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2018

Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS

Zhang, Q., Hu, X. F., Xin, M. M., Liu, H. B., Sun, L. J., Morris-Natschke, S. L., Chen, Y. & Lee, K. H., Oct 28 2018, In : Journal of Ethnopharmacology. 225, p. 202-210 9 p.

Research output: Contribution to journalArticle

Physalis
Hypoglycemic Agents
Fasting
High Pressure Liquid Chromatography
Insulin Resistance
4 Citations

Biologically active quinoline and quinazoline alkaloids part I

Shang, X. F., Morris-Natschke, S. L., Liu, Y. Q., Guo, X., Xu, X. S., Goto, M., Li, J. C., Yang, G. Z. & Lee, K. H., May 1 2018, In : Medicinal Research Reviews. 38, 3, p. 775-828 54 p.

Research output: Contribution to journalReview article

2 Citations

Biologically active quinoline and quinazoline alkaloids part II

Shang, X. F., Morris-Natschke, S. L., Yang, G. Z., Liu, Y. Q., Guo, X., Xu, X. S., Goto, M., Li, J. C., Zhang, J. Y. & Lee, K. H., Sep 1 2018, In : Medicinal Research Reviews. 38, 5, p. 1614-1660 47 p.

Research output: Contribution to journalReview article

Quinazolines
Alkaloids
Antitussive Agents
Antiparasitic Agents
Biological Products

Chemical structures and biological activities of limonoids from the genus swietenia (meliaceae)

Sun, Y. P., Jin, W. F., Wang, Y. Y., Wang, G., Morris-Natschke, S. L., Liu, J. S., Wang, G. K. & Lee, K. H., Jan 1 2018, In : Molecules. 23, 7, 1588

Research output: Contribution to journalReview article

subtropical regions
Limonins
Meliaceae
terpenes
activity (biology)

Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives

Chen, Z., Duan, H., Tong, X., Hsu, P., Han, L., Morris-Natschke, S. L., Yang, S., Liu, W. & Lee, K. H., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 465-474 10 p.

Research output: Contribution to journalArticle

Apoptosis
Lung Neoplasms
Gasohol
Structure-Activity Relationship
Antineoplastic Agents

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities

Ling, Y., Yang, Q. X., Teng, Y. N., Chen, S., Gao, W. J., Guo, J., Hsu, P. L., Liu, Y., Morris-Natschke, S. L., Hung, C. C. & Lee, K. H., Jun 25 2018, In : European Journal of Medicinal Chemistry. 154, p. 199-209 11 p.

Research output: Contribution to journalArticle

Slip forming
KB Cells
NAD
Oxidoreductases
Pharmaceutical Preparations
4 Citations

Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study

Chang, L. C., Hsieh, M. T., Yang, J. S., Lu, C. C., Tsai, F. J., Tsao, J. W., Chiu, Y. J., Kuo, S. C. & Lee, K. H., Jan 1 2018, In : International Journal of Oncology. 52, 1, p. 67-76 10 p.

Research output: Contribution to journalArticle

Autophagy
Cell Cycle Checkpoints
Adenocarcinoma
Breast
Apoptosis
2 Citations

Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor

Huang, L., Lai, W. H., Zhu, L., Li, W., Wei, L., Lee, K. H., Xie, L. & Chen, C. H., Mar 8 2018, In : ACS Medicinal Chemistry Letters. 9, 3, p. 268-273 6 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
HIV-1
Trickling filtration
Blood Cells
gnidimacrin
2 Citations

Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi

Hu, X. F., Zhang, Q., Zhang, P. P., Sun, L. J., Liang, J. C., Morris-Natschke, S. L., Chen, Y. & Lee, K. H., Jun 1 2018, In : Fitoterapia. 127, p. 129-137 9 p.

Research output: Contribution to journalArticle

Physalis
Cytochrome P-450 CYP2E1
Insulin Resistance
Antioxidants
Flavonoids

Four new C19-diterpenoid alkaloids from Delphinium elatum

Yamashita, H., Katoh, M., Kokubun, A., Uchimura, A., Mikami, S., Takeuchi, A., Kaneda, K., Suzuki, Y., Mizukami, M., Goto, M., Lee, K. H. & Wada, K., Apr 1 2018, In : Phytochemistry Letters. 24, p. 6-9 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
Computer operating procedures
diterpenoid alkaloids
Applicators
1 Citations

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

Yamashita, H., Takeda, K., Haraguchi, M., Abe, Y., Kuwahara, N., Suzuki, S., Terui, A., Masaka, T., Munakata, N., Uchida, M., Nunokawa, M., Kaneda, K., Goto, M., Lee, K. H. & Wada, K., Jan 1 2018, In : Journal of Natural Medicines. 72, 1, p. 230-237 8 p.

Research output: Contribution to journalArticle

Aconitum
Computer operating procedures
Applicators
Diterpenes
Alkaloids

Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui

Liu, Q., Li, W., Huang, L., Asada, Y., Morris-Natschke, S. L., Chen, C. H., Lee, K. H. & Koike, K., Aug 5 2018, In : European Journal of Medicinal Chemistry. 156, p. 618-627 10 p.

Research output: Contribution to journalArticle

Euphorbia
Virus Replication
HIV-1
Esters
Thymelaeaceae

Kleinhospitine e and Cycloartane Triterpenoids from Kleinhovia hospita

Rahim, A., Saito, Y., Miyake, K., Goto, M., Chen, C. H., Alam, G., Morris-Natschke, S., Lee, K. H. & Nakagawa-Goto, K., Jul 27 2018, In : Journal of Natural Products. 81, 7, p. 1619-1627 9 p.

Research output: Contribution to journalArticle

Applicators
Alkaloids
Carry logic
Lactams
Tumor Cell Line
1 Citations

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris

Teng, Y. N., Wang, Y., Hsu, P. L., Xin, G., Zhang, Y., Morris-Natschke, S. L., Goto, M. & Lee, K. H., Mar 1 2018, In : Phytomedicine. 41, p. 62-66 5 p.

Research output: Contribution to journalArticle

Euphorbia
Multiple Drug Resistance
Diterpenes
Seeds
lissamine rhodamine B

SAR study on: N 2, N 4-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents

Jing, L., Tang, Y., Goto, M., Lee, K. H. & Xiao, Z., Jan 1 2018, In : RSC Advances. 8, 22, p. 11871-11885 15 p.

Research output: Contribution to journalArticle

Cold rolling
Cells
Transcription
Tumors
Assays

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata

Tsurumi, F., Miura, Y., Saito, Y., Miyake, K., Fujie, T., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Apr 20 2018, In : Organic Letters. 20, 8, p. 2282-2286 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Polyketides
nonanes
Monoterpenes
metabolites

Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents

Wang, Y., Chen, S. R., Yang, X., Lee, K. H. & Cheng, Y. C., Feb 1 2018, In : Bioorganic and Medicinal Chemistry. 26, 3, p. 630-636 7 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Structure-Activity Relationship
Hepacivirus
Natural gas well logging
Virus Replication

Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells

Hsieh, M. T., Huang, L. J., Wu, T. S., Lin, H. Y., Morris-Natschke, S. L., Lee, K. H. & Kuo, S. C., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Semiconductor optical amplifiers
Mouth Neoplasms
Propionates
Cisplatin
Slip forming
2 Citations

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Zhang, Y., Yuan, Y. X., Goto, M., Guo, L. L., Li, X. N., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 562-571 10 p.

Research output: Contribution to journalArticle

Tabernaemontana
Applicators
Alkaloids
KB Cells
P-Glycoprotein
2017
2 Citations

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Double-Stranded DNA Breaks
Alkaloids
Tumor Cell Line
Tumors
3 Citations

Bioactive chemical constituents from the root bark of Morus australis

Liao, Y. R., Kuo, P. C., Tsai, W. J., Huang, G. J., Lee, K. H. & Wu, T. S., Jan 15 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

Morus
Platelets
Platelet Aggregation
Arachidonic Acid
Adenosine Diphosphate
4 Citations

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O’Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Apr 28 2017, In : Journal of Natural Products. 80, 4, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Antitumor Drug Screening Assays
Salicaceae
Clerodane Diterpenes
Plant Bark

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives

Yang, C. J., Song, Z. L., Goto, M., Hsu, P. L., Zhang, X. S., Yang, Q. R., Liu, Y. Q., Wang, M. J., Morris-Natschke, S. L., Shang, X. F. & Lee, K. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 20, p. 4694-4697 4 p.

Research output: Contribution to journalArticle

2 Citations

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties

Yang, C. J., Song, Z. L., Goto, M., Liu, Y. Q., Hsieh, K. Y., Morris-Natschke, S. L., Zhao, Y. L., Zhang, J. X. & Lee, K. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 3959-3962 4 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Antitumor Drug Screening Assays
irinotecan
Piperazines
Amidines
3 Citations

Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds

Zhou, A., Yan, L., Lai, F., Chen, X., Goto, M., Lee, K. H. & Xiao, Z., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 15, p. 3326-3331 6 p.

Research output: Contribution to journalArticle

Slip forming
Gasohol
Triple Negative Breast Neoplasms
HCT116 Cells
Cell Line
3 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxicity
Derivatives
irinotecan
lissamine rhodamine B

Design, synthesis and structure-activity relationships of (±)-isochaihulactone derivatives

Zhao, Y., Liu, P. Y., Hsieh, K. Y., Hsu, P. L., Goto, M., Morris-Natschke, S. L., Harn, H. J. & Lee, K. H., Jan 1 2017, In : MedChemComm. 8, 11, p. 2040-2049 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
KB Cells
G2 Phase
P-Glycoprotein
Cell Cycle Checkpoints
Rilpivirine
Drug Dose Response Relationship
Slip forming
Aniline Compounds
Viral Drug Resistance
Staurosporine
Pharmaceutical Chemistry
Protein-Tyrosine Kinases
Paclitaxel
Publications
2 Citations

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents

Cui, M. T., Jiang, L., Goto, M., Hsu, P. L., Li, L., Zhang, Q., Wei, L., Yuan, S. J., Hamel, E., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Jul 13 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5586-5598 13 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Molecular Docking Simulation
Quinazolines
Angiogenesis Inhibitors
Tubulin
4 Citations

New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo

Hsieh, M. T., Chang, L. C., Hung, H. Y., Lin, H. Y., Shih, M. H., Tsai, C. H., Kuo, S. C. & Lee, K. H., May 5 2017, In : European Journal of Medicinal Chemistry. 131, p. 141-151 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Curcumin
Derivatives
Breast Neoplasms
Heterografts
2 Citations

Phytoagent deoxyelephantopin and its derivative inhibit triple negative breast cancer cell activity through ROS-mediated exosomal activity and protein functions

Shiau, J. Y., Chang, Y. Q., Nakagawa-Goto, K., Lee, K. H. & Shyur, L. F., Jun 29 2017, In : Frontiers in Pharmacology. 8, JUN, 398

Research output: Contribution to journalArticle

DEET
Triple Negative Breast Neoplasms
Exosomes
Reactive Oxygen Species
Oxidative Stress
3 Citations

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Li, Q., Qu, F. L., Gao, Y., Jiang, Y. P., Rahman, K., Lee, K. H., Han, T. & Qin, L. P., Mar 6 2017, In : Journal of Ethnopharmacology. 199, p. 9-19 11 p.

Research output: Contribution to journalArticle

Piper
MAP Kinase Signaling System
Brain-Derived Neurotrophic Factor
Antidepressive Agents
Rodentia
10 Citations

Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents

Vijaya Bhaskar Reddy, M., Hung, H. Y., Kuo, P. C., Huang, G. J., Chan, Y. Y., Huang, S. C., Wu, S. J., Morris-Natschke, S. L., Lee, K. H. & Wu, T. S., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1547-1550 4 p.

Research output: Contribution to journalArticle

Chalcones
Lead compounds
Chalcone
Macrophages
Peritoneal Macrophages
4 Citations

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Yuan, Y. X., Zhang, Y., Guo, L. L., Wang, Y. H., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J., Sep 15 2017, In : Organic Letters. 19, 18, p. 4964-4967 4 p.

Research output: Contribution to journalArticle

Tabernaemontana
Applicators
alkaloids
Alkaloids
Vincristine
1 Citations

Total Synthesis of (+)-Medicarpin

Yang, X., Zhao, Y., Hsieh, M. T., Xin, G., Wu, R. T., Hsu, P. L., Horng, L. Y., Sung, H. C., Cheng, C. H. & Lee, K. H., Dec 22 2017, In : Journal of Natural Products. 80, 12, p. 3284-3288 5 p.

Research output: Contribution to journalArticle

Erythropoietin
Crystallites
Oxazolidinones
Research
medicarpin
2 Citations

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication

Wang, Y., Lee, S., Ha, Y., Lam, W., Chen, S. R., Dutschman, G. E., Gullen, E. A., Grill, S. P., Cheng, Y., Fürstner, A., Francis, S., Baker, D. C., Yang, X., Lee, K. H. & Cheng, Y. C., Dec 1 2017, In : Scientific Reports. 7, 1, 10037

Research output: Contribution to journalArticle

2 Citations

Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia

Luo, P., Xia, W., Morris-Natschke, S. L., Lee, K. H., Zhao, Y., Gu, Q. & Xu, J., May 26 2017, In : Journal of Natural Products. 80, 5, p. 1558-1562 5 p.

Research output: Contribution to journalArticle

4 Citations

Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release

Xin, G., Wei, Z., Ji, C., Zheng, H., Gu, J., Ma, L., Huang, W., Morris-Natschke, S. L., Yeh, J. L., Zhang, R., Qin, C., Wen, L., Xing, Z., Cao, Y., Xia, Q., Li, K., Niu, H., Lee, K. H. & Huang, W., Jul 1 2017, In : Free Radical Biology and Medicine. 108, p. 247-257 11 p.

Research output: Contribution to journalArticle

Humulus
Platelet Activation
Platelets
Mitochondrial DNA
Thrombosis
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y., Mar 1 2016, In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
alkaloids
5 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K., Nov 23 2016, In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Contribution to journalArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Monomers
Cells
11 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H., Mar 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Contribution to journalArticle

Oxytropis
Alkaloids
Cells
Derivatives
Cell Line
16 Citations

Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors

Dang, Z., Zhu, L., Lai, W., Bogerd, H., Lee, K. H., Huang, L. & Chen, C. H., Mar 10 2016, In : ACS Medicinal Chemistry Letters. 7, 3, p. 240-244 5 p.

Research output: Contribution to journalArticle

HIV Fusion Inhibitors
HIV-1
Derivatives
Cell Fusion
Fusion reactions
6 Citations

A novel plant sesquiterpene lactone derivative, DETD-35, Suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice

Feng, J. H., Nakagawa-Goto, K., Lee, K. H. & Shyur, L. F., Jun 1 2016, In : Molecular Cancer Therapeutics. 15, 6, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

Sesquiterpenes
Lactones
Melanoma
Growth
Mitogen-Activated Protein Kinase Kinases
3 Citations

Anti-inflammatory neolignans from the roots of Magnolia officinalis

Shih, H. C., Kuo, P. C., Wu, S. J., Hwang, T. L., Hung, H. Y., Shen, D. Y., Shieh, P. C., Liao, Y. R., Lee, E. J., Gu, Q., Lee, K. H. & Wu, T. S., Apr 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 7, p. 1439-1445 7 p.

Research output: Contribution to journalArticle

Magnolia
Lignans
Anti-Inflammatory Agents
Derivatives
Pancreatic Elastase
8 Citations

Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity

Jiang, C., Luo, P., Zhao, Y., Hong, J., Morris-Natschke, S. L., Xu, J., Chen, C. H., Lee, K. H. & Gu, Q., Mar 25 2016, In : Journal of Natural Products. 79, 3, p. 578-583 6 p.

Research output: Contribution to journalArticle

Euphorbia
Lignans
Spectroscopic analysis
Enantiomers
Polyphenols

Chinese herbal medicine-derived products for prevention or treatment of diseases affecting quality of life

Lee, K. H., Morris-Natschke, S. L., Zhao, Y. & Musgrove, K., Jan 1 2016, Medicinal Plants - Recent Advances in Research and Development. Springer Singapore, p. 1-35 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxicity
Dietary supplements
Standardization
Medicine
Quality control
34 Citations

Clerodane diterpenes: Sources, structures, and biological activities

Li, R., Morris-Natschke, S. L. & Lee, K. H., Oct 1 2016, In : Natural Product Reports. 33, 10, p. 1166-1226 61 p.

Research output: Contribution to journalReview article

Clerodane Diterpenes
Bioactivity
Opioid Receptors
Salvia
Diterpenes
7 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H., Jun 10 2016, In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
irinotecan
Structure-Activity Relationship
7 Citations

Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii

Liu, S. N., Huang, D., Morris-Natschke, S. L., Ma, H., Liu, Z. H., Seeram, N. P., Xu, J., Lee, K. H. & Gu, Q., Dec 2 2016, In : Organic Letters. 18, 23, p. 6132-6135 4 p.

Research output: Contribution to journalArticle

Euphorbia
RANK Ligand
Diterpenes
Osteoclasts
Circular Dichroism