Find Research Outputs — University of North Carolina at Chapel Hill

2017

1 Citations

A Powerful Test for SNP Effects on Multivariate Binary Outcomes Using Kernel Machine Regression

Davenport, C. A., Maity, A., Sullivan, P. F. & Tzeng, J. Y. Mar 24 2017 (Accepted/In press) In : Statistics in Biosciences. p. 1-22 22 p.

Research output: Contribution to journal › Article

Kernel Machines

Binary Outcomes

Single Nucleotide Polymorphism

Regression

Polymorphism

1 Citations

Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence

Clark, S. L. , McClay, J. L. , Adkins, D. E. , Kumar, G. , Aberg, K. A. , Nerella, S. , Xie, L. , Collins, A. L. , Crowley, J. J. , Quackenbush, C. R. , Hilliard, C. E. , Shabalin, A. A. , Vrieze, S. I. , Peterson, R. E. , Copeland, W. E. , Silberg, J. L. , McGue, M. , Maes, H. , Iacono, W. G. , Sullivan, P. F. & 2 others Costello, E. J. & van den Oord, E. J. Jan 1 2017 In : Alcoholism: Clinical and Experimental Research. 41, 4, p. 711-718 8 p.

Research output: Contribution to journal › Article

High-Throughput Nucleotide Sequencing

Alcoholism

Genes

Alcohols

Alcohol Dehydrogenase

Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa

Yilmaz, Z., Szatkiewicz, J. P., Crowley, J. J., Ancalade, N., Brandys, M. K., Van Elburg, A., De Kovel, C. G. F., Adan, R. A. H., Hinney, A., Hebebrand, J., Gratacos, M., Fernandez-Aranda, F., Escaramis, G., Gonzalez, J. R., Estivill, X., Zeggini, E., Sullivan, P. F. & Bulik, C. M. Jan 1 2017 In : Psychiatric Genetics. 27, 4, p. 152-158 7 p.

Research output: Contribution to journal › Article

Anorexia Nervosa

Psychiatry

Neurodevelopmental Disorders

Quality Control

Sample Size

4 Citations

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues

Liu, X., Finucane, H. K., Gusev, A., Bhatia, G., Gazal, S., O'Connor, L., Bulik-Sullivan, B., Wright, F. A., Sullivan, P. F., Neale, B. M. & Price, A. L. Apr 6 2017 In : American Journal of Human Genetics. 100, 4, p. 605-616 12 p.

Research output: Contribution to journal › Article

Gene Expression Regulation

Histone Code

Gene Expression

3 Citations

Obstetrical, pregnancy and socio-economic predictors for new-onset severe postpartum psychiatric disorders in primiparous women

Meltzer-Brody, S., Maegbaek, M. L., Medland, S. E., Miller, W. C., Sullivan, P. & Munk-Olsen, T. Jun 1 2017 In : Psychological Medicine. 47, 8, p. 1427-1441 15 p.

Research output: Contribution to journal › Article

Postpartum Period

Psychiatry

Economics

Pregnancy

Confidence Intervals

1 Citations

Schizophrenia and the dynamic genome

Sullivan, P. F. Mar 2 2017 In : Genome Medicine. 9, 1, 22

Research output: Contribution to journal › Comment/debate

Schizophrenia

Genome

2016

1 Citations

Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses

Clark, S. L., McClay, J. L., Adkins, D. E., Aberg, K. A., Kumar, G., Nerella, S., Xie, L., Collins, A. L., Crowley, J. J., Quakenbush, C. R., Hillard, C. E., Gao, G., Shabalin, A. A., Peterson, R. E., Copeland, W. E., Silberg, J. L., Maes, H., Sullivan, P. F., Elizabeth, J. C. & van den Oord, E. J. May 1 2016 In : Nicotine and Tobacco Research. 18, 5, p. 626-631 6 p.

Research output: Contribution to journal › Article

High-Throughput Nucleotide Sequencing

Genome-Wide Association Study

Gene Frequency

Meta-Analysis

Smoking

8 Citations

Heritability of perinatal depression and genetic overlap with nonperinatal depression

Viktorin, A., Meltzer-Brody, S., Kuja-Halkola, R., Sullivan, P. F., Landén, M., Lichtenstein, P. & Magnusson, P. K. E. Feb 1 2016 In : American Journal of Psychiatry. 173, 2, p. 158-165 8 p.

Research output: Contribution to journal › Article

Depression

Siblings

Postpartum Depression

Twin Studies

Counseling

72 Citations

Integrative approaches for large-scale transcriptome-wide association studies

Gusev, A. , Ko, A. , Shi, H. , Bhatia, G. , Chung, W. , Penninx, B. W. J. H. , Jansen, R. , De Geus, E. J. C. , Boomsma, D. I. , Wright, F. A. , Sullivan, P. F. , Nikkola, E. , Alvarez, M. , Civelek, M. , Lusis, A. J. , Lehtimäki, T. , Raitoharju, E. , Kähönen, M. , Seppälä, I. , Raitakari, O. T. & 5 others Kuusisto, J., Laakso, M., Price, A. L., Pajukanta, P. & Pasaniuc, B. Mar 1 2016 In : Nature Genetics. 48, 3, p. 245-252 8 p.

Research output: Contribution to journal › Article

Transcriptome

Gene Expression

Genome-Wide Association Study

Phenotype

Genes

8 Citations

Nationwide genomic study in Denmark reveals remarkable population homogeneity

Athanasiadis, G., Cheng, J. Y., Vilhjálmsson, B. J., Jørgensen, F. G., Als, T. D., Le Hellard, S., Espeseth, T., Sullivan, P. F., Hultman, C. M., Kjærgaard, P. C., Schierup, M. H. & Mailund, T. Oct 1 2016 In : Genetics. 204, 2, p. 711-722 12 p.

Research output: Contribution to journal › Article

Denmark

Norway

Sweden

Population

History

1 Citations

One CNV Discordance in NRXN1 Observed Upon Genome-wide Screening in 38 Pairs of Adult Healthy Monozygotic Twins

Magnusson, P. K. E., Lee, D., Chen, X., Szatkiewicz, J., Pramana, S., Teo, S., Sullivan, P. F., Feuk, L. & Pawitan, Y. Apr 1 2016 In : Twin Research and Human Genetics. 19, 2, p. 97-103 7 p.

Research output: Contribution to journal › Article

Monozygotic Twins

Genome

Exons

Dizygotic Twins

Twin Studies

18 Citations

Polygenic overlap between schizophrenia risk and antipsychotic response: A genomic medicine approach

Ruderfer, D. M., Charney, A. W., Readhead, B., Kidd, B. A., Kähler, A. K., Kenny, P. J., Keiser, M. J., Moran, J. L., Hultman, C. M., Scott, S. A., Sullivan, P. F., Purcell, S. M., Dudley, J. T. & Sklar, P. Apr 1 2016 In : The Lancet Psychiatry. 3, 4, p. 350-357 8 p.

Research output: Contribution to journal › Article

Antipsychotic Agents

Schizophrenia

Medicine

Genes

Therapeutics

21 Citations

The mouse universal genotyping array: From substrains to subspecies

Morgan, A. P. , Fu, C. P. , Kao, C. Y. , Welsh, C. E. , Didion, J. P. , Yadgary, L. , Hyacinth, L. , Ferris, M. T. , Bell, T. A. , Miller, D. R. , Giusti-Rodriguez, P. , Nonneman, R. J. , Cook, K. D. , Whitmire, J. K. , Gralinski, L. E. , Keller, M. , Attie, A. D. , Churchill, G. A. , Petkov, P. , Sullivan, P. F. & 3 others Brennan, J. R., McMillan, L. & Villena, F. P. M. D. Jan 1 2016 In : G3: Genes, Genomes, Genetics. 6, 2, p. 263-279 17 p.

Research output: Contribution to journal › Article

Population Genetics

Quality Control

Single Nucleotide Polymorphism

Genome

Population

13 Citations

Translating genome-wide association findings into new therapeutics for psychiatry

Breen, G., Li, Q., Roth, B. L., O'Donnell, P., Didriksen, M., Dolmetsch, R., O'Reilly, P. F., Gaspar, H. A., Manji, H., Huebel, C., Kelsoe, J. R., Malhotra, D., Bertolino, A., Posthuma, D., Sklar, P., Kapur, S., Sullivan, P. F., Collier, D. A. & Edenberg, H. J. Oct 26 2016 In : Nature Neuroscience. 19, 11, p. 1392-1396 5 p.

Research output: Contribution to journal › Review article

Psychiatry

Genome

Genome-Wide Association Study

Genomics

Sample Size

2 Citations

What next in schizophrenia genetics for the psychiatric genomics consortium?

Corvin, A. & Sullivan, P. F. May 1 2016 In : Schizophrenia Bulletin. 42, 3, p. 538-541 4 p.

Research output: Contribution to journal › Review article

Genome-Wide Association Study

Genomics

Psychiatry

Schizophrenia

2015

14 Citations

A Multi-Megabase Copy Number Gain Causes Maternal Transmission Ratio Distortion on Mouse Chromosome 2

Didion, J. P. , Morgan, A. P. , Clayshulte, A. M. F. , Mcmullan, R. C. , Yadgary, L. , Petkov, P. M. , Bell, T. A. , Gatti, D. M. , Crowley, J. J. , Hua, K. , Aylor, D. L. , Bai, L. , Calaway, M. , Chesler, E. J. , French, J. E. , Geiger, T. R. , Gooch, T. J. , Garland, T. , Harrill, A. H. , Hunter, K. & 16 others McMillan, L., Holt, M., Miller, D. R., O'Brien, D. A., Paigen, K., Pan, W., Rowe, L. B., Shaw, G. D., Simecek, P., Sullivan, P. F., Svenson, K. L., Weinstock, G. M., Threadgill, D. W., Pomp, D., Churchill, G. A. & Pardo-Manuel de Villena, F. Jan 1 2015 In : PLoS Genetics. 11, 2, p. 1-29 29 p., e1004850

Research output: Contribution to journal › Article

Chromosomes, Human, Pair 2

chromosome

Mothers

meiotic drive

chromosomes

56 Citations

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

Crowley, J. J. , Zhabotynsky, V. , Sun, W. , Huang, S. , Pakatci, I. K. , Kim, Y. , Wang, J. R. , Morgan, A. P. , Calaway, J. D. , Aylor, D. L. , Yun, Z. , Bell, T. A. , Buus, R. J. , Calaway, M. E. , Didion, J. P. , Gooch, T. J. , Hansen, S. D. , Robinson, N. N. , Shaw, G. D. , Spence, J. S. & 21 others Quackenbush, C. R., Barrick, C. J., Nonneman, R. J., Kim, K., Xenakis, J., Xie, Y., Valdar, W., Lenarcic, A. B., Wang, W., Welsh, C. E., Fu, C. P., Zhang, Z., Holt, J., Guo, Z., Threadgill, D. W., Tarantino, L. M., Miller, D. R., Zou, F., McMillan, L., Sullivan, P. F. & De Villena, F. P. M. Jan 1 2015 In : Nature Genetics. 47, 4, p. 353-360 8 p.

Research output: Contribution to journal › Article

Allelic Imbalance

Alleles

Gene Expression

Genetic Transcription

Single Nucleotide Polymorphism

2 Citations

A New Method for Detecting Associations with Rare Copy-Number Variants

Tzeng, J. Y., Magnusson, P. K. E., Sullivan, P. F., Szatkiewicz, J. P. & The Swedish Schizophrenia Consortium Jan 1 2015 In : PLoS Genetics. 11, 10, e1005403

Research output: Contribution to journal › Article

DNA Copy Number Variations

methodology

loci

behavior disorders

Gene Dosage

8 Citations

Biological pathways and networks implicated in psychiatric disorders

Sullivan, P. F. & Posthuma, D. Apr 1 2015 In : Current Opinion in Behavioral Sciences. 2, p. 58-68 11 p.

Research output: Contribution to journal › Review article

Psychiatry

Multifactorial Inheritance

Bipolar Disorder

Genes

Schizophrenia

11 Citations

CNV concordance in 1,097 MZ twin pairs

Abdellaoui, A., Ehli, E. A., Hottenga, J. J., Weber, Z., Mbarek, H., Willemsen, G., Van Beijsterveldt, T., Brooks, A., Hudziak, J. J., Sullivan, P. F., De Geus, E. J., Davies, G. E. & Boomsma, D. I. Feb 11 2015 In : Twin Research and Human Genetics. 18, 1, p. 1-12 12 p.

Research output: Contribution to journal › Article

Monozygotic Twins

Cheek

DNA

Epithelium

Overlapping Genes

7 Citations

Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use

Clark, S. L., Aberg, K. A., Nerella, S., Kumar, G., Mcclay, J. L., Chen, W., Xie, L. Y., Harada, A., Shabalin, A. A., Gao, G., Bergen, S. E., Hultman, C. M., Magnusson, P. K. E., Sullivan, P. F. & van den Oord, E. J. C. G. Aug 1 2015 In : Alcoholism: Clinical and Experimental Research. 39, 8, p. 1396-1405 10 p.

Research output: Contribution to journal › Article

Methylation

Alcohols

Association reactions

Single Nucleotide Polymorphism

Polymorphism

8 Citations

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

Pers, T. H., Timshel, P., Ripke, S., Lent, S., Sullivan, P. F., O'Donovan, M. C., Franke, L., Hirschhorn, J. N. & Schizophrenia Working Group of the Psychiatric Genomics Consortium Aug 17 2015 In : Human Molecular Genetics. 25, 6, p. 1247-1254 8 p., ddw007

Research output: Contribution to journal › Article

Ion Channels

Schizophrenia

Genes

Odds Ratio

Post-Synaptic Density

7 Citations

Disruption of the MicroRNA 137 primary transcript results in early embryonic lethality in mice

Crowley, J. J., Collins, A. L., Lee, R. J., Nonneman, R. J., Farrell, M. S., Ancalade, N., Mugford, J. W., Agster, K. L., Nikolova, V. D., Moy, S. S. & Sullivan, P. F. Jan 1 2015 In : Biological Psychiatry. 77, 2, p. e5-e7

Research output: Contribution to journal › Letter

Mammalian Embryo

Fetal Diseases

MicroRNAs

Inbred C57BL Mouse

Knockout Mice

10 Citations

Educational attainment influences levels of homozygosity through migration and assortative mating

Abdellaoui, A., Hottenga, J. J., Willemsen, G., Bartels, M., Van Beijsterveldt, T., Ehli, E. A., Davies, G. E., Brooks, A., Sullivan, P. F., Penninx, B. W. J. H., De Geus, E. J. & Boomsma, D. I. Mar 3 2015 In : PLoS ONE. 10, 3, e0118935

Research output: Contribution to journal › Article

assortative mating

homozygosity

education

ancestry

spouses

1 Citations

Erratum: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance (Nature Genetics (2015) 47 (353-360))

Crowley, J. J. , Zhabotynsky, V. , Sun, W. , Huang, S. , Pakatci, I. K. , Kim, Y. , Wang, J. R. , Morgan, A. P. , Calaway, J. D. , Aylor, D. L. , Yun, Z. , Bell, T. A. , Buus, R. J. , Calaway, M. E. , Didion, J. P. , Gooch, T. J. , Hansen, S. D. , Robinson, N. N. , Shaw, G. D. , Spence, J. S. & 21 others Quackenbush, C. R., Barrick, C. J., Nonneman, R. J., Kim, K., Xenakis, J., Xie, Y., Valdar, W., Lenarcic, A. B., Wang, W., Welsh, C. E., Fu, C. P., Zhang, Z., Holt, J., Guo, Z., Threadgill, D. W., Tarantino, L. M., Miller, D. R., Zou, F., McMillan, L., Sullivan, P. F. & De Villena, F. P. M. Jan 1 2015 In : Nature Genetics. 47, 6, 1 p.

Research output: Contribution to journal › Comment/debate

Allelic Imbalance

Alleles

Gene Expression

68 Citations

Evaluating historical candidate genes for schizophrenia

Farrell, M. S., Werge, T., Sklar, P., Owen, M. J., Ophoff, R. A., O'donovan, M. C., Corvin, A., Cichon, S. & Sullivan, P. F. Jan 1 2015 In : Molecular Psychiatry. 20, 5, p. 555-562 8 p.

Research output: Contribution to journal › Article

Schizophrenia

Genes

Genetic Association Studies

Meta-Analysis

Research Personnel

2 Citations

Fast eQTL Analysis for Twin Studies

Yin, Z., Xia, K., Chung, W., Sullivan, P. F. & Zou, F. Jul 1 2015 In : Genetic Epidemiology. 39, 5, p. 357-365 9 p.

Research output: Contribution to journal › Article

Twin Studies

Quantitative Trait Loci

Netherlands

Single Nucleotide Polymorphism

Psychiatry

2 Citations

Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences

Giniatullina, A. , Maroteaux, G. , Geerts, C. J. , Koopmans, B. , Loos, M. , Klaassen, R. , Chen, N. , van der Schors, R. C. , van Nierop, P. , Li, K. W. , de Jong, J. , Altrock, W. D. , Cornelisse, L. N. , Toonen, R. F. , van der Sluis, S. , Sullivan, P. F. , Stiedl, O. , Posthuma, D. , Smit, A. B. , Groffen, A. J. & 1 others Verhage, M. Aug 6 2015 In : Neuroscience. 300, p. 518-538 21 p.

Research output: Contribution to journal › Article

Major Depressive Disorder

Phenotype

Calcium

Genetic Heterogeneity

Synaptic Vesicles

7 Citations

Genetics of disease: Associations with depression

Sullivan, P. F. Jul 30 2015 In : Nature. 523, 7562, p. 539-540 2 p.

Research output: Contribution to journal › Short survey

nervous system disorder

neurology

womens health

genetic engineering

health risk

6 Citations

Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood

Adkins, D. E., Clark, S. L., Copeland, W. E., Kennedy, M., Conway, K., Angold, A., Maes, H., Liu, Y., Kumar, G., Erkanli, A., Patkar, A. A., Silberg, J., Brown, T. H., Fergusson, D. M., Horwood, L. J., Eaves, L., Van Den Oord, E. J. C. G., Sullivan, P. F. & Costello, E. J. Jan 1 2015 In : Twin Research and Human Genetics. 18, 4, p. 335-347 13 p.

Research output: Contribution to journal › Article

Meta-Analysis

Genome

Alcohol Drinking

Genotype

GABA Plasma Membrane Transport Proteins

32 Citations

Heterogeneity of postpartum depression: A latent class analysis

Putnam, K. , Robertson-Blackmore, E. , Sharkey, K. , Payne, J. , Bergink, V. , Munk-Olsen, T. , Deligiannidis, K. , Altemus, M. , Newport, J. , Apter, G. , Devouche, E. , Vikorin, A. , Magnusson, P. , Lichtenstein, P. , Penninx, B. , Buist, A. , Bilszta, J. , O'Hara, M. , Stuart, S. , Brock, R. & 14 others Roza, S., Tiemeier, H., Guille, C., Neill Epperson, C., Kim, D., Schmidt, P., Martinez, P., Wisner, K. L., Stowe, Z., Jones, I., Rubinow, D., Sullivan, P., Meltzer-Brody, S. & Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium Jan 1 2015 In : The Lancet Psychiatry. 2, 1, p. 59-67 9 p.

Research output: Contribution to journal › Article

Postpartum Depression

Suicidal Ideation

Pregnancy Complications

Tuberculin

Postpartum Period

22 Citations

High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction

McClay, J. L., Shabalin, A. A., Dozmorov, M. G., Adkins, D. E., Kumar, G., Nerella, S., Clark, S. L., Bergen, S. E., Hultman, C. M., Magnusson, P. K. E., Sullivan, P. F., Aberg, K. A. & van den Oord, E. J. C. G. Dec 23 2015 In : Genome Biology. 16, 1, 291

Research output: Contribution to journal › Article

methylation

Methylation

single nucleotide polymorphism

Single Nucleotide Polymorphism

quantitative trait loci

4 Citations

IsoDOT Detects Differential RNA-Isoform Expression/Usage With Respect to a Categorical or Continuous Covariate With High Sensitivity and Specificity

Sun, W., Liu, Y., Crowley, J. J., Chen, T. H., Zhou, H., Chu, H., Huang, S., Kuan, P. F., Li, Y., Miller, D., Shaw, G., Wu, Y., Zhabotynsky, V., McMillan, L., Zou, F., Sullivan, P. F. & De Villena, F. P. M. Jul 3 2015 In : Journal of the American Statistical Association. 110, 511, p. 975-986 12 p.

Research output: Contribution to journal › Article

Differential Expression

Categorical

Specificity

Covariates

Gene

252 Citations

Meta-analysis of the heritability of human traits based on fifty years of twin studies

Polderman, T. J. C., Benyamin, B., De Leeuw, C. A., Sullivan, P. F., Van Bochoven, A., Visscher, P. M. & Posthuma, D. Jan 1 2015 In : Nature Genetics. 47, 7, p. 702-709 8 p.

Research output: Contribution to journal › Article

Twin Studies

Meta-Analysis

Chromosome Mapping

Individuality

Publications

4 Citations

Multiple SNP Set Analysis for Genome-Wide Association Studies Through Bayesian Latent Variable Selection

Lu, Z. H., Zhu, H., Knickmeyer, R. C., Sullivan, P. F., Williams, S. N. & Zou, F. Dec 1 2015 In : Genetic Epidemiology. 39, 8, p. 664-677 14 p.

Research output: Contribution to journal › Article

Genome-Wide Association Study

Single Nucleotide Polymorphism

Markov Chains

6 Citations

No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia

Ruderfer, D. M., Lim, E. T., Genovese, G., Moran, J. L., Hultman, C. M., Sullivan, P. F., McCarroll, S. A., Holmans, P., Sklar, P. & Purcell, S. M. Jan 1 2015 In : European Journal of Human Genetics. 23, 4, p. 555-557 3 p.

Research output: Contribution to journal › Article

Exome

Schizophrenia

Recessive Genes

Population Genetics

Autistic Disorder

49 Citations

Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: A Danish population-based study and meta-analysis

Agerbo, E., Sullivan, P. F., Vilhjálmsson, B. J., Pedersen, C. B., Mors, O., Børglum, A. D., Hougaard, D. M., Hollegaard, M. V., Meier, S., Mattheisen, M., Ripke, S., Wray, N. R. & Mortensen, P. B. Jul 1 2015 In : JAMA Psychiatry. 72, 7, p. 635-641 7 p.

Research output: Contribution to journal › Article

Social Class

Psychiatry

Meta-Analysis

Schizophrenia

Population

9 Citations

The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjects

Peyrot, W. J. , Lee, S. H. , Milaneschi, Y. , Abdellaoui, A. , Byrne, E. M. , Esko, T. , De Geus, E. J. C. , Hemani, G. , Hottenga, J. J. , Kloiber, S. , Levinson, D. F. , Lucae, S. , Martin, N. G. , Medland, S. E. , Metspalu, A. , Milani, L. , Noethen, M. M. , Potash, J. B. , Rietschel, M. , Rietveld, C. A. & 30 others Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Penninx, B. W. J. H., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Blackwood, D. H., Cichon, S., Heath, A. C., Holsboer, F., Madden, P. A., McGuffin, P., Muglia, P., Pergadia, M. L., Lin, D., Müller-Myhsok, B., Steinberg, S., Grabe, H. J., Lichtenstein, P., Magnusson, P., Perlis, R. H., Preisig, M., Smoller, J. W., Stefansson, K. & Uher, R. Jan 1 2015 In : Molecular Psychiatry. 20, 6, p. 735-743 9 p.

Research output: Contribution to journal › Article

Major Depressive Disorder

Depression

Single Nucleotide Polymorphism

Genomics

Mental Disorders

2014

106 Citations

A genome-wide association study of anorexia nervosa

The Wellcome Trust Case Control Consortium 3 Oct 1 2014 In : Molecular Psychiatry. 19, 10, p. 1085-1094 10 p.

Research output: Contribution to journal › Article

Genome-Wide Association Study

Anorexia Nervosa

Computer Simulation

Single Nucleotide Polymorphism

Meta-Analysis

29 Citations

Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility

Li, M. , Luo, X. J. , Rietschel, M. , Lewis, C. M. , Mattheisen, M. , Müller-Myhsok, B. , Jamain, S. , Leboyer, M. , Landén, M. , Thompson, P. M. , Cichon, S. , Nöthen, M. M. , Schulze, T. G. , Sullivan, P. F. , Bergen, S. E. , Donohoe, G. , Morris, D. W. , Hargreaves, A. , Gill, M. , Corvin, A. & 28 others Hultman, C., Toga, A. W., Shi, L., Lin, Q., Shi, H., Gan, L., Meyer-Lindenberg, A., Czamara, D., Henry, C., Etain, B., Bis, J. C., Ikram, M. A., Fornage, M., Debette, S., Launer, L. J., Seshadri, S., Erk, S., Walter, H., Heinz, A., Bellivier, F., Stein, J. L., Medland, S. E., Arias Vasquez, A., Hibar, D. P., Franke, B., Martin, N. G., Wright, M. J. & Su, B. Jan 1 2014 In : Molecular Psychiatry. 19, 4, p. 452-461 10 p.

Research output: Contribution to journal › Article

Gene Expression Regulation

Bipolar Disorder

Single Nucleotide Polymorphism

Population

Genetic Selection

62 Citations

A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects

Mcclay, J. L., Aberg, K. A., Clark, S. L., Nerella, S., Kumar, G., Xie, L. Y., Hudson, A. D., Harada, A., Hultman, C. M., Magnusson, P. K. E., Sullivan, P. F. & Van den oord, E. J. C. G. Mar 2014 In : Human Molecular Genetics. 23, 5, p. 1175-1185 11 p., ddt511

Research output: Contribution to journal › Article

High-Throughput Nucleotide Sequencing

Methylation

DNA

Histone Code

Ryanodine Receptor Calcium Release Channel

11 Citations

An inherited duplication at the gene p21 protein-activated Kinase 7 (PAK7) is a risk factor for psychosis

Morris, D. W. , Pearson, R. D. , Cormican, P. , Kenny, E. M. , O'Dushlaine, C. T. , Perreault, L. P. L. , Giannoulatou, E. , Tropea, D. , Maher, B. S. , Wormley, B. , Kelleher, E. , Fahey, C. , Molinos, I. , Bellini, S. , Pirinen, M. , Strange, A. , Freeman, C. , Thiselton, D. L. , Elves, R. L. , Regan, R. & 30 others Ennis, S., Dinan, T. G., McDonald, C., Murphy, K. C., O'Callaghan, E., Waddington, J. L., Walsh, D., O'Donovan, M., Grozeva, D., Craddock, N., Stone, J., Scolnick, E., Purcell, S., Sklar, P., Coe, B., Eichler, E. E., Ophoff, R., Buizer, J., Szatkiewicz, J., Hultman, C., Sullivan, P., Gurling, H., Mcquillin, A., St Clair, D., Rees, E., Kirov, G., Walters, J., Blackwood, D., Johnstone, M. & Donohoe, G. Jan 1 2014 In : Human molecular genetics. 23, 12, p. 3316-3326 11 p.

Research output: Contribution to journal › Article

p21-Activated Kinases

Psychotic Disorders

Protein Kinases

Schizophrenia

Bipolar Disorder

9 Citations

A novel statistical approach for jointly analyzing RNA-Seq data from F1 reciprocal crosses and inbred lines

Zou, F., Sun, W., Crowley, J. J., Zhabotynsky, V., Sullivan, P. F. & de Villena, F. P. M. Jan 1 2014 In : Genetics. 197, 1, p. 389-399 11 p.

Research output: Contribution to journal › Article

RNA Sequence Analysis

RNA

X Chromosome

Gene Expression

Chromosomes

519 Citations

A polygenic burden of rare disruptive mutations in schizophrenia

Purcell, S. M. , Moran, J. L. , Fromer, M. , Ruderfer, D. , Solovieff, N. , Roussos, P. , O'Dushlaine, C. , Chambert, K. , Bergen, S. E. , Kähler, A. , Duncan, L. , Stahl, E. , Genovese, G. , Fernández, E. , Collins, M. O. , Komiyama, N. H. , Choudhary, J. S. , Magnusson, P. K. E. , Banks, E. , Shakir, K. & 12 others Garimella, K., Fennell, T., Depristo, M., Grant, S. G. N., Haggarty, S. J., Gabriel, S., Scolnick, E. M., Lander, E. S., Hultman, C. M., Sullivan, P. F., McCarroll, S. A. & Sklar, P. Jan 28 2014 In : Nature. 506, 7487, p. 185-190 6 p.

Research output: Contribution to journal › Article

Exome

Schizophrenia

Mutation

Fragile X Mental Retardation Protein

Alleles

15 Citations

Applying polygenic risk scores to postpartum depression

Byrne, E. M. , Carrillo-Roa, T. , Penninx, B. W. J. H. , Sallis, H. M. , Viktorin, A. , Chapman, B. , Henders, A. K. , Pergadia, M. L. , Heath, A. C. , Madden, P. A. F. , Sullivan, P. F. , Boschloo, L. , van Grootheest, G. , McMahon, G. , Lawlor, D. A. , Landén, M. , Lichtenstein, P. , Magnusson, P. K. E. , Evans, D. M. , Montgomery, G. W. & 4 others Boomsma, D. I., Martin, N. G., Meltzer-Brody, S. & Wray, N. R. Nov 20 2014 In : Archives of Women's Mental Health. 17, 6, p. 519-528 10 p.

Research output: Contribution to journal › Article

Postpartum Depression

Major Depressive Disorder

Bipolar Disorder

Genomics

Single Nucleotide Polymorphism

11 Citations

A recessive genetic model and runs of homozygosity in major depressive disorder

Power, R. A., Keller, M. C., Ripke, S., Abdellaoui, A., Wray, N. R., Sullivan, P. F. & Breen, G. Mar 2014 In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 165, 2, p. 157-166 10 p.

Research output: Contribution to journal › Article

Genome-Wide Association Study

Genetic Models

Major Depressive Disorder

Genome

Schizophrenia

1815 Citations

Biological insights from 108 schizophrenia-associated genetic loci

Ripke, S. , Neale, B. M. , Corvin, A. , Walters, J. T. R. , Farh, K. H. , Holmans, P. A. , Lee, P. , Bulik-Sullivan, B. , Collier, D. A. , Huang, H. , Pers, T. H. , Agartz, I. , Agerbo, E. , Albus, M. , Alexander, M. , Amin, F. , Bacanu, S. A. , Begemann, M. , Belliveau, R. A. , Bene, J. & 30 others Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D. & Davidson, M. Jan 1 2014 In : Nature. 511, 7510, p. 421-427 7 p.

Research output: Contribution to journal › Article

Genetic Loci

Schizophrenia

Genome-Wide Association Study

Genes

Alleles

518 Citations

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G. , Kähler, A. K. , Handsaker, R. E. , Lindberg, J. , Rose, S. A. , Bakhoum, S. F. , Chambert, K. , Mick, E. , Neale, B. M. , Fromer, M. , Purcell, S. M. , Svantesson, O. , Landén, M. , Höglund, M. , Lehmann, S. , Gabriel, S. B. , Moran, J. L. , Lander, E. S. , Sullivan, P. F. , Sklar, P. & 3 others Grönberg, H., Hultman, C. M. & McCarroll, S. A. Dec 25 2014 In : New England Journal of Medicine. 371, 26, p. 2477-2487 11 p.

Research output: Contribution to journal › Article

Hematopoiesis

Neoplasms

Mutation

DNA Sequence Analysis

Exome

54 Citations

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

Goldstein, J. I. , Fredrik Jarskog, L. , Hilliard, C. , Alfirevic, A. , Duncan, L. , Fourches, D. , Huang, H. , Lek, M. , Neale, B. M. , Ripke, S. , Shianna, K. , Szatkiewicz, J. P. , Tropsha, A. , Van Den Oord, E. J. , Cascorbi, I. , Dettling, M. , Gazit, E. , Goff, D. C. , Holden, A. L. , Kelly, D. L. & 11 others Malhotra, A. K., Nielsen, J., Pirmohamed, M., Rujescu, D., Werge, T., Levy, D. L., Josiassen, R. C., Kennedy, J. L., Lieberman, J. A., Daly, M. J. & Sullivan, P. F. Jan 1 2014 In : Nature Communications. 5, 4757

Research output: Contribution to journal › Article

Agranulocytosis

HLA-B Antigens

Clozapine

amino acids

confidence

34 Citations

CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1

Rees, E. , Walters, J. T. R. , Chambert, K. D. , O'Dushlaine, C. , Szatkiewicz, J. , Richards, A. L. , Georgieva, L. , Mahoney-Davies, G. , Legge, S. E. , Moran, J. L. , Genovese, G. , Levinson, D. , Morris, D. W. , Cormican, P. , Kendler, K. S. , O'neill, F. A. , Riley, B. , Gill, M. , Corvin, A. , Sklar, P. & 9 others Hultman, C., Pato, C., Pato, M., Sullivan, P. F., Gejman, P. V., Mccarroll, S. A., O'donovan, M. C., Owen, M. J. & Kirov, G. Mar 1 2014 In : Human molecular genetics. 23, 6, p. 1669-1676 8 p.

Research output: Contribution to journal › Article

Schizophrenia

Amino Acid Transport System X-AG

Genes

Neurodevelopmental Disorders