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2018

Activation mechanisms for a universal signalling protein news-and-views

Krumm, B. & Roth, B. L., May 17 2018, In : Nature. 557, 7705, p. 318-319 2 p.

Research output: Contribution to journalArticle

Arrestin
Drug Discovery
G-Protein-Coupled Receptors
Proteins
1 Citations

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

Pera, T., Deshpande, D. A., Ippolito, M., Wang, B., Gavrila, A., Michael, J. V., Nayak, A. P., Tompkins, E., Farrell, E., Kroeze, W. K., Roth, B. L., Panettieri, R. A., Benovic, J. L., An, S. S., Dulin, N. O. & Penn, R. B., Feb 1 2018, In : FASEB Journal. 32, 2, p. 862-874 13 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Protons
Asthma
GTP-Binding Proteins
Ligands

Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017

Gaspar, H. A., Collier, D. A., Geschwind, D. H., Lewis, C. M., Li, Q., Roth, B. L., Sullivan, P. F. & Breen, G., Sep 15 2018, In : Biological psychiatry. 84, 6, p. e49-e50

Research output: Contribution to journalArticle

Genomics
Psychiatry
Pharmaceutical Preparations
1 Citations

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

Qin, S., Meng, M., Yang, D., Bai, W., Lu, Y., Peng, Y., Song, G., Wu, Y., Zhou, Q., Zhao, S., Huang, X., McCorvy, J. D., Cai, X., Dai, A., Roth, B. L., Hanson, M. A., Liu, Z. J., Wang, M. W., Stevens, R. C. & Shui, W., Jan 1 2018, In : Chemical Science. 9, 12, p. 3192-3199 8 p.

Research output: Contribution to journalArticle

Modulators
Mass spectrometry
Screening
Throughput
Proteins
5 Citations

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Baumann, M. H., Majumdar, S., Le Rouzic, V., Hunkele, A., Uprety, R., Huang, X. P., Xu, J., Roth, B. L., Pan, Y. X. & Pasternak, G. W., May 15 2018, In : Neuropharmacology. 134, p. 101-107 7 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Street Drugs
Analgesia
Opioid Analgesics
Pharmacology
9 Citations

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

McCorvy, J. D., Butler, K. V., Kelly, B., Rechsteiner, K., Karpiak, J., Betz, R. M., Kormos, B. L., Shoichet, B. K., Dror, R. O., Jin, J. & Roth, B. L., Feb 1 2018, In : Nature Chemical Biology. 14, 2, p. 126-134 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Ligands
Arrestin
beta-Arrestins
Drug Design
18 Citations

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

Wang, S., Che, T., Levit, A., Shoichet, B. K., Wacker, D. & Roth, B. L., Mar 8 2018, In : Nature. 555, 7695, p. 269-273 5 p.

Research output: Contribution to journalArticle

Risperidone
Dopamine D2 Receptors
Antipsychotic Agents
Parkinson Disease
Dopamine
14 Citations

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Che, T. , Majumdar, S. , Zaidi, S. A. , Ondachi, P. , McCorvy, J. D. , Wang, S. , Mosier, P. D. , Uprety, R. , Vardy, E. , Krumm, B. E. , Han, G. W. , Lee, M. Y. , Pardon, E. , Steyaert, J. , Huang, X. P. , Strachan, R. T. , Tribo, A. R. , Pasternak, G. W. , Carroll, F. I. , Stevens, R. C. & 4 others Cherezov, V., Katritch, V., Wacker, D. & Roth, B. L., Jan 11 2018, In : Cell. 172, 1-2, p. 55-67.e15

Research output: Contribution to journalArticle

Morphinans
Hulls (ship)
Single-Domain Antibodies
Hydrofoil boats
kappa Opioid Receptor
2017
4 Citations

5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice

Pogorelov, V. M., Rodriguiz, R. M., Cheng, J., Huang, M., Schmerberg, C. M., Meltzer, H. Y., Roth, B. L., Kozikowski, A. P. & Wetsel, W. C., Apr 12 2017, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Antipsychotic Agents
Dopamine
Schizophrenia
Amphetamine
Reversal Learning

A Simple Representation of Three-Dimensional Molecular Structure

Axen, S. D., Huang, X. P., Cáceres, E. L., Gendelev, L., Roth, B. L. & Keiser, M. J., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7393-7409 17 p.

Research output: Contribution to journalArticle

Small Molecule Libraries
Molecular Conformation
Computer-Aided Design
Molecular Models
Drug Design
59 Citations

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Wacker, D., Wang, S., McCorvy, J. D., Betz, R. M., Venkatakrishnan, A. J., Levit, A., Lansu, K., Schools, Z. L., Che, T., Nichols, D. E., Shoichet, B. K., Dror, R. O. & Roth, B. L., Jan 26 2017, In : Cell. 168, 3, p. 377-389.e12

Research output: Contribution to journalArticle

Lysergic Acid Diethylamide
Serotonin Receptors
Crystal structure
Serotonin
Kinetics
16 Citations

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists

Wang, S., Wacker, D., Levit, A., Che, T., Betz, R. M., McCorvy, J. D., Venkatakrishnan, A. J., Huang, X. P., Dror, R. O., Shoichet, B. K. & Roth, B. L., Oct 20 2017, In : Science. 358, 6361, p. 381-386 6 p.

Research output: Contribution to journalArticle

12 Citations

Discovery of new GPCR ligands to illuminate new biology

Roth, B. L., Irwin, J. J. & Shoichet, B. K., Nov 1 2017, In : Nature Chemical Biology. 13, 11, p. 1143-1151 9 p.

Research output: Contribution to journalReview article

Molecular Docking Simulation
Allosteric Regulation
Allosteric Site
Drug Design
Drug Discovery
1 Citations

Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications

Zhang, G., Cheng, J., McCorvy, J. D., Lorello, P. J., Caldarone, B. J., Roth, B. L. & Kozikowski, A. P., Jul 27 2017, In : Journal of Medicinal Chemistry. 60, 14, p. 6273-6288 16 p.

Research output: Contribution to journalArticle

46 Citations

How Ligands Illuminate GPCR Molecular Pharmacology

Wacker, D., Stevens, R. C. & Roth, B. L., Jul 27 2017, In : Cell. 170, 3, p. 414-427 14 p.

Research output: Contribution to journalReview article

29 Citations

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, K., Karpiak, J., Liu, J., Huang, X. P., McCorvy, J. D., Kroeze, W. K., Che, T., Nagase, H., Carroll, F. I., Jin, J., Shoichet, B. K. & Roth, B. L., May 1 2017, In : Nature Chemical Biology. 13, 5, p. 529-536 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Mast Cells
Computer Simulation
Hydrocodone
Dextromethorphan
2 Citations

Protamine is an antagonist of Apelin receptor, and its activity is reversed by heparin

Le Gonidec, S., Chaves-Almagro, C., Bai, Y., Kang, H. J., Smith, A., Wanecq, E., Huang, X. P., Prats, H., Knibiehler, B., Roth, B. L., Barak, L. S., Caron, M. G., Valet, P., Audigier, Y. & Masri, B., Jun 1 2017, In : FASEB Journal. 31, 6, p. 2507-2519 13 p.

Research output: Contribution to journalArticle

10 Citations

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G. W., Basu, S., Patel, N., Messerschmidt, M., Weierstall, U., Liu, W., Katritch, V., Roth, B. L., Stevens, R. C. & Cherezov, V., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8223-8228 6 p.

Research output: Contribution to journalArticle

4 Citations

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

Zheng, Z., Huang, X. P., Mangano, T. J., Zou, R., Chen, X., Zaidi, S. A., Roth, B. L., Stevens, R. C. & Katritch, V., Apr 13 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 3070-3081 12 p.

Research output: Contribution to journalArticle

Molecular Docking Simulation
kappa Opioid Receptor
Narcotic Antagonists
HEK293 Cells
Drug Design
9 Citations

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Chan, J. D., Cupit, P. M., Gunaratne, G. S., McCorvy, J. D., Yang, Y., Stoltz, K., Webb, T. R., Dosa, P. I., Roth, B. L., Abagyan, R., Cunningham, C. & Marchant, J. S., Dec 1 2017, In : Nature Communications. 8, 1, 1910

Research output: Contribution to journalArticle

parasitic diseases
drug prescribing
parasitic disease
schistosomiasis
Drug Prescriptions
2016
10 Citations

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

Chan, J. D., McCorvy, J. D., Acharya, S., Johns, M. E., Day, T. A., Roth, B. L. & Marchant, J. S., May 1 2016, In : PLoS Pathogens. 12, 5, e1005651

Research output: Contribution to journalArticle

Schistosoma mansoni
G-Protein-Coupled Receptors
Parasites
Anthelmintics
Platyhelminths
2 Citations

An alerting structure: Human orexin receptor 1

Wacker, D. & Roth, B. L. Apr 5 2016 In : Nature Structural and Molecular Biology. 23, 4, p. 265-266 2 p.

Research output: Contribution to journalShort survey

Intracellular Signaling Peptides and Proteins
Orexin Receptors
G-Protein-Coupled Receptors
Orexin Receptor Antagonists
26 Citations

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Marchant, N. J., Whitaker, L. R., Bossert, J. M., Harvey, B. K., Hope, B. T., Kaganovsky, K., Adhikary, S., Prisinzano, T. E., Vardy, E., Roth, B. L. & Shaham, Y., Jan 1 2016, In : Neuropsychopharmacology. 41, 2, p. 402-409 8 p.

Research output: Contribution to journalArticle

Designer Drugs
kappa Opioid Receptor
Mesencephalon
Brain
Ventral Tegmental Area
12 Citations

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

Zhu, H., Aryal, D. K., Olsen, R. H. J., Urban, D. J., Swearingen, A., Forbes, S., Roth, B. L. & Hochgeschwender, U., Aug 1 2016, In : Genesis. 54, 8, p. 439-446 8 p.

Research output: Contribution to journalArticle

Designer Drugs
G-Protein-Coupled Receptors
Technology
Insulin-Secreting Cells
Neuroglia
6 Citations

Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists

Cheng, J., McCorvy, J. D., Giguere, P. M., Zhu, H., Kenakin, T., Roth, B. L. & Kozikowski, A. P., Nov 10 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9866-9880 15 p.

Research output: Contribution to journalArticle

Serotonin
Melatonin Receptors
Calcium-Sensing Receptors
Phosphatidylinositols
GTP-Binding Proteins
2 Citations

Design and synthesis of dual 5-HT1Aand 5-HT7receptor ligands

Ofori, E., Zhu, X. Y., Etukala, J. R., Peprah, K., Jordan, K. R., Adkins, A. A., Bricker, B. A., Kang, H. J., Huang, X. P., Roth, B. L. & Ablordeppey, S. Y. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3464-3471 8 p.

Research output: Contribution to journalArticle

Serotonin
Ligands
Central Nervous System Diseases
Butyrophenones
Tetrahydroisoquinolines
2 Citations

Development of CNS multi-receptor ligands: Modification of known D2pharmacophores

Etukala, J. R., Zhu, X. Y., Eyunni, S. V. K., Onyameh, E. K., Ofori, E., Bricker, B. A., Kang, H. J., Huang, X. P., Roth, B. L. & Ablordeppey, S. Y. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3671-3679 9 p.

Research output: Contribution to journalArticle

Serotonin
Ligands
Antipsychotic Agents
Animals
Animal Models
4 Citations

Discovery and characterization of novel GPR39 agonists allosterically modulated by zinc

Sato, S., Huang, X. P., Kroeze, W. K. & Roth, B. L., Dec 1 2016, In : Molecular Pharmacology. 90, 6, p. 726-737 12 p.

Research output: Contribution to journalArticle

LY2784544
Zinc
Phosphotransferases
G-Protein-Coupled Receptors
Carboxylic Acids
13 Citations

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists

Chen, X., McCorvy, J. D., Fischer, M. G., Butler, K. V., Shen, Y., Roth, B. L. & Jin, J., Dec 8 2016, In : Journal of Medicinal Chemistry. 59, 23, p. 10601-10618 18 p.

Research output: Contribution to journalArticle

Dopamine Agonists
GTP-Binding Proteins
Ligands
Dopamine D2 Receptors
G-Protein-Coupled Receptors
28 Citations

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

Urs, N. M., Gee, S. M., Pack, T. F., McCorvy, J. D., Evron, T., Snyder, J. C., Yang, X., Rodriguiz, R. M., Borrelli, E., Wetsel, W. C., Jin, J., Roth, B. L., O'Donnell, P., Caron, M. G. & Snyder, S. H., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8178-E8186

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine D2 Receptors
Antipsychotic Agents
Ligands
Interneurons
171 Citations

DREADDs for Neuroscientists

Roth, B. L., Feb 17 2016, In : Neuron. 89, 4, p. 683-694 12 p.

Research output: Contribution to journalReview article

Designer Drugs
Brain
Diptera
Primates
Signal Transduction
28 Citations

Elucidation of the Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

Urban, D. J., Zhu, H., Marcinkiewcz, C. A., Michaelides, M., Oshibuchi, H., Rhea, D., Aryal, D. K., Farrell, M. S., Lowery-Gionta, E., Olsen, R. H. J., Wetsel, W. C., Kash, T. L., Hurd, Y. L., Tecott, L. H. & Roth, B. L., Apr 1 2016, In : Neuropsychopharmacology. 41, 5, p. 1404-1415 12 p.

Research output: Contribution to journalArticle

Serotonergic Neurons
Designer Drugs
Brain
Technology
Neurons
8 Citations

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models

Cheng, J., Giguere, P. M., Schmerberg, C. M., Pogorelov, V. M., Rodriguiz, R. M., Huang, X. P., Zhu, H., McCorvy, J. D., Wetsel, W. C., Roth, B. L. & Kozikowski, A. P., Jan 28 2016, In : Journal of Medicinal Chemistry. 59, 2, p. 578-591 14 p.

Research output: Contribution to journalArticle

Methylamines
Serotonin Receptor Agonists
Cognition
Serotonin
Dextroamphetamine
7 Citations

In vitro and in vivo characterization of the alkaloid nuciferine

Farrell, M. S. , McCorvy, J. D. , Huang, X. P. , Urban, D. J. , White, K. L. , Giguere, P. M. , Doak, A. K. , Bernstein, A. I. , Stout, K. A. , Park, S. M. , Rodriguiz, R. M. , Gray, B. W. , Hyatt, W. S. , Norwood, A. P. , Webster, K. A. , Gannon, B. M. , Miller, G. W. , Porter, J. H. , Shoichet, B. K. , Fantegrossi, W. E. & 2 others Wetsel, W. C. & Roth, B. L., Mar 1 2016, In : PLoS One. 11, 3, e0150602

Research output: Contribution to journalArticle

Alkaloids
serotonin
alkaloids
agonists
Serotonin
54 Citations

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Grace, P. M., Strand, K. A., Galer, E. L., Urban, D. J., Wang, X., Baratta, M. V., Fabisiak, T. J., Anderson, N. D., Cheng, K., Greene, L. I., Berkelhammer, D., Zhang, Y., Ellis, A. L., Yin, H. H., Campeau, S., Ricei, K. C., Roth, B. L., Maier, S. F. & Watkins, L. R., Jun 14 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 24, p. E3441-E3450

Research output: Contribution to journalArticle

Inflammasomes
Neuralgia
Morphine
Opioid Analgesics
Designer Drugs
9 Citations

New Technologies for Elucidating Opioid Receptor Function

Bruchas, M. R. & Roth, B. L., Apr 1 2016, In : Trends in Pharmacological Sciences. 37, 4, p. 279-289 11 p.

Research output: Contribution to journalReview article

Opioid Receptors
Opioid Analgesics
Technology
Optogenetics
Crystal structure
2 Citations

Psilocybin for depression and anxiety associated with life-threatening illnesses

McCorvy, J. D., Olsen, R. H. J. & Roth, B. L., Dec 1 2016, In : Journal of Psychopharmacology. 30, 12, p. 1209-1210 2 p.

Research output: Contribution to journalComment/debate

24 Citations

Translating genome-wide association findings into new therapeutics for psychiatry

Breen, G., Li, Q., Roth, B. L., O'Donnell, P., Didriksen, M., Dolmetsch, R., O'Reilly, P. F., Gaspar, H. A., Manji, H., Huebel, C., Kelsoe, J. R., Malhotra, D., Bertolino, A., Posthuma, D., Sklar, P., Kapur, S., Sullivan, P. F., Collier, D. A. & Edenberg, H. J., Oct 26 2016, In : Nature neuroscience. 19, 11, p. 1392-1396 5 p.

Research output: Contribution to journalReview article

Psychiatry
Genome
Genome-Wide Association Study
Genomics
Sample Size
23 Citations

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

Bruni, G., Rennekamp, A. J., Velenich, A., McCarroll, M., Gendelev, L., Fertsch, E., Taylor, J., Lakhani, P., Lensen, D., Evron, T., Lorello, P. J., Huang, X. P., Kolczewski, S., Carey, G., Caldarone, B. J., Prinssen, E., Roth, B. L., Keiser, M. J., Peterson, R. T. & Kokel, D., Jul 1 2016, In : Nature Chemical Biology. 12, 7, p. 559-566 8 p.

Research output: Contribution to journalArticle

Zebrafish
Antipsychotic Agents
Haloperidol
Psychiatry
Pharmaceutical Preparations
9 Citations

σ 1 receptor ligands control a switch between passive and active threat responses

Rennekamp, A. J., Huang, X. P., Wang, Y., Patel, S., Lorello, P. J., Cade, L., Gonzales, A. P. W., Yeh, J. R. J., Caldarone, B. J., Roth, B. L., Kokel, D. & Peterson, R. T., Jul 1 2016, In : Nature Chemical Biology. 12, 7, p. 552-558 7 p.

Research output: Contribution to journalArticle

Freezing
Ligands
Zebrafish
Cluster Analysis
Vertebrates
2015
66 Citations

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Huang, X. P., Karpiak, J., Kroeze, W. K., Zhu, H., Chen, X., Moy, S. S., Saddoris, K. A., Nikolova, V. D., Farrell, M. S., Wang, S., Mangano, T. J., Deshpande, D. A., Jiang, A., Penn, R. B., Jin, J., Koller, B. H., Kenakin, T., Shoichet, B. K. & Roth, B. L., Nov 26 2015, In : Nature. 527, 7579, p. 477-483 7 p.

Research output: Contribution to journalArticle

Lorazepam
Ligands
Allosteric Site
Human Genome
G-Protein-Coupled Receptors
91 Citations

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Vardy, E. , Robinson, J. E. , Li, C. , Olsen, R. H. J. , DiBerto, J. F. , Giguere, P. M. , Sassano, F. M. , Huang, X. P. , Zhu, H. , Urban, D. J. , White, K. L. , Rittiner, J. E. , Crowley, N. A. , Pleil, K. E. , Mazzone, C. M. , Mosier, P. D. , Song, J. , Kash, T. L. , Malanga, C. J. , Krashes, M. J. & 1 others Roth, B. L., May 20 2015, In : Neuron. 86, 4, p. 936-946 11 p.

Research output: Contribution to journalArticle

Ligands
kappa Opioid Receptor
Behavior Control
Population
salvinorin B
42 Citations

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

Kaniskan, H. Ü. , Szewczyk, M. M. , Yu, Z. , Eram, M. S. , Yang, X. , Schmidt, K. , Luo, X. , Dai, M. , He, F. , Zang, I. , Lin, Y. , Kennedy, S. , Li, F. , Dobrovetsky, E. , Dong, A. , Smil, D. , Min, S. J. , Landon, M. , Lin-Jones, J. , Huang, X. P. & 9 others Roth, B. L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Arrowsmith, C. H., Brown, P. J., Zhao, K., Jin, J. & Vedadi, M., Apr 20 2015, In : Angewandte Chemie - International Edition. 54, 17, p. 5166-5170 5 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Arginine
Proteins
Methyltransferases
Animals
14 Citations

Chemogenetics-a transformational and translational platform

English, J. G. & Roth, B. L. Jan 1 2015 In : JAMA Neurology. 72, 11, p. 1361-1366 6 p.

Research output: Contribution to journalArticle

Neuroglia
Designer Drugs
Neurons
Nervous System Diseases
Technology
6 Citations
Serotonin Receptor Agonists
Serotonin
Bearings (structural)
Data storage equipment
Alkylation
14 Citations

DREADD: A chemogenetic GPCR signaling platform

Zhu, H. & Roth, B. L., Jan 1 2015, In : International Journal of Neuropsychopharmacology. 18, 1, pyu007

Research output: Contribution to journalReview article

Designer Drugs
G-Protein-Coupled Receptors
Technology
Drug Discovery
Tissue Engineering
183 Citations

DREADDs (designer receptors exclusively activated by designer drugs): Chemogenetic tools with therapeutic utility

Urban, D. J. & Roth, B. L., Jan 1 2015, In : Annual review of pharmacology and toxicology. 55, p. 399-417 19 p.

Research output: Contribution to journalReview article

Designer Drugs
G-Protein-Coupled Receptors
Technology
Obesity
Synthetic Biology
29 Citations
G-Protein-Coupled Receptors
Genes
Genome
Human Genome
Drug Discovery
3 Citations

Molecular interactions between general anesthetics and the 5HT2B receptor

Matsunaga, F., Gao, L., Huang, X. P., Saven, J. G., Roth, B. L. & Liu, R., Jan 2 2015, In : Journal of Biomolecular Structure and Dynamics. 33, 1, p. 211-218 8 p.

Research output: Contribution to journalArticle

General Anesthetics
Isoflurane
Propofol
Anesthetics
Serotonin Receptors
22 Citations

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

O'Connor, C., White, K. L., Doncescu, N., Didenko, T., Roth, B. L., Czaplicki, G., Stevens, R. C., Wüthrich, K., Milon, A. & Summers, M. F., Sep 22 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 38, p. 11852-11857 6 p.

Research output: Contribution to journalArticle

Dynorphins
kappa Opioid Receptor
Nuclear magnetic resonance
Peptides
Molecular modeling