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2018

A Phase I Trial of the PI3K Inhibitor Buparlisib Combined With Capecitabine in Patients With Metastatic Breast Cancer

McRee, A. J., Marcom, P. K., Moore, D. T., Zamboni, W. C., Kornblum, Z. A., Hu, Z., Phipps, R., Anders, C. K., Reeder-Hayes, K., Carey, L. A., Weck, K. E., Perou, C. M. & Dees, E. C., Aug 1 2018, In : Clinical Breast Cancer. 18, 4, p. 289-297 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Breast Neoplasms
Maximum Tolerated Dose
Pharmacokinetics
Aspartate Aminotransferases
7 Citations

Asparagine bioavailability governs metastasis in a model of breast cancer

Knott, S. R. V. , Wagenblast, E. , Khan, S. , Kim, S. Y. , Soto, M. , Wagner, M. , Turgeon, M. O. , Fish, L. , Erard, N. , Gable, A. L. , MacEli, A. R. , DIckopf, S. , Papachristou, E. K. , D'Santos, C. S. , Carey, L. A. , Wilkinson, J. E. , Harrell, J. C. , Perou, C. M. , Goodarzi, H. , Poulogiannis, G. & 1 others Hannon, G. J., Feb 15 2018, In : Nature. 554, 7692, p. 378-381 4 p.

Research output: Contribution to journalArticle

Asparagine
Aspartate-Ammonia Ligase
Biological Availability
Breast Neoplasms
Neoplasm Metastasis

Clinical implications of the non-luminal intrinsic subtypes in hormone receptor-positive breast cancer

Cejalvo, J. M., Pascual, T., Fernández-Martínez, A., Brasó-Maristany, F., Gomis, R. R., Perou, C. M., Muñoz, M. & Prat, A., Jun 1 2018, In : Cancer Treatment Reviews. 67, p. 63-70 8 p.

Research output: Contribution to journalReview article

Hormones
Breast Neoplasms
Gene Expression Profiling
Protein-Tyrosine Kinases
Estrogens

FGFR1-activated translation of WNT pathway components with structured 50 utrs is vulnerable to inhibition of EIF4A-dependent translation initiation

Nguyen, T. M., Kabotyanski, E. B., Dou, Y., Reineke, L. C., Zhang, P., Zhang, X. H. F., Malovannaya, A., Jung, S. Y., Mo, Q., Roarty, K. P., Chen, Y., Zhang, B., Neilson, J. R., Lloyd, R. E., Perou, C. M., Ellis, M. J. & Rosen, J. M., Aug 1 2018, In : Cancer Research. 78, 15, p. 4229-4240 12 p.

Research output: Contribution to journalArticle

RNA
Ribosomes
RNA Helicases
G-Quadruplexes
Genes

Frequency of breast cancer subtypes among African American women in the AMBER consortium: Breast Cancer Res

Allott, E. H. , Geradts, J. , Cohen, S. M. , Khoury, T. , Zirpoli, G. R. , Bshara, W. , Davis, W. , Omilian, A. , Nair, P. , Ondracek, R. P. , Cheng, T. D. , Miller, C. R. , Hwang, H. , Thorne, L. B. , O'Connor, S. , Bethea, T. N. , Bell, M. E. , Hu, Z. , Li, Y. , Kirk, E. L. & 7 others Sun, X., Ruiz-Narvaez, E. A., Perou, C. M., Palmer, J. R., Olshan, A. F., Ambrosone, C. B. & Troester, M. A., Feb 8 2018, In : Breast cancer research : BCR. 20, 1

Research output: Contribution to journalArticle

African Americans
Epidemiology
Breast Neoplasms
Estrogen Receptors
Neoplasms
1 Citations

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

Takaku, M., Grimm, S. A., Roberts, J. D., Chrysovergis, K., Bennett, B. D., Myers, P., Perera, L., Tucker, C. J., Perou, C. M. & Wade, P. A., Dec 1 2018, In : Nature Communications. 9, 1, 1059

Research output: Contribution to journalArticle

Gene Regulatory Networks
Zinc Fingers
mutations
breast
mutation

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer

Siegel, M. B. , He, X. , Hoadley, K. A. , Hoyle, A. , Pearce, J. B. , Garrett, A. L. , Kumar, S. , Moylan, V. J. , Brady, C. M. , Van Swearingen, A. E. D. , Marron, D. , Gupta, G. P. , Thorne, L. B. , Kieran, N. , Livasy, C. , Mardis, E. R. , Parker, J. S. , Chen, M. , Anders, C. K. , Carey, L. A. & 1 others Perou, C. M., Apr 2 2018, In : Journal of Clinical Investigation. 128, 4, p. 1371-1383 13 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
DNA Sequence Analysis
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Intrinsic molecular subtypes of breast cancers categorized as HER2-positive using an alternative chromosome 17 probe assay

Desai, N. V., Torous, V., Parker, J., Auman, J. T., Rosson, G. B., Cruz, C., Perou, C. M., Schnitt, S. J. & Tung, N., Jul 11 2018, In : Breast Cancer Research. 20, 1, 75

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 17
Breast Neoplasms
Fluorescence In Situ Hybridization
Estrogen Receptors
human ERBB2 protein
2 Citations

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy–results from two independent randomized trials

Laurberg, T., Tramm, T., Nielsen, T., Alsner, J., Nord, S., Myhre, S., Sørlie, T., Leung, S., Fan, C., Perou, C., Gelmon, K., Overgaard, J., Voduc, D., Prat, A. & Cheang, M. C. U., Jan 2 2018, In : Acta Oncologica. 57, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

Local Neoplasm Recurrences
Premenopause
ErbB-2 Receptor
Dose Fractionation
Carcinoma, Ductal, Breast

PAM50 and risk of recurrence scores for interval breast cancers

Puvanesarajah, S., Nyante, S. J., Kuzmiak, C. M., Chen, M., Tse, C. K., Sun, X., Allott, E. H., Kirk, E. L., Carey, L. A., Perou, C. M., Olshan, A. F., Henderson, L. M. & Troester, M. A., Jun 1 2018, In : Cancer Prevention Research. 11, 6, p. 327-335 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Recurrence
Neoplasms
Confidence Intervals
Registries
1 Citations

Pathological response in a triple-negative breast cancer cohort treated with neoadjuvant carboplatin and docetaxel according to Lehmann's refined classification

Echavarria, I. , Lopez-Tarruella, S. , Picornell, A. , García-Saenz, J. A. , Jerez, Y. , Hoadley, K. , Gomez, H. L. , Moreno, F. , Monte-Millan, M. D. , Marquez-Rodas, I. , Alvarez, E. , Ramos-Medina, R. , Gayarre, J. , Massarrah, T. , Ocaña, I. , Cebollero, M. , Fuentes, H. , Barnadas, A. , Ballesteros, A. I. , Bohn, U. & 2 others Perou, C. M. & Martin, M., Apr 15 2018, In : Clinical Cancer Research. 24, 8, p. 1845-1852 8 p.

Research output: Contribution to journalArticle

docetaxel
Triple Negative Breast Neoplasms
Carboplatin
Drug Therapy
Germ-Line Mutation
3 Citations

Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study

Troester, M. A., Sun, X., Allott, E. H., Geradts, J., Cohen, S. M., Tse, C. K., Kirk, E. L., Thorne, L. B., Mathews, M., Li, Y., Hu, Z., Robinson, W. R., Hoadley, K. A., Olopade, O. I., Reeder-Hayes, K. E., Earp, H. S., Olshan, A. F., Carey, L. A. & Perou, C. M., Feb 1 2018, In : Journal of the National Cancer Institute. 110, 2, djx135

Research output: Contribution to journalArticle

Neoplasm RNA
ErbB-2 Receptor
Progesterone Receptors
Tumor Burden
Estrogen Receptors

Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study

Williams, L. A., Nichols, H. B., Hoadley, K. A., Tse, C. K., Geradts, J., Bell, M. E., Perou, C. M., Love, M. I., Olshan, A. F. & Troester, M. A., Jan 1 2018, In : Cancer Causes and Control. 29, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Ductal Carcinoma
Histology
Breast Neoplasms
Odds Ratio

Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development

Giraddi, R. R., Chung, C. Y., Heinz, R. E., Balcioglu, O., Novotny, M., Trejo, C. L., Dravis, C., Hagos, B. M., Mehrabad, E. M., Rodewald, L. W., Hwang, J. Y., Fan, C., Lasken, R., Varley, K. E., Perou, C. M., Wahl, G. M. & Spike, B. T., Aug 7 2018, In : Cell Reports. 24, 6, p. 1653-1666.e7

Research output: Contribution to journalArticle

Thermionic emission
Human Mammary Glands
Transcriptome
Breast
Stem Cells

The association between copy number aberration, DNA methylation and gene expression in tumor samples

Sun, W., Bunn, P., Jin, C., Little, P., Zhabotynsky, V., Perou, C. M., Hayes, D. N., Chen, M. & Lin, D. Y., Jan 1 2018, In : Nucleic acids research. 46, 6, p. 3009-3018 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Gene Expression
Neoplasms
Colonic Neoplasms
Breast Neoplasms

Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

Thomas, A., Routh, E. D., Pullikuth, A., Jin, G., Su, J., Chou, J. W., Hoadley, K. A., Print, C., Knowlton, N., Black, M. A., Demaria, S., Wang, E., Bedognetti, D., Jones, W. D., Mehta, G. A., Gatza, M. L., Perou, C. M., Page, D. B., Triozzi, P. & Miller, L. D., Jan 1 2018, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

Tumor Burden
Breast Neoplasms
Survival
Neoplasms
Atlases
2017

Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer

Mehta, G. A., Parker, J. S., Silva, G. O., Hoadley, K. A., Perou, C. M. & Gatza, M. L., Apr 1 2017, In : Breast Cancer Research and Treatment. 162, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Family Therapy
Genomic Instability
RNA Interference
3 Citations

A murine preclinical syngeneic transplantation model for breast cancer precision medicine

Federico, L. , Chong, Z. , Zhang, D. , McGrail, D. J. , Zhao, W. , Jeong, K. J. , Vellano, C. P. , Ju, Z. , Gagea, M. , Liu, S. , Mitra, S. , Dennison, J. B. , Lorenzi, P. L. , Cardnell, R. , Diao, L. , Wang, J. , Lu, Y. , Byers, L. A. , Perou, C. M. , Lin, S. Y. & 1 others Mills, G. B., Apr 1 2017, In : Science Advances. 3, 4, e1600957

Research output: Contribution to journalArticle

Isogeneic Transplantation
Transplantation (surgical)
Precision Medicine
Transplants
Medicine
5 Citations

A PAM50-based chemoendocrine score for hormone receptor-positive breast cancer with an intermediate risk of relapse

Prat, A. , Lluch, A. , Turnbull, A. K. , Dunbier, A. K. , Calvo, L. , Albanell, J. , De La Haba-Rodríguez, J. , Arcusa, A. , Chacón, J. I. , Sánchez-Rovira, P. , Plazaola, A. , Muñoz, M. , Paré, L. , Parker, J. S. , Ribelles, N. , Jimenez, B. , Bin Aiderus, A. A. , Caballero, R. , Adamo, B. , Dowsett, M. & 5 others Carrasco, E., Martín, M., Dixon, J. M., Perou, C. M. & Alba, E., Jun 15 2017, In : Clinical Cancer Research. 23, 12, p. 3035-3044 10 p.

Research output: Contribution to journalArticle

24 Citations

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Nolan, E., Savas, P., Policheni, A. N., Darcy, P. K., Vaillant, F., Mintoff, C. P., Dushyanthen, S., Mansour, M., Pang, J. M. B., Fox, S. B., Perou, C. M., Visvader, J. E., Gray, D. H. D., Loi, S. & Lindeman, G. J., Jun 7 2017, In : Science Translational Medicine. 9, 393, eaal4922

Research output: Contribution to journalArticle

1 Citations

Docetaxel-loaded PLGA nanoparticles improve efficacy in taxane-resistant triple-negative breast cancer

Bowerman, C. J., Byrne, J. D., Chu, K. S., Schorzman, A. N., Keeler, A. W., Sherwood, C. A., Perry, J. L., Luft, J. C., Darr, D. B., Deal, A. M., Napier, M. E., Zamboni, W. C., Sharpless, N. E., Perou, C. M. & DeSimone, J. M., Jan 1 2017, In : Nano Letters. 17, 1, p. 242-248 7 p.

Research output: Contribution to journalArticle

docetaxel
breast
cancer
Nanoparticles
nanoparticles
22 Citations

Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

Zawistowski, J. S. , Bevill, S. M. , Goulet, D. R. , Stuhlmiller, T. J. , Beltran, A. S. , Olivares-Quintero, J. F. , Singh, D. , Sciaky, N. , Parker, J. S. , Rashid, N. U. , Chen, X. , Duncan, J. S. , Whittle, M. C. , Angus, S. P. , Velarde, S. H. , Golitz, B. T. , He, X. , Santos, C. , Darr, D. B. , Gallagher, K. & 5 others Graves, L. M., Perou, C. M., Carey, L. A., Shelton Earp, H. & Johnson, G. L., Mar 1 2017, In : Cancer Discovery. 7, 3, p. 302-321 20 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Mitogen-Activated Protein Kinase Kinases
Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Neoplasms
2 Citations

Gene expression signatures and immunohistochemical subtypes add prognostic value to each other in breast cancer cohorts

Lundberg, A., Lindstrom, L. S., Harrell, J. C., Falato, C., Carlson, J. W., Wright, P. K., Foukakis, T., Perou, C. M., Czene, K., Bergh, J. & Tobin, N. P., Jan 1 2017, In : Clinical Cancer Research. 23, 24, p. 7512-7520 9 p.

Research output: Contribution to journalArticle

Transcriptome
Breast Neoplasms
Recurrence
cdc Genes
Proportional Hazards Models
11 Citations

Intrinsic subtype and therapeutic response among HER2-positive breast tumors from the NCCTG (Alliance) N9831 trial

Perez, E. A., Ballman, K. V., Mashadi-Hossein, A., Tenner, K. S., Kachergus, J. M., Norton, N., Necela, B. M., Carr, J. M., Ferree, S., Perou, C. M., Baehner, F., Cheang, M. C. U. & Thompson, E. A., Jan 1 2017, In : Journal of the National Cancer Institute. 109, 2

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
ErbB-2 Receptor
Adjuvant Chemotherapy
Paclitaxel
Tumor Burden
9 Citations

Lung Adenocarcinoma and Squamous Cell Carcinoma Gene Expression Subtypes Demonstrate Significant Differences in Tumor Immune Landscape

Faruki, H., Mayhew, G. M., Serody, J. S., Hayes, D. N., Perou, C. M. & Lai-Goldman, M., Jun 1 2017, In : Journal of Thoracic Oncology. 12, 6, p. 943-953 11 p.

Research output: Contribution to journalArticle

4 Citations

Nuclear localized LSR: A novel regulator of breast cancer behavior and tumorigenesis

Reaves, D. K., Hoadley, K. A., Fagan-Solis, K. D., Jima, D. D., Bereman, M., Thorpe, L., Hicks, J., McDonald, D., Troester, M. A., Perou, C. M. & Fleming, J. M., Feb 1 2017, In : Molecular Cancer Research. 15, 2, p. 165-178 14 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Carcinogenesis
Breast Neoplasms
Neoplasms
Post Translational Protein Processing
2 Citations

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

Kechele, D. O., Blue, R. E., Zwarycz, B., Espenschied, S. T., Mah, A. T., Siegel, M. B., Perou, C. M., Ding, S., Magness, S. T., Lund, P. K. & Caron, K. M., Feb 1 2017, In : Journal of Clinical Investigation. 127, 2, p. 593-607 15 p.

Research output: Contribution to journalArticle

Orphaned Children
Adenoma
Regeneration
Stem Cells
Organoids

PAM50 provides prognostic information when applied to the lymph node metastases of advanced breast cancer patients

TEX Trialists Group, Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7225-7231 7 p.

Research output: Contribution to journalArticle

Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
Recurrence
Survival
4 Citations

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

Bower, J. J., Vance, L. D., Psioda, M., Smith-Roe, S. L., Simpson, D. A., Ibrahim, J. G., Hoadley, K. A., Perou, C. M. & Kaufmann, W. K., Dec 1 2017, In : npj Breast Cancer. 3, 1, 0009

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Breast Neoplasms
M Phase Cell Cycle Checkpoints
Cell Line
Genomic Instability
4 Citations

Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers

Thomas, C., Henry, W., Cuiffo, B. G., Collmann, A. Y., Marangoni, E., Benhamo, V., Bhasin, M. K., Fan, C., Fuhrmann, L., Baldwin, A. S., Perou, C., Vincent-Salomon, A., Toker, A. & Karnoub, A. E., Feb 21 2017, In : Science Signaling. 10, 467, eaah4674

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Stem cells
Phosphotransferases
Stem Cells
3 Citations

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness

Rojas, P. A., May, M., Sequeira, G. R., Elia, A., Alvarez, M., Martínez, P., Gonzalez, P., Hewitt, S., He, X., Perou, C. M., Molinolo, A., Gibbons, L., Abba, M. C., Gass, H. & Lanari, C., Jul 1 2017, In : Journal of the National Cancer Institute. 109, 7, djw317

Research output: Contribution to journalArticle

Progesterone Receptors
Protein Isoforms
Breast Neoplasms
Neoplasms
Mifepristone
1 Citations

Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study

Parada, H., Sun, X., Fleming, J. M., Williams-DeVane, C. L. R., Kirk, E. L., Olsson, L. T., Perou, C. M., Olshan, A. F. & Troester, M. A., Dec 11 2017, In : Breast Cancer Research. 19, 1, 131

Research output: Contribution to journalArticle

Confidence Intervals
Breast Neoplasms
Gene Expression
Recurrence
Genes
2 Citations

Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression

Roarty, K., Pfefferle, A. D., Creighton, C. J., Perou, C. M. & Rosen, J. M., Oct 26 2017, In : Oncogene. 36, 43, p. 5958-5968 11 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Receptor Tyrosine Kinase-like Orphan Receptors
Animal Mammary Neoplasms
Tumor Suppressor Protein p53
rho-Associated Kinases
4 Citations

SynthEx: A synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Silva, G. O., Siegel, M. B., Mose, L. E., Parker, J. S., Sun, W., Perou, C. M. & Chen, M., Apr 8 2017, In : Genome biology. 18, 1, 66

Research output: Contribution to journalArticle

DNA Copy Number Variations
Exome
gene dosage
High-Throughput Nucleotide Sequencing
Gene Dosage
11 Citations

Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer

Taylor, N. A., Vick, S. C., Iglesia, M. D., Brickey, W. J., Midkiff, B. R., McKinnon, K. P., Reisdorf, S., Anders, C. K., Carey, L. A., Parker, J. S., Perou, C. M., Vincent, B. G. & Serody, J. S., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3472-3483 12 p.

Research output: Contribution to journalArticle

Programmed Cell Death 1 Receptor
Animal Mammary Neoplasms
Claudins
Inbred BALB C Mouse
CTLA-4 Antigen
2016
32 Citations

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

He, Z., Wan, X., Schulz, A., Bludau, H., Dobrovolskaia, M. A., Stern, S. T., Montgomery, S. A., Yuan, H., Li, Z., Alakhova, D., Sokolsky, M., Darr, D. B., Perou, C. M., Jordan, R., Luxenhofer, R. & Kabanov, A. V., Sep 1 2016, In : Biomaterials. 101, p. 296-309 14 p.

Research output: Contribution to journalArticle

Drug therapy
Micelles
Paclitaxel
Tumors
Solubility
8 Citations

Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V'DJer

Mose, L. E., Selitsky, S. R., Bixby, L. M., Marron, D. L., Iglesia, M. D., Serody, J. S., Perou, C. M., Vincent, B. G. & Parker, J. S., Dec 15 2016, In : Bioinformatics (Oxford, England). 32, 24, p. 3729-3734 6 p.

Research output: Contribution to journalArticle

B Lymphocytes
RNA Sequence Analysis
Thermionic emission
B-Cell Antigen Receptors
B Cells
3 Citations

Collective Wisdom: Lobular Carcinoma of the Breast

Sledge, G. W., Chagpar, A. & Perou, C., Jan 1 2016, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting. 35, p. 18-21 4 p.

Research output: Contribution to journalArticle

Hormone-Dependent Neoplasms
ErbB-2 Receptor
Lobular Carcinoma
Genetic Heterogeneity
Estrogen Receptor alpha
41 Citations
B-Lymphocytes
Confidence Intervals
Neoplasms
Melanoma
Survival
6 Citations

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

Pfefferle, A. D., Agrawal, Y. N., Koboldt, D. C., Kanchi, K. L., Herschkowitz, J. I., Mardis, E. R., Rosen, J. M. & Perou, C. M., Jul 1 2016, In : DMM Disease Models and Mechanisms. 9, 7, p. 749-757 9 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Pharmaceutical Preparations
Neoplasms
Triple Negative Breast Neoplasms
6 Citations

High intratumoral stromal content defines reactive breast cancer as a low-risk breast cancer subtype

Dennison, J. B., Shahmoradgoli, M., Liu, W., Ju, Z., Meric-Bernstam, F., Perou, C. M., Sahin, A. A., Welm, A., Oesterreich, S., Sikora, M. J., Brown, R. E. & Mills, G. B., Oct 15 2016, In : Clinical Cancer Research. 22, 20, p. 5068-5078 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogen Receptors
Protein Array Analysis
Neoplasms
Proteins
3 Citations

Identification of mRNA isoform switching in breast cancer

Zhao, W., Hoadley, K. A., Parker, J. S. & Perou, C. M., Jan 1 2016, In : BMC genomics. 17, 1, 181

Research output: Contribution to journalArticle

RNA Isoforms
Protein Isoforms
Breast Neoplasms
Genes
Neoplasms
6 Citations

Insulin receptor substrate adaptor proteins mediate prognostic gene expression profiles in breast cancer

Becker, M. A., Ibrahim, Y. H., Oh, A. S., Fagan, D. H., Byron, S. A., Sarver, A. L., Lee, A. V., Shaw, L. M., Fan, C., Perou, C. M. & Yee, D., Mar 1 2016, In : PloS one. 11, 3, e0150564

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin Receptor
Transcriptome
Gene expression
breast neoplasms
88 Citations

Molecular heterogeneity and response to neoadjuvant human epidermal growth factor receptor 2 targeting in CALGB 40601, a randomized phase III trial of paclitaxel plus trastuzumab with or without lapatinib

Carey, L. A., Berry, D. A., Cirrincione, C. T., Barry, W. T., Pitcher, B. N., Harris, L. N., Ollila, D. W., Krop, I. E., Henry, N. L., Weckstein, D. J., Anders, C. K., Singh, B., Hoadley, K. A., Iglesia, M., Cheang, M. C. U., Perou, C. M., Winer, E. P. & Hudis, C. A., Feb 20 2016, In : Journal of Clinical Oncology. 34, 6, p. 542-549 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Tumor Microenvironment
Gene Expression
Arm
Hormones
56 Citations

MR imaging radiomics signatures for predicting the risk of breast cancer recurrence as given by research versions of MammaPrint, oncotype DX, and PAM50 gene assays

Li, H., Zhu, Y., Burnside, E. S., Drukker, K., Hoadley, K. A., Fan, C., Conzen, S. D., Whitman, G. J., Sutton, E. J., Net, J. M., Ganott, M., Huang, E., Morris, E. A., Perou, C. M., Ji, Y. & Giger, M. L., Jan 1 2016, In : Radiology. 281, 2, p. 382-391 10 p.

Research output: Contribution to journalReview article

Magnetic Resonance Imaging
Breast Neoplasms
Recurrence
Research
Genes
2 Citations

Overview of genetically engineered mouse models of distinct breast cancer subtypes

Usary, J., Darr, D. B., Pfefferle, A. D. & Perou, C. M., Mar 1 2016, In : Current Protocols in Pharmacology. 2016, p. 14.38.1-14.38.11

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Drug Discovery
Heterografts
Cause of Death
18 Citations

Performance of three-biomarker immunohistochemistry for intrinsic breast cancer subtyping in the AMBER consortium

Allott, E. H. , Cohen, S. M. , Geradts, J. , Sun, X. , Khoury, T. , Bshara, W. , Zirpoli, G. R. , Miller, C. R. , Hwang, H. , Thorne, L. B. , O'Connor, S. , Tse, C. K. , Bell, M. B. , Hu, Z. , Li, Y. , Kirk, E. L. , Bethea, T. N. , Perou, C. M. , Palmer, J. R. , Ambrosone, C. B. & 2 others Olshan, A. F. & Troester, M. A., Mar 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 3, p. 470-478 9 p.

Research output: Contribution to journalArticle

Epidemiology
Biomarkers
Immunohistochemistry
Breast Neoplasms
Progesterone Receptors
15 Citations

Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study

Martin, M., Brase, J. C., Ruiz, A., Prat, A., Kronenwett, R., Calvo, L., Petry, C., Bernard, P. S., Ruiz-Borrego, M., Weber, K. E., Rodriguez, C. A., Alvarez, I. M., Segui, M. A., Perou, C. M., Casas, M., Carrasco, E., Caballero, R. & Rodriguez-Lescure, A., Feb 1 2016, In : Breast Cancer Research and Treatment. 156, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Recurrence
Research
Neoplasm Metastasis
6 Citations

Rho GTPase transcriptome analysis reveals oncogenic roles for rho GTPase-activating proteins in basal-like breast cancers

Lawson, C. D., Fan, C., Mitin, N., Baker, N. M., George, S. D., Graham, D. M., Perou, C. M., Burridge, K., Der, C. J. & Rossman, K. L., Jul 1 2016, In : Cancer Research. 76, 13, p. 3826-3837 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Gene Expression Profiling
Breast Neoplasms
Growth
Cell Proliferation
19 Citations

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases

Hoadley, K. A., Siegel, M. B., Kanchi, K. L., Miller, C. A., Ding, L., Zhao, W., He, X., Parker, J. S., Wendl, M. C., Fulton, R. S., Demeter, R. T., Wilson, R. K., Carey, L. A., Perou, C. M. & Mardis, E. R., Dec 1 2016, In : PLoS medicine. 13, 12, e1002174

Research output: Contribution to journalArticle

Genomics
Retrospective Studies
Breast Neoplasms
Neoplasm Metastasis
Neoplasms