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2018

Assessing Positive Child Health among Individuals Born Extremely Preterm

Bangma, J. T., Kwiatkowski, E., Psioda, M., Santos, H. P., Hooper, S. R., Douglass, L., Joseph, R. M., Frazier, J. A., Kuban, K. C. K., O'Shea, T. M. & Fry, R. C., Jan 1 2018, (Accepted/In press) In : Journal of Pediatrics.

Research output: Contribution to journalArticle

Quality of Life
Gestational Age
Newborn Infant
Child Health
Linear Models
1 Citations
Placentation
Trophoblasts
Cadmium
Transforming Growth Factor beta
Reactive Oxygen Species

Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi

To, K. T., Fry, R. C. & Reif, D. M., Jun 13 2018, In : BioData Mining. 11, 1, 10

Research output: Contribution to journalArticle

Prioritization
Imputation
Missing Data
Toxicology
Assays

Discrimination exposure and DNA methylation of stress-related genes in Latina mothers

Santos, H. P., Nephew, B. C., Bhattacharya, A., Tan, X., Smith, L., Alyamani, R. A. S., Martin, E. M., Perreira, K., Fry, R. C. & Murgatroyd, C., Dec 1 2018, In : Psychoneuroendocrinology. 98, p. 131-138 8 p.

Research output: Contribution to journalArticle

DNA Methylation
Hispanic Americans
Mothers
Genes
Epigenomics
1 Citations
Acrylic monomers
isoprene
Aerosols
Oxidative Stress
Epithelial Cells
2 Citations

Environmental Influences on the Epigenome: Exposure- Associated DNA Methylation in Human Populations

Martin, E. M. & Fry, R. C., Apr 1 2018, In : Annual Review of Public Health. 39, p. 309-333 25 p.

Research output: Contribution to journalReview article

DNA Methylation
Environmental Exposure
Methylation
Population
Organ Specificity

Epigenetic Regulation of the Nitric Oxide Pathway, 17-α Hydroxyprogesterone Caproate, and Recurrent Preterm Birth

Manuck, T. A., Smeester, L., Martin, E. M., Tomlinson, M. S., Smith, C., Varner, M. W. & Fry, R. C., Jul 1 2018, In : American Journal of Perinatology. 35, 8, p. 721-728 8 p.

Research output: Contribution to journalArticle

Premature Birth
Epigenomics
Nitric Oxide
Placenta
Gene Expression

Maternal one carbon metabolism and arsenic methylation in a pregnancy cohort in Mexico

Laine, J. E., Ilievski, V., Richardson, D. B., Herring, A. H., Stýblo, M., Rubio-Andrade, M., Garcia-Vargas, G., Gamble, M. V. & Fry, R. C., Sep 1 2018, In : Journal of Exposure Science and Environmental Epidemiology. 28, 5, p. 505-514 10 p.

Research output: Contribution to journalArticle

Methylation
Arsenic
Mexico
Metabolism
Carbon

Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm

Meakin, C. J., Martin, E. M., Santos, H. P., Mokrova, I., Kuban, K., O'Shea, T. M., Joseph, R. M., Smeester, L. & Fry, R. C., May 1 2018, In : Hormones and Behavior. 101, p. 29-35 7 p.

Research output: Contribution to journalArticle

Epigenomics
Placenta
Methylation
Genes
Cognitive Dysfunction
1 Citations

Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life

Tilley, S. K., Martin, E. M., Smeester, L., Joseph, R. M., Kuban, K. C. K., Heeren, T. C., Dammann, O. U., O'Shea, T. M. & Fry, R. C., Mar 1 2018, In : PloS one. 13, 3, e0193271

Research output: Contribution to journalArticle

methylation
Methylation
Atmospheric humidity
premature birth
Premature Birth

Quality Improvement in Perinatal Medicine and Translation of Preterm Birth Research Findings into Clinical Care

Manuck, T. A., Fry, R. C. & McFarlin, B. L., Jun 1 2018, In : Clinics in Perinatology. 45, 2, p. 155-163 9 p.

Research output: Contribution to journalReview article

Premature Birth
Quality Improvement
Medicine
Research

Targeted Multiplex Gene Expression Profiling to Measure High-Fat Diet and Metformin Effects on Fetal Gene Expression in a Mouse Model

Vora, N. L., Grace, M. R., Smeester, L., Dotters-Katz, S. K., Fry, R. C., Bae-Jump, V. & Boggess, K., Jan 1 2018, (Accepted/In press) In : Reproductive Sciences.

Research output: Contribution to journalArticle

Metformin
High Fat Diet
Gene Expression Profiling
Gene Expression
Liver
2017
1 Citations
Atlases
Cytosine
Glutamate Receptors
Guanine
Urinary Bladder Neoplasms
2 Citations

Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort

Rager, J. E., Auerbach, S. S., Chappell, G. A., Martin, E., Thompson, C. M. & Fry, R. C., Oct 16 2017, In : Chemical Research in Toxicology. 30, 10, p. 1911-1920 10 p.

Research output: Contribution to journalArticle

Chemical Models
Benchmarking
Arsenic
Proteome
Transcriptome
2 Citations
pre-eclampsia
trophoblast
transforming growth factor beta
Trophoblasts
Pre-Eclampsia
1 Citations

Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response

Smeester, L., Bommarito, P. A., Martin, E. M., Recio-Vega, R., Gonzalez-Cortes, T., Olivas-Calderon, E., Lantz, R. C. & Fry, R. C., Jun 1 2017, In : Environmental Toxicology and Pharmacology. 52, p. 183-187 5 p.

Research output: Contribution to journalArticle

Arsenicals
Environmental Exposure
Arsenic
Mexico
Proteomics
9 Citations

Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome

Bommarito, P. A., Martin, E. & Fry, R. C., Mar 1 2017, In : Epigenomics. 9, 3, p. 333-350 18 p.

Research output: Contribution to journalReview article

Endocrine Disruptors
Poisons
Epigenomics
Metals
Health
1 Citations

Epigenetic mechanisms underlying arsenic-induced toxicity

Meakin, C. J., Martin, E. M. & Fry, R. C., Oct 1 2017, In : Current Opinion in Toxicology. 6, p. 1-9 9 p.

Research output: Contribution to journalReview article

Histone Code
Arsenic
Epigenomics
Amino acids
Modifier Genes
1 Citations

Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire

Bommarito, P. A., Martin, E., Smeester, L., Palys, T., Baker, E. R., Karagas, M. R. & Fry, R. C., Oct 1 2017, In : Reproductive Toxicology. 73, p. 184-195 12 p.

Research output: Contribution to journalArticle

Maternal Exposure
Arsenic
Amino acids
Pregnant Women
Lymphocytes
11 Citations

Gene Expression Profiling in Human Lung Cells Exposed to Isoprene-Derived Secondary Organic Aerosol

Lin, Y. H., Arashiro, M., Clapp, P. W., Cui, T., Sexton, K. G., Vizuete, W., Gold, A., Jaspers, I., Fry, R. C. & Surratt, J. D., Jul 18 2017, In : Environmental Science and Technology. 51, 14, p. 8166-8175 10 p.

Research output: Contribution to journalArticle

6 Citations

Genetic and epigenetic mechanisms underlying arsenic-associated diabetes mellitus: A perspective of the current evidence

Martin, E. M., Stýblo, M. & Fry, R. C., May 1 2017, In : Epigenomics. 9, 5, p. 701-710 10 p.

Research output: Contribution to journalReview article

4 Citations

Genomic biomarkers of prenatal intrauterine inflammation in umbilical cord tissue predict later life neurological outcomes

Tilley, S. K., Joseph, R. M., Kuban, K. C. K., Dammann, O. U., O'Shea, T. M. & Fry, R. C., May 1 2017, In : PLoS One. 12, 5, e0176953

Research output: Contribution to journalArticle

umbilical cord
Umbilical Cord
biomarkers
inflammation
Biomarkers
6 Citations

High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr(VI) exposure

Rager, J. E., Ring, C. L., Fry, R. C., Suh, M., Proctor, D. M., Haws, L. C., Harris, M. A. & Thompson, C. M., Jul 1 2017, In : Toxicological Sciences. 158, 1, p. 199-212 14 p.

Research output: Contribution to journalArticle

Identification of endocrine active disinfection by-products (DBPs) that bind to the androgen receptor

Holmes, B. E., Smeester, L., Fry, R. C. & Weinberg, H. S., Nov 1 2017, In : Chemosphere. 187, p. 114-122 9 p.

Research output: Contribution to journalArticle

androgen
disinfection
phenol
chlorine
drinking water
3 Citations

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina

Tilley, S. K., Reif, D. M. & Fry, R. C., Jan 1 2017, In : Environment International. 101, p. 19-26 8 p.

Research output: Contribution to journalArticle

Superfund
methodology
tetrachloroethylene
toxic substance
barium
2 Citations

Investigating the Role of Fetal Gene Expression in Preterm Birth

Vora, N. L., Smeester, L., Boggess, K. & Fry, R. C., Jan 1 2017, In : Reproductive Sciences. 24, 6, p. 824-828 5 p.

Research output: Contribution to journalArticle

5 Citations

Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure

Huang, M. C., Douillet, C., Su, M., Zhou, K., Wu, T., Chen, W., Galanko, J. A., Drobná, Z., Saunders, R. J., Martin, E., Fry, R. C., Jia, W. & Stýblo, M., Jan 1 2017, In : Archives of Toxicology. 91, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Metabolomics
Methyltransferases
Arsenic
Knockout Mice
Oxidation

Microorganisms in the human placenta are associated with altered CpG methylation of immune and inflammation-related genes

Tomlinson, M. S., Bommarito, P. A., Martin, E. M., Smeester, L., Fichorova, R. N., Onderdonk, A. B., Kuban, K. C. K., O’Shea, T. M. & Fry, R. C., Dec 1 2017, In : PloS one. 12, 12, e0188664

Research output: Contribution to journalArticle

middle-aged adults
CpG Islands
DNA methylation
DNA Methylation
young adults
4 Citations

Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure

Laine, J. E., Bailey, K. A., Olshan, A. F., Smeester, L., Drobná, Z., Stýblo, M., Douillet, C., García-Vargas, G., Rubio-Andrade, M., Pathmasiri, W., McRitchie, S., Sumner, S. J. & Fry, R. C., Jan 3 2017, In : Environmental Science and Technology. 51, 1, p. 625-633 9 p.

Research output: Contribution to journalArticle

cohort analysis
Arsenicals
pollution exposure
Inorganic compounds
body fluid
8 Citations

Sexual epigenetic dimorphism in the human placenta: Implications for susceptibility during the prenatal period

Martin, E., Smeester, L., Bommarito, P. A., Grace, M. R., Boggess, K., Kuban, K., Karagas, M. R., Marsit, C. J., O'Shea, T. M. & Fry, R. C., Mar 1 2017, In : Epigenomics. 9, 3, p. 267-278 12 p.

Research output: Contribution to journalArticle

Epigenomics
Sex Characteristics
Placenta
DNA Methylation
Gestational Age

Toxic metals in amniotic fluid and altered gene expression in cell-free fetal RNA

Smeester, L., Martin, E. M., Cable, P., Bodnar, W., Boggess, K., Vora, N. L. & Fry, R. C., Dec 1 2017, In : Prenatal Diagnosis. 37, 13, p. 1364-1366 3 p.

Research output: Contribution to journalArticle

Poisons
Amniotic Fluid
Metals
RNA
Gene Expression
2016

Advancing Dose-Response Assessment Methods for Environmental Regulatory Impact Analysis: A Bayesian Belief Network Approach Applied to Inorganic Arsenic

Zabinski, J. W., Garcia-Vargas, G., Rubio-Andrade, M., Fry, R. C. & Gibson, J. M. D., May 10 2016, In : Environmental Science and Technology Letters. 3, 5, p. 200-204 5 p.

Research output: Contribution to journalArticle

Bayes Theorem
Arsenic
Bayesian networks
assessment method
arsenic
11 Citations

Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis

Drobná, Z., Martin, E., Kim, K. S., Smeester, L., Bommarito, P., Rubio-Andrade, M., García-Vargas, G. G., Stýblo, M., Zou, F. & Fry, R. C., Jun 1 2016, In : Reproductive Toxicology. 61, p. 28-38 11 p.

Research output: Contribution to journalArticle

Methyltransferases
Arsenic
Risk analysis
Polymorphism
Metabolism
3 Citations

Association between variants in arsenic (+3 oxidation state) methyltranserase (AS3MT) and urinary metabolites of inorganic arsenic: Role of exposure level

Xu, X., Drobná, Z., Voruganti, V. S., Barron, K., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Cerón, R. H., Morales, D. V., Terrazas, F. A. B., Ishida, M. C., Gutiérrez-Torres, D. S., Saunders, R. J., Crandell, J., Fry, R. C., Loomis, D., García-Vargas, G. G., Del Razo, L. M., Stỳblo, M. & Mendez, M. A., Sep 1 2016, In : Toxicological Sciences. 153, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

Arsenic
Metabolites
Oxidation
Metabolism
Genotype
3 Citations

A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure

Laine, J. E. & Fry, R. C., Jan 1 2016, In : Annals of Global Health. 82, 1, p. 189-196 8 p.

Research output: Contribution to journalArticle

Arsenic
Toxicology
Proteins
Fetal Proteins
Genes
26 Citations

Chronic exposure to arsenic and markers of cardiometabolic risk: A cross-sectional study in Chihuahua, Mexico

Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Cerón, R. H., Morales, D. V., Baeza Terrazas, F. A., Ishida, M. C., Gutiérrez-Torres, D. S., Saunders, R. J., Drobná, Z., Fry, R. C., Buse, J. B., Loomis, D., García-Vargas, G. G., Del Razo, L. M. & Stýblo, M., Jan 1 2016, In : Environmental health perspectives. 124, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

Arsenic
Mexico
Cross-Sectional Studies
Drinking Water
HDL Cholesterol
3 Citations

Developmental windows of susceptibility to inorganic arsenic: A survey of current toxicologic and epidemiologic data

Bommarito, P. A. & Fry, R. C., Jan 1 2016, In : Toxicology Research. 5, 6, p. 1503-1511 9 p.

Research output: Contribution to journalReview article

Arsenic
Health
Disease Susceptibility
Skin Neoplasms
Epigenomics
31 Citations

E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke

Martin, E. M., Clapp, P. W., Rebuli, M. E., Pawlak, E. A., Glista-Baker, E., Benowitz, N. L., Fry, R. C. & Jaspers, I., Jul 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L135-L144

Research output: Contribution to journalArticle

Nose
Smoke
Tobacco Products
Epithelial Cells
Genes
6 Citations
MicroRNAs
Transcription Factors
Impurities
Genetic Promoter Regions
Transcription Initiation Site
8 Citations

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X., Apr 1 2016, In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331

Research output: Contribution to journalArticle

Welding
Caudate Nucleus
Manganese
Basal Ganglia
Blood
2 Citations

Inflammation in induced sputum after aluminium oxide exposure: An experimental chamber study

Sikkeland, L. I. B., Alexis, N. E., Fry, R. C., Martin, E., Danielsen, T. E., Søstrand, P. & Kongerud, J., Mar 1 2016, In : Occupational and Environmental Medicine. 73, 3, p. 199-205 7 p.

Research output: Contribution to journalArticle

Aluminum Oxide
Sputum
Inflammation
Interleukin-8
Neutrophils
9 Citations

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

Arashiro, M., Lin, Y. H., Sexton, K. G., Zhang, Z., Jaspers, I., Fry, R. C., Vizuete, W. G., Gold, A. & Surratt, J. D., Nov 15 2016, In : Atmospheric Chemistry and Physics. 16, 22, p. 14079-14090 12 p.

Research output: Contribution to journalArticle

isoprene
gene expression
aerosol
aerosol formation
nonmethane hydrocarbon
19 Citations

Isoprene-derived secondary organic aerosol induces the expression of oxidative stress response genes in human lung cells

Lin, Y. H., Arashiro, M., Martin, E., Chen, Y., Zhang, Z., Sexton, K. G., Gold, A., Jaspers, I., Fry, R. C. & Surratt, J. D., Jul 20 2016, In : Environmental Science and Technology Letters. 3, 6, p. 250-254 5 p.

Research output: Contribution to journalArticle

Isoprene
Oxidative stress
isoprene
Aerosols
Oxidative Stress
6 Citations

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X., Dec 1 2016, In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journalArticle

Welding
Blood
Globus Pallidus
Biomarkers
Brain

Maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT are associated with arsenic metabolism and newborn birth outcomes: Implications of major risk alleles and fetal health outcomes

Fry, R. C., Martin, E., Kim, K. S., Smeester, L., Stýblo, M., Zou, F., Drobná, Z., Rubio-Andrade, M. & García-Vargas, G. G., Jan 1 2016, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 441-442 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Methyltransferases
Arsenic
Polymorphism
Metabolism
arsenic
13 Citations

Mechanisms underlying latent disease risk associated with early-life arsenic exposure: Current research trends and scientific gaps

Bailey, K. A., Smith, A. H., Tokar, E. J., Graziano, J. H., Kim, K. W., Navasumrit, P., Ruchirawat, M., Thiantanawat, A., Suk, W. A. & Fry, R. C., Feb 1 2016, In : Environmental health perspectives. 124, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

Arsenic
Research
Neoplasms
Immunomodulation
Neoplastic Stem Cells

Metabolomics of arsenic exposure: The man vs. the mouse

Stýblo, M., Fry, R. C., Huang, M. C., Martin, E., Douillet, C., Drobná, Z., Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, M. L., Del Razo, L. M. & García-Vargas, G. G., 2016, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 425-427 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arsenic
arsenic
Metabolites
metabolite
Plasmas
23 Citations

Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2

Wilmot, B., Fry, R., Smeester, L., Musser, E. D., Mill, J. & Nigg, J. T., Feb 1 2016, In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 57, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Attention Deficit Disorder with Hyperactivity
DNA
Methylation
Genes
5 Citations
pre-eclampsia
trophoblast
transforming growth factor beta
Trophoblasts
Pre-Eclampsia
7 Citations
Premature Birth
Gestational Age
Odds Ratio
Confidence Intervals
Pregnancy