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2018

Activation mechanisms for a universal signalling protein news-and-views

Krumm, B. & Roth, B. L., May 17 2018, In : Nature. 557, 7705, p. 318-319 2 p.

Research output: Contribution to journalArticle

Arrestin
Drug Discovery
G-Protein-Coupled Receptors
Proteins
1 Citations

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines

Pera, T., Deshpande, D. A., Ippolito, M., Wang, B., Gavrila, A., Michael, J. V., Nayak, A. P., Tompkins, E., Farrell, E., Kroeze, W. K., Roth, B. L., Panettieri, R. A., Benovic, J. L., An, S. S., Dulin, N. O. & Penn, R. B., Feb 1 2018, In : FASEB Journal. 32, 2, p. 862-874 13 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Benzodiazepines
Protons
GTP-Binding Proteins
Ligands

Conference Report: Psychiatric Genomics Consortium Meeting: Pathways to Drugs, London, March 2017

Gaspar, H. A., Collier, D. A., Geschwind, D. H., Lewis, C. M., Li, Q., Roth, B. L., Sullivan, P. F. & Breen, G., Sep 15 2018, In : Biological psychiatry. 84, 6, p. e49-e50

Research output: Contribution to journalArticle

Genomics
Psychiatry
Pharmaceutical Preparations
1 Citations

Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging

Placzek, M. S., Schroeder, F. A., Che, T., Wey, H. Y., Neelamegam, R., Wang, C., Roth, B. L. & Hooker, J. M., Jan 1 2018, (Accepted/In press) In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Positron emission tomography
Positron-Emission Tomography
3-chloro-4-(4-((2-(3-pyridyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide
Opioid Analgesics
kappa Opioid Receptor

Far away from the lamppost

Oprea, T. I., Jan, L., Johnson, G. L., Roth, B. L., Ma'ayan, A., Schürer, S., Shoichet, B. K., Sklar, L. A. & McManus, M. T., Dec 1 2018, In : PLoS biology. 16, 12, p. e3000067

Research output: Contribution to journalArticle

Research
funding
Genes
Genome
genome
1 Citations

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

Qin, S., Meng, M., Yang, D., Bai, W., Lu, Y., Peng, Y., Song, G., Wu, Y., Zhou, Q., Zhao, S., Huang, X., McCorvy, J. D., Cai, X., Dai, A., Roth, B. L., Hanson, M. A., Liu, Z. J., Wang, M. W., Stevens, R. C. & Shui, W., Jan 1 2018, In : Chemical Science. 9, 12, p. 3192-3199 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Modulators
Mass spectrometry
Screening
Throughput
11 Citations

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

Baumann, M. H., Majumdar, S., Le Rouzic, V., Hunkele, A., Uprety, R., Huang, X. P., Xu, J., Roth, B. L., Pan, Y. X. & Pasternak, G. W., May 15 2018, In : Neuropharmacology. 134, p. 101-107 7 p.

Research output: Contribution to journalArticle

Street Drugs
Opioid Analgesics
Pharmacology
Morphine
Heroin

Phosphoproteomics Illuminates Opioid Actions

Che, T. & Roth, B. L., Sep 25 2018, In : Biochemistry. 57, 38, p. 5505-5506 2 p.

Research output: Contribution to journalReview article

Opioid Analgesics
Analgesics
kappa Opioid Receptor
G-Protein-Coupled Receptors
Cause of Death

Structural determinants of 5-HT2B receptor activation and biased agonism

McCorvy, J. D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A. R., Olsen, R. H. J., Che, T., Jin, J. & Roth, B. L., Sep 1 2018, In : Nature Structural and Molecular Biology. 25, 9, p. 787-796 10 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2B
Serotonin Receptors
Methylergonovine
Lisuride
Physiological Phenomena
13 Citations

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

McCorvy, J. D., Butler, K. V., Kelly, B., Rechsteiner, K., Karpiak, J., Betz, R. M., Kormos, B. L., Shoichet, B. K., Dror, R. O., Jin, J. & Roth, B. L., Feb 1 2018, In : Nature Chemical Biology. 14, 2, p. 126-134 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Ligands
Arrestin
beta-Arrestins
Drug Design
28 Citations

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

Wang, S., Che, T., Levit, A., Shoichet, B. K., Wacker, D. & Roth, B. L., Mar 8 2018, In : Nature. 555, 7695, p. 269-273 5 p.

Research output: Contribution to journalArticle

Risperidone
Dopamine D2 Receptors
Antipsychotic Agents
Parkinson Disease
Dopamine
25 Citations

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

Che, T., Majumdar, S., Zaidi, S. A., Ondachi, P., McCorvy, J. D., Wang, S., Mosier, P. D., Uprety, R., Vardy, E., Krumm, B. E., Han, G. W., Lee, M. Y., Pardon, E., Steyaert, J., Huang, X. P., Strachan, R. T., Tribo, A. R., Pasternak, G. W., Carroll, F. I., Stevens, R. C. & 4 othersCherezov, V., Katritch, V., Wacker, D. & Roth, B. L., Jan 11 2018, In : Cell. 172, 1-2, p. 55-67.e15

Research output: Contribution to journalArticle

Single-Domain Antibodies
kappa Opioid Receptor
Analgesics
Opioid Analgesics
Crystal structure
2017
8 Citations

5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice

Pogorelov, V. M., Rodriguiz, R. M., Cheng, J., Huang, M., Schmerberg, C. M., Meltzer, H. Y., Roth, B. L., Kozikowski, A. P. & Wetsel, W. C., Apr 12 2017, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Serotonin 5-HT2 Receptor Agonists
Receptor, Serotonin, 5-HT2C
Antipsychotic Agents
Dopamine
Schizophrenia

A Simple Representation of Three-Dimensional Molecular Structure

Axen, S. D., Huang, X. P., Cáceres, E. L., Gendelev, L., Roth, B. L. & Keiser, M. J., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7393-7409 17 p.

Research output: Contribution to journalArticle

Molecular Conformation
Dermatoglyphics
ROC Curve
Pharmaceutical Preparations
Ligands
73 Citations

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Wacker, D., Wang, S., McCorvy, J. D., Betz, R. M., Venkatakrishnan, A. J., Levit, A., Lansu, K., Schools, Z. L., Che, T., Nichols, D. E., Shoichet, B. K., Dror, R. O. & Roth, B. L., Jan 26 2017, In : Cell. 168, 3, p. 377-389.e12

Research output: Contribution to journalArticle

Lysergic Acid Diethylamide
Serotonin Receptors
Crystal structure
Kinetics
Receptor, Serotonin, 5-HT2B
21 Citations

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists

Wang, S., Wacker, D., Levit, A., Che, T., Betz, R. M., McCorvy, J. D., Venkatakrishnan, A. J., Huang, X. P., Dror, R. O., Shoichet, B. K. & Roth, B. L., Oct 20 2017, In : Science. 358, 6361, p. 381-386 6 p.

Research output: Contribution to journalArticle

Dopamine D4 Receptors
Dopamine Receptors
Drug Receptors
Dopamine Agents
Drug Design
16 Citations

Discovery of new GPCR ligands to illuminate new biology

Roth, B. L., Irwin, J. J. & Shoichet, B. K., Nov 1 2017, In : Nature Chemical Biology. 13, 11, p. 1143-1151 9 p.

Research output: Contribution to journalReview article

G-Protein-Coupled Receptors
Ligands
Allosteric Site
Pharmaceutical Chemistry
Pharmaceutical Preparations
3 Citations

Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications

Zhang, G., Cheng, J., McCorvy, J. D., Lorello, P. J., Caldarone, B. J., Roth, B. L. & Kozikowski, A. P., Jul 27 2017, In : Journal of Medicinal Chemistry. 60, 14, p. 6273-6288 16 p.

Research output: Contribution to journalArticle

Methylamines
Serotonin 5-HT2 Receptor Agonists
Receptor, Serotonin, 5-HT2C
Serotonin Receptor Agonists
Antipsychotic Agents
63 Citations

How Ligands Illuminate GPCR Molecular Pharmacology

Wacker, D., Stevens, R. C. & Roth, B. L., Jul 27 2017, In : Cell. 170, 3, p. 414-427 14 p.

Research output: Contribution to journalReview article

G-Protein-Coupled Receptors
Pharmacology
Ligands
Human Genome
Computational methods
34 Citations

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, K., Karpiak, J., Liu, J., Huang, X. P., McCorvy, J. D., Kroeze, W. K., Che, T., Nagase, H., Carroll, F. I., Jin, J., Shoichet, B. K. & Roth, B. L., May 1 2017, In : Nature Chemical Biology. 13, 5, p. 529-536 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Mast Cells
Computer Simulation
Hydrocodone
Dextromethorphan
3 Citations

Protamine is an antagonist of Apelin receptor, and its activity is reversed by heparin

Le Gonidec, S., Chaves-Almagro, C., Bai, Y., Kang, H. J., Smith, A., Wanecq, E., Huang, X. P., Prats, H., Knibiehler, B., Roth, B. L., Barak, L. S., Caron, M. G., Valet, P., Audigier, Y. & Masri, B., Jun 1 2017, In : FASEB Journal. 31, 6, p. 2507-2519 13 p.

Research output: Contribution to journalArticle

Protamines
Heparin
Arrestin
Fluorescence microscopy
United States Food and Drug Administration
12 Citations

Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody

Ishchenko, A., Wacker, D., Kapoor, M., Zhang, A., Han, G. W., Basu, S., Patel, N., Messerschmidt, M., Weierstall, U., Liu, W., Katritch, V., Roth, B. L., Stevens, R. C. & Cherezov, V., Aug 1 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. 8223-8228 6 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2B
G-Protein-Coupled Receptors
Serotonin Receptors
Monoclonal Antibodies
Antibodies
8 Citations

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

Zheng, Z., Huang, X. P., Mangano, T. J., Zou, R., Chen, X., Zaidi, S. A., Roth, B. L., Stevens, R. C. & Katritch, V., Apr 13 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 3070-3081 12 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Ligands
GTP-Binding Proteins
Opioid Analgesics
Libraries
13 Citations

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Chan, J. D., Cupit, P. M., Gunaratne, G. S., McCorvy, J. D., Yang, Y., Stoltz, K., Webb, T. R., Dosa, P. I., Roth, B. L., Abagyan, R., Cunningham, C. & Marchant, J. S., Dec 1 2017, In : Nature Communications. 8, 1, 1910.

Research output: Contribution to journalArticle

parasites
Praziquantel
Anthelmintics
infectious diseases
G-Protein-Coupled Receptors
2016
13 Citations

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

Chan, J. D., McCorvy, J. D., Acharya, S., Johns, M. E., Day, T. A., Roth, B. L. & Marchant, J. S., May 1 2016, In : PLoS Pathogens. 12, 5, e1005651.

Research output: Contribution to journalArticle

Schistosoma mansoni
G-Protein-Coupled Receptors
Parasites
Anthelmintics
Platyhelminths
2 Citations

An alerting structure: Human orexin receptor 1

Wacker, D. & Roth, B. L., Apr 5 2016, In : Nature Structural and Molecular Biology. 23, 4, p. 265-266 2 p.

Research output: Contribution to journalShort survey

Intracellular Signaling Peptides and Proteins
Orexin Receptors
G-Protein-Coupled Receptors
Orexin Receptor Antagonists
29 Citations

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Marchant, N. J., Whitaker, L. R., Bossert, J. M., Harvey, B. K., Hope, B. T., Kaganovsky, K., Adhikary, S., Prisinzano, T. E., Vardy, E., Roth, B. L. & Shaham, Y., Jan 1 2016, In : Neuropsychopharmacology. 41, 2, p. 402-409 8 p.

Research output: Contribution to journalArticle

Designer Drugs
kappa Opioid Receptor
Mesencephalon
Brain
Ventral Tegmental Area
15 Citations

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

Zhu, H., Aryal, D. K., Olsen, R. H. J., Urban, D. J., Swearingen, A., Forbes, S., Roth, B. L. & Hochgeschwender, U., Aug 1 2016, In : Genesis. 54, 8, p. 439-446 8 p.

Research output: Contribution to journalArticle

Designer Drugs
G-Protein-Coupled Receptors
Technology
Insulin-Secreting Cells
Neuroglia
10 Citations

Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists

Cheng, J., McCorvy, J. D., Giguere, P. M., Zhu, H., Kenakin, T. P., Roth, B. L. & Kozikowski, A. P., Nov 10 2016, In : Journal of Medicinal Chemistry. 59, 21, p. 9866-9880 15 p.

Research output: Contribution to journalArticle

Serotonin 5-HT2 Receptor Agonists
Melatonin Receptors
Receptor, Serotonin, 5-HT2C
Calcium
Phosphatidylinositols
3 Citations

Design and synthesis of dual 5-HT1Aand 5-HT7receptor ligands

Ofori, E., Zhu, X. Y., Etukala, J. R., Peprah, K., Jordan, K. R., Adkins, A. A., Bricker, B. A., Kang, H. J., Huang, X. P., Roth, B. L. & Ablordeppey, S. Y., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3464-3471 8 p.

Research output: Contribution to journalArticle

Ligands
Central Nervous System Diseases
Butyrophenones
Tetrahydroisoquinolines
Dopamine Receptors
2 Citations

Development of CNS multi-receptor ligands: Modification of known D2pharmacophores

Etukala, J. R., Zhu, X. Y., Eyunni, S. V. K., Onyameh, E. K., Ofori, E., Bricker, B. A., Kang, H. J., Huang, X. P., Roth, B. L. & Ablordeppey, S. Y., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3671-3679 9 p.

Research output: Contribution to journalArticle

Ligands
Antipsychotic Agents
Animals
Animal Models
Serotonin Receptors
5 Citations

Discovery and characterization of novel GPR39 agonists allosterically modulated by zinc

Sato, S., Huang, X. P., Kroeze, W. K. & Roth, B. L., Dec 1 2016, In : Molecular Pharmacology. 90, 6, p. 726-737 12 p.

Research output: Contribution to journalArticle

LY2784544
Zinc
Phosphotransferases
G-Protein-Coupled Receptors
Carboxylic Acids
14 Citations

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists

Chen, X., McCorvy, J. D., Fischer, M. G., Butler, K. V., Shen, Y., Roth, B. L. & Jin, J., Dec 8 2016, In : Journal of Medicinal Chemistry. 59, 23, p. 10601-10618 18 p.

Research output: Contribution to journalArticle

Dopamine Agonists
GTP-Binding Proteins
Ligands
Dopamine D2 Receptors
G-Protein-Coupled Receptors
31 Citations

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

Urs, N. M., Gee, S. M., Pack, T. F., McCorvy, J. D., Evron, T., Snyder, J. C., Yang, X., Rodriguiz, R. M., Borrelli, E., Wetsel, W. C., Jin, J., Roth, B. L., O'Donnell, P., Caron, M. G. & Snyder, S. H., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8178-E8186

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine D2 Receptors
Antipsychotic Agents
Ligands
Interneurons
194 Citations

DREADDs for Neuroscientists

Roth, B. L., Feb 17 2016, In : Neuron. 89, 4, p. 683-694 12 p.

Research output: Contribution to journalReview article

Designer Drugs
Brain
Diptera
Primates
Signal Transduction
32 Citations

Elucidation of the Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

Urban, D. J., Zhu, H., Marcinkiewcz, C. A., Michaelides, M., Oshibuchi, H., Rhea, D., Aryal, D. K., Farrell, M. S., Lowery-Gionta, E., Olsen, R. H. J., Wetsel, W. C., Kash, T. L., Hurd, Y. L., Tecott, L. H. & Roth, B. L., Apr 1 2016, In : Neuropsychopharmacology. 41, 5, p. 1404-1415 12 p.

Research output: Contribution to journalArticle

Serotonergic Neurons
Designer Drugs
Brain
Technology
Neurons
9 Citations

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models

Cheng, J., Giguere, P. M., Schmerberg, C. M., Pogorelov, V. M., Rodriguiz, R. M., Huang, X. P., Zhu, H., McCorvy, J. D., Wetsel, W. C., Roth, B. L. & Kozikowski, A. P., Jan 28 2016, In : Journal of Medicinal Chemistry. 59, 2, p. 578-591 14 p.

Research output: Contribution to journalArticle

Methylamines
Serotonin 5-HT2 Receptor Agonists
Serotonin Receptor Agonists
Dextroamphetamine
Cognition
8 Citations

In vitro and in vivo characterization of the alkaloid nuciferine

Farrell, M. S., McCorvy, J. D., Huang, X. P., Urban, D. J., White, K. L., Giguere, P. M., Doak, A. K., Bernstein, A. I., Stout, K. A., Park, S. M., Rodriguiz, R. M., Gray, B. W., Hyatt, W. S., Norwood, A. P., Webster, K. A., Gannon, B. M., Miller, G. W., Porter, J. H., Shoichet, B. K., Fantegrossi, W. E. & 2 othersWetsel, W. C. & Roth, B. L., Mar 1 2016, In : PLoS One. 11, 3, e0150602.

Research output: Contribution to journalArticle

Alkaloids
alkaloids
agonists
Nelumbo nucifera
Nelumbo
66 Citations

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Grace, P. M., Strand, K. A., Galer, E. L., Urban, D. J., Wang, X., Baratta, M. V., Fabisiak, T. J., Anderson, N. D., Cheng, K., Greene, L. I., Berkelhammer, D., Zhang, Y., Ellis, A. L., Yin, H. H., Campeau, S., Ricei, K. C., Roth, B. L., Maier, S. F. & Watkins, L. R., Jun 14 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 24, p. E3441-E3450

Research output: Contribution to journalArticle

Inflammasomes
Neuralgia
Morphine
Opioid Analgesics
Designer Drugs
14 Citations

New Technologies for Elucidating Opioid Receptor Function

Bruchas, M. R. & Roth, B. L., Apr 1 2016, In : Trends in Pharmacological Sciences. 37, 4, p. 279-289 11 p.

Research output: Contribution to journalReview article

Opioid Receptors
Opioid Analgesics
Technology
Optogenetics
Crystal structure
3 Citations

Psilocybin for depression and anxiety associated with life-threatening illnesses

McCorvy, J. D., Olsen, R. H. J. & Roth, B. L., Dec 1 2016, In : Journal of Psychopharmacology. 30, 12, p. 1209-1210 2 p.

Research output: Contribution to journalComment/debate

28 Citations

Translating genome-wide association findings into new therapeutics for psychiatry

Breen, G., Li, Q., Roth, B. L., O'Donnell, P., Didriksen, M., Dolmetsch, R., O'Reilly, P. F., Gaspar, H. A., Manji, H., Huebel, C., Kelsoe, J. R., Malhotra, D., Bertolino, A., Posthuma, D., Sklar, P., Kapur, S., Sullivan, P. F., Collier, D. A. & Edenberg, H. J., Oct 26 2016, In : Nature neuroscience. 19, 11, p. 1392-1396 5 p.

Research output: Contribution to journalReview article

Psychiatry
Genome
Genome-Wide Association Study
Genomics
Sample Size
26 Citations

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

Bruni, G., Rennekamp, A. J., Velenich, A., McCarroll, M., Gendelev, L., Fertsch, E., Taylor, J., Lakhani, P., Lensen, D., Evron, T., Lorello, P. J., Huang, X. P., Kolczewski, S., Carey, G., Caldarone, B. J., Prinssen, E., Roth, B. L., Keiser, M. J., Peterson, R. T. & Kokel, D., Jul 1 2016, In : Nature Chemical Biology. 12, 7, p. 559-566 8 p.

Research output: Contribution to journalArticle

Zebrafish
Antipsychotic Agents
Haloperidol
Psychiatry
Pharmaceutical Preparations
9 Citations

σ 1 receptor ligands control a switch between passive and active threat responses

Rennekamp, A. J., Huang, X. P., Wang, Y., Patel, S., Lorello, P. J., Cade, L., Gonzales, A. P. W., Yeh, J. R. J., Caldarone, B. J., Roth, B. L., Kokel, D. & Peterson, R. T., Jul 1 2016, In : Nature Chemical Biology. 12, 7, p. 552-558 7 p.

Research output: Contribution to journalArticle

Freezing
Ligands
Zebrafish
Cluster Analysis
Vertebrates
2015
68 Citations

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Huang, X. P., Karpiak, J., Kroeze, W. K., Zhu, H., Chen, X., Moy, S. S., Saddoris, K. A., Nikolova, V. D., Farrell, M. S., Wang, S., Mangano, T. J., Deshpande, D. A., Jiang, A., Penn, R. B., Jin, J., Koller, B. H., Kenakin, T., Shoichet, B. K. & Roth, B. L., Nov 26 2015, In : Nature. 527, 7579, p. 477-483 7 p.

Research output: Contribution to journalArticle

Lorazepam
Ligands
Allosteric Site
Human Genome
G-Protein-Coupled Receptors
101 Citations

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Vardy, E., Robinson, J. E., Li, C., Olsen, R. H. J., DiBerto, J. F., Giguere, P. M., Sassano, F. M., Huang, X. P., Zhu, H., Urban, D. J., White, K. L., Rittiner, J. E., Crowley, N. A., Pleil, K. E., Mazzone, C. M., Mosier, P. D., Song, J., Kash, T. L., Malanga, C. J., Krashes, M. J. & 1 othersRoth, B. L., May 20 2015, In : Neuron. 86, 4, p. 936-946 11 p.

Research output: Contribution to journalArticle

Ligands
kappa Opioid Receptor
Behavior Control
Population
salvinorin B
44 Citations

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

Kaniskan, H. Ü., Szewczyk, M. M., Yu, Z., Eram, M. S., Yang, X., Schmidt, K., Luo, X., Dai, M., He, F., Zang, I., Lin, Y., Kennedy, S., Li, F., Dobrovetsky, E., Dong, A., Smil, D., Min, S. J., Landon, M., Lin-Jones, J., Huang, X. P. & 9 othersRoth, B. L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Arrowsmith, C. H., Brown, P. J., Zhao, K., Jin, J. & Vedadi, M., Apr 20 2015, In : Angewandte Chemie - International Edition. 54, 17, p. 5166-5170 5 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Arginine
Proteins
Methyltransferases
Animals
14 Citations

Chemogenetics-a transformational and translational platform

English, J. G. & Roth, B. L., Jan 1 2015, In : JAMA Neurology. 72, 11, p. 1361-1366 6 p.

Research output: Contribution to journalArticle

Neuroglia
Designer Drugs
Neurons
Nervous System Diseases
Technology
9 Citations
Serotonin Receptor Agonists
Serotonin
Bearings (structural)
Data storage equipment
Alkylation
15 Citations

DREADD: A chemogenetic GPCR signaling platform

Zhu, H. & Roth, B. L., Jan 1 2015, In : International Journal of Neuropsychopharmacology. 18, 1, pyu007.

Research output: Contribution to journalReview article

Designer Drugs
G-Protein-Coupled Receptors
Technology
Drug Discovery
Tissue Engineering