thomas, C., Henry, W., Cuiffo, B. G., Collmann, A. Y., Marangoni, E., Benhamo, V., Bhasin, M. K., Fan, C., Fuhrmann, L., Baldwin, A. S., Perou, C., Vincent-Salomon, A., Toker, A. & Karnoub, A. E. Feb 21 2017 In : Science Signaling. 10, 467, eaah4674

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Stem cells
Phosphotransferases
Stem Cells
2 Citations

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness

Rojas, P. A., May, M., Sequeira, G. R., Elia, A., Alvarez, M., Martínez, P., Gonzalez, P., Hewitt, S., He, X., Perou, C. M., Molinolo, A., Gibbons, L., Abba, M. C., Gass, H. & Lanari, C. Jul 1 2017 In : Journal of the National Cancer Institute. 109, 7, djw317

Research output: Contribution to journalArticle

Progesterone Receptors
Protein Isoforms
Breast Neoplasms
Neoplasms
Mifepristone

Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study

Parada, H., Sun, X., Fleming, J. M., Williams-DeVane, C. L. R., Kirk, E. L., Olsson, L. T., Perou, C. M., Olshan, A. F. & Troester, M. A. Dec 11 2017 In : Breast Cancer Research. 19, 1, 131

Research output: Contribution to journalArticle

Confidence Intervals
Breast Neoplasms
Gene Expression
Recurrence
Genes
1 Citations

Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression

Roarty, K., Pfefferle, A. D., Creighton, C. J., Perou, C. M. & Rosen, J. M. Oct 26 2017 In : Oncogene. 36, 43, p. 5958-5968 11 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Receptor Tyrosine Kinase-like Orphan Receptors
Animal Mammary Neoplasms
Tumor Suppressor Protein p53
rho-Associated Kinases
3 Citations

SynthEx: A synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Silva, G. O., Siegel, M. B., Mose, L. E., Parker, J. S., Sun, W., Perou, C. M. & Chen, M. Apr 8 2017 In : Genome biology. 18, 1, 66

Research output: Contribution to journalArticle

DNA Copy Number Variations
Exome
gene dosage
High-Throughput Nucleotide Sequencing
Gene Dosage
9 Citations

Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer

Taylor, N. A., Vick, S. C., Iglesia, M. D., Brickey, W. J., Midkiff, B. R., McKinnon, K. P., Reisdorf, S., Anders, C. K., Carey, L. A., Parker, J. S., Perou, C. M., Vincent, B. G. & Serody, J. S. Sep 1 2017 In : Journal of Clinical Investigation. 127, 9, p. 3472-3483 12 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Animal Mammary Neoplasms
Claudins
Inbred BALB C Mouse
CTLA-4 Antigen
2016
24 Citations

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

He, Z., Wan, X., Schulz, A., Bludau, H., Dobrovolskaia, M. A., Stern, S. T., Montgomery, S. A., Yuan, H., Li, Z., Alakhova, D., Sokolsky, M., Darr, D. B., Perou, C. M., Jordan, R., Luxenhofer, R. & Kabanov, A. V. Sep 1 2016 In : Biomaterials. 101, p. 296-309 14 p.

Research output: Contribution to journalArticle

Drug therapy
Micelles
Paclitaxel
Tumors
Solubility
6 Citations

Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V'DJer

Mose, L. E., Selitsky, S. R., Bixby, L. M., Marron, D. L., Iglesia, M. D., Serody, J. S., Perou, C. M., Vincent, B. G. & Parker, J. S. Dec 15 2016 In : Bioinformatics (Oxford, England). 32, 24, p. 3729-3734 6 p.

Research output: Contribution to journalArticle

B Lymphocytes
RNA Sequence Analysis
Thermionic emission
B-Cell Antigen Receptors
B Cells
1 Citations

Collective Wisdom: Lobular Carcinoma of the Breast

Sledge, G. W., Chagpar, A. & Perou, C. Jan 1 2016 In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting. 35, p. 18-21 4 p.

Research output: Contribution to journalArticle

Hormone-Dependent Neoplasms
ErbB-2 Receptor
Lobular Carcinoma
Genetic Heterogeneity
Estrogen Receptor alpha
33 Citations
B-Lymphocytes
Confidence Intervals
Neoplasms
Melanoma
Survival
6 Citations

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

Pfefferle, A. D., Agrawal, Y. N., Koboldt, D. C., Kanchi, K. L., Herschkowitz, J. I., Mardis, E. R., Rosen, J. M. & Perou, C. M. Jul 1 2016 In : DMM Disease Models and Mechanisms. 9, 7, p. 749-757 9 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Pharmaceutical Preparations
Neoplasms
Triple Negative Breast Neoplasms
5 Citations

High intratumoral stromal content defines reactive breast cancer as a low-risk breast cancer subtype

Dennison, J. B., Shahmoradgoli, M., Liu, W., Ju, Z., Meric-Bernstam, F., Perou, C. M., Sahin, A. A., Welm, A., Oesterreich, S., Sikora, M. J., Brown, R. E. & Mills, G. B. Oct 15 2016 In : Clinical Cancer Research. 22, 20, p. 5068-5078 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogen Receptors
Protein Array Analysis
Neoplasms
Proteins
2 Citations

Identification of mRNA isoform switching in breast cancer

Zhao, W., Hoadley, K. A., Parker, J. S. & Perou, C. M. 2016 In : BMC Genomics. 17, 1, 181

Research output: Contribution to journalArticle

RNA Isoforms
Protein Isoforms
Breast Neoplasms
Genes
Neoplasms
4 Citations

Insulin receptor substrate adaptor proteins mediate prognostic gene expression profiles in breast cancer

Becker, M. A., Ibrahim, Y. H., Oh, A. S., Fagan, D. H., Byron, S. A., Sarver, A. L., Lee, A. V., Shaw, L. M., Fan, C., Perou, C. M. & Yee, D. Mar 1 2016 In : PLoS One. 11, 3, e0150564

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin Receptor
Transcriptome
Gene expression
breast neoplasms
72 Citations

Molecular heterogeneity and response to neoadjuvant human epidermal growth factor receptor 2 targeting in CALGB 40601, a randomized phase III trial of paclitaxel plus trastuzumab with or without lapatinib

Carey, L. A., Berry, D. A., Cirrincione, C. T., Barry, W. T., Pitcher, B. N., Harris, L. N., Ollila, D. W., Krop, I. E., Henry, N. L., Weckstein, D. J., Anders, C. K., Singh, B., Hoadley, K. A., Iglesia, M., Cheang, M. C. U., Perou, C. M., Winer, E. P. & Hudis, C. A. Feb 20 2016 In : Journal of Clinical Oncology. 34, 6, p. 542-549 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Tumor Microenvironment
Gene Expression
Arm
Hormones
42 Citations

MR imaging radiomics signatures for predicting the risk of breast cancer recurrence as given by research versions of MammaPrint, oncotype DX, and PAM50 gene assays

Li, H., Zhu, Y., Burnside, E. S., Drukker, K., Hoadley, K. A., Fan, C., Conzen, S. D., Whitman, G. J., Sutton, E. J., Net, J. M., Ganott, M., Huang, E., Morris, E. A., Perou, C. M., Ji, Y. & Giger, M. L. Jan 1 2016 In : Radiology. 281, 2, p. 382-391 10 p.

Research output: Contribution to journalReview article

Magnetic Resonance Imaging
Breast Neoplasms
Recurrence
Research
Genes
2 Citations

Overview of genetically engineered mouse models of distinct breast cancer subtypes

Usary, J., Darr, D. B., Pfefferle, A. D. & Perou, C. M. Mar 1 2016 In : Current Protocols in Pharmacology. 2016, p. 14.38.1-14.38.11

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Drug Discovery
Heterografts
Cause of Death
16 Citations

Performance of three-biomarker immunohistochemistry for intrinsic breast cancer subtyping in the AMBER consortium

Allott, E. H. , Cohen, S. M. , Geradts, J. , Sun, X. , Khoury, T. , Bshara, W. , Zirpoli, G. R. , Miller, C. R. , Hwang, H. , Thorne, L. B. , O'Connor, S. , Tse, C. K. , Bell, M. B. , Hu, Z. , Li, Y. , Kirk, E. L. , Bethea, T. N. , Perou, C. M. , Palmer, J. R. , Ambrosone, C. B. & 2 others Olshan, A. F. & Troester, M. A. Mar 1 2016 In : Cancer Epidemiology Biomarkers and Prevention. 25, 3, p. 470-478 9 p.

Research output: Contribution to journalArticle

Epidemiology
Biomarkers
Immunohistochemistry
Breast Neoplasms
Progesterone Receptors
15 Citations

Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study

Martin, M., Brase, J. C., Ruiz, A., Prat, A., Kronenwett, R., Calvo, L., Petry, C., Bernard, P. S., Ruiz-Borrego, M., Weber, K. E., Rodriguez, C. A., Alvarez, I. M., Segui, M. A., Perou, C. M., Casas, M., Carrasco, E., Caballero, R. & Rodriguez-Lescure, A. Feb 1 2016 In : Breast Cancer Research and Treatment. 156, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Recurrence
Research
Neoplasm Metastasis
5 Citations

Rho GTPase transcriptome analysis reveals oncogenic roles for rho GTPase-activating proteins in basal-like breast cancers

Lawson, C. D., Fan, C., Mitin, N., Baker, N. M., George, S. D., Graham, D. M., Perou, C. M., Burridge, K., Der, C. J. & Rossman, K. L. Jul 1 2016 In : Cancer Research. 76, 13, p. 3826-3837 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Gene Expression Profiling
Breast Neoplasms
Growth
Cell Proliferation
15 Citations

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases

Hoadley, K. A., Siegel, M. B., Kanchi, K. L., Miller, C. A., Ding, L., Zhao, W., He, X., Parker, J. S., Wendl, M. C., Fulton, R. S., Demeter, R. T., Wilson, R. K., Carey, L. A., Perou, C. M. & Mardis, E. R. Dec 1 2016 In : PLoS Medicine. 13, 12, e1002174

Research output: Contribution to journalArticle

Genomics
Retrospective Studies
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Validation of the lung subtyping panel in multiple fresh-frozen and formalin-fixed, paraffin-embedded lung tumor gene expression data sets

Faruki, H., Mayhew, G. M., Fan, C., Wilkerson, M. D., Parker, S., Kam-Morgan, L., Eisenberg, M., Horten, B., Hayes, D. N., Perou, C. M. & Lai-Goldman, M. Jun 1 2016 In : Archives of Pathology and Laboratory Medicine. 140, 6, p. 536-542 7 p.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Gene Expression
Lung
Neoplasms
2015
13 Citations

Activating PIK3CA mutations induce an epidermal growth factor receptor (EGFR)/extracellular signal-regulated Kinase (ERK) paracrine signaling axis in basal-like breast cancer

Young, C. D. , Zimmerman, L. J. , Hoshino, D. , Formisano, L. , Hanker, A. B. , Gatza, M. L. , Morrison, M. M. , Moore, P. D. , Whitwell, C. A. , Dave, B. , Stricker, T. , Bhola, N. E. , Silva, G. O. , Patel, P. , Brantley-Sieders, D. M. , Levin, M. , Horiates, M. , Palma, N. A. , Wang, K. , Stephens, P. J. & 8 others Perou, C. M., Weaver, A. M., O'Shaughnessy, J. A., Chang, J. C., Park, B. H., Liebler, D. C., Cook, R. S. & Arteaga, C. L. Jan 1 2015 In : Molecular and Cellular Proteomics. 14, 7, p. 1959-1976 18 p.

Research output: Contribution to journalArticle

Paracrine Communication
Extracellular Signal-Regulated MAP Kinases
Epidermal Growth Factor Receptor
Breast Neoplasms
Mutation
90 Citations

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

Wagenblast, E., Soto, M., Gutiérrez-Ángel, S., Hartl, C. A., Gable, A. L., Maceli, A. R., Erard, N., Williams, A. M., Kim, S. Y., Dickopf, S., Harrell, J. C., Smith, A. D., Perou, C. M., Wilkinson, J. E., Hannon, G. J. & Knott, S. R. V. Apr 15 2015 In : Nature. 520, 7547, p. 358-362 5 p.

Research output: Contribution to journalArticle

Blood Vessels
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Clone Cells
18 Citations

Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance)

Ligibel, J. A., Cirrincione, C. T., Liu, M., Citron, M., Ingle, J. N., Gradishar, W., Martino, S., Sikov, W., Michaelson, R., Mardis, E., Perou, C. M., Ellis, M., Winer, E., Hudis, C. A., Berry, D. & Barry, W. T. Sep 1 2015 In : Journal of the National Cancer Institute. 107, 9, djv179

Research output: Contribution to journalArticle

Body Mass Index
Breast Neoplasms
Confidence Intervals
Weights and Measures
Drug Therapy
7 Citations

CCR 20th anniversary commentary: The development of breast cancer molecular subtyping

Nielsen, T. O. & Perou, C. M. Apr 15 2015 In : Clinical Cancer Research. 21, 8, p. 1779-1781 3 p.

Research output: Contribution to journalComment/debate

Anniversaries and Special Events
Breast Neoplasms
Gene Expression Profiling
Neoplasms
Cohort Studies
9 Citations

CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer

Black, J. L., Harrell, J. C., Leisner, T. M., Fellmeth, M. J., George, S. D., Reinhold, D., Baker, N. M., Jones, C. D., Der, C. J., Perou, C. M. & Parise, L. V. Jun 24 2015 In : Breast Cancer Research and Treatment. 152, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cell Survival
Growth
Neoplasms
RNA Sequence Analysis
3 Citations

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

Cantrell, M. A., Ebelt, N. D., Pfefferle, A. D., Perou, C. M. & Van Den Berg, C. L. Jan 1 2015 In : Oncotarget. 6, 14, p. 11863-11881 19 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 9
Neoplasm Genes
Human Mammary Glands
Phosphotransferases
Breast Neoplasms
553 Citations

Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas

Brat, D. J. , Verhaak, R. G. W. , Aldape, K. D. , Yung, W. K. A. , Salama, S. R. , Cooper, L. A. D. , Rheinbay, E. , Miller, C. R. , Vitucci, M. , Morozova, O. , Robertson, A. G. , Noushmehr, H. , Laird, P. W. , Cherniack, A. D. , Akbani, R. , Huse, J. T. , Ciriello, G. , Poisson, L. M. , Barnholtz-Sloan, J. S. , Berger, M. S. & 30 others Brennan, C., Colen, R. R., Colman, H., Flanders, A. E., Giannini, C., Grifford, M., Iavarone, A., Jain, R., Joseph, I., Kim, J., Kasaian, K., Mikkelsen, T., Murray, B. A., O'Neill, B. P., Pachter, L., Parsons, D. W., Sougnez, C., Sulman, E. P., Vandenberg, S. R., Van Meir, E. G., Von Deimling, A., Zhang, H., Crain, D., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, T. & Sherman, M. Jun 25 2015 In : New England Journal of Medicine. 372, 26, p. 2481-2498 18 p.

Research output: Contribution to journalArticle

Glioma
Mutation
Glioblastoma
DNA Methylation
Exome
764 Citations

Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas Network Jan 29 2015 In : Nature. 517, 7536, p. 576-582 7 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
TNF Receptor-Associated Factor 3
cdc Genes
Atlases