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2017
2 Citations

Effects of prenatal exposure to endocrine disruptors and toxic metals on the fetal epigenome

Bommarito, P. A., Martin, E. & Fry, R. C. Mar 1 2017 In : Epigenomics. 9, 3, p. 333-350 18 p.

Research output: Research - peer-reviewReview article

Endocrine Disruptors
Poisons
Epigenomics
Metals
Health

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina

Tilley, S. K., Reif, D. M. & Fry, R. C. 2017 In : Environment International. 101, p. 19-26 8 p.

Research output: Research - peer-reviewArticle

Superfund
biological activity
chemical
methodology
programme
3 Citations

Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure

Huang, M. C., Douillet, C., Su, M., Zhou, K., Wu, T., Chen, W., Galanko, J. A., Drobná, Z., Saunders, R. J., Martin, E., Fry, R. C., Jia, W. & Stýblo, M. Jan 1 2017 In : Archives of Toxicology. 91, 1, p. 189-202 14 p.

Research output: Research - peer-reviewArticle

Methyltransferases
Arsenic
Oxidation
Metabolomics
Knockout Mice

Sexual epigenetic dimorphism in the human placenta: Implications for susceptibility during the prenatal period

Martin, E., Smeester, L., Bommarito, P. A., Grace, M. R., Boggess, K., Kuban, K., Karagas, M. R., Marsit, C. J., O'Shea, T. M. & Fry, R. C. Mar 1 2017 In : Epigenomics. 9, 3, p. 267-278 12 p.

Research output: Research - peer-reviewArticle

Epigenomics
Sex Characteristics
Placenta
DNA Methylation
Gestational Age
2016

Advancing Dose-Response Assessment Methods for Environmental Regulatory Impact Analysis: A Bayesian Belief Network Approach Applied to Inorganic Arsenic

Zabinski, J. W., Garcia-Vargas, G., Rubio-Andrade, M., Fry, R. C. & Gibson, J. M. D. May 10 2016 In : Environmental Science and Technology Letters. 3, 5, p. 200-204 5 p.

Research output: Research - peer-reviewArticle

assessment method
arsenic
dose
analysis
Bayes Theorem
5 Citations

Analysis of maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT and fetal sex in relation to arsenic metabolism and infant birth outcomes: Implications for risk analysis

Drobná, Z., Martin, E., Kim, K. S., Smeester, L., Bommarito, P., Rubio-Andrade, M., García-Vargas, G. G., Stýblo, M., Zou, F. & Fry, R. C. Jun 1 2016 In : Reproductive Toxicology. 61, p. 28-38 11 p.

Research output: Research - peer-reviewArticle

Methyltransferases
Arsenic
Risk analysis
Polymorphism
Metabolism
1 Citations

Association between variants in arsenic (+3 oxidation state) methyltranserase (AS3MT) and urinary metabolites of inorganic arsenic: Role of exposure level

Xu, X., Drobná, Z., Voruganti, V. S., Barron, K., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Cerón, R. H., Morales, D. V., Terrazas, F. A. B., Ishida, M. C., Gutiérrez-Torres, D. S., Saunders, R. J., Crandell, J., Fry, R. C., Loomis, D., García-Vargas, G. G., Del Razo, L. M., Stỳblo, M. & Mendez, M. A. Sep 1 2016 In : Toxicological Sciences. 153, 1, p. 112-123 12 p., kfw112

Research output: Research - peer-reviewArticle

Arsenic
Metabolites
Oxidation
Metabolism
Genotype
2 Citations

A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure

Laine, J. E. & Fry, R. C. Jan 1 2016 In : Annals of Global Health. 82, 1, p. 189-196 8 p.

Research output: Research - peer-reviewArticle

Arsenic
Toxicology
Proteins
Genes
Datasets
17 Citations

Chronic exposure to arsenic and markers of cardiometabolic risk: A cross-sectional study in Chihuahua, Mexico

Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Cerón, R. H., Morales, D. V., Baeza Terrazas, F. A., Ishida, M. C., Gutiérrez-Torres, D. S., Saunders, R. J., Drobná, Z., Fry, R. C., Buse, J. B., Loomis, D., García-Vargas, G. G., Del Razo, L. M. & Stýblo, M. Jan 1 2016 In : Environmental Health Perspectives. 124, 1, p. 104-111 8 p.

Research output: Research - peer-reviewArticle

Arsenic
Mexico
Cross-Sectional Studies
Water
Drinking Water
2 Citations

Developmental windows of susceptibility to inorganic arsenic: A survey of current toxicologic and epidemiologic data

Bommarito, P. A. & Fry, R. C. 2016 In : Toxicology Research. 5, 6, p. 1503-1511 9 p.

Research output: Research - peer-reviewReview article

Arsenic
Surveys and Questionnaires
Health
Disease Susceptibility
Skin Neoplasms
15 Citations

E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke

Martin, E. M., Clapp, P. W., Rebuli, M. E., Pawlak, E. A., Glista-Baker, E., Benowitz, N. L., Fry, R. C. & Jaspers, I. Jul 1 2016 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L135-L144

Research output: Research - peer-reviewArticle

Nose
Smoke
Tobacco Products
Epithelial Cells
Genes
4 Citations
MicroRNAs
Transcription Factors
Impurities
Genetic Promoter Regions
Transcription Initiation Site
3 Citations

Increased R2* in the caudate nucleus of asymptomatic welders

Lee, E. Y., Flynn, M. R., Du, G., Li, Y., Lewis, M. M., Herring, A. H., Buren, E. V., Buren, S. V., Kong, L., Fry, R. C., Snyder, A. M., Connor, J. R., Yang, Q. X., Mailman, R. B. & Huang, X. Apr 1 2016 In : Toxicological Sciences. 150, 2, p. 369-377 9 p., kfv331

Research output: Research - peer-reviewArticle

Welding
Caudate Nucleus
Manganese
Basal Ganglia
Blood

Inflammation in induced sputum after aluminium oxide exposure: An experimental chamber study

Sikkeland, L. I. B., Alexis, N. E., Fry, R. C., Martin, E., Danielsen, T. E., Søstrand, P. & Kongerud, J. Mar 1 2016 In : Occupational and Environmental Medicine. 73, 3, p. 199-205 7 p.

Research output: Research - peer-reviewArticle

Aluminum Oxide
Sputum
Inflammation
Interleukin-8
Neutrophils
4 Citations

In vitro exposure to isoprene-derived secondary organic aerosol by direct deposition and its effects on COX-2 and IL-8 gene expression

Arashiro, M., Lin, Y. H., Sexton, K. G., Zhang, Z., Jaspers, I., Fry, R. C., Vizuete, W. G., Gold, A. & Surratt, J. D. Nov 15 2016 In : Atmospheric Chemistry and Physics. 16, 22, p. 14079-14090 12 p.

Research output: Research - peer-reviewArticle

isoprene
gene expression
aerosol
exposure
effect
11 Citations

Isoprene-derived secondary organic aerosol induces the expression of oxidative stress response genes in human lung cells

Lin, Y. H., Arashiro, M., Martin, E., Chen, Y., Zhang, Z., Sexton, K. G., Gold, A., Jaspers, I., Fry, R. C. & Surratt, J. D. Jul 20 2016 In : Environmental Science and Technology Letters. 3, 6, p. 250-254 5 p.

Research output: Research - peer-reviewArticle

Aerosols
Oxidative Stress
Lung
Genes
isoprene

Longitudinal T1 relaxation rate (R1) captures changes in short-term Mn exposure in welders

Lewis, M. M., Flynn, M. R., Lee, E. Y., Van Buren, S., Van Buren, E., Du, G., Fry, R. C., Herring, A. H., Kong, L., Mailman, R. B. & Huang, X. Dec 1 2016 In : NeuroToxicology. 57, p. 39-44 6 p.

Research output: Research - peer-reviewArticle

Welding
Blood
Globus Pallidus
Biomarkers
Brain

Maternal polymorphisms in arsenic (+3 oxidation state)-methyltransferase AS3MT are associated with arsenic metabolism and newborn birth outcomes: Implications of major risk alleles and fetal health outcomes

Fry, R. C., Martin, E., Kim, K. S., Smeester, L., Stýblo, M., Zou, F., Drobná, Z., Rubio-Andrade, M. & García-Vargas, G. G. 2016 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 441-442 2 p.

Research output: ResearchConference contribution

arsenic
allele
polymorphism
metabolism
oxidation
11 Citations

Mechanisms underlying latent disease risk associated with early-life arsenic exposure: Current research trends and scientific gaps

Bailey, K. A., Smith, A. H., Tokar, E. J., Graziano, J. H., Kim, K. W., Navasumrit, P., Ruchirawat, M., Thiantanawat, A., Suk, W. A. & Fry, R. C. Feb 1 2016 In : Environmental Health Perspectives. 124, 2, p. 170-175 6 p.

Research output: Research - peer-reviewArticle

Arsenic
Research
Neoplasms
Immunomodulation
Neoplastic Stem Cells

Metabolomics of arsenic exposure: The man vs. the mouse

Stýblo, M., Fry, R. C., Huang, M. C., Martin, E., Douillet, C., Drobná, Z., Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, M. L., Del Razo, L. M. & García-Vargas, G. G. 2016 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 425-427 3 p.

Research output: ResearchConference contribution

arsenic
exposure
Arsenic
Metabolomics
metabolite
10 Citations

Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2

Wilmot, B., Fry, R., Smeester, L., Musser, E. D., Mill, J. & Nigg, J. T. Feb 1 2016 In : Journal of Child Psychology and Psychiatry and Allied Disciplines. 57, 2, p. 152-160 9 p.

Research output: Research - peer-reviewArticle

DNA Methylation
Attention Deficit Disorder with Hyperactivity
DNA
Genes
Methylation
3 Citations
Trophoblasts
Pre-Eclampsia
MicroRNAs
Cadmium
Transforming Growth Factor beta
6 Citations
Premature Birth
17-alpha-hydroxy-progesterone caproate
Gestational Age
Odds Ratio
Confidence Intervals
4 Citations

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors

Chitforoushzadeh, Z., Ye, Z., Sheng, Z., La Rue, S., Fry, R. C., Lauffenburger, D. A. & Janes, K. A. Jun 7 2016 In : Science Signaling. 9, 431, ra59

Research output: Research - peer-reviewArticle

GATA6 Transcription Factor
Crosstalk
Tensors
Tumor Necrosis Factor-alpha
Insulin
2 Citations

Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment

Thompson, C. M., Rager, J. E., Suh, M., Ring, C. L., Proctor, D. M., Haws, L. C., Fry, R. C. & Harris, M. A. Dec 1 2016 In : Environmental and Molecular Mutagenesis. 57, 9, p. 706-716 11 p.

Research output: Research - peer-reviewArticle

Inbred F344 Rats
Mouth Mucosa
Mouth
chromium hexavalent ion
Genes
1 Citations

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Harrington, J. M., Young, D. J., Fry, R. C., Weber, F. X., Sumner, S. S. & Levine, K. E. Feb 1 2016 In : Biological Trace Element Research. 169, 2, p. 164-173 10 p.

Research output: Research - peer-reviewArticle

Trace Elements
Placenta
Mass Spectrometry
Inductively coupled plasma mass spectrometry
Tissue
2015
2 Citations

Arsenic, the "King of Poisons", in food and water

Yosim, A., Bailey, K. & Fry, R. C. Jan 1 2015 American Scientist, 103, 1, p. 34-41 8 p.

Research output: ResearchArticle

arsenic
food
water
poison
rice
6 Citations

Cadmium levels in a North Carolina cohort: Identifying risk factors for elevated levels during pregnancy

Edwards, S. E., Maxson, P., Miranda, M. L. & Fry, R. C. Jan 1 2015 In : Journal of Exposure Science and Environmental Epidemiology. 25, 4, p. 427-432 6 p.

Research output: Research - peer-reviewArticle

Cadmium
Pregnancy
Blood
Smoking
Cotinine

Chemical hazards

Smeester, L., Yosim, A. E. & Fry, R. C. Sep 25 2015 Routledge Handbook of Water and Health. Taylor and Francis Inc., p. 107-121 15 p.

Research output: ResearchChapter

hazard
chemical
1 Citations

Environmental Contaminants and the Immune System: A Systems Perspective

Sollome, J. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 171-186 16 p.

Research output: ResearchChapter

Immune System Diseases
Immune System
immune system
pollution
Immune system

Environmental Contaminants and Their Relationship to the Epigenome

Yosim, A. E., Nye, M. D. & Fry, R. C. Jun 1 2015 Personalized Epigenetics. Elsevier Inc., p. 285-312 28 p.

Research output: ResearchChapter

Epigenomics
Impurities
Poisons
Air Pollution
Occupations
11 Citations

Epigenetics and preeclampsia: Defining functional epimutations in the preeclamptic placenta related to the TGF-β pathway

Martin, E., Ray, P. D., Smeester, L., Grace, M. R., Boggess, K. & Fry, R. C. Oct 28 2015 In : PLoS One. 10, 10, e0141294

Research output: Research - peer-reviewArticle

pre-eclampsia
transforming growth factor beta
placenta
epigenetics
methylation

Health Effects of Prenatal and Early-Life Exposure to Arsenic

Bailey, K. A. & Fry, R. C. Jan 8 2015 Handbook of Arsenic Toxicology. Elsevier Inc., p. 405-428 24 p.

Research output: ResearchChapter

Arsenic
Health
Epidemiologic Studies
Mortality
Global Burden of Disease
1 Citations

Hormone Response Pathways as Responders to Environmental Contaminants and Their Roles in Disease

Tilley, S. K. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 225-238 14 p.

Research output: ResearchChapter

pollution
hormones
Hormones
Impurities
endocrine system
7 Citations

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Rager, J. E., Tilley, S. K., Tulenko, S. E., Smeester, L., Ray, P. D., Yosim, A., Currier, J. M., Ishida, M. C., González-Horta, M. D. C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Gutiérrez-Torres, D. S., Drobná, Z., Del Razo, L. M., García-Vargas, G. G., Kim, W. Y., Zhou, Y. H., Wright, F. A., Stýblo, M. & Fry, R. C. Jun 15 2015 In : Chemical Research in Toxicology. 28, 6, p. 1144-1155 12 p.

Research output: Research - peer-reviewArticle

Arsenic
DNA Methylation
Urinary Bladder Neoplasms
Genes
Methylation
32 Citations

Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the biomarkers of exposure to ARsenic (BEAR) pregnancy cohort in Mexico

Laine, J. E., Bailey, K. A., Rubio-Andrade, M., Olshan, A. F., Smeester, L., Drobná, Z., Herring, A. H., Stýblo, M., García-Vargas, G. G. & Fry, R. C. Jan 1 2015 In : Environmental Health Perspectives. 123, 2, p. 186-192 7 p.

Research output: Research - peer-reviewArticle

Maternal Exposure
Arsenic
Mexico
Methylation
Biomarkers
9 Citations

Maternal arsenic exposure, arsenic methylation efficiency, and birth outcomes in the Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Mexico

Laine, J. E., Bailey, K. A., Rubio-Andrade, M., Olshan, A. F., Smeester, L., Drobná, Z., Herring, A. H., Stýblo, M., García-Vargas, G. G. & Fry, R. C. Feb 1 2015 In : Environmental Health Perspectives. 123, 2, p. 186-192 7 p.

Research output: Research - peer-reviewArticle

Maternal Exposure
Arsenic
Mexico
Methylation
Biomarkers
19 Citations

Maternal cadmium, iron and zinc levels, DNA methylation and birth weight

Vidal, A. C., Semenova, V., Darrah, T., Vengosh, A., Huang, Z., King, K., Nye, M. D., Fry, R., Skaar, D., Maguire, R., Murtha, A., Schildkraut, J., Murphy, S. & Hoyo, C. Jul 15 2015 In : BMC Pharmacology and Toxicology. 16, 1, 20

Research output: Research - peer-reviewArticle

DNA Methylation
Cadmium
Birth Weight
Zinc
Iron
15 Citations

Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico

Martin, E. , González-Horta, C. , Rager, J. , Bailey, K. A. , Sánchez-Ramírez, B. , Ballinas-Casarrubias, L. , Ishida, M. C. , Gutiérrez-Torres, D. S. , Cerón, R. H. , Morales, D. V. , Terrazas, F. A. B. , Jesse Saunders, R. , Drobná, Z. , Mendez, M. A. , Buse, J. B. , Loomisk, D. , Jiakj, W. , García-Vargaskk, G. G. , Del Razo, L. M. , Stýblo, M. & 1 others Fry, R. Jan 1 2015 In : Toxicological Sciences. 144, 2, p. 338-346 9 p.

Research output: Research - peer-reviewArticle

Arsenic
Medical problems
Metabolomics
Mexico
Metabolites
11 Citations

Placental cadmium levels are associated with increased preeclampsia risk

Laine, J. E., Ray, P., Bodnar, W., Cable, P. H., Boggess, K., Offenbacher, S. & Fry, R. C. Sep 30 2015 In : PLoS One. 10, 9, e0139341

Research output: Research - peer-reviewArticle

Pre-Eclampsia
Cadmium
pre-eclampsia
cadmium
Odds Ratio

Preface

Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. vi-vii

Research output: ResearchForeword/postscript

45 Citations

Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes

Rojas, D., Rager, J. E., Smeester, L., Bailey, K. A., Drobná, Z., Rubio-Andrade, M., Stýblo, M., García-Vargas, G. & Fry, R. C. Jan 1 2015 In : Toxicological sciences : an official journal of the Society of Toxicology. 143, 1, p. 97-106 10 p.

Research output: Research - peer-reviewArticle

5-Methylcytosine
Arsenic
Fetal Blood
Parturition
Gene Expression
1 Citations

Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs

Gona, S., Sanders, A. P., Miranda, M. L. & Fry, R. C. Sep 1 2015 In : Genomics Data. 5, p. 378-380 3 p.

Research output: Research - peer-reviewArticle

Cotinine
CpG Islands
DNA Methylation
Cadmium
Methylation
1 Citations

Priority Environmental Contaminants: Understanding Their Sources of Exposure, Biological Mechanisms, and Impacts on Health

Tilley, S. K. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 117-169 53 p.

Research output: ResearchChapter

pollution
Health
Impurities
toxic substances
public health
1 Citations

Systems Biology in Toxicology and Environmental Health

Fry, R. C. Jul 7 2015 Elsevier Inc.272 p.

Research output: ResearchBook

toxicology
Biological Sciences
environmental health
Systems Biology
Environmental Health

Systems Biology in Toxicology and Environmental Health

Yosim, A. E. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 1-10 10 p.

Research output: ResearchChapter

toxicology
Biological Sciences
environmental health
Systems Biology
Environmental Health
7 Citations

T1 relaxation rate (R1) indicates nonlinear mn accumulation in brain tissue of welders with low-level exposure

Lee, E. Y., Flynn, M. R., Du, G., Lewis, M. M., Fry, R., Herring, A. H., Van Buren, E., Van Buren, S., Smeester, L., Kong, L., Yang, Q., Mailman, R. B. & Huang, X. Aug 1 2015 In : Toxicological Sciences. 146, 2, p. 281-289 9 p.

Research output: Research - peer-reviewArticle

Manganese
Brain
Tissue
Welding
Globus Pallidus
10 Citations

T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX

Cook, K. D., Shpargel, K. B., Starmer, J., Whitfield-Larry, F., Conley, B., Allard, D. E., Rager, J. E., Fry, R. C., Davenport, M. L., Magnuson, T., Whitmire, J. K. & Su, M. A. Oct 20 2015 In : Immunity. 43, 4, p. 703-714 12 p., 3173

Research output: Research - peer-reviewArticle

Histone Demethylases
Virus Diseases
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Histones

The Cell: The Fundamental Unit in Systems Biology

Ray, P. D. & Fry, R. C. Jul 7 2015 Systems Biology in Toxicology and Environmental Health. Elsevier Inc., p. 11-42 32 p.

Research output: ResearchChapter

toxic substances
Biological Sciences
cells
Biological systems
Systems Biology
5 Citations
Toxicology
Oxidative Stress
Metals
Genes
Oxidative stress