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2017
31 Citations

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Wacker, D., Wang, S., McCorvy, J. D., Betz, R. M., Venkatakrishnan, A. J., Levit, A., Lansu, K., Schools, Z. L., Che, T., Nichols, D. E., Shoichet, B. K., Dror, R. O. & Roth, B. L. Jan 26 2017 In : Cell. 168, 3, p. 377-389.e12

Research output: Contribution to journalArticle

Lysergic Acid Diethylamide
Serotonin Receptors
Crystal structure
Serotonin
Kinetics
17 Citations

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Lansu, K., Karpiak, J., Liu, J., Huang, X. P., McCorvy, J. D., Kroeze, W. K., Che, T., Nagase, H., Carroll, F. I., Jin, J., Shoichet, B. K. & Roth, B. L. May 1 2017 In : Nature Chemical Biology. 13, 5, p. 529-536 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Mast Cells
Computer Simulation
Hydrocodone
Dextromethorphan
2016
6 Citations

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

Chan, J. D., McCorvy, J. D., Acharya, S., Johns, M. E., Day, T. A., Roth, B. L. & Marchant, J. S. May 1 2016 In : PLoS Pathogens. 12, 5, e1005651

Research output: Contribution to journalArticle

Schistosoma mansoni
G-Protein-Coupled Receptors
Parasites
Anthelmintics
Platyhelminths
1 Citations

An alerting structure: Human orexin receptor 1

Wacker, D. & Roth, B. L. Apr 5 2016 In : Nature Structural and Molecular Biology. 23, 4, p. 265-266 2 p.

Research output: Contribution to journalShort survey

Intracellular Signaling Peptides and Proteins
Orexin Receptors
G-Protein-Coupled Receptors
Orexin Receptor Antagonists
23 Citations

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

Marchant, N. J., Whitaker, L. R., Bossert, J. M., Harvey, B. K., Hope, B. T., Kaganovsky, K., Adhikary, S., Prisinzano, T. E., Vardy, E., Roth, B. L. & Shaham, Y. Jan 1 2016 In : Neuropsychopharmacology. 41, 2, p. 402-409 8 p.

Research output: Contribution to journalArticle

Designer Drugs
kappa Opioid Receptor
Mesencephalon
Brain
Ventral Tegmental Area
9 Citations

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice

Zhu, H., Aryal, D. K., Olsen, R. H. J., Urban, D. J., Swearingen, A., Forbes, S., Roth, B. L. & Hochgeschwender, U. Aug 1 2016 In : Genesis. 54, 8, p. 439-446 8 p.

Research output: Contribution to journalArticle

Designer Drugs
G-Protein-Coupled Receptors
Technology
Insulin-Secreting Cells
Neuroglia
5 Citations

Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists

Cheng, J., McCorvy, J. D., Giguere, P. M., Zhu, H., Kenakin, T., Roth, B. L. & Kozikowski, A. P. Nov 10 2016 In : Journal of Medicinal Chemistry. 59, 21, p. 9866-9880 15 p.

Research output: Contribution to journalArticle

Serotonin
Melatonin Receptors
Calcium-Sensing Receptors
Phosphatidylinositols
GTP-Binding Proteins
2 Citations

Design and synthesis of dual 5-HT1Aand 5-HT7receptor ligands

Ofori, E., Zhu, X. Y., Etukala, J. R., Peprah, K., Jordan, K. R., Adkins, A. A., Bricker, B. A., Kang, H. J., Huang, X. P., Roth, B. L. & Ablordeppey, S. Y. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3464-3471 8 p.

Research output: Contribution to journalArticle

Serotonin
Ligands
Central Nervous System Diseases
Butyrophenones
Tetrahydroisoquinolines

Development of CNS multi-receptor ligands: Modification of known D2pharmacophores

Etukala, J. R., Zhu, X. Y., Eyunni, S. V. K., Onyameh, E. K., Ofori, E., Bricker, B. A., Kang, H. J., Huang, X. P., Roth, B. L. & Ablordeppey, S. Y. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3671-3679 9 p.

Research output: Contribution to journalArticle

Serotonin
Ligands
Antipsychotic Agents
Animals
Animal Models
3 Citations

Discovery and characterization of novel GPR39 agonists allosterically modulated by zinc

Sato, S., Huang, X. P., Kroeze, W. K. & Roth, B. L. Dec 1 2016 In : Molecular Pharmacology. 90, 6, p. 726-737 12 p.

Research output: Contribution to journalArticle

LY2784544
Zinc
Phosphotransferases
G-Protein-Coupled Receptors
Carboxylic Acids
9 Citations

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists

Chen, X., McCorvy, J. D., Fischer, M. G., Butler, K. V., Shen, Y., Roth, B. L. & Jin, J. Dec 8 2016 In : Journal of Medicinal Chemistry. 59, 23, p. 10601-10618 18 p.

Research output: Contribution to journalArticle

Dopamine Agonists
GTP-Binding Proteins
Ligands
Dopamine D2 Receptors
G-Protein-Coupled Receptors
18 Citations

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

Urs, N. M., Gee, S. M., Pack, T. F., McCorvy, J. D., Evron, T., Snyder, J. C., Yang, X., Rodriguiz, R. M., Borrelli, E., Wetsel, W. C., Jin, J., Roth, B. L., O'Donnell, P., Caron, M. G. & Snyder, S. H. Dec 13 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8178-E8186

Research output: Contribution to journalArticle

Corpus Striatum
Dopamine D2 Receptors
Antipsychotic Agents
Ligands
Interneurons
113 Citations

DREADDs for Neuroscientists

Roth, B. L. Feb 17 2016 In : Neuron. 89, 4, p. 683-694 12 p.

Research output: Contribution to journalReview article

Designer Drugs
Brain
Diptera
Primates
Signal Transduction
20 Citations

Elucidation of the Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

Urban, D. J., Zhu, H., Marcinkiewcz, C. A., Michaelides, M., Oshibuchi, H., Rhea, D., Aryal, D. K., Farrell, M. S., Lowery-Gionta, E., Olsen, R. H. J., Wetsel, W. C., Kash, T. L., Hurd, Y. L., Tecott, L. H. & Roth, B. L. Apr 1 2016 In : Neuropsychopharmacology. 41, 5, p. 1404-1415 12 p.

Research output: Contribution to journalArticle

Serotonergic Neurons
Designer Drugs
Brain
Technology
Neurons
6 Citations

Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models

Cheng, J., Giguere, P. M., Schmerberg, C. M., Pogorelov, V. M., Rodriguiz, R. M., Huang, X. P., Zhu, H., McCorvy, J. D., Wetsel, W. C., Roth, B. L. & Kozikowski, A. P. Jan 28 2016 In : Journal of Medicinal Chemistry. 59, 2, p. 578-591 14 p.

Research output: Contribution to journalArticle

Methylamines
Serotonin Receptor Agonists
Cognition
Serotonin
Dextroamphetamine
4 Citations

In vitro and in vivo characterization of the alkaloid nuciferine

Farrell, M. S. , McCorvy, J. D. , Huang, X. P. , Urban, D. J. , White, K. L. , Giguere, P. M. , Doak, A. K. , Bernstein, A. I. , Stout, K. A. , Park, S. M. , Rodriguiz, R. M. , Gray, B. W. , Hyatt, W. S. , Norwood, A. P. , Webster, K. A. , Gannon, B. M. , Miller, G. W. , Porter, J. H. , Shoichet, B. K. , Fantegrossi, W. E. & 2 others Wetsel, W. C. & Roth, B. L. Mar 1 2016 In : PLoS ONE. 11, 3, e0150602

Research output: Contribution to journalArticle

Alkaloids
serotonin
alkaloids
agonists
Serotonin
41 Citations

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

Grace, P. M., Strand, K. A., Galer, E. L., Urban, D. J., Wang, X., Baratta, M. V., Fabisiak, T. J., Anderson, N. D., Cheng, K., Greene, L. I., Berkelhammer, D., Zhang, Y., Ellis, A. L., Yin, H. H., Campeau, S., Ricei, K. C., Roth, B. L., Maier, S. F. & Watkins, L. R. Jun 14 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 24, p. E3441-E3450

Research output: Contribution to journalArticle

Inflammasomes
Neuralgia
Morphine
Opioid Analgesics
Designer Drugs
4 Citations

New Technologies for Elucidating Opioid Receptor Function

Bruchas, M. R. & Roth, B. L. Apr 1 2016 In : Trends in Pharmacological Sciences. 37, 4, p. 279-289 11 p.

Research output: Contribution to journalReview article

Opioid Receptors
Opioid Analgesics
Technology
Optogenetics
Crystal structure
1 Citations

Psilocybin for depression and anxiety associated with life-threatening illnesses

McCorvy, J. D., Olsen, R. H. J. & Roth, B. L. Dec 1 2016 In : Journal of Psychopharmacology. 30, 12, p. 1209-1210 2 p.

Research output: Contribution to journalComment/debate

13 Citations

Translating genome-wide association findings into new therapeutics for psychiatry

Breen, G., Li, Q., Roth, B. L., O'Donnell, P., Didriksen, M., Dolmetsch, R., O'Reilly, P. F., Gaspar, H. A., Manji, H., Huebel, C., Kelsoe, J. R., Malhotra, D., Bertolino, A., Posthuma, D., Sklar, P., Kapur, S., Sullivan, P. F., Collier, D. A. & Edenberg, H. J. Oct 26 2016 In : Nature Neuroscience. 19, 11, p. 1392-1396 5 p.

Research output: Contribution to journalReview article

Psychiatry
Genome
Genome-Wide Association Study
Genomics
Sample Size
19 Citations

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

Bruni, G., Rennekamp, A. J., Velenich, A., McCarroll, M., Gendelev, L., Fertsch, E., Taylor, J., Lakhani, P., Lensen, D., Evron, T., Lorello, P. J., Huang, X. P., Kolczewski, S., Carey, G., Caldarone, B. J., Prinssen, E., Roth, B. L., Keiser, M. J., Peterson, R. T. & Kokel, D. Jul 1 2016 In : Nature Chemical Biology. 12, 7, p. 559-566 8 p.

Research output: Contribution to journalArticle

Zebrafish
Antipsychotic Agents
Haloperidol
Psychiatry
Pharmaceutical Preparations
8 Citations

σ 1 receptor ligands control a switch between passive and active threat responses

Rennekamp, A. J., Huang, X. P., Wang, Y., Patel, S., Lorello, P. J., Cade, L., Gonzales, A. P. W., Yeh, J. R. J., Caldarone, B. J., Roth, B. L., Kokel, D. & Peterson, R. T. Jul 1 2016 In : Nature Chemical Biology. 12, 7, p. 552-558 7 p.

Research output: Contribution to journalArticle

Freezing
Ligands
Zebrafish
Cluster Analysis
Vertebrates
2015
48 Citations

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Huang, X. P., Karpiak, J., Kroeze, W. K., Zhu, H., Chen, X., Moy, S. S., Saddoris, K. A., Nikolova, V. D., Farrell, M. S., Wang, S., Mangano, T. J., Deshpande, D. A., Jiang, A., Penn, R. B., Jin, J., Koller, B. H., Kenakin, T., Shoichet, B. K. & Roth, B. L. Nov 26 2015 In : Nature. 527, 7579, p. 477-483 7 p.

Research output: Contribution to journalArticle

Lorazepam
Ligands
Allosteric Site
Human Genome
G-Protein-Coupled Receptors
73 Citations

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

Vardy, E. , Robinson, J. E. , Li, C. , Olsen, R. H. J. , DiBerto, J. F. , Giguere, P. M. , Sassano, F. M. , Huang, X. P. , Zhu, H. , Urban, D. J. , White, K. L. , Rittiner, J. E. , Crowley, N. A. , Pleil, K. E. , Mazzone, C. M. , Mosier, P. D. , Song, J. , Kash, T. L. , Malanga, C. J. , Krashes, M. J. & 1 others Roth, B. L. May 20 2015 In : Neuron. 86, 4, p. 936-946 11 p.

Research output: Contribution to journalArticle

Ligands
kappa Opioid Receptor
Behavior Control
Population
salvinorin B
34 Citations

A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)

Kaniskan, H. Ü. , Szewczyk, M. M. , Yu, Z. , Eram, M. S. , Yang, X. , Schmidt, K. , Luo, X. , Dai, M. , He, F. , Zang, I. , Lin, Y. , Kennedy, S. , Li, F. , Dobrovetsky, E. , Dong, A. , Smil, D. , Min, S. J. , Landon, M. , Lin-Jones, J. , Huang, X. P. & 9 others Roth, B. L., Schapira, M., Atadja, P., Barsyte-Lovejoy, D., Arrowsmith, C. H., Brown, P. J., Zhao, K., Jin, J. & Vedadi, M. Apr 20 2015 In : Angewandte Chemie - International Edition. 54, 17, p. 5166-5170 5 p.

Research output: Contribution to journalArticle

Protein-Arginine N-Methyltransferases
Arginine
Proteins
Methyltransferases
Animals
9 Citations

Chemogenetics-a transformational and translational platform

English, J. G. & Roth, B. L. Nov 1 2015 In : JAMA Neurology. 72, 11, p. 1361-1366 6 p.

Research output: Contribution to journalArticle

Neuroglia
Designer Drugs
Neurons
Nervous System Diseases
Technology
5 Citations
Serotonin Receptor Agonists
Serotonin
Bearings (structural)
Data storage equipment
Alkylation
9 Citations

DREADD: A chemogenetic GPCR signaling platform

Zhu, H. & Roth, B. L. Jan 1 2015 In : International Journal of Neuropsychopharmacology. 18, 1, pyu007

Research output: Contribution to journalReview article

Designer Drugs
G-Protein-Coupled Receptors
Technology
Drug Discovery
Tissue Engineering
162 Citations
Designer Drugs
G-Protein-Coupled Receptors
Technology
Obesity
Synthetic Biology
24 Citations
G-Protein-Coupled Receptors
Genes
Genome
Human Genome
Drug Discovery
2 Citations

Molecular interactions between general anesthetics and the 5HT2B receptor

Matsunaga, F., Gao, L., Huang, X. P., Saven, J. G., Roth, B. L. & Liu, R. Jan 2 2015 In : Journal of Biomolecular Structure and Dynamics. 33, 1, p. 211-218 8 p.

Research output: Contribution to journalArticle

General Anesthetics
Isoflurane
Propofol
Anesthetics
Serotonin Receptors
20 Citations

NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

O'Connor, C., White, K. L., Doncescu, N., Didenko, T., Roth, B. L., Czaplicki, G., Stevens, R. C., Wüthrich, K., Milon, A. & Summers, M. F. Sep 22 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 38, p. 11852-11857 6 p.

Research output: Contribution to journalArticle

Dynorphins
kappa Opioid Receptor
Nuclear magnetic resonance
Peptides
Molecular modeling
13 Citations

Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents

Cheng, J., Giguère, P. M., Onajole, O. K., Lv, W., Gaisin, A., Gunosewoyo, H., Schmerberg, C. M., Pogorelov, V. M., Rodriguiz, R. M., Vistoli, G., Wetsel, W. C., Roth, B. L. & Kozikowski, A. P. Feb 26 2015 In : Journal of Medicinal Chemistry. 58, 4, p. 1992-2002 11 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2C
Serotonin Receptor Agonists
Antipsychotic Agents
Serotonin
Amphetamine
62 Citations

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Kroeze, W. K., Sassano, M. F., Huang, X. P., Lansu, K., McCorvy, J. D., Giguère, P. M., Sciaky, N. & Roth, B. L. Jan 1 2015 In : Nature Structural and Molecular Biology. 22, 5, p. 362-369 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Orphaned Children
Ligands
Arrestin
GTP-Binding Proteins
7 Citations

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism

Robinson, J. E., Vardy, E., Diberto, J. F., Chefer, V. I., White, K. L., Fish, E. W., Chen, M., Gigante, E., Krouse, M. C., Sun, H., Thorsell, A., Roth, B. L., Heilig, M. & Malanga, C. J. Oct 12 2015 In : Neuropsychopharmacology. 40, 11, p. 2614-2622 9 p.

Research output: Contribution to journalArticle

Morphine
Opioid Analgesics
Fentanyl
Hydrocodone
Self Stimulation
4 Citations

Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability

Zhang, Z., Kil, K. E., Poutiainen, P., Choi, J. K., Kang, H. J., Huang, X. P., Roth, B. L. & Brownell, A. L. Aug 17 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 18, p. 3956-3960 5 p., 22920

Research output: Contribution to journalArticle

Ligands
Derivatives
Brain Diseases
Modulators
Parkinson Disease
4 Citations

Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice

Salaga, M., Polepally, P. R., Zielinska, M., Marynowski, M., Fabisiak, A., Murawska, N., Sobczak, K., Sacharczuk, M., Do Rego, J. C., Roth, B. L., Zjawiony, J. K. & Fichna, J. Sep 1 2015 In : British Journal of Pharmacology. 172, 17, p. 4331-4341 11 p.

Research output: Contribution to journalArticle

salvinorin A
p-Methoxy-N-methylphenethylamine
Narcotic Antagonists
Antipruritics
beta-funaltrexamine
15 Citations

Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex

Nocjar, C., Alex, K. D., Sonneborn, A., Abbas, A. I., Roth, B. L. & Pehek, E. A. Jun 5 2015 In : Neuroscience. 297, p. 22-37 16 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2C
Receptor, Serotonin, 5-HT2A
Prefrontal Cortex
Serotonin
Pyramidal Cells
5 Citations

Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides

Vardy, E., Sassano, M. F., Rennekamp, A. J., Kroeze, W. K., Mosier, P. D., Westkaemper, R. B., Stevens, C. W., Katritch, V., Stevens, R. C., Peterson, R. T. & Roth, B. L. Jun 20 2015 In : Chemistry and Biology. 22, 6, p. 764-775 12 p.

Research output: Contribution to journalArticle

Opioid Peptides
Opioid Receptors
Amphibians
Opioid Analgesics
Skin
61 Citations

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

Fenalti, G. , Zatsepin, N. A. , Betti, C. , Giguere, P. , Han, G. W. , Ishchenko, A. , Liu, W. , Guillemyn, K. , Zhang, H. , James, D. , Wang, D. , Weierstall, U. , Spence, J. C. H. , Boutet, S. , Messerschmidt, M. , Williams, G. J. , Gati, C. , Yefanov, O. M. , White, T. A. , Oberthuer, D. & 16 others Metz, M., Yoon, C. H., Barty, A., Chapman, H. N., Basu, S., Coe, J., Conrad, C. E., Fromme, R., Fromme, P., Tourwé, D., Schiller, P. W., Roth, B. L., Ballet, S., Katritch, V., Stevens, R. C. & Cherezov, V. Mar 6 2015 In : Nature Structural and Molecular Biology. 22, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

delta Opioid Receptor
Peptides
mu Opioid Receptor
Analgesics
Opiate Alkaloids
48 Citations

Structure and function of serotonin G protein-coupled receptors

McCorvy, J. D. & Roth, B. L. Jun 1 2015 In : Pharmacology and Therapeutics. 150, p. 129-142 14 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Serotonin Receptors
Serotonin
Ergotamine
Drug Design
23 Citations

The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs

Chen, X., Choo, H., Huang, X. P., Yang, X., Stone, O., Roth, B. L. & Jin, J. Mar 18 2015 In : ACS Chemical Neuroscience. 6, 3, p. 476-484 9 p.

Research output: Contribution to journalArticle

Designer Drugs
Structure-Activity Relationship
Ligands
Directed Molecular Evolution
Optogenetics
44 Citations

The G protein-biased κ-Opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo

White, K. L., Robinson, J. E., Zhu, H., DiBerto, J. F., Polepally, P. R., Zjawiony, J. K., Nichols, D. E., Malanga, C. J. & Roth, B. L. Jan 1 2015 In : Journal of Pharmacology and Experimental Therapeutics. 352, 1, p. 98-109 12 p., A21

Research output: Contribution to journalArticle

kappa Opioid Receptor
GTP-Binding Proteins
Opioid Receptors
Analgesics
Ataxia
2014
131 Citations

Allosteric sodium in class A GPCR signaling

Katritch, V., Fenalti, G., Abola, E. E., Roth, B. L., Cherezov, V. & Stevens, R. C. Jan 1 2014 In : Trends in Biochemical Sciences. 39, 5, p. 233-244 12 p.

Research output: Contribution to journalReview article

G-Protein-Coupled Receptors
Sodium
Chemical activation
Signal transduction
Signal Transduction
11 Citations
activity structure
Serotonin
Screening
Ligands
drug
31 Citations

Chemogenetic inactivation of ventral hippocampal glutamatergic neurons disrupts consolidation of contextual fear memory

Zhu, H., Pleil, K. E., Urban, D. J., Moy, S. S., Kash, T. L. & Roth, B. L. Jan 1 2014 In : Neuropsychopharmacology. 39, 8, p. 1880-1892 13 p.

Research output: Contribution to journalArticle

Fear
Hippocampus
Neurons
Pyramidal Cells
Clozapine
121 Citations

Chemogenetic tools to interrogate brain functions

Sternson, S. M. & Roth, B. L. 2014 In : Annual Review of Neuroscience. 37, p. 387-407 21 p.

Research output: Contribution to journalReview article

Brain
Neurons
Cell Physiological Phenomena
Pharmacology
Population
35 Citations

DREADDs: Novel tools for drug discovery and development

Lee, H. M., Giguere, P. M. & Roth, B. L. Jan 1 2014 In : Drug Discovery Today. 19, 4, p. 469-473 5 p.

Research output: Contribution to journalReview article

Designer Drugs
Drug Discovery
G-Protein-Coupled Receptors
Biological Phenomena
Research Personnel
1 Citations

Further evaluation of the tropane analogs of haloperidol

Sampson, D., Bricker, B., Zhu, X. Y., Peprah, K., Lamango, N. S., Setola, V., Roth, B. L. & Ablordeppey, S. Y. Sep 1 2014 In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4294-4297 4 p.

Research output: Contribution to journalArticle

Tropanes
Catalepsy
Haloperidol
Rats
Metabolites
5 Citations

HTS navigator: Freely accessible cheminformatics software for analyzing high-throughput screening data

Fourches, D., Sassano, M. F., Roth, B. L. & Tropsha, A. Feb 15 2014 In : Bioinformatics. 30, 4, p. 588-589 2 p.

Research output: Contribution to journalArticle

High-throughput Screening
Screening
Software
Throughput
Hits