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2017
4 Citations

Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome

Bommarito, P. A., Martin, E. & Fry, R. C. Mar 1 2017 In : Epigenomics. 9, 3, p. 333-350 18 p.

Research output: Contribution to journalReview article

Endocrine Disruptors
Poisons
Epigenomics
Metals
Health
1 Citations

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina

Tilley, S. K., Reif, D. M. & Fry, R. C. Jan 1 2017 In : Environment International. 101, p. 19-26 8 p.

Research output: Contribution to journalArticle

Superfund
methodology
tetrachloroethylene
toxic substance
barium
3 Citations

Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure

Huang, M. C., Douillet, C., Su, M., Zhou, K., Wu, T., Chen, W., Galanko, J. A., Drobná, Z., Saunders, R. J., Martin, E., Fry, R. C., Jia, W. & Stýblo, M. Jan 1 2017 In : Archives of Toxicology. 91, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Metabolomics
Methyltransferases
Arsenic
Knockout Mice
Oxidation
4 Citations

Sexual epigenetic dimorphism in the human placenta: Implications for susceptibility during the prenatal period

Martin, E., Smeester, L., Bommarito, P. A., Grace, M. R., Boggess, K., Kuban, K., Karagas, M. R., Marsit, C. J., O'Shea, T. M. & Fry, R. C. Mar 1 2017 In : Epigenomics. 9, 3, p. 267-278 12 p.

Research output: Contribution to journalArticle

Epigenomics
Sex Characteristics
Placenta
DNA Methylation
Gestational Age
2016

Advancing Dose-Response Assessment Methods for Environmental Regulatory Impact Analysis: A Bayesian Belief Network Approach Applied to Inorganic Arsenic

Zabinski, J. W., Garcia-Vargas, G., Rubio-Andrade, M., Fry, R. C. & Gibson, J. M. D. May 10 2016 In : Environmental Science and Technology Letters. 3, 5, p. 200-204 5 p.

Research output: Contribution to journalArticle

Bayes Theorem
Arsenic
Bayesian networks
assessment method
arsenic
6 Citations

Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis

Drobná, Z., Martin, E., Kim, K. S., Smeester, L., Bommarito, P., Rubio-Andrade, M., García-Vargas, G. G., Stýblo, M., Zou, F. & Fry, R. C. Jun 1 2016 In : Reproductive Toxicology. 61, p. 28-38 11 p.

Research output: Contribution to journalArticle

Methyltransferases
Arsenic
Risk analysis
Polymorphism
Metabolism
1 Citations

Association between variants in arsenic (+3 oxidation state) methyltranserase (AS3MT) and urinary metabolites of inorganic arsenic: Role of exposure level

Xu, X., Drobn�, Z., Voruganti, V. S., Barron, K., Gonz�lez-Horta, C., S�nchez-Ram�rez, B., Ballinas-Casarrubias, L., Cer�n, R. H., Morales, D. V., Terrazas, F. A. B., Ishida, M. C., Guti�rrez-Torres, D. S., Saunders, R. J., Crandell, J., Fry, R. C., Loomis, D., Garc�a-Vargas, G. G., Del Razo, L. M., Stỳblo, M. & Mendez, M. A. Sep 1 2016 In : Toxicological Sciences. 153, 1, p. 112-123 12 p.

Research output: Contribution to journalArticle

Arsenic
Metabolites
Oxidation
Metabolism
Genotype
2 Citations

A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure

Laine, J. E. & Fry, R. C. Jan 1 2016 In : Annals of Global Health. 82, 1, p. 189-196 8 p.

Research output: Contribution to journalArticle

Arsenic
Toxicology
Proteins
Fetal Proteins
Genes
20 Citations

Chronic exposure to arsenic and markers of cardiometabolic risk: A cross-sectional study in Chihuahua, Mexico

Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Cerón, R. H., Morales, D. V., Baeza Terrazas, F. A., Ishida, M. C., Gutiérrez-Torres, D. S., Saunders, R. J., Drobná, Z., Fry, R. C., Buse, J. B., Loomis, D., García-Vargas, G. G., Del Razo, L. M. & Stýblo, M. Jan 1 2016 In : Environmental Health Perspectives. 124, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

Arsenic
Mexico
Cross-Sectional Studies
Drinking Water
HDL Cholesterol
2 Citations

Developmental windows of susceptibility to inorganic arsenic: A survey of current toxicologic and epidemiologic data

Bommarito, P. A. & Fry, R. C. 2016 In : Toxicology Research. 5, 6, p. 1503-1511 9 p.

Research output: Contribution to journalReview article

Arsenic
Health
Disease Susceptibility
Skin Neoplasms
Epigenomics
21 Citations

E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke

Martin, E. M., Clapp, P. W., Rebuli, M. E., Pawlak, E. A., Glista-Baker, E., Benowitz, N. L., Fry, R. C. & Jaspers, I. Jul 1 2016 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L135-L144

Research output: Contribution to journalArticle

Nose
Smoke
Tobacco Products
Epithelial Cells
Genes
6 Citations
MicroRNAs
Transcription Factors
Impurities
Genetic Promoter Regions
Transcription Initiation Site
7 Citations

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X. Apr 1 2016 In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331

Research output: Contribution to journalArticle

Welding
Caudate Nucleus
Manganese
Basal Ganglia
Blood

Inflammation in induced sputum after aluminium oxide exposure: An experimental chamber study

Sikkeland, L. I. B., Alexis, N. E., Fry, R. C., Martin, E., Danielsen, T. E., Søstrand, P. & Kongerud, J. Mar 1 2016 In : Occupational and Environmental Medicine. 73, 3, p. 199-205 7 p.

Research output: Contribution to journalArticle

Aluminum Oxide
Sputum
Inflammation
Interleukin-8
Neutrophils
7 Citations

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

Arashiro, M., Lin, Y. H., Sexton, K. G., Zhang, Z., Jaspers, I., Fry, R. C., Vizuete, W. G., Gold, A. & Surratt, J. D. Nov 15 2016 In : Atmospheric Chemistry and Physics. 16, 22, p. 14079-14090 12 p.

Research output: Contribution to journalArticle

isoprene
gene expression
aerosol
aerosol formation
nonmethane hydrocarbon
16 Citations

Isoprene-derived secondary organic aerosol induces the expression of oxidative stress response genes in human lung cells

Lin, Y. H., Arashiro, M., Martin, E., Chen, Y., Zhang, Z., Sexton, K. G., Gold, A., Jaspers, I., Fry, R. C. & Surratt, J. D. Jul 20 2016 In : Environmental Science and Technology Letters. 3, 6, p. 250-254 5 p.

Research output: Contribution to journalArticle

Isoprene
Oxidative stress
isoprene
Aerosols
Oxidative Stress
5 Citations

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X. Dec 1 2016 In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Contribution to journalArticle

Welding
Blood
Globus Pallidus
Biomarkers
Brain

Maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT are associated with arsenic metabolism and newborn birth outcomes: Implications of major risk alleles and fetal health outcomes

Fry, R. C., Martin, E., Kim, K. S., Smeester, L., Stýblo, M., Zou, F., Drobná, Z., Rubio-Andrade, M. & García-Vargas, G. G. Jan 1 2016 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 441-442 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Methyltransferases
Arsenic
Polymorphism
Metabolism
arsenic
12 Citations

Mechanisms underlying latent disease risk associated with early-life arsenic exposure: Current research trends and scientific gaps

Bailey, K. A., Smith, A. H., Tokar, E. J., Graziano, J. H., Kim, K. W., Navasumrit, P., Ruchirawat, M., Thiantanawat, A., Suk, W. A. & Fry, R. C. Feb 1 2016 In : Environmental Health Perspectives. 124, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

Arsenic
Research
Neoplasms
Immunomodulation
Neoplastic Stem Cells

Metabolomics of arsenic exposure: The man vs. the mouse

Stýblo, M., Fry, R. C., Huang, M. C., Martin, E., Douillet, C., Drobná, Z., Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, M. L., Del Razo, L. M. & García-Vargas, G. G. 2016 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 425-427 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arsenic
arsenic
Metabolites
metabolite
Plasmas
12 Citations

Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2

Wilmot, B., Fry, R., Smeester, L., Musser, E. D., Mill, J. & Nigg, J. T. Feb 1 2016 In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 57, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Attention Deficit Disorder with Hyperactivity
DNA
Methylation
Genes
3 Citations
pre-eclampsia
trophoblast
transforming growth factor beta
Trophoblasts
Pre-Eclampsia
6 Citations
Premature Birth
Gestational Age
Odds Ratio
Confidence Intervals
Pregnancy
4 Citations

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors

Chitforoushzadeh, Z., Ye, Z., Sheng, Z., La Rue, S., Fry, R. C., Lauffenburger, D. A. & Janes, K. A. Jun 7 2016 In : Science Signaling. 9, 431, ra59

Research output: Contribution to journalArticle

GATA6 Transcription Factor
Crosstalk
Tensors
Phosphorylation
Tumor Necrosis Factor-alpha
3 Citations

Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment

Thompson, C. M., Rager, J. E., Suh, M., Ring, C. L., Proctor, D. M., Haws, L. C., Fry, R. C. & Harris, M. A. Dec 1 2016 In : Environmental and Molecular Mutagenesis. 57, 9, p. 706-716 11 p.

Research output: Contribution to journalArticle

Inbred F344 Rats
Mouth Mucosa
Mouth
Chromium
Genes
1 Citations

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Harrington, J. M., Young, D. J., Fry, R. C., Weber, F. X., Sumner, S. S. & Levine, K. E. Feb 1 2016 In : Biological Trace Element Research. 169, 2, p. 164-173 10 p.

Research output: Contribution to journalArticle

Inductively coupled plasma mass spectrometry
Trace Elements
Placenta
Poisons
Mass Spectrometry
2015
2 Citations

Arsenic, the "King of Poisons", in food and water

Yosim, A., Bailey, K. & Fry, R. C. Jan 1 2015 American Scientist, 103, 1, p. 34-41 8 p.

Research output: Contribution to specialist publicationArticle

arsenic
food
rice
water
immune system
6 Citations

Cadmium levels in a North Carolina cohort: Identifying risk factors for elevated levels during pregnancy

Edwards, S. E., Maxson, P., Miranda, M. L. & Fry, R. C. Jul 19 2015 In : Journal of Exposure Science and Environmental Epidemiology. 25, 4, p. 427-432 6 p.

Research output: Contribution to journalArticle

Cadmium
Pregnancy
Blood
Cotinine
Smoking

Chemical hazards

Smeester, L., Yosim, A. E. & Fry, R. C. Sep 25 2015 Routledge Handbook of Water and Health. Taylor and Francis Inc., p. 107-121 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

hazard
chemical
1 Citations

Environmental Contaminants and the Immune System: A Systems Perspective

Sollome, J. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 171-186 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immune system
Immune System Diseases
immune system
Immune System
pollution

Environmental Contaminants and Their Relationship to the Epigenome

Yosim, A. E., Nye, M. D. & Fry, R. C. Jun 1 2015 Personalized Epigenetics. Elsevier Inc., p. 285-312 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Impurities
Poisons
Air Pollution
Cell signaling
12 Citations

Epigenetics and preeclampsia: Defining functional epimutations in the preeclamptic placenta related to the TGF-β pathway

Martin, E., Ray, P. D., Smeester, L., Grace, M. R., Boggess, K. & Fry, R. C. Oct 28 2015 In : PLoS ONE. 10, 10, e0141294

Research output: Contribution to journalArticle

pre-eclampsia
transforming growth factor beta
Pre-Eclampsia
placenta
Epigenomics

Health Effects of Prenatal and Early-Life Exposure to Arsenic

Bailey, K. A. & Fry, R. C. Jan 8 2015 Handbook of Arsenic Toxicology. Elsevier Inc., p. 405-428 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Arsenic
Health
Epidemiologic Studies
Mortality
1 Citations

Hormone Response Pathways as Responders to Environmental Contaminants and Their Roles in Disease

Tilley, S. K. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 225-238 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

endocrine system
Endocrine System
pollution
hormones
Hormones
8 Citations

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Rager, J. E., Tilley, S. K., Tulenko, S. E., Smeester, L., Ray, P. D., Yosim, A., Currier, J. M., Ishida, M. C., González-Horta, M. D. C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Gutiérrez-Torres, D. S., Drobná, Z., Del Razo, L. M., García-Vargas, G. G., Kim, W. Y., Zhou, Y. H., Wright, F. A., Stýblo, M. & Fry, R. C. Jun 15 2015 In : Chemical Research in Toxicology. 28, 6, p. 1144-1155 12 p.

Research output: Contribution to journalArticle

Arsenic
DNA Methylation
Urinary Bladder Neoplasms
Genes
Methylation
36 Citations

Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the biomarkers of exposure to ARsenic (BEAR) pregnancy cohort in Mexico

Laine, J. E., Bailey, K. A., Rubio-Andrade, M., Olshan, A. F., Smeester, L., Drobná, Z., Herring, A. H., Stýblo, M., García-Vargas, G. G. & Fry, R. C. Jan 1 2015 In : Environmental Health Perspectives. 123, 2, p. 186-192 7 p.

Research output: Contribution to journalArticle

Maternal Exposure
Arsenic
Mexico
Methylation
Biomarkers
23 Citations

Maternal cadmium, iron and zinc levels, DNA methylation and birth weight

Vidal, A. C., Semenova, V., Darrah, T., Vengosh, A., Huang, Z., King, K., Nye, M. D., Fry, R., Skaar, D., Maguire, R., Murtha, A., Schildkraut, J., Murphy, S. & Hoyo, C. Jul 15 2015 In : BMC Pharmacology and Toxicology. 16, 1, 20

Research output: Contribution to journalArticle

DNA Methylation
Cadmium
Birth Weight
Zinc
Iron
16 Citations

Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico

Martin, E. , González-Horta, C. , Rager, J. , Bailey, K. A. , Sánchez-Ramírez, B. , Ballinas-Casarrubias, L. , Ishida, M. C. , Gutiérrez-Torres, D. S. , Cerón, R. H. , Morales, D. V. , Terrazas, F. A. B. , Jesse Saunders, R. , Drobná, Z. , Mendez, M. A. , Buse, J. B. , Loomisk, D. , Jiakj, W. , García-Vargaskk, G. G. , Del Razo, L. M. , Stýblo, M. & 1 others Fry, R. Jan 1 2015 In : Toxicological Sciences. 144, 2, p. 338-346 9 p.

Research output: Contribution to journalArticle

Metabolomics
Arsenic
Medical problems
Mexico
Metabolites
15 Citations

Placental cadmium levels are associated with increased preeclampsia risk

Laine, J. E., Ray, P., Bodnar, W., Cable, P. H., Boggess, K., Offenbacher, S. & Fry, R. C. Sep 30 2015 In : PLoS ONE. 10, 9, e0139341

Research output: Contribution to journalArticle

pre-eclampsia
Pre-Eclampsia
Cadmium
cadmium
odds ratio

Preface

Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. vi-vii

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

50 Citations

Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes

Rojas, D., Rager, J. E., Smeester, L., Bailey, K. A., Drobná, Z., Rubio-Andrade, M., Stýblo, M., García-Vargas, G. & Fry, R. C. Jan 1 2015 In : Toxicological sciences : an official journal of the Society of Toxicology. 143, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Arsenic
Fetal Blood
Gene expression
Blood
1 Citations

Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs

Gona, S., Sanders, A. P., Miranda, M. L. & Fry, R. C. Sep 1 2015 In : Genomics Data. 5, p. 378-380 3 p.

Research output: Contribution to journalArticle

Cotinine
CpG Islands
Methylation
DNA Methylation
Cadmium
1 Citations

Priority Environmental Contaminants: Understanding Their Sources of Exposure, Biological Mechanisms, and Impacts on Health

Tilley, S. K. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 117-169 53 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

pollution
Health
Impurities
toxic substances
public health
1 Citations

Systems Biology in Toxicology and Environmental Health

Fry, R. C. Jul 7 2015 Elsevier Inc.272 p.

Research output: Book/ReportBook

Systems Biology
Environmental Health
toxicology
Toxicology
Health

Systems Biology in Toxicology and Environmental Health

Yosim, A. E. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 1-10 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Systems Biology
Environmental Health
toxicology
Toxicology
Poisons
16 Citations

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. B. & Huang, X. Aug 1 2015 In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Manganese
Brain
Tissue
Welding
Globus Pallidus
11 Citations

T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX

Cook, K. D., Shpargel, K. B., Starmer, J., Whitfield-Larry, F., Conley, B., Allard, D. E., Rager, J. E., Fry, R. C., Davenport, M. L., Magnuson, T., Whitmire, J. K. & Su, M. A. Oct 20 2015 In : Immunity. 43, 4, p. 703-714 12 p., 3173

Research output: Contribution to journalArticle

Histone Demethylases
Virus Diseases
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Histones

The Cell: The Fundamental Unit in Systems Biology

Ray, P. D. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 11-42 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Systems Biology
Biological systems
toxic substances
Epigenomics
epigenetics
7 Citations
Oxidative stress
Toxicology
Oxidative Stress
Genes
Metals
2014
27 Citations
Poisons
Ozone
Sputum
MicroRNAs
Epigenomics