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2017
1 Citations

Association of cardiometabolic genes with arsenic metabolism biomarkers in American Indian communities: The strong heart family study (SHFS)

Balakrishnan, P., Vaidya, D., Franceschini, N., Saroja Voruganti, V., Gribble, M. O., Haack, K., Laston, S., Umans, J. G., Francesconi, K. A., Goessler, W., North, K. E., Lee, E., Yracheta, J., Best, L. G., Maccluer, J. W., Kent, J., Cole, S. A. & Navas-Acien, A. Jan 1 2017 In : Environmental Health Perspectives. 125, 1, p. 15-22 8 p.

Research output: Research - peer-reviewArticle

North American Indians
Arsenic
Biomarkers
Genes
Cacodylic Acid
2 Citations

Dietary determinants of cadmium exposure in the Strong Heart Family Study

Olmedo, P., Grau-Perez, M., Fretts, A., Tellez-Plaza, M., Gil, F., Yeh, F., Umans, J. G., Francesconi, K. A., Goessler, W., Franceschini, N., Lee, E. T., Best, L. G., Cole, S. A., Howard, B. V. & Navas-Acien, A. Feb 1 2017 In : Food and Chemical Toxicology. 100, p. 239-246 8 p.

Research output: Research - peer-reviewArticle

family studies
cadmium
heart
Cadmium
processed meat

Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure

He, K. Y., Wang, H., Cade, B. E., Nandakumar, P., Giri, A., Ware, E. B., Haessler, J., Liang, J., Smith, J. A., Franceschini, N., Le, T. H., Kooperberg, C., Edwards, T. L., Kardia, S. L. R., Lin, X., Chakravarti, A., Redline, S. & Zhu, X. Mar 1 2017 In : PLoS Genetics. 13, 3, e1006678

Research output: Research - peer-reviewArticle

hypotension
foxes
linkage (genetics)
blood
family
2016

A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women

Taylor, K. C. , Evans, D. S. , Edwards, D. R. V. , Edwards, T. L. , Sofer, T. , Li, G. , Liu, Y. , Franceschini, N. , Jackson, R. D. , Giri, A. , Donneyong, M. , Psaty, B. , Rotter, J. I. , LaCroix, A. Z. , Jordan, J. M. , Robbins, J. A. , Lewis, B. , Stefanick, M. L. , Liu, Y. , Garcia, M. & 3 others Harris, T., Cauley, J. A. & North, K. E. Dec 1 2016 In : Bone Reports. 5, p. 233-242 10 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
African Americans
Meta-Analysis
Health
Single Nucleotide Polymorphism

AS3MT, locus 10q24 and arsenic metabolism biomarkers in American Indians: The strong heart family study

Balakrishnan, P., Vaidya, D., Franceschini, N., Voruganti, V. S., Gribble, M., Haack, K., Laston, S., Umans, J., Francesconi, K., Goessler, W., North, K., Lee, E., Yracheta, J., Best, L., Maccluer, J., Kent, J., Cole, S. & Navas-Acien, A. 2016 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema, p. 443-445 3 p.

Research output: ResearchConference contribution

biomarker
arsenic
metabolism
family
Arsenic
2 Citations

Comparison of 2 models for gene-environment interactions: An example of simulated gene-medication interactions on systolic blood pressure in family-based data

Fernández-Rhodes, L., Hodonsky, C. J., Graff, M., Love, S. A. M., Howard, A. G., Seyerle, A. A., Avery, C. L., Chittoor, G., Franceschini, N., Voruganti, V. S., Young, K., O'Connell, J. R., North, K. E. & Justice, A. E. Jan 1 2016 In : BMC Proceedings. 10, 65

Research output: Research - peer-reviewArticle

Gene-Environment Interaction
Single Nucleotide Polymorphism
Blood Pressure
Genes
Blood pressure

Genome-wide association of trajectories of systolic blood pressure change

Justice, A. E., Howard, A. G., Chittoor, G., Fernandez-Rhodes, L., Graff, M., Voruganti, V. S., Diao, G., Love, S. A. M., Franceschini, N., O'Connell, J. R., Avery, C. L., Young, K. L. & North, K. E. Jan 1 2016 In : BMC Proceedings. 10, 56

Research output: Research - peer-reviewArticle

Blood pressure
Genes
Trajectories
Genome
Blood Pressure
4 Citations

Kidney Function and Cardiovascular Events in Postmenopausal Women: The Impact of Race and Ethnicity in the Women's Health Initiative

Arce, C. M., Rhee, J. J., Cheung, K. L., Hedlin, H., Kapphahn, K., Franceschini, N., Kalil, R. S., Martin, L. W., Qi, L., Shara, N. M., Desai, M., Stefanick, M. L. & Winkelmayer, W. C. Feb 1 2016 In : American Journal of Kidney Diseases. 67, 2, p. 198-208 11 p.

Research output: Research - peer-reviewArticle

Women's Health
Glomerular Filtration Rate
Kidney
Hispanic Americans
African Americans
1 Citations

Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos

Franceschini, N., Deng, Y., Flessner, M. F., Eckfeldt, J. H., Kramer, H. J., Lash, J. P., Lee, D. J., Melamed, M. L., Moncrieft, A. E., Ricardo, A. C., Rosas, S. E., Kaplan, R. C., Raij, L. & Cai, J. Oct 1 2016 In : Nephrology Dialysis Transplantation. 31, 10, p. 1670-1676 7 p.

Research output: Research - peer-reviewArticle

Chronic Renal Insufficiency
Hispanic Americans
Smoking
Health
Population
2015
218 Citations

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Nikpay, M. , Goel, A. , Won, H. H. , Hall, L. M. , Willenborg, C. , Kanoni, S. , Saleheen, D. , Kyriakou, T. , Nelson, C. P. , CHopewell, J. , Webb, T. R. , Zeng, L. , Dehghan, A. , Alver, M. , MArmasu, S. , Auro, K. , Bjonnes, A. , Chasman, D. I. , Chen, S. , Ford, I. & 131 others Franceschini, N., Gieger, C., Grace, C., Gustafsson, S., Huang, J., Hwang, S. J., Kim, Y. K., Kleber, M. E., Lau, K. W., Lu, X., Lu, Y., Lyytikäinen, L. P., Mihailov, E., Morrison, A. C., Pervjakova, N., Qu, L., Rose, L. M., Salfati, E., Saxena, R., Scholz, M., Smith, A. V., Tikkanen, E., Uitterlinden, A., Yang, X., Zhang, W., Zhao, W., De Andrade, M., De Vries, P. S., Van Zuydam, N. R., Anand, S. S., Bertram, L., Beutner, F., Dedoussis, G., Frossard, P., Gauguier, D., Goodall, A. H., Gottesman, O., Haber, M., Han, B. G., Huang, J., Jalilzadeh, S., Kessler, T., König, I. R., Lannfelt, L., Lieb, W., Lind, L., MLindgren, C., Lokki, M. L., Magnusson, P. K., Mallick, N. H., Mehra, N., Meitinger, T., Memon, F. U. R., Morris, A. P., Nieminen, M. S., Pedersen, N. L., Peters, A., Rallidis, L. S., Rasheed, A., Samuel, M., Shah, S. H., Sinisalo, J., EStirrups, K., Trompet, S., Wang, L., Zaman, K. S., Ardissino, D., Boerwinkle, E., Borecki, I. B., Bottinger, E. P., Buring, J. E., Chambers, J. C., Collins, R., Cupples, L., Danesh, J., Demuth, I., Elosua, R., Epstein, S. E., Esko, T., Feitosa, M. F., Franco, O. H., Franzosi, M. G., Granger, C. B., Gu, D., Gudnason, V., SHall, A., Hamsten, A., Harris, T. B., LHazen, S., Hengstenberg, C., Hofman, A., Ingelsson, E., Iribarren, C., Jukema, J. W., Karhunen, P. J., Kim, B. J., Kooner, J. S., Kullo, I. J., Lehtimäki, T., Loos, R. J. F., Melander, O., Metspalu, A., März, W., Palmer, C. N., Perola, M., Quertermous, T., Rader, D. J., Ridker, P. M., Ripatti, S., Roberts, R., Salomaa, V., Sanghera, D. K., Schwartz, S. M., Seedorf, U., Stewart, A. F., Stott, D. J., Thiery, J., Zalloua, P. A., O'Donnell, C. J., Reilly, M. P., Assimes, T. L., Thompson, J. R., Erdmann, J., Clarke, R., Watkins, H., Kathiresan, S., McPherson, R., Deloukas, P., Schunkert, H., Samani, N. J. & Farrall, M. Jan 1 2015 In : Nature Genetics. 47, 10, p. 1121-1130 10 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Meta-Analysis
Coronary Artery Disease
Genome
Gene Frequency
6 Citations

Adiposity patterns and the risk for ESRD in postmenopausal women

Franceschini, N., Gouskova, N. A., Reiner, A. P., Bostom, A., Howard, B. V., Pettinger, M., Umans, J. G., Brookhart, M. A., Winkelmayer, W. C., Eaton, C. B., Heiss, G. & Fine, J. P. Jan 1 2015 In : Clinical Journal of the American Society of Nephrology. 10, 2, p. 241-250 10 p.

Research output: Research - peer-reviewArticle

Adiposity
Chronic Kidney Failure
Body Mass Index
Confidence Intervals
Waist Circumference
2 Citations

Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling

Tao, R., Zeng, D., Franceschini, N., North, K. E., Boerwinkle, E. & Lin, D. Y. Apr 3 2015 In : Journal of the American Statistical Association. 110, 510, p. 560-572 13 p.

Research output: Research - peer-reviewArticle

Dependent
Sampling
Linear regression
Sequencing
Heart
7 Citations

Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians

Tsai, C. W., North, K. E., Tin, A., Haack, K., Franceschini, N., Voruganti, V. S., Laston, S., Zhang, Y., Best, L. G., MacCluer, J. W., Beaty, T. H., Navas-Acien, A., Kao, W. H. L. & Howard, B. V. Feb 1 2015 In : Journal of Clinical Endocrinology and Metabolism. 100, 2, p. E345-E349

Research output: Research - peer-reviewArticle

North American Indians
LDL Cholesterol
Proprotein Convertase 9
Proprotein Convertases
Subtilisin
32 Citations

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis

Freitag, D. , Butterworth, A. S. , Willeit, P. , Howson, J. M. M. , Burgess, S. , Kaptoge, S. , Young, R. , Ho, W. K. , Wood, A. M. , Sweeting, M. , Spackman, S. , Staley, J. R. , Ramond, A. , Harshfield, E. , Nielsen, S. F. , Grande, P. , Lange, L. A. , Bown, M. J. , Jones, G. T. , Scott, R. A. & 133 others Bevan, S., Porcu, E., Thorleifsson, G., Zeng, L., Kessler, T., Nikpay, M., Do, R., Zhang, W., Hopewell, J. C., Kleber, M., Delgado, G. E., Nelson, C. P., Goel, A., Bis, J. C., Dehghan, A., Ligthart, S., Smith, A. V., Qu, L., van 't Hof, F. N. G., de Bakker, P. I. W., Baas, A. F., van Rij, A., Tromp, G., Kuivaniemi, H., Ritchie, M. D., Verma, S. S., Crawford, D. C., Malinowski, J., de Andrade, M., Kullo, I. J., Peissig, P. L., McCarty, C. A., Böttinger, E. P., Gottesman, O., Crosslin, D. R., Carrell, D. S., Rasmussen-Torvik, L. J., Pacheco, J. A., Huang, J., Timpson, N. J., Kettunen, J., Ala-Korpela, M., Mitchell, G. F., Parsa, A., Wilkinson, I. B., Gorski, M., Li, Y., Franceschini, N., Keller, M. F., Ganesh, S. K., Langefeld, C. D., Bruijn, L., Brown, M. A., Evans, D. M., Baltic, S., Ferreira, M. A., Baurecht, H., Weidinger, S., Franke, A., Lubitz, S. A., Müller-Nurasyid, M., Felix, J. F., Smith, N. L., Sudman, M., Thompson, S. D., Zeggini, E., Panoutsopoulou, K., Nalls, M. A., Singleton, A., Polychronakos, C., Bradfield, J. P., Hakonarson, H., Easton, D. F., Thompson, D., Tomlinson, I. P., Dunlop, M., Hemminki, K., Morgan, G., Eisen, T., Goldschmidt, H., Allan, J. M., Henrion, M., Whiffin, N., Wang, Y., Chubb, D., Iles, M. M., Bishop, D. T., Law, M. H., Hayward, N. K., Luo, Y., Nejentsev, S., Barbalic, M., Crossman, D., Sanna, S., Soranzo, N., Markus, H. S., Wareham, N. J., Rader, D. J., Reilly, M., Assimes, T., Harris, T. B., Hofman, A., Franco, O. H., Gudnason, V., Tracy, R., Psaty, B. M., Farrall, M., Watkins, H., Hall, A. S., Samani, N. J., März, W., Clarke, R., Collins, R., Kooner, J. S., Chambers, J. C., Kathiresan, S., McPherson, R., Erdmann, J., Kastrati, A., Schunkert, H., Stefánsson, K., Thorsteinsdottir, U., Walston, J. D., Tybjærg-Hansen, A., Alam, D. S., Al Shafi Majumder, A., Angelantonio, E. D., Chowdhury, R., Nordestgaard, B. G., Saleheen, D., Thompson, S. G., Danesh, J. & Houlston, R. S. Jan 1 2015 In : The Lancet Diabetes and Endocrinology. 3, 4, p. 243-253 11 p.

Research output: Research - peer-reviewArticle

Mendelian Randomization Analysis
Interleukin 1 Receptor Antagonist Protein
Interleukin-1 Receptors
Up-Regulation
Alleles
38 Citations

Directional dominance on stature and cognition in diverse human populations

Joshi, P. K. , Esko, T. , Mattsson, H. , Eklund, N. , Gandin, I. , Nutile, T. , Jackson, A. U. , Schurmann, C. , Smith, A. V. , Zhang, W. , Okada, Y. , Stančáková, A. , Faul, J. D. , Zhao, W. , Bartz, T. M. , Concas, M. P. , Franceschini, N. , Enroth, S. , Vitart, V. , Trompet, S. & 340 others Guo, X., Chasman, D. I., O'Connel, J. R., Corre, T., Nongmaithem, S. S., Chen, Y., Mangino, M., Ruggiero, D., Traglia, M., Farmaki, A. E., Kacprowski, T., Bjonnes, A., Van Der Spek, A., Wu, Y., Giri, A. K., Yanek, L. R., Wang, L., Hofer, E., Rietveld, C. A., McLeod, O., Cornelis, M. C., Pattaro, C., Verweij, N., Baumbach, C., Abdellaoui, A., Warren, H. R., Vuckovic, D., Mei, H., Bouchard, C., Perry, J. R. B., Cappellani, S., Mirza, S. S., Benton, M. C., Broeckel, U., Medland, S. E., Lind, P. A., Malerba, G., Drong, A., Yengo, L., Bielak, L. F., Zhi, D., Van Der Most, P. J., Shriner, D., Mägi, R., Hemani, G., Karaderi, T., Wang, Z., Liu, T., Demuth, I., Zhao, J. H., Meng, W., Lataniotis, L., Van Der Laan, S. W., Bradfield, J. P., Wood, A. R., Bonnefond, A., Ahluwalia, T. S., Hall, L. M., Salvi, E., Yazar, S., Carstensen, L., De Haan, H. G., Abney, M., Afzal, U., Allison, M. A., Amin, N., Asselbergs, F. W., Bakker, S. J. L., Barr, R. G., Baumeister, S. E., Benjamin, D. J., Bergmann, S., Boerwinkle, E., Bottinger, E. P., Campbell, A., Chakravarti, A., Chan, Y., Chanock, S. J., Chen, C., Chen, Y. D. I., Collins, F. S., Connell, J., Correa, A., Cupples, L. A., Smith, G. D., Davies, G., Dörr, M., Ehret, G., Ellis, S. B., Feenstra, B., Feitosa, M. F., Ford, I., Fox, C. S., Frayling, T. M., Friedrich, N., Geller, F., Scotland, G., Gillham-Nasenya, I., Gottesman, O., Graff, M., Grodstein, F., Gu, C., Haley, C., Hammond, C. J., Harris, S. E., Harris, T. B., Hastie, N. D., Heard-Costa, N. L., Heikkilä, K., Hocking, L. J., Homuth, G., Hottenga, J. J., Huang, J., Huffman, J. E., Hysi, P. G., Ikram, M. A., Ingelsson, E., Joensuu, A., Johansson, Å., Jousilahti, P., Jukema, J. W., Kähönen, M., Kamatani, Y., Kanoni, S., Kerr, S. M., Khan, N. M., Koellinger, P., Koistinen, H. A., Kooner, M. K., Kubo, M., Kuusisto, J., Lahti, J., Launer, L. J., Lea, R. A., Lehne, B., Lehtimäki, T., Liewald, D. C. M., Lind, L., Loh, M., Lokki, M. L., London, S. J., Loomis, S. J., Loukola, A., Lu, Y., Lumley, T., Lundqvist, A., Männistö, S., Marques-Vidal, P., Masciullo, C., Matchan, A., Mathias, R. A., Matsuda, K., Meigs, J. B., Meisinger, C., Meitinger, T., Menni, C., Mentch, F. D., Mihailov, E., Milani, L., Montasser, M. E., Montgomery, G. W., Morrison, A., Myers, R. H., Nadukuru, R., Navarro, P., Nalis, M., Nieminen, M. S., Nolte, I. M., O'Connor, G. T., Ogunniyi, A., Padmanabhan, S., Palmas, W. R., Pankow, J. S., Patarcic, I., Pavani, F., Peyser, P. A., Pietilainen, K., Poulter, N., Prokopenko, I., Ralhan, S., Redmond, P., Rich, S. S., Rissanen, H., Robino, A., Rose, L. M., Rose, R., Sala, C., Salako, B., Salomaa, V., Sarin, A. P., Saxena, R., Schmidt, H., Scott, L. J., Scott, W. R., Sennblad, B., Seshadri, S., Sever, P., Shrestha, S., Smith, B. H., Smith, J. A., Soranzo, N., Sotoodehnia, N., Southam, L., Stanton, A. V., Stathopoulou, M. G., Strauch, K., Strawbridge, R. J., Suderman, M. J., Tandon, N., Tang, S. T., Taylor, K. D., Tayo, B. O., Töglhofer, A. M., Tomaszewski, M., Tšernikova, N., Tuomilehto, J., Uitterlinden, A. G., Vaidya, D., Van Hylckama Vlieg, A., Van Setten, J., Vasankari, T., Vedantam, S., Vlachopoulou, E., Vozzi, D., Vuoksimaa, E., Waldenberger, M., Ware, E. B., Wentworth-Shields, W., Whitfield, J. B., Wild, S., Willemsen, G., Yajnik, C. S., Yao, J., Zaza, G., Zhu, X., Salem, R. M., Melbye, M., Bisgaard, H., Samani, N. J., Cusi, D., Mackey, D. A., Cooper, R. S., Froguel, P., Pasterkamp, G., Grant, S. F. A., Hakonarson, H., Ferrucci, L., Scott, R. A., Morris, A. D., Palmer, C. N. A., Dedoussis, G., Deloukas, P., Bertram, L., Lindenberger, U., Berndt, S. I., Lindgren, C. M., Timpson, N. J., Tönjes, A., Munroe, P. B., Sørensen, T. I. A., Rotimi, C. N., Arnett, D. K., Oldehinkel, A. J., Kardia, S. L. R., Balkau, B., Gambaro, G., Morris, A. P., Eriksson, J. G., Wright, M. J., Martin, N. G., Hunt, S. C., Starr, J. M., Deary, I. J., Griffiths, L. R., Tiemeier, H., Pirastu, N., Kaprio, J., Wareham, N. J., Pérusse, L., Wilson, J. G., Girotto, G., Caulfield, M. J., Raitakari, O., Boomsma, D. I., Gieger, C., Van Der Harst, P., Hicks, A. A., Kraft, P., Sinisalo, J., Knekt, P., Johannesson, M., Magnusson, P. K. E., Hamsten, A., Schmidt, R., Borecki, I. B., Vartiainen, E., Becker, D. M., Bharadwaj, D., Mohlke, K. L., Boehnke, M., Van Duijn, C. M., Sanghera, D. K., Teumer, A., Zeggini, E., Metspalu, A., Gasparini, P., Ulivi, S., Ober, C., Toniolo, D., Rudan, I., Porteous, D. J., Ciullo, M., Spector, T. D., Hayward, C., Dupuis, J., Loos, R. J. F., Wright, A. F., Chandak, G. R., Vollenweider, P., Shuldiner, A. R., Ridker, P. M., Rotter, J. I., Sattar, N., Gyllensten, U., North, K. E., Pirastu, M., Psaty, B. M., Weir, D. R., Laakso, M., Gudnason, V., Takahashi, A., Chambers, J. C., Kooner, J. S., Strachan, D. P., Campbell, H., Hirschhorn, J. N., Perola, M., Polašek, O., Wilson, J. F. & The Bio Bank Japan Project Jul 23 2015 In : Nature. 523, 7561, p. 459-462 4 p.

Research output: Research - peer-reviewArticle

Cognition
Genome
Population
Aptitude
Inbreeding
4 Citations

Linkage analysis of urine arsenic species patterns in the Strong Heart Family Study

Gribble, M. O., Voruganti, V. S., Cole, S. A., Haack, K., Balakrishnan, P., Laston, S. L., Tellez-Plaza, M., Francesconi, K. A., Goessler, W., Umans, J. G., Thomas, D. C., Gilliland, F., North, K. E., Franceschini, N. & Navas-Acien, A. Jan 1 2015 In : Toxicological Sciences. 148, 1, p. 89-100 12 p., kfv164

Research output: Research - peer-reviewArticle

Arsenic
Urine
Genes
Quantitative Trait Loci
Principal Component Analysis
47 Citations

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension

Zhu, X. , Feng, T. , Tayo, B. O. , Liang, J. , Young, J. H. , Franceschini, N. , Smith, J. A. , Yanek, L. R. , Sun, Y. V. , Edwards, T. L. , Chen, W. , Nalls, M. , Fox, E. , Sale, M. , Bottinger, E. , Rotimi, C. , Liu, Y. , McKnight, B. , Liu, K. , Arnett, D. K. & 4 others Chakravati, A., Cooper, R. S., Redline, S. & Levy, D. Jan 8 2015 In : American Journal of Human Genetics. 96, 1, p. 21-36 16 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Meta-Analysis
Hypertension
Phenotype
Genetic Loci
16 Citations

Molecular mechanisms underlying variations in lung function: A systems genetics analysis

Obeidat, M. , Hao, K. , Bossé, Y. , Nickle, D. C. , Nie, Y. , Postma, D. S. , Laviolette, M. , Sandford, A. J. , Daley, D. D. , Hogg, J. C. , Elliott, W. M. , Fishbane, N. , Timens, W. , Hysi, P. G. , Kaprio, J. , Wilson, J. F. , Hui, J. , Rawal, R. , Schulz, H. , Stubbe, B. & 26 others Hayward, C., Polasek, O., Järvelin, M. R., Zhao, J. H., Jarvis, D., Kähönen, M., Franceschini, N., North, K. E., Loth, D. W., Brusselle, G. G., Smith, A. V., Gudnason, V., Bartz, T. M., Wilk, J. B., O'Connor, G. T., Cassano, P. A., Tang, W., Wain, L. V., Artigas, M. S., Gharib, S. A., Strachan, D. P., Sin, D. D., Tobin, M. D., London, S. J., Hall, I. P. & Paré, P. D. Jan 1 2015 In : The Lancet Respiratory Medicine. 3, 10, p. 782-795 14 p.

Research output: Research - peer-reviewArticle

Lung
Genes
Chronic Obstructive Pulmonary Disease
Quantitative Trait Loci
Genome-Wide Association Study
15 Citations

Phosphodiesterase 1 regulation is a key mechanism in vascular aging

Bautista Niño, P. K., Durik, M., Jan Danser, A. H., De Vries, R., Musterd-Bhaggoe, U. M., Meima, M. E., Kavousi, M., Ghanbari, M., Hoeijmakers, J. H., O'Donnell, C. J., Franceschini, N., Janssen, G. M. J., de Mey, J. G. R., Liu, Y., Shanahan, C. M., Franco, O. H., Dehghan, A. & Roks, A. J. M. 2015 In : Clinical Science. 129, 12, p. 1061-1075 15 p.

Research output: Research - peer-reviewArticle

Phosphoric Diester Hydrolases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Genomic Instability
9 Citations

Prevalence and correlates of CKD in hispanics/latinos in the United States

Ricardo, A. C., Flessner, M. F., Eckfeldt, J. H., Eggers, P. W., Franceschini, N., Go, A. S., Gotman, N. M., Kramer, H. J., Kusek, J. W., Loehr, L. R., Melamed, M. L., Peralta, C. A., Raij, L., Rosas, S. E., Talavera, G. A. & Lash, J. P. Oct 7 2015 In : Clinical Journal of the American Society of Nephrology. 10, 10, p. 1757-1766 10 p.

Research output: Research - peer-reviewArticle

Hispanic Americans
Health
Nutrition Surveys
Cross-Sectional Studies
9 Citations

Rare coding variants and X-linked loci associated with age at menarche

Lunetta, K. L. , Day, F. R. , Sulem, P. , Ruth, K. S. , Tung, J. Y. , Hinds, D. A. , Esko, T. , Elks, C. E. , Altmaier, E. , He, C. , Huffman, J. E. , Mihailov, E. , Porcu, E. , Robino, A. , Rose, L. M. , Schick, U. M. , Stolk, L. , Teumer, A. , Thompson, D. J. , Traglia, M. & 101 others Wang, C. A., Yerges-Armstrong, L. M., Antoniou, A. C., Barbieri, C., Coviello, A. D., Cucca, F., Demerath, E. W., Dunning, A. M., Gandin, I., Grove, M. L., Gudbjartsson, D. F., Hocking, L. J., Hofman, A., Huang, J., Jackson, R. D., Karasik, D., Kriebel, J., Lange, E. M., Lange, L. A., Langenberg, C., Li, X., Luan, J., Mägi, R., Morrison, A. C., Padmanabhan, S., Pirie, A., Polasek, O., Porteous, D., Reiner, A. P., Rivadeneira, F., Rudan, I., Sala, C. F., Schlessinger, D., Scott, R. A., Stöckl, D., Visser, J. A., Völker, U., Vozzi, D., Wilson, J. G., Zygmunt, M., Boerwinkle, E., Buring, J. E., Crisponi, L., Easton, D. F., Hayward, C., Hu, F. B., Liu, S., Metspalu, A., Pennell, C. E., Ridker, P. M., Strauch, K., Streeten, E. A., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Wellons, M., Franceschini, N., Chasman, D. I., Thorsteinsdottir, U., Murray, A., Stefansson, K., Murabito, J. M., Ong, K. K., Perry, J. R. B., Forouhi, N. G., Kerrison, N. D., Sharp, S. J., Sims, M., Barroso, I., Deloukas, P., McCarthy, M. I., Arriola, L., Balkau, B., Barricarte, A., Boeing, H., Franks, P. W., Gonzalez, C., Grioni, S., Kaaks, R., Key, T. J., Navarro, C., Nilsson, P. M., Overvad, K., Palli, D., Panico, S., Quirós, J. R., Rolandsson, O., Sacerdote, C., Sánchez, M. J., Slimani, N., Tjonneland, A., Tumino, R., Van Der A, D. L., Van Der Schouw, Y. T., Riboli, E., Smith, B. H., Campbell, A., Deary, I. J. & McIntosh, A. M. Aug 4 2015 In : Nature Communications. 6, 7756

Research output: Research - peer-reviewArticle

chromosomes
loci
mutations
genes
coding
9 Citations

Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study

Bressler, J., Franceschini, N., Demerath, E. W., Mosley, T. H., Folsom, A. R. & Boerwinkle, E. Jul 23 2015 In : BMC Medical Genetics. 16, 1, 52

Research output: Research - peer-reviewArticle

Telomerase
Atherosclerosis
Cardiovascular Diseases
Telomere
Mortality
2014
4 Citations

ADAM19 and HTR4 variants and pulmonary function cohorts for heart and aging research in genomic epidemiology (charge) consortium targeted sequencing study

London, S. J., Gao, W., Gharib, S. A., Hancock, D. B., Wilk, J. B., House, J. S., Gibbs, R. A., Muzny, D. M., Lumley, T., Franceschini, N., North, K. E., Psaty, B. M., Kovar, C. L., Coresh, J., Zhou, Y., Heckbert, S. R., Brody, J. A. & Morrison, A. C. 2014 In : Circulation: Cardiovascular Genetics. 7, 3, p. 350-358 9 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Forced Expiratory Volume
Epidemiology
Lung
Research
36 Citations

Association of sickle cell trait with chronic kidney disease and Albuminuria in African Americans

Naik, R. P. , Derebail, V. K. , Grams, M. E. , Franceschini, N. , Auer, P. L. , Peloso, G. M. , Young, B. A. , Lettre, G. , Peralta, C. A. , Katz, R. , Hyacinth, H. I. , Quarells, R. C. , Grove, M. L. , Bick, A. G. , Fontanillas, P. , Rich, S. S. , Smith, J. D. , Boerwinkle, E. , Rosamond, W. D. , Ito, K. & 11 others Lanzkron, S., Coresh, J., Correa, A., Sarto, G. E., Key, N. S., Jacobs, D. R., Kathiresan, S., Bibbins-Domingo, K., Kshirsagar, A. V., Wilson, J. G. & Reiner, A. P. Jan 1 2014 In : JAMA - Journal of the American Medical Association. 312, 20, p. 2115-2125 11 p.

Research output: Research - peer-reviewArticle

Sickle Cell Trait
Albuminuria
Chronic Renal Insufficiency
African Americans
Glomerular Filtration Rate
70 Citations

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

Tragante, V. , Barnes, M. R. , Ganesh, S. K. , Lanktree, M. B. , Guo, W. , Franceschini, N. , Smith, E. N. , Johnson, T. , Holmes, M. V. , Padmanabhan, S. , Karczewski, K. J. , Almoguera, B. , Barnard, J. , Baumert, J. , Chang, Y. P. C. , Elbers, C. C. , Farrall, M. , Fischer, M. E. , Gaunt, T. R. , Gho, J. M. I. H. & 116 others Gieger, C., Goel, A., Gong, Y., Isaacs, A., Kleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Melander, O., Nelson, C. P., Nolte, I. M., Pankratz, N., Price, T. S., Shaffer, J., Shah, S., Tomaszewski, M., Van Der Most, P. J., Van Iperen, E. P. A., Vonk, J. M., Witkowska, K., Wong, C. O. L., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Brown, M., Burt, A., Cooper-Dehoff, R. M., Connell, J. M., Cruickshanks, K. J., Curtis, S. P., Davey-Smith, G., Delles, C., Gansevoort, R. T., Guo, X., Haiqing, S., Hastie, C. E., Hofker, M. H., Hovingh, G. K., Kim, D. S., Kirkland, S. A., Klein, B. E., Klein, R., Li, Y. R., Maiwald, S., Newton-Cheh, C., O'Brien, E. T., Onland-Moret, N. C., Palmas, W., Parsa, A., Penninx, B. W., Pettinger, M., Vasan, R. S., Ranchalis, J. E., M Ridker, P., Rose, L. M., Sever, P., Shimbo, D., Steele, L., Stolk, R. P., Thorand, B., Trip, M. D., Van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Wyatt, S., Young, J. H., Zwinderman, A. H., Bezzina, C. R., Boerwinkle, E., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Dominiczak, A. F., Fitzgerald, G. A., Gums, J. G., Fornage, M., Hakonarson, H., Halder, I., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Kumari, M., März, W., Murray, S. S., O'Connell, J. R., Oldehinkel, A. J., Pankow, J. S., Rader, D. J., Redline, S., Reilly, M. P., Schadt, E. E., Kottke-Marchant, K., Snieder, H., Snyder, M., Stanton, A. V., Tobin, M. D., Uitterlinden, A. G., Van Der Harst, P., Van Der Schouw, Y. T., Samani, N. J., Watkins, H., Johnson, A. D., Reiner, A. P., Zhu, X., De Bakker, P. I. W., Levy, D., Asselbergs, F. W., Munroe, P. B. & Keating, B. J. Mar 6 2014 In : American Journal of Human Genetics. 94, 3, p. 349-360 12 p.

Research output: Research - peer-reviewArticle

Meta-Analysis
Blood Pressure
Genes
Computational Biology
Single Nucleotide Polymorphism
7 Citations

Generalization of associations of kidney-related genetic loci to American Indians

Franceschini, N., Haack, K., Almasy, L., Laston, S., Lee, E. T., Best, L. G., Fabsitz, R. R., MacCluer, J. W., Howard, B. V., Umans, J. G. & Cole, S. A. Jan 7 2014 In : Clinical Journal of the American Society of Nephrology. 9, 1, p. 150-158 9 p.

Research output: Research - peer-reviewArticle

Genetic Loci
North American Indians
Kidney
Single Nucleotide Polymorphism
Albumins
43 Citations

Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes

Yaghootkar, H. , Scott, R. A. , White, C. C. , Zhang, W. , Speliotes, E. , Munroe, P. B. , Ehret, G. B. , Bis, J. C. , Fox, C. S. , Walker, M. , Borecki, I. B. , Knowles, J. W. , Yerges-Armstrong, L. , Ohlsson, C. , Perry, J. R. B. , Chambers, J. C. , Kooner, J. S. , Franceschini, N. , Langenberg, C. , Hivert, M. F. & 4 others Dastani, Z., Richards, J. B., Semple, R. K. & Frayling, T. M. Jan 1 2014 In : Diabetes. 63, 12, p. 4369-4377 9 p.

Research output: Research - peer-reviewArticle

Type 2 Diabetes Mellitus
Insulin Resistance
Coronary Artery Disease
Alleles
Hypertension
9 Citations

Genetics, ancestry, and hypertension: Implications for targeted antihypertensive therapies

Franceschini, N., Chasman, D. I., Cooper-DeHoff, R. M. & Arnett, D. K. 2014 In : Current Hypertension Reports. 16, 8, 461

Research output: Research - peer-reviewReview article

Antihypertensive Agents
Blood Pressure
Hypertension
Therapeutics
Genome-Wide Association Study
11 Citations

Genetics of hypertension: Discoveries from the bench to human populations

Franceschini, N. & Le, T. H. Jan 1 2014 In : American Journal of Physiology - Renal Physiology. 306, 1

Research output: Research - peer-reviewReview article

Hypertension
Population
Research
Genome-Wide Association Study
Genetic Models
2 Citations

Genetic variants in nicotinic acetylcholine receptor genes jointly contribute to kidney function in American Indians: The Strong Heart Family Study

Zhu, Y., Yang, J., Li, S., Cole, S. A., Haack, K., Umans, J. G., Franceschini, N., Howard, B. V., Lee, E. T. & Zhao, J. Jan 1 2014 In : Journal of Hypertension. 32, 5, p. 1042-1049 8 p.

Research output: Research - peer-reviewArticle

North American Indians
Nicotinic Receptors
Kidney
Genes
Smoking
42 Citations

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Loth, D. W. , Artigas, M. S. , Gharib, S. A. , Wain, L. V. , Franceschini, N. , Koch, B. , Pottinger, T. D. , Smith, A. V. , Duan, Q. , Oldmeadow, C. , Lee, M. K. , Strachan, D. P. , James, A. L. , Huffman, J. E. , Vitart, V. , Ramasamy, A. , Wareham, N. J. , Kaprio, J. , Wang, X. Q. , Trochet, H. & 140 others Kähönen, M., Flexeder, C., Albrecht, E., Lopez, L. M., De Jong, K., Thyagarajan, B., Alves, A. C., Enroth, S., Omenaas, E., Joshi, P. K., Fall, T., Viñuela, A., Launer, L. J., Loehr, L. R., Fornage, M., Li, G., Wilk, J. B., Tang, W., Manichaikul, A., Lahousse, L., Harris, T. B., North, K. E., Rudnicka, A. R., Hui, J., Gu, X., Lumley, T., Wright, A. F., Hastie, N. D., Campbell, S., Kumar, R., Pin, I., Scott, R. A., Pietiläinen, K. H., Surakka, I., Liu, Y., Holliday, E. G., Schulz, H., Heinrich, J., Davies, G., Vonk, J. M., Wojczynski, M., Pouta, A., Johansson, A., Wild, S. H., Ingelsson, E., Rivadeneira, F., Völzke, H., Hysi, P. G., Eiriksdottir, G., Morrison, A. C., Rotter, J. I., Gao, W., Postma, D. S., White, W. B., Rich, S. S., Hofman, A., Aspelund, T., Couper, D., Smith, L. J., Psaty, B. M., Lohman, K., Burchard, E. G., Uitterlinden, A. G., Garcia, M., Joubert, B. R., McArdle, W. L., Musk, A. B., Hansel, N., Heckbert, S. R., Zgaga, L., Van Meurs, J. B. J., Navarro, P., Rudan, I., Oh, Y. M., Redline, S., Jarvis, D. L., Zhao, J. H., Rantanen, T., O'Connor, G. T., Ripatti, S., Scott, R. J., Karrasch, S., Grallert, H., Gaddis, N. C., Starr, J. M., Wijmenga, C., Minster, R. L., Lederer, D. J., Pekkanen, J., Gyllensten, U., Campbell, H., Morris, A. P., Gläser, S., Hammond, C. J., Burkart, K. M., Beilby, J., Kritchevsky, S. B., Gudnason, V., Hancock, D. B., Williams, O. D., Polasek, O., Zemunik, T., Kolcic, I., Petrini, M. F., Wjst, M., Kim, W. J., Porteous, D. J., Scotland, G., Smith, B. H., Viljanen, A., Heliövaara, M., Attia, J. R., Sayers, I., Hampel, R., Gieger, C., Deary, I. J., Boezen, H. M., Newman, A., Jarvelin, M. R., Wilson, J. F., Lind, L., Stricker, B. H., Teumer, A., Spector, T. D., Melén, E., Peters, M. J., Lange, L. A., Barr, R. G., Bracke, K. R., Verhamme, F. M., Sung, J., Hiemstra, P. S., Cassano, P. A., Sood, A., Hayward, C., Dupuis, J., Hall, I. P., Brusselle, G. G., Tobin, M. D. & London, S. J. Jan 1 2014 In : Nature Genetics. 46, 7, p. 669-677 9 p.

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Vital Capacity
Lung
Lung Diseases
Hispanic Americans
19 Citations

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

Tang, W. , Kowgier, M. , Loth, D. W. , Soler Artigas, M. , Joubert, B. R. , Hodge, E. , Gharib, S. A. , Smith, A. V. , Ruczinski, I. , Gudnason, V. , Mathias, R. A. , Harris, T. B. , Hansel, N. N. , Launer, L. J. , Barnes, K. C. , Hansen, J. G. , Albrecht, E. , Aldrich, M. C. , Allerhand, M. , Barr, R. G. & 61 others Brusselle, G. G., Couper, D. J., Curjuric, I., Davies, G., Deary, I. J., Dupuis, J., Fall, T., Foy, M., Franceschini, N., Gao, W., Gläser, S., Gu, X., Hancock, D. B., Heinrich, J., Hofman, A., Imboden, M., Ingelsson, E., James, A., Karrasch, S., Koch, B., Kritchevsky, S. B., Kumar, A., Lahousse, L., Li, G., Lind, L., Lindgren, C., Liu, Y., Lohman, K., Lumley, T., McArdle, W. L., Meibohm, B., Morris, A. P., Morrison, A. C., Musk, B., North, K. E., Palmer, L. J., Probst-Hensch, N. M., Psaty, B. M., Rivadeneira, F., Rotter, J. I., Schulz, H., Smith, L. J., Sood, A., Starr, J. M., Strachan, D. P., Teumer, A., Uitterlinden, A. G., Völzke, H., Voorman, A., Wain, L. V., Wells, M. T., Wilk, J. B., Williams, O. D., Heckbert, S. R., Stricker, B. H., London, S. J., Fornage, M., Tobin, M. D., O'Connor, G. T., Hall, I. P. & Cassano, P. A. Jul 1 2014 In : PLoS ONE. 9, 7, e100776

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Meta-Analysis
Lung
lung function
loci
22 Citations

Leveraging population admixture to characterize the heritability of complex traits

Zaitlen, N. , Pasaniuc, B. , Sankararaman, S. , Bhatia, G. , Zhang, J. , Gusev, A. , Young, T. , Tandon, A. , Pollack, S. , Vilhjálmsson, B. J. , Assimes, T. L. , Berndt, S. I. , Blot, W. J. , Chanock, S. , Franceschini, N. , Goodman, P. G. , He, J. , Hennis, A. J. M. , Hsing, A. , Ingles, S. A. & 21 others Isaacs, W., Kittles, R. A., Klein, E. A., Lange, L. A., Nemesure, B., Patterson, N., Reich, D., Rybicki, B. A., Stanford, J. L., Stevens, V. L., Strom, S. S., Whitsel, E. A., Witte, J. S., Xu, J., Haiman, C., Wilson, J. G., Kooperberg, C., Stram, D., Reiner, A. P., Tang, H. & Price, A. L. Jan 1 2014 In : Nature Genetics. 46, 12, p. 1356-1362 7 p.

Research output: Research - peer-reviewArticle

Population
African Americans
Single Nucleotide Polymorphism
Body Mass Index
Genome
326 Citations

Loss-of-function mutations in APOC3, triglycerides, and coronary disease

Crosby, J. , Peloso, G. M. , Auer, P. L. , Crosslin, D. R. , Stitziel, N. O. , Lange, L. A. , Lu, Y. , Tang, Z. Z. , Zhang, H. , Hindy, G. , Masca, N. , Stirrups, K. , Kanoni, S. , Do, R. , Jun, G. , Hu, Y. , Kang, H. M. , Xue, C. , Goel, A. , Farrall, M. & 66 others Duga, S., Merlini, P. A., Asselta, R., Girelli, D., Olivieri, O., Martinelli, N., Yin, W., Reilly, D., Speliotes, E., Fox, C. S., Hveem, K., Holmen, O. L., Nikpay, M., Farlow, D. N., Assimes, T. L., Franceschini, N., Robinson, J., North, K. E., Martin, L. W., DePristo, M., Gupta, N., Escher, S. A., Jansson, J. H., Van Zuydam, N., Palmer, C. N. A., Wareham, N., Koch, W., Meitinger, T., Peters, A., Lieb, W., Erbel, R., Konig, I. R., Kruppa, J., Degenhardt, F., Gottesman, O., Bottinger, E. P., O'Donnell, C. J., Psaty, B. M., Ballantyne, C. M., Abecasis, G., Ordovas, J. M., Melander, O., Watkins, H., Orho-Melander, M., Ardissino, D., Loos, R. J. F., McPherson, R., Willer, C. J., Erdmann, J., Hall, A. S., Samani, N. J., Deloukas, P., Schunkert, H., Wilson, J. G., Kooperberg, C., Rich, S. S., Tracy, R. P., Lin, D. Y., Altshuler, D., Gabriel, S., Nickerson, D. A., Jarvik, G. P., Cupples, L. A., Reiner, A. P., Boerwinkle, E. & Kathiresan, S. Jan 1 2014 In : New England Journal of Medicine. 371, 1, p. 22-31 10 p.

Research output: Research - peer-reviewArticle

Apolipoproteins
Coronary Disease
Triglycerides
Mutation
Genes
1 Citations

Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study

Franceschini, N., Tao, R., Liu, L., Rutherford, S., Haack, K., Almasy, L., Göring, H. H. H., Laston, S., Lee, E. T., Best, L. G., Fabsitz, R., Cole, S. A. & North, K. E. 2014 In : BMC Cardiovascular Disorders. 14, 1, 158

Research output: Research - peer-reviewArticle

Chromosomes, Human, Pair 17
North American Indians
Blood Pressure
Genes
Single Nucleotide Polymorphism
21 Citations

Meta-analysis of loci associated with age at natural menopause in African-American women

Chen, C. T. L. , Liu, C. T. , Chen, G. K. , Andrews, J. S. , Arnold, A. M. , Dreyfus, J. , Franceschini, N. , Garcia, M. E. , Kerr, K. F. , Li, G. , Lohman, K. K. , Musani, S. K. , Nalls, M. A. , Raffel, L. J. , Smith, J. , Ambrosone, C. B. , Bandera, E. V. , Bernstein, L. , Britton, A. , Brzyski, R. G. & 36 others Cappola, A., Carlson, C. S., Couper, D., Deming, S. L., Goodarzi, M. O., Heiss, G., John, E. M., Lu, X., Marchand, L. L., Marciante, K., Mcknight, B., Millikan, R., Nock, N. L., Olshan, A. F., Press, M. F., Vaiyda, D., Woods, N. F., Taylor, H. A., Zhao, W., Zheng, W., Evans, M. K., Harris, T. B., Henderson, B. E., Kardia, S. L. R., Kooperberg, C., Liu, Y., Mosley, T. H., Psaty, B., Wellons, M., Windham, B. G., Zonderman, A. B., Cupples, L. A., Demerath, E. W., Haiman, C., Murabito, J. M. & Rajkovic, A. 2014 In : Human Molecular Genetics. 23, 12, p. 3327-3342 16 p.

Research output: Research - peer-reviewArticle

Menopause
African Americans
Meta-Analysis
Genome-Wide Association Study
Bone Neoplasms
140 Citations

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry, J. R. B. , Day, F. , Elks, C. E. , Sulem, P. , Thompson, D. J. , Ferreira, T. , He, C. , Chasman, D. I. , Esko, T. , Thorleifsson, G. , Albrecht, E. , Ang, W. Q. , Corre, T. , Cousminer, D. L. , Feenstra, B. , Franceschini, N. , Ganna, A. , Johnson, A. D. , Kjellqvist, S. , Lunetta, K. L. & 178 others McMahon, G., Nolte, I. M., Paternoster, L., Porcu, E., Smith, A. V., Stolk, L., Teumer, A., Tšernikova, N., Tikkanen, E., Ulivi, S., Wagner, E. K., Amin, N., Bierut, L. J., Byrne, E. M., Hottenga, J. J., Koller, D. L., Mangino, M., Pers, T. H., Yerges-Armstrong, L. M., Zhao, J. H., Andrulis, I. L., Anton-Culver, H., Atsma, F., Bandinelli, S., Beckmann, M. W., Benitez, J., Blomqvist, C., Bojesen, S. E., Bolla, M. K., Bonanni, B., Brauch, H., Brenner, H., Buring, J. E., Chang-Claude, J., Chanock, S., Chen, J., Chenevix-Trench, G., Collée, J. M., Couch, F. J., Couper, D., Coviello, A. D., Cox, A., Czene, K., D'adamo, A. P., Smith, G. D., De Vivo, I., Demerath, E. W., Dennis, J., Devilee, P., Dieffenbach, A. K., Dunning, A. M., Eiriksdottir, G., Eriksson, J. G., Fasching, P. A., Ferrucci, L., Flesch-Janys, D., Flyger, H., Foroud, T., Franke, L., Garcia, M. E., García-Closas, M., Geller, F., De Geus, E. E. J., Giles, G. G., Gudbjartsson, D. F., Gudnason, V., Guénel, P., Guo, S., Hall, P., Hamann, U., Haring, R., Hartman, C. A., Heath, A. C., Hofman, A., Hooning, M. J., Hopper, J. L., Hu, F. B., Hunter, D. J., Karasik, D., Kiel, D. P., Knight, J. A., Kosma, V. M., Kutalik, Z., Lai, S., Lambrechts, D., Lindblom, A., Mägi, R., Magnusson, P. K., Mannermaa, A., Martin, N. G., Masson, G., McArdle, P. F., McArdle, W. L., Melbye, M., Michailidou, K., Mihailov, E., Milani, L., Milne, R. L., Nevanlinna, H., Neven, P., Nohr, E. A., Oldehinkel, A. J., Oostra, B. A., Palotie, A., Peacock, M., Pedersen, N. L., Peterlongo, P., Peto, J., Pharoah, P. D. P., Postma, D. S., Pouta, A., Pylkäs, K., Radice, P., Ring, S., Rivadeneira, F., Robino, A., Rose, L. M., Rudolph, A., Salomaa, V., Sanna, S., Schlessinger, D., Schmidt, M. K., Southey, M. C., Sovio, U., Stampfer, M. J., Stöckl, D., Storniolo, A. M., Timpson, N. J., Tyrer, J., Visser, J. A., Vollenweider, P., Völzke, H., Waeber, G., Waldenberger, M., Wallaschofski, H., Wang, Q., Willemsen, G., Winqvist, R., Wolffenbuttel, B. H. R., Wright, M. J., Boomsma, D. I., Econs, M. J., Khaw, K. T., Loos, R. J. F., McCarthy, M. I., Montgomery, G. W., Rice, J. P., Streeten, E. A., Thorsteinsdottir, U., Van Duijn, C. M., Alizadeh, B. Z., Bergmann, S., Boerwinkle, E., Boyd, H. A., Crisponi, L., Gasparini, P., Gieger, C., Harris, T. B., Ingelsson, E., Järvelin, M. R., Kraft, P., Lawlor, D., Metspalu, A., Pennell, C. E., Ridker, P. M., Snieder, H., Sørensen, T. I. A., Spector, T. D., Strachan, D. P., Uitterlinden, A. G., Wareham, N. J., Widen, E., Zygmunt, M., Murray, A., Easton, D. F., Stefansson, K., Murabito, J. M. & Ong, K. K. Oct 2 2014 In : Nature. 514, 7520, p. 92-97 6 p.

Research output: Research - peer-reviewArticle

Menarche
Puberty
GABA Receptors
Cytoplasmic and Nuclear Receptors
Rare Diseases
6 Citations

Prospective associations of coronary heart disease loci in African Americans using the MetaboChip: The PAGE study

Franceschini, N. , Hu, Y. , Reiner, A. P. , Buyske, S. , Nalls, M. , Yanek, L. R. , Li, Y. , Hindorff, L. A. , Cole, S. A. , Howard, B. V. , Stafford, J. M. , Carty, C. L. , Sethupathy, P. , Martin, L. W. , Lin, D. Y. , Johnson, K. C. , Becker, L. C. , North, K. E. , Dehghan, A. , Bis, J. C. & 11 others Liu, Y., Greenland, P., Manson, J. A. E., Maeda, N., Garcia, M., Harris, T. B., Becker, D. M., O'Donnell, C., Heiss, G., Kooperberg, C. & Boerwinkle, E. Dec 26 2014 In : PLoS ONE. 9, 12, e113203

Research output: Research - peer-reviewArticle

African Americans
loci
coronary disease
Coronary Disease
ancestry
14 Citations

Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians

Voruganti, V. S., Franceschini, N., Haack, K., Laston, S., MacCluer, J. W., Umans, J. G., Comuzzie, A. G., North, K. E. & Cole, S. A. Jan 1 2014 In : European Journal of Human Genetics. 22, 7, p. 938-943 6 p.

Research output: Research - peer-reviewArticle

North American Indians
Uric Acid
Serum
Genes
Population
5 Citations

Sequencing of 2 subclinical atherosclerosis candidate regions in 3669 individuals cohorts for heart and aging research in genomic epidemiology (charge) consortium targeted sequencing study

Bis, J. C., White, C. C., Franceschini, N., Brody, J., Zhang, X., Muzny, D., Santibanez, J., Gibbs, R., Liu, X., Lin, H., Boerwinkle, E., Psaty, B. M., North, K. E., Cupples, L. A. & O'Donnell, C. J. 2014 In : Circulation: Cardiovascular Genetics. 7, 3, p. 359-364 6 p.

Research output: Research - peer-reviewArticle

Carotid Intima-Media Thickness
Atherosclerosis
Epidemiology
Research
Genome-Wide Association Study
13 Citations

Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity

Ferrara, L. A., Wang, H., Umans, J. G., Franceschini, N., Jolly, S., Lee, E. T., Yeh, J., Devereux, R. B., Howard, B. V. & de Simone, G. Dec 1 2014 In : Nutrition, Metabolism and Cardiovascular Diseases. 24, 12, p. 1360-1364 5 p.

Research output: Research - peer-reviewArticle

Uric Acid
Obesity
Serum
Population
Fats
8 Citations

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function

Wang, Y. J., Tayo, B. O., Bandyopadhyay, A., Wang, H., Feng, T., Franceschini, N., Tang, H., Gao, J., Sung, Y. J., Elston, R. C., Williams, S. M., Cooper, R. S., Mu, T. W., Zhu, X. & Levy, D. Sep 1 2014 In : PLoS Genetics. 10, 9

Research output: Research - peer-reviewArticle

Endoplasmic Reticulum-Associated Degradation
Blood Pressure
endoplasmic reticulum
blood pressure
degradation
109 Citations

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

Lange, L. A. , Hu, Y. , Zhang, H. , Xue, C. , Schmidt, E. M. , Tang, Z. Z. , Bizon, C. , Lange, E. M. , Smith, J. D. , Turner, E. H. , Jun, G. , Kang, H. M. , Peloso, G. , Auer, P. , Li, K. P. , Flannick, J. , Zhang, J. , Fuchsberger, C. , Gaulton, K. , Lindgren, C. & 82 others Locke, A., Manning, A., Sim, X., Rivas, M. A., Holmen, O. L., Gottesman, O., Lu, Y., Ruderfer, D., Stahl, E. A., Duan, Q., Li, Y., Durda, P., Jiao, S., Isaacs, A., Hofman, A., Bis, J. C., Correa, A., Griswold, M. E., Jakobsdottir, J., Smith, A. V., Schreiner, P. J., Feitosa, M. F., Zhang, Q., Huffman, J. E., Crosby, J., Wassel, C. L., Do, R., Franceschini, N., Martin, L. W., Robinson, J. G., Assimes, T. L., Crosslin, D. R., Rosenthal, E. A., Tsai, M., Rieder, M. J., Farlow, D. N., Folsom, A. R., Lumley, T., Fox, E. R., Carlson, C. S., Peters, U., Jackson, R. D., Van Duijn, C. M., Uitterlinden, A. G., Levy, D., Rotter, J. I., Taylor, H. A., Gudnason, V., Siscovick, D. S., Fornage, M., Borecki, I. B., Hayward, C., Rudan, I., Chen, Y. E., Bottinger, E. P., Loos, R. J. F., Sætrom, P., Hveem, K., Boehnke, M., Groop, L., McCarthy, M., Meitinger, T., Ballantyne, C. M., Gabriel, S. B., O'Donnell, C. J., Post, W. S., North, K. E., Reiner, A. P., Boerwinkle, E., Psaty, B. M., Altshuler, D., Kathiresan, S., Lin, D. Y., Jarvik, G. P., Cupples, L. A., Kooperberg, C., Wilson, J. G., Nickerson, D. A., Abecasis, G. R., Rich, S. S., Tracy, R. P. & Willer, C. J. Feb 6 2014 In : American Journal of Human Genetics. 94, 2, p. 233-245 13 p.

Research output: Research - peer-reviewArticle

Exome
LDL Cholesterol
Genes
Genome-Wide Association Study
Lipids
2013
17 Citations

A common biological basis of obesity and nicotine addiction

Thorgeirsson, T. E. , Gudbjartsson, D. F. , Sulem, P. , Besenbacher, S. , Styrkarsdottir, U. , Thorleifsson, G. , Walters, G. B. , Furberg, H. , Sullivan, P. F. , Marchini, J. , McCarthy, M. I. , Steinthorsdottir, V. , Thorsteinsdottir, U. , Stefansson, K. , Surakka, I. , Vink, J. M. , Amin, N. , Geller, F. , Rafnar, T. , Esko, T. & 258 others Walter, S., Gieger, C., Rawal, R., Mangino, M., Prokopenko, I., Mägi, R., Keskitalo, K., Gudjonsdottir, I. H., Gretarsdottir, S., Stefansson, H., Aulchenko, Y. S., Nelis, M., Aben, K. K., Den Heijer, M., Soranzo, N., Valdes, A. M., Steves, C., Uitterlinden, A. G., Hofman, A., Tönjes, A., Kovacs, P., Hottenga, J. J., Willemsen, G., Vogelzangs, N., Döring, A., Dahmen, N., Nitz, B., Ripatti, S., Perola, M., Kettunen, J., Hartikainen, A. L., Pouta, A., Laitinen, J., Isohanni, M., Huei-Yi, S., Allen, M., Krestyaninova, M., Hall, A. S., Thompson, J. R., Oskarsson, H., Tyrfingsson, T., Kiemeney, L. A., Järvelin, M. R., Salomaa, V., Stumvoll, M., Spector, T. D., Wichmann, H. E., Metspalu, A., Samani, N. J., Penninx, B. W., Oostra, B. A., Boomsma, D. I., Tiemeier, H., Van Duijn, C. M., Kaprio, J., Gulcher, J. R., Kim, Y. J., Dackor, J., Boerwinkle, E., Franceschini, N., Ardissino, D., Bernardinelli, L., Mannucci, P. M., Mauri, F., Merlini, P. A., Absher, D., Assimes, T. L., Fortmann, S. P., Iribarren, C., Knowles, J. W., Quertermous, T., Ferrucci, L., Tanaka, T., Bis, J. C., Furberg, C. D., Haritunians, T., McKnight, B., Psaty, B. M., Taylor, K. D., Thacker, E. L., Almgren, P., Groop, L., Ladenvall, C., Boehnke, M., Jackson, A. U., Mohlke, K. L., Stringham, H. M., Tuomilehto, J., Benjamin, E. J., Hwang, S. J., Levy, D., Preis, S. R., Vasan, R. S., Duan, J., Gejman, P. V., Levinson, D. F., Sanders, A. R., Shi, J., Lips, E. H., McKay, J. D., Agudo, A., Barzan, L., Bencko, V., Benhamou, S., Castellsagué, X., Canova, C., Conway, D. I., Fabianova, E., Foretova, L., Janout, V., Healy, C. M., Holcátová, I., Kjaerheim, K., Lagiou, P., Lissowska, J., Lowry, R., Macfarlane, T. V., Mates, D., Richiardi, L., Rudnai, P., Szeszenia-Dabrowska, N., Zaridze, D., Znaor, A., Lathrop, M., Brennan, P., Bandinelli, S., Frayling, T. M., Guralnik, J. M., Milaneschi, Y., Perry, J. R. B., Altshuler, D., Elosua, R., Kathiresan, S., Lucas, G., Melander, O., O'Donnell, C. J., Schwartz, S. M., Voight, B. F., Smit, J. H., De Geus, E. J. C., Chanock, S. J., Gu, F., Hankinson, S. E., Hunter, D. J., Chasman, D. I., Everett, B. M., Paré, G., Ridker, P. M., Li, M. D., Maes, H. H., Audrain-McGovern, J., Posthuma, D., Thornton, L. M., Lerman, C., Rose, J. E., Ioannidis, J. P. A., Kraft, P., Lin, D. Y., Liu, J. S., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., Berrettini, W., Knouff, C. W., Yuan, X., Waeber, G., Vollenweider, P., Preisig, M., Wareham, N. J., Zhao, J. H., Loos, R. J. F., Barroso, I., Khaw, K. T., Grundy, S., Barter, P., Mahley, R., Kesaniemi, A., McPherson, R., Vincent, J., Strauss, J., Kennedy, J., Farmer, A., McGuffin, P., Day, R., Matthews, K., Bakke, P., Gulsvik, A., Lucae, S., Ising, M., Brueckl, T., Horstmann, S., Heinrich, J., Lamina, C., Polasek, O., Zgaga, L., Huffman, J., Campbell, S., Kooner, J., Chambers, J. C., Burnett, M. S., Devaney, J., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Epstein, S., Wilson, J. F., Wild, S. H., Campbell, H., Vitart, V., Reilly, M. P., Li, M., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Rader, D. J., Franke, A., Wittig, M., Schäfer, A., Uda, M., Terracciano, A., Xiao, X., Busonero, F., Scheet, P., Schlessinger, D., Clair, D. S., Rujescu, D., Abecasis, G. R., Grabe, H. J., Teumer, A., Völzke, H., Petersmann, A., John, U., Rudan, I., Hayward, C., Wright, A. F., Kolcic, I., Wright, B. J., Balmforth, A. J., Anderson, C. A., Ahmed, T., Mathew, C. G., Parkes, M., Satsangi, J., Caulfield, M., Munroe, P. B., Farrall, M., Dominiczak, A., Worthington, J., Thomson, W., Eyre, S., Barton, A., Mooser, V. & Francks, C. Nov 4 2013 In : Translational Psychiatry. 3, p. 1-7 7 p., e308

Research output: Research - peer-reviewArticle

Nicotine
Obesity
Smoking
Single Nucleotide Polymorphism
Body Mass Index
40 Citations

A genome-wide association study of early menopause and the combined impact of identified variants

Perry, J. R. B. , Corre, T. , Esko, T. , Chasman, D. I. , Fischer, K. , Franceschini, N. , He, C. , Kutalik, Z. , Mangino, M. , Rose, L. M. , Vernon smith, A. , Stolk, L. , Sulem, P. , Weedon, M. N. , Zhuang, W. V. , Arnold, A. , Ashworth, A. , Bergmann, S. , Buring, J. E. , Burri, A. & 46 others Chen, C., Cornelis, M. C., Couper, D. J., Goodarzi, M. O., Gudnason, V., Harris, T., Hofman, A., Jones, M., Kraft, P., Launer, L., Laven, J. S. E., Li, G., Mcknight, B., Masciullo, C., Milani, L., Orr, N., Psaty, B. M., Ridker, P. M., Rivadeneira, F., Sala, C., Salumets, A., Schoemaker, M., Traglia, M., Waeber, G., Chanock, S. J., Demerath, E. W., Garcia, M., Hankinson, S. E., Hu, F. B., Hunter, D. J., Lunetta, K. L., Metspalu, A., Montgomery, G. W., Murabito, J. M., Newman, A. B., Ong, K. K., Spector, T. D., Stefansson, K., Swerdlow, A. J., Thorsteinsdottir, U., Van dam, R. M., Uitterlinden, A. G., Visser, J. A., Vollenweider, P., Toniolo, D. & Murray, A. Apr 2013 In : Human Molecular Genetics. 22, 7, p. 1465-1472 8 p., dds551

Research output: Research - peer-reviewArticle

Genome-Wide Association Study
Menopause
Primary Ovarian Insufficiency
Western World
Infertility
80 Citations

APOL1 variants associate with increased risk of CKD among African Americans

Foster, M. C., Coresh, J., Fornage, M., Astor, B. C., Grams, M., Franceschini, N., Boerwinkle, E., Parekh, R. S. & Kao, W. H. L. Sep 2013 In : Journal of the American Society of Nephrology. 24, 9, p. 1484-1491 8 p.

Research output: Research - peer-reviewArticle

African Americans
Chronic Kidney Failure
Alleles
AIDS-Associated Nephropathy
Focal Segmental Glomerulosclerosis
23 Citations

Association of adiposity genetic variants with menarche timing in 92,105 women of European descent

Fernández-Rhodes, L. , Demerath, E. W. , Cousminer, D. L. , Tao, R. , Dreyfus, J. G. , Esko, T. , Smith, A. V. , Gudnason, V. , Harris, T. B. , Launer, L. , McArdle, P. F. , Yerges-Armstrong, L. M. , Elks, C. E. , Strachan, D. P. , Kutalik, Z. , Vollenweider, P. , Feenstra, B. , Boyd, H. A. , Metspalu, A. , Mihailov, E. & 55 others Broer, L., Carola Zillikens, M., Oostra, B., Van Duijn, C. M., Lunetta, K. L., Perry, J. R. B., Murray, A., Koller, D. L., Lai, D., Corre, T., Toniolo, D., Albrecht, E., Stöckl, D., Grallert, H., Gieger, C., Hayward, C., Polasek, O., Rudan, I., Wilson, J. F., He, C., Kraft, P., Hu, F. B., Hunter, D. J., Hottenga, J. J., Willemsen, G., Boomsma, D. I., Byrne, E. M., Martin, N. G., Montgomery, G. W., Warrington, N. M., Pennell, C. E., Stolk, L., Visser, J. A., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Lin, P., Fisher, S. L., Bierut, L. J., Crisponi, L., Porcu, E., Mangino, M., Zhai, G., Spector, T. D., Buring, J. E., Rose, L. M., Ridker, P. M., Poole, C., Hirschhorn, J. N., Murabito, J. M., Chasman, D. I., Widen, E., North, K. E., Ong, K. K. & Franceschini, N. Aug 1 2013 In : American Journal of Epidemiology. 178, 3, p. 451-460 10 p.

Research output: Research - peer-reviewArticle

Menarche
Adiposity
Obesity
Single Nucleotide Polymorphism
Linear Models
30 Citations

Association of functional polymorphism rs2231142 (Q141K) in the ABCG2 gene with serum uric acid and gout in 4 US populations

Zhang, L. , Spencer, K. L. , Voruganti, V. S. , Jorgensen, N. W. , Fornage, M. , Best, L. G. , Brown-Gentry, K. D. , Cole, S. A. , Crawford, D. C. , Deelman, E. , Franceschini, N. , Gaffo, A. L. , Glenn, K. R. , Heiss, G. , Jenny, N. S. , Kottgen, A. , Li, Q. , Liu, K. , Matise, T. C. , North, K. E. & 2 others Umans, J. G. & Kao, W. H. L. May 1 2013 In : American Journal of Epidemiology. 177, 9, p. 923-932 10 p.

Research output: Research - peer-reviewArticle

Gout
Uric Acid
Adenosine Triphosphate
Serum
Population
3 Citations

Association of heat shock proteins with all-cause mortality

Broer, L. , Demerath, E. W. , Garcia, M. E. , Homuth, G. , Kaplan, R. C. , Lunetta, K. L. , Tanaka, T. , Tranah, G. J. , Walter, S. , Arnold, A. M. , Atzmon, G. , Harris, T. B. , Hoffmann, W. , Karasik, D. , Kiel, D. P. , Kocher, T. , Launer, L. J. , Lohman, K. K. , Rotter, J. I. , Tiemeier, H. & 15 others Uitterlinden, A. G., Wallaschofski, H., Bandinelli, S., Dörr, M., Ferrucci, L., Franceschini, N., Gudnason, V., Hofman, A., Liu, Y., Murabito, J. M., Newman, A. B., Oostra, B. A., Psaty, B. M., Smith, A. V. & Van Duijn, C. M. Aug 2013 In : Age. 35, 4, p. 1367-1376 10 p.

Research output: Research - peer-reviewArticle

Heat-Shock Proteins
Shock
Hot Temperature
Mortality
Single Nucleotide Polymorphism
40 Citations

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling

Ho, J. E. , Chen, W. Y. , Chen, M. H. , Larson, M. G. , McCabe, E. L. , Cheng, S. , Ghorbani, A. , Coglianese, E. , Emilsson, V. , Johnson, A. D. , Walter, S. , Franceschini, N. , O'Donnell, C. J. , Dehghan, A. , Lu, C. , Levy, D. , Newton-Cheh, C. , Lin, H. , Felix, J. F. , Schreiter, E. R. & 4 others Vasan, R. S., Januzzi, J. L., Lee, R. T. & Wang, T. J. Oct 1 2013 In : Journal of Clinical Investigation. 123, 10, p. 4208-4218 11 p.

Research output: Research - peer-reviewArticle

Interleukin-33
Protein Isoforms
Genome-Wide Association Study
Immune System Diseases
Single Nucleotide Polymorphism