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2018

Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study

Balakrishnan, P., Navas-Acien, A., Haack, K., Vaidya, D., Umans, J. G., Best, L. G., Goessler, W., Francesconi, K. A., Franceschini, N., North, K. E., Cole, S. A., Voruganti, V. S. & Gribble, M. O., Jun 1 2018, In : Toxicology and Applied Pharmacology. 348, p. 123-129 7 p.

Research output: Contribution to journalArticle

Arsenic
Cell Communication
Amino acids
Genes
Single Nucleotide Polymorphism

Association of APOL1 with heart failure with preserved ejection fraction in postmenopausal African American women

Franceschini, N., Kopp, J. B., Barac, A., Martin, L. W., Li, Y., Qian, H., Reiner, A. P., Pollak, M., Wallace, R. B., Rosamond, W. D. & Winkler, C. A., Aug 1 2018, In : JAMA Cardiology. 3, 8, p. 712-720 9 p.

Research output: Contribution to journalArticle

African Americans
Heart Failure
Genotype
Glomerular Filtration Rate
Coronary Disease

Author Correction: GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk (Nature Communications (2017) DOI: 10.1038/s41467-017-01490-8)

Pirastu, N., Joshi, P. K., De Vries, P. S., Cornelis, M. C., McKeigue, P. M., Keum, N., Franceschini, N., Colombo, M., Giovannucci, E. L., Spiliopoulou, A., Franke, L., North, K. E., Kraft, P., Morrison, A. C., Esko, T. & Wilson, J. F., Dec 1 2018, In : Nature Communications. 9, 1, 2536

Research output: Contribution to journalComment/debate

Genome-Wide Association Study
Alopecia
loci
communication
liabilities
1 Citations

Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians

Oliver-Williams, C., Howard, A. G., Navas-Acien, A., Howard, B. V., Tellez-Plaza, M. & Franceschini, N., Jun 1 2018, In : Journal of the American Society of Hypertension. 12, 6, p. 426-437.e9

Research output: Contribution to journalArticle

Body Burden
North American Indians
Cadmium
Cohort Studies
Prospective Studies

Effect of pregnancy on disease flares in patients with systemic lupus erythematosus

Eudy, A. M., Siega-Riz, A. M., Engel, S. M., Franceschini, N., Howard, A. G., Clowse, M. E. B. & Petri, M., Jun 1 2018, In : Annals of the Rheumatic Diseases. 77, 6, p. 855-860 6 p.

Research output: Contribution to journalArticle

Open channel flow
Systemic Lupus Erythematosus
Hydroxychloroquine
Pregnancy
Postpartum Period

Genetic Testing in Clinical Settings

Franceschini, N., Frick, A. & Kopp, J. B., Jan 1 2018, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

Genetic Testing
Health Literacy
Incidental Findings
Pharmacogenetics
Pharmaceutical Preparations

Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women

Sarnowski, C., Kavousi, M., Isaacs, S., Demerath, E. W., Broer, L., Muka, T., Franco, O. H., Ikram, M. A., Uitterlinden, A., Franceschini, N., Lunetta, K. L. & Murabito, J. M., Apr 1 2018, In : Menopause. 25, 4, p. 451-457 7 p.

Research output: Contribution to journalArticle

Menopause
Cardiovascular Diseases
Genetic Pleiotropy
Alleles
Genome-Wide Association Study

Low agreement between modified-Schwartz and CKD-EPI eGFR in young adults: A retrospective longitudinal cohort study

Webster-Clark, M., Jaeger, B., Zhong, Y., Filler, G., Alvarez-Elias, A., Franceschini, N. & Díaz-González De Ferris, M. E., Aug 6 2018, In : BMC Nephrology. 19, 1, 194

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Chronic Renal Insufficiency
Longitudinal Studies
Young Adult
Cohort Studies

Reply to 'Misestimation of heritability and prediction accuracy of male-pattern baldness'

Pirastu, N., Joshi, P. K., De Vries, P. S., Cornelis, M. C., Keum, N., Franceschini, N., Colombo, M., Giovannucci, E. L., Spiliopoulou, A., Franke, L., North, K. E., Kraft, P., Morrison, A. C., Esko, T. & Wilson, J. F., Dec 1 2018, In : Nature Communications. 9, 1, 2538

Research output: Contribution to journalLetter

Alopecia
predictions

Response to: 'Postpartum breastfeeding status' by Betzold

Eudy, A. M., Siega-Riz, A. M., Engel, S. M., Franceschini, N., Howard, A. G., Clowse, M. E. B. & Petri, M., Apr 11 2018, (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Breast Feeding
Postpartum Period

Serum Calcification Propensity and Fetuin-A: Biomarkers of Cardiovascular Disease in Kidney Transplant Recipients

Bostom, A., Pasch, A., Madsen, T., Roberts, M. B., Franceschini, N., Steubl, D., Garimella, P. S., Ix, J. H., Tuttle, K. R., Ivanova, A., Shireman, T., Gohh, R., Merhi, B., Jarolim, P., Kusek, J. W., Pfeffer, M. A., Liu, S. & Eaton, C. B., Jul 11 2018, (Accepted/In press) In : American Journal of Nephrology. p. 21-31 11 p.

Research output: Contribution to journalArticle

alpha-2-HS-Glycoprotein
Cardiovascular Diseases
Biomarkers
Kidney
Serum

Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure

Bostom, A., Steubl, D., Garimella, P. S., Franceschini, N., Roberts, M. B., Pasch, A., Ix, J. H., Tuttle, K. R., Ivanova, A., Shireman, T., Kim, S. J., Gohh, R., Weiner, D. E., Levey, A. S., Hsu, C. Y., Kusek, J. W. & Eaton, C. B., May 1 2018, In : American Journal of Nephrology. 47, 4, p. 275-282 8 p.

Research output: Contribution to journalArticle

Uromodulin
Renal Insufficiency
Allografts
Biomarkers
Serum
2017

Accuracy of self-reported weight in Hispanic/Latino adults of the hispanic community health study/study of latinos

Fernández-Rhodes, L., Robinson, W. R., Sotres-Alvarez, D., Franceschini, N., Castañeda, S. F., Buelna, C., Moncrieft, A., Llabre, M., Daviglus, M. L., Qi, Q., Agarwal, A., Isasi, C. R., Smokowski, P., North, K. E. & Gordon-Larsen, P., Jan 1 2017, In : Epidemiology. 28, 6, p. 847-853 7 p.

Research output: Contribution to journalArticle

Hispanic Americans
Weights and Measures
Health
Body Weight
Body Size
4 Citations

Admixture mapping identifies an amerindian ancestry locus associated with albuminuria in hispanics in the United States

Brown, L. A., Sofer, T., Stilp, A. M., Baier, L. J., Kramer, H. J., Masindova, I., Levy, D., Hanson, R. L., Moncrieft, A. E., Redline, S., Rosas, S. E., Lash, J. P., Cai, J., Laurie, C. C., Browning, S., Thornton, T. & Franceschini, N., Jul 1 2017, In : Journal of the American Society of Nephrology. 28, 7, p. 2211-2220 10 p.

Research output: Contribution to journalArticle

1 Citations

Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits

Sofer, T., Baier, L. J., Browning, S. R., Thornton, T. A., Talavera, G. A., Wassertheil-Smoller, S., Daviglus, M. L., Hanson, R., Kobes, S., Cooper, R. S., Cai, J., Levy, D., Reiner, A. P. & Franceschini, N., Nov 1 2017, In : PloS one. 12, 11, e0188400

Research output: Contribution to journalArticle

Heritable Quantitative Trait
Hispanic Americans
community health
Diastole
North American Indians
8 Citations

African ancestry-specific alleles and kidney disease risk in hispanics/latinos

Kramer, H. J. , Stilp, A. M. , Laurie, C. C. , Reiner, A. P. , Lash, J. , Daviglus, M. L. , Rosas, S. E. , Ricardo, A. C. , Tayo, B. O. , Flessner, M. F. , Kerr, K. F. , Peralta, C. , Durazo-Arvizu, R. , Conomos, M. , Thornton, T. , Rotter, J. , Taylor, K. D. , Cai, J. , Eckfeldt, J. , Chen, H. & 2 others Papanicolau, G. & Franceschini, N., Mar 1 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 915-922 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Kidney Diseases
Chronic Renal Insufficiency
Hispanic Americans
Alleles
8 Citations

Association of cardiometabolic genes with arsenic metabolism biomarkers in American Indian communities: The strong heart family study (SHFS)

Balakrishnan, P., Vaidya, D., Franceschini, N., Saroja Voruganti, V., Gribble, M. O., Haack, K., Laston, S., Umans, J. G., Francesconi, K. A., Goessler, W., North, K. E., Lee, E., Yracheta, J., Best, L. G., Maccluer, J. W., Kent, J., Cole, S. A. & Navas-Acien, A., Jan 1 2017, In : Environmental health perspectives. 125, 1, p. 15-22 8 p.

Research output: Contribution to journalArticle

North American Indians
Arsenic
Biomarkers
Genes
Cacodylic Acid
4 Citations

Dietary determinants of cadmium exposure in the Strong Heart Family Study

Olmedo, P., Grau-Perez, M., Fretts, A., Tellez-Plaza, M., Gil, F., Yeh, F., Umans, J. G., Francesconi, K. A., Goessler, W., Franceschini, N., Lee, E. T., Best, L. G., Cole, S. A., Howard, B. V. & Navas-Acien, A., Feb 1 2017, In : Food and Chemical Toxicology. 100, p. 239-246 8 p.

Research output: Contribution to journalArticle

family studies
Cadmium
cadmium
heart
Meats
2 Citations

Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: The Hispanic Community Health Study/Study of Latinos

Sofer, T., Wong, Q., Hartwig, F. P., Taylor, K., Warren, H. R., Evangelou, E., Cabrera, C. P., Levy, D., Kramer, H., Lange, L. A., Horta, B. L., Kerr, K. F., Reiner, A. P. & Franceschini, N., Dec 1 2017, In : Scientific Reports. 7, 1, 10348

Research output: Contribution to journalArticle

2 Citations

GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk

Pirastu, N., Joshi, P. K., De Vries, P. S., Cornelis, M. C., McKeigue, P. M., Keum, N., Franceschini, N., Colombo, M., Giovannucci, E. L., Spiliopoulou, A., Franke, L., North, K. E., Kraft, P., Morrison, A. C., Esko, T. & Wilson, J. F., Dec 1 2017, In : Nature Communications. 8, 1, 1490

Research output: Contribution to journalArticle

disease prevalence
risk assessment
genome
gene expression
Genome-Wide Association Study
3 Citations

Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure

He, K. Y., Wang, H., Cade, B. E., Nandakumar, P., Giri, A., Ware, E. B., Haessler, J., Liang, J., Smith, J. A., Franceschini, N., Le, T. H., Kooperberg, C., Edwards, T. L., Kardia, S. L. R., Lin, X., Chakravarti, A., Redline, S. & Zhu, X., Mar 1 2017, In : PLoS genetics. 13, 3, e1006678

Research output: Contribution to journalArticle

hypotension
foxes
linkage (genetics)
family studies
blood
2016
2 Citations

A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women

Taylor, K. C. , Evans, D. S. , Edwards, D. R. V. , Edwards, T. L. , Sofer, T. , Li, G. , Liu, Y. , Franceschini, N. , Jackson, R. D. , Giri, A. , Donneyong, M. , Psaty, B. , Rotter, J. I. , LaCroix, A. Z. , Jordan, J. M. , Robbins, J. A. , Lewis, B. , Stefanick, M. L. , Liu, Y. , Garcia, M. & 3 others Harris, T., Cauley, J. A. & North, K. E., Dec 1 2016, In : Bone Reports. 5, p. 233-242 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
African Americans
Meta-Analysis
Single Nucleotide Polymorphism
Health

AS3MT, locus 10q24 and arsenic metabolism biomarkers in American Indians: The strong heart family study

Balakrishnan, P., Vaidya, D., Franceschini, N., Voruganti, V. S., Gribble, M., Haack, K., Laston, S., Umans, J., Francesconi, K., Goessler, W., North, K., Lee, E., Yracheta, J., Best, L., Maccluer, J., Kent, J., Cole, S. & Navas-Acien, A., Jan 1 2016, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. Bhattacharya, P., Jacks, G., Bundschuh, J., Naidu, R., Bhattacharya, P., Sparrenbom, C., Jarsjo, J., Kumpiene, J., Bundschuh, J., Naidu, R., Vahter, M., Donselaar, M. E., Ahmad, A. & Jarsjo, J. (eds.). CRC Press/Balkema, p. 443-445 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arsenic
Biomarkers
Metabolism
biomarker
arsenic
2 Citations

Comparison of 2 models for gene-environment interactions: An example of simulated gene-medication interactions on systolic blood pressure in family-based data

Fernández-Rhodes, L., Hodonsky, C. J., Graff, M., Love, S. A. M., Howard, A. G., Seyerle, A. A., Avery, C. L., Chittoor, G., Franceschini, N., Voruganti, V. S., Young, K., O'Connell, J. R., North, K. E. & Justice, A. E., Jan 1 2016, In : BMC Proceedings. 10, 65

Research output: Contribution to journalArticle

Gene-Environment Interaction
Blood pressure
Single Nucleotide Polymorphism
Genes
Blood Pressure

Genome-wide association of trajectories of systolic blood pressure change

Justice, A. E., Howard, A. G., Chittoor, G., Fernandez-Rhodes, L., Graff, M., Voruganti, V. S., Diao, G., Love, S. A. M., Franceschini, N., O'Connell, J. R., Avery, C. L., Young, K. L. & North, K. E., Jan 1 2016, In : BMC Proceedings. 10, 56

Research output: Contribution to journalArticle

Blood pressure
Genes
Trajectories
Genome
Blood Pressure
4 Citations

Kidney Function and Cardiovascular Events in Postmenopausal Women: The Impact of Race and Ethnicity in the Women's Health Initiative

Arce, C. M., Rhee, J. J., Cheung, K. L., Hedlin, H., Kapphahn, K., Franceschini, N., Kalil, R. S., Martin, L. W., Qi, L., Shara, N. M., Desai, M., Stefanick, M. L. & Winkelmayer, W. C., Feb 1 2016, In : American Journal of Kidney Diseases. 67, 2, p. 198-208 11 p.

Research output: Contribution to journalArticle

Women's Health
Glomerular Filtration Rate
Kidney
Hispanic Americans
African Americans
2 Citations

Smoking patterns and chronic kidney disease in US Hispanics: Hispanic Community Health Study/Study of Latinos

Franceschini, N., Deng, Y., Flessner, M. F., Eckfeldt, J. H., Kramer, H. J., Lash, J. P., Lee, D. J., Melamed, M. L., Moncrieft, A. E., Ricardo, A. C., Rosas, S. E., Kaplan, R. C., Raij, L. & Cai, J., Oct 1 2016, In : Nephrology Dialysis Transplantation. 31, 10, p. 1670-1676 7 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Hispanic Americans
Smoking
Health
Odds Ratio
2015
319 Citations

A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

Nikpay, M. , Goel, A. , Won, H. H. , Hall, L. M. , Willenborg, C. , Kanoni, S. , Saleheen, D. , Kyriakou, T. , Nelson, C. P. , CHopewell, J. , Webb, T. R. , Zeng, L. , Dehghan, A. , Alver, M. , MArmasu, S. , Auro, K. , Bjonnes, A. , Chasman, D. I. , Chen, S. , Ford, I. & 131 others Franceschini, N., Gieger, C., Grace, C., Gustafsson, S., Huang, J., Hwang, S. J., Kim, Y. K., Kleber, M. E., Lau, K. W., Lu, X., Lu, Y., Lyytikäinen, L. P., Mihailov, E., Morrison, A. C., Pervjakova, N., Qu, L., Rose, L. M., Salfati, E., Saxena, R., Scholz, M., Smith, A. V., Tikkanen, E., Uitterlinden, A., Yang, X., Zhang, W., Zhao, W., De Andrade, M., De Vries, P. S., Van Zuydam, N. R., Anand, S. S., Bertram, L., Beutner, F., Dedoussis, G., Frossard, P., Gauguier, D., Goodall, A. H., Gottesman, O., Haber, M., Han, B. G., Huang, J., Jalilzadeh, S., Kessler, T., König, I. R., Lannfelt, L., Lieb, W., Lind, L., MLindgren, C., Lokki, M. L., Magnusson, P. K., Mallick, N. H., Mehra, N., Meitinger, T., Memon, F. U. R., Morris, A. P., Nieminen, M. S., Pedersen, N. L., Peters, A., Rallidis, L. S., Rasheed, A., Samuel, M., Shah, S. H., Sinisalo, J., EStirrups, K., Trompet, S., Wang, L., Zaman, K. S., Ardissino, D., Boerwinkle, E., Borecki, I. B., Bottinger, E. P., Buring, J. E., Chambers, J. C., Collins, R., Cupples, L., Danesh, J., Demuth, I., Elosua, R., Epstein, S. E., Esko, T., Feitosa, M. F., Franco, O. H., Franzosi, M. G., Granger, C. B., Gu, D., Gudnason, V., SHall, A., Hamsten, A., Harris, T. B., LHazen, S., Hengstenberg, C., Hofman, A., Ingelsson, E., Iribarren, C., Jukema, J. W., Karhunen, P. J., Kim, B. J., Kooner, J. S., Kullo, I. J., Lehtimäki, T., Loos, R. J. F., Melander, O., Metspalu, A., März, W., Palmer, C. N., Perola, M., Quertermous, T., Rader, D. J., Ridker, P. M., Ripatti, S., Roberts, R., Salomaa, V., Sanghera, D. K., Schwartz, S. M., Seedorf, U., Stewart, A. F., Stott, D. J., Thiery, J., Zalloua, P. A., O'Donnell, C. J., Reilly, M. P., Assimes, T. L., Thompson, J. R., Erdmann, J., Clarke, R., Watkins, H., Kathiresan, S., McPherson, R., Deloukas, P., Schunkert, H., Samani, N. J. & Farrall, M., Jan 1 2015, In : Nature Genetics. 47, 10, p. 1121-1130 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Meta-Analysis
Coronary Artery Disease
Genome
Gene Frequency
8 Citations

Adiposity patterns and the risk for ESRD in postmenopausal women

Franceschini, N., Gouskova, N. A., Reiner, A. P., Bostom, A., Howard, B. V., Pettinger, M., Umans, J. G., Brookhart, M. A., Winkelmayer, W. C., Eaton, C. B., Heiss, G. & Fine, J. P., Jan 1 2015, In : Clinical Journal of the American Society of Nephrology. 10, 2, p. 241-250 10 p.

Research output: Contribution to journalArticle

Adiposity
Chronic Kidney Failure
Waist Circumference
Body Mass Index
Confidence Intervals
5 Citations

Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling

Tao, R., Zeng, D., Franceschini, N., North, K. E., Boerwinkle, E. & Lin, D. Y., Apr 3 2015, In : Journal of the American Statistical Association. 110, 510, p. 560-572 13 p.

Research output: Contribution to journalArticle

Linear regression
Sequencing
Dependent
Simultaneous Inference
Genetic Association
8 Citations

Both rare and common variants in PCSK9 influence plasma low-density lipoprotein cholesterol level in American Indians

Tsai, C. W., North, K. E., Tin, A., Haack, K., Franceschini, N., Voruganti, V. S., Laston, S., Zhang, Y., Best, L. G., MacCluer, J. W., Beaty, T. H., Navas-Acien, A., Kao, W. H. L. & Howard, B. V., Feb 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 2, p. E345-E349

Research output: Contribution to journalArticle

Proprotein Convertases
Subtilisin
North American Indians
LDL Cholesterol
Plasmas
39 Citations

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis

Freitag, D. , Butterworth, A. S. , Willeit, P. , Howson, J. M. M. , Burgess, S. , Kaptoge, S. , Young, R. , Ho, W. K. , Wood, A. M. , Sweeting, M. , Spackman, S. , Staley, J. R. , Ramond, A. , Harshfield, E. , Nielsen, S. F. , Grande, P. , Lange, L. A. , Bown, M. J. , Jones, G. T. , Scott, R. A. & 133 others Bevan, S., Porcu, E., Thorleifsson, G., Zeng, L., Kessler, T., Nikpay, M., Do, R., Zhang, W., Hopewell, J. C., Kleber, M., Delgado, G. E., Nelson, C. P., Goel, A., Bis, J. C., Dehghan, A., Ligthart, S., Smith, A. V., Qu, L., van 't Hof, F. N. G., de Bakker, P. I. W., Baas, A. F., van Rij, A., Tromp, G., Kuivaniemi, H., Ritchie, M. D., Verma, S. S., Crawford, D. C., Malinowski, J., de Andrade, M., Kullo, I. J., Peissig, P. L., McCarty, C. A., Böttinger, E. P., Gottesman, O., Crosslin, D. R., Carrell, D. S., Rasmussen-Torvik, L. J., Pacheco, J. A., Huang, J., Timpson, N. J., Kettunen, J., Ala-Korpela, M., Mitchell, G. F., Parsa, A., Wilkinson, I. B., Gorski, M., Li, Y., Franceschini, N., Keller, M. F., Ganesh, S. K., Langefeld, C. D., Bruijn, L., Brown, M. A., Evans, D. M., Baltic, S., Ferreira, M. A., Baurecht, H., Weidinger, S., Franke, A., Lubitz, S. A., Müller-Nurasyid, M., Felix, J. F., Smith, N. L., Sudman, M., Thompson, S. D., Zeggini, E., Panoutsopoulou, K., Nalls, M. A., Singleton, A., Polychronakos, C., Bradfield, J. P., Hakonarson, H., Easton, D. F., Thompson, D., Tomlinson, I. P., Dunlop, M., Hemminki, K., Morgan, G., Eisen, T., Goldschmidt, H., Allan, J. M., Henrion, M., Whiffin, N., Wang, Y., Chubb, D., Iles, M. M., Bishop, D. T., Law, M. H., Hayward, N. K., Luo, Y., Nejentsev, S., Barbalic, M., Crossman, D., Sanna, S., Soranzo, N., Markus, H. S., Wareham, N. J., Rader, D. J., Reilly, M., Assimes, T., Harris, T. B., Hofman, A., Franco, O. H., Gudnason, V., Tracy, R., Psaty, B. M., Farrall, M., Watkins, H., Hall, A. S., Samani, N. J., März, W., Clarke, R., Collins, R., Kooner, J. S., Chambers, J. C., Kathiresan, S., McPherson, R., Erdmann, J., Kastrati, A., Schunkert, H., Stefánsson, K., Thorsteinsdottir, U., Walston, J. D., Tybjærg-Hansen, A., Alam, D. S., Al Shafi Majumder, A., Angelantonio, E. D., Chowdhury, R., Nordestgaard, B. G., Saleheen, D., Thompson, S. G., Danesh, J. & Houlston, R. S., Jan 1 2015, In : The Lancet Diabetes and Endocrinology. 3, 4, p. 243-253 11 p.

Research output: Contribution to journalArticle

Mendelian Randomization Analysis
Interleukin 1 Receptor Antagonist Protein
Interleukin-1 Receptors
Up-Regulation
Alleles
51 Citations

Directional dominance on stature and cognition in diverse human populations

The Bio Bank Japan Project, Jul 23 2015, In : Nature. 523, 7561, p. 459-462 4 p.

Research output: Contribution to journalArticle

Cognition
Genome
Population
Aptitude
Inbreeding
4 Citations

Linkage analysis of urine arsenic species patterns in the Strong Heart Family Study

Gribble, M. O., Voruganti, V. S., Cole, S. A., Haack, K., Balakrishnan, P., Laston, S. L., Tellez-Plaza, M., Francesconi, K. A., Goessler, W., Umans, J. G., Thomas, D. C., Gilliland, F., North, K. E., Franceschini, N. & Navas-Acien, A., Jan 1 2015, In : Toxicological Sciences. 148, 1, p. 89-100 12 p., kfv164

Research output: Contribution to journalArticle

Arsenic
Urine
Genes
Quantitative Trait Loci
Dynamic mechanical analysis
66 Citations

Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension

Zhu, X. , Feng, T. , Tayo, B. O. , Liang, J. , Young, J. H. , Franceschini, N. , Smith, J. A. , Yanek, L. R. , Sun, Y. V. , Edwards, T. L. , Chen, W. , Nalls, M. , Fox, E. , Sale, M. , Bottinger, E. , Rotimi, C. , Liu, Y. , McKnight, B. , Liu, K. , Arnett, D. K. & 4 others Chakravati, A., Cooper, R. S., Redline, S. & Levy, D., Jan 8 2015, In : American journal of human genetics. 96, 1, p. 21-36 16 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Meta-Analysis
Hypertension
Phenotype
Genetic Loci
26 Citations

Molecular mechanisms underlying variations in lung function: A systems genetics analysis

Obeidat, M. , Hao, K. , Bossé, Y. , Nickle, D. C. , Nie, Y. , Postma, D. S. , Laviolette, M. , Sandford, A. J. , Daley, D. D. , Hogg, J. C. , Elliott, W. M. , Fishbane, N. , Timens, W. , Hysi, P. G. , Kaprio, J. , Wilson, J. F. , Hui, J. , Rawal, R. , Schulz, H. , Stubbe, B. & 26 others Hayward, C., Polasek, O., Järvelin, M. R., Zhao, J. H., Jarvis, D., Kähönen, M., Franceschini, N., North, K. E., Loth, D. W., Brusselle, G. G., Smith, A. V., Gudnason, V., Bartz, T. M., Wilk, J. B., O'Connor, G. T., Cassano, P. A., Tang, W., Wain, L. V., Artigas, M. S., Gharib, S. A., Strachan, D. P., Sin, D. D., Tobin, M. D., London, S. J., Hall, I. P. & Paré, P. D., Jan 1 2015, In : The Lancet Respiratory Medicine. 3, 10, p. 782-795 14 p.

Research output: Contribution to journalArticle

Lung
Chronic Obstructive Pulmonary Disease
Quantitative Trait Loci
Genome-Wide Association Study
Genes
18 Citations

Phosphodiesterase 1 regulation is a key mechanism in vascular aging

Bautista Niño, P. K., Durik, M., Jan Danser, A. H., De Vries, R., Musterd-Bhaggoe, U. M., Meima, M. E., Kavousi, M., Ghanbari, M., Hoeijmakers, J. H., O'Donnell, C. J., Franceschini, N., Janssen, G. M. J., de Mey, J. G. R., Liu, Y., Shanahan, C. M., Franco, O. H., Dehghan, A. & Roks, A. J. M., Jan 1 2015, In : Clinical Science. 129, 12, p. 1061-1075 15 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Genomic Instability
11 Citations

Prevalence and correlates of CKD in hispanics/latinos in the United States

Ricardo, A. C., Flessner, M. F., Eckfeldt, J. H., Eggers, P. W., Franceschini, N., Go, A. S., Gotman, N. M., Kramer, H. J., Kusek, J. W., Loehr, L. R., Melamed, M. L., Peralta, C. A., Raij, L., Rosas, S. E., Talavera, G. A. & Lash, J. P., Oct 7 2015, In : Clinical Journal of the American Society of Nephrology. 10, 10, p. 1757-1766 10 p.

Research output: Contribution to journalArticle

Hispanic Americans
Nutrition Surveys
Health
Cross-Sectional Studies
Cystatin C
13 Citations

Rare coding variants and X-linked loci associated with age at menarche

Lunetta, K. L. , Day, F. R. , Sulem, P. , Ruth, K. S. , Tung, J. Y. , Hinds, D. A. , Esko, T. , Elks, C. E. , Altmaier, E. , He, C. , Huffman, J. E. , Mihailov, E. , Porcu, E. , Robino, A. , Rose, L. M. , Schick, U. M. , Stolk, L. , Teumer, A. , Thompson, D. J. , Traglia, M. & 101 others Wang, C. A., Yerges-Armstrong, L. M., Antoniou, A. C., Barbieri, C., Coviello, A. D., Cucca, F., Demerath, E. W., Dunning, A. M., Gandin, I., Grove, M. L., Gudbjartsson, D. F., Hocking, L. J., Hofman, A., Huang, J., Jackson, R. D., Karasik, D., Kriebel, J., Lange, E. M., Lange, L. A., Langenberg, C., Li, X., Luan, J., Mägi, R., Morrison, A. C., Padmanabhan, S., Pirie, A., Polasek, O., Porteous, D., Reiner, A. P., Rivadeneira, F., Rudan, I., Sala, C. F., Schlessinger, D., Scott, R. A., Stöckl, D., Visser, J. A., Völker, U., Vozzi, D., Wilson, J. G., Zygmunt, M., Boerwinkle, E., Buring, J. E., Crisponi, L., Easton, D. F., Hayward, C., Hu, F. B., Liu, S., Metspalu, A., Pennell, C. E., Ridker, P. M., Strauch, K., Streeten, E. A., Toniolo, D., Uitterlinden, A. G., Ulivi, S., Völzke, H., Wareham, N. J., Wellons, M., Franceschini, N., Chasman, D. I., Thorsteinsdottir, U., Murray, A., Stefansson, K., Murabito, J. M., Ong, K. K., Perry, J. R. B., Forouhi, N. G., Kerrison, N. D., Sharp, S. J., Sims, M., Barroso, I., Deloukas, P., McCarthy, M. I., Arriola, L., Balkau, B., Barricarte, A., Boeing, H., Franks, P. W., Gonzalez, C., Grioni, S., Kaaks, R., Key, T. J., Navarro, C., Nilsson, P. M., Overvad, K., Palli, D., Panico, S., Quirós, J. R., Rolandsson, O., Sacerdote, C., Sánchez, M. J., Slimani, N., Tjonneland, A., Tumino, R., Van Der A, D. L., Van Der Schouw, Y. T., Riboli, E., Smith, B. H., Campbell, A., Deary, I. J. & McIntosh, A. M., Aug 4 2015, In : Nature Communications. 6, 7756

Research output: Contribution to journalArticle

Menarche
chromosomes
loci
mutations
genes
10 Citations

Sequence variation in telomerase reverse transcriptase (TERT) as a determinant of risk of cardiovascular disease: The Atherosclerosis Risk in Communities (ARIC) study

Bressler, J., Franceschini, N., Demerath, E. W., Mosley, T. H., Folsom, A. R. & Boerwinkle, E., Jul 23 2015, In : BMC Medical Genetics. 16, 1, 52

Research output: Contribution to journalArticle

Telomerase
Telomere
Atherosclerosis
Cardiovascular Diseases
Telomere Homeostasis
2014
5 Citations

ADAM19 and HTR4 variants and pulmonary function cohorts for heart and aging research in genomic epidemiology (charge) consortium targeted sequencing study

London, S. J., Gao, W., Gharib, S. A., Hancock, D. B., Wilk, J. B., House, J. S., Gibbs, R. A., Muzny, D. M., Lumley, T., Franceschini, N., North, K. E., Psaty, B. M., Kovar, C. L., Coresh, J., Zhou, Y., Heckbert, S. R., Brody, J. A. & Morrison, A. C., 2014, In : Circulation: Cardiovascular Genetics. 7, 3, p. 350-358 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Forced Expiratory Volume
Vital Capacity
Epidemiology
Lung
53 Citations

Association of sickle cell trait with chronic kidney disease and Albuminuria in African Americans

Naik, R. P. , Derebail, V. K. , Grams, M. E. , Franceschini, N. , Auer, P. L. , Peloso, G. M. , Young, B. A. , Lettre, G. , Peralta, C. A. , Katz, R. , Hyacinth, H. I. , Quarells, R. C. , Grove, M. L. , Bick, A. G. , Fontanillas, P. , Rich, S. S. , Smith, J. D. , Boerwinkle, E. , Rosamond, W. D. , Ito, K. & 11 others Lanzkron, S., Coresh, J., Correa, A., Sarto, G. E., Key, N. S., Jacobs, D. R., Kathiresan, S., Bibbins-Domingo, K., Kshirsagar, A. V., Wilson, J. G. & Reiner, A. P., Jan 1 2014, In : JAMA - Journal of the American Medical Association. 312, 20, p. 2115-2125 11 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
Albuminuria
Chronic Renal Insufficiency
African Americans
Glomerular Filtration Rate
84 Citations

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

Tragante, V. , Barnes, M. R. , Ganesh, S. K. , Lanktree, M. B. , Guo, W. , Franceschini, N. , Smith, E. N. , Johnson, T. , Holmes, M. V. , Padmanabhan, S. , Karczewski, K. J. , Almoguera, B. , Barnard, J. , Baumert, J. , Chang, Y. P. C. , Elbers, C. C. , Farrall, M. , Fischer, M. E. , Gaunt, T. R. , Gho, J. M. I. H. & 116 others Gieger, C., Goel, A., Gong, Y., Isaacs, A., Kleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Melander, O., Nelson, C. P., Nolte, I. M., Pankratz, N., Price, T. S., Shaffer, J., Shah, S., Tomaszewski, M., Van Der Most, P. J., Van Iperen, E. P. A., Vonk, J. M., Witkowska, K., Wong, C. O. L., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Brown, M., Burt, A., Cooper-Dehoff, R. M., Connell, J. M., Cruickshanks, K. J., Curtis, S. P., Davey-Smith, G., Delles, C., Gansevoort, R. T., Guo, X., Haiqing, S., Hastie, C. E., Hofker, M. H., Hovingh, G. K., Kim, D. S., Kirkland, S. A., Klein, B. E., Klein, R., Li, Y. R., Maiwald, S., Newton-Cheh, C., O'Brien, E. T., Onland-Moret, N. C., Palmas, W., Parsa, A., Penninx, B. W., Pettinger, M., Vasan, R. S., Ranchalis, J. E., M Ridker, P., Rose, L. M., Sever, P., Shimbo, D., Steele, L., Stolk, R. P., Thorand, B., Trip, M. D., Van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Wyatt, S., Young, J. H., Zwinderman, A. H., Bezzina, C. R., Boerwinkle, E., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chasman, D. I., Davidson, K. W., Doevendans, P. A., Dominiczak, A. F., Fitzgerald, G. A., Gums, J. G., Fornage, M., Hakonarson, H., Halder, I., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Kumari, M., März, W., Murray, S. S., O'Connell, J. R., Oldehinkel, A. J., Pankow, J. S., Rader, D. J., Redline, S., Reilly, M. P., Schadt, E. E., Kottke-Marchant, K., Snieder, H., Snyder, M., Stanton, A. V., Tobin, M. D., Uitterlinden, A. G., Van Der Harst, P., Van Der Schouw, Y. T., Samani, N. J., Watkins, H., Johnson, A. D., Reiner, A. P., Zhu, X., De Bakker, P. I. W., Levy, D., Asselbergs, F. W., Munroe, P. B. & Keating, B. J., Mar 6 2014, In : American journal of human genetics. 94, 3, p. 349-360 12 p.

Research output: Contribution to journalArticle

Meta-Analysis
Blood Pressure
Genes
Computational Biology
Single Nucleotide Polymorphism
10 Citations

Generalization of associations of kidney-related genetic loci to American Indians

Franceschini, N., Haack, K., Almasy, L., Laston, S., Lee, E. T., Best, L. G., Fabsitz, R. R., MacCluer, J. W., Howard, B. V., Umans, J. G. & Cole, S. A., Jan 7 2014, In : Clinical Journal of the American Society of Nephrology. 9, 1, p. 150-158 9 p.

Research output: Contribution to journalArticle

Genetic Loci
North American Indians
Single Nucleotide Polymorphism
Kidney
Albumins
62 Citations

Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes

Yaghootkar, H. , Scott, R. A. , White, C. C. , Zhang, W. , Speliotes, E. , Munroe, P. B. , Ehret, G. B. , Bis, J. C. , Fox, C. S. , Walker, M. , Borecki, I. B. , Knowles, J. W. , Yerges-Armstrong, L. , Ohlsson, C. , Perry, J. R. B. , Chambers, J. C. , Kooner, J. S. , Franceschini, N. , Langenberg, C. , Hivert, M. F. & 4 others Dastani, Z., Richards, J. B., Semple, R. K. & Frayling, T. M., Jan 1 2014, In : Diabetes. 63, 12, p. 4369-4377 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Insulin Resistance
Coronary Artery Disease
Alleles
Hypertension
10 Citations

Genetics, ancestry, and hypertension: Implications for targeted antihypertensive therapies

Franceschini, N., Chasman, D. I., Cooper-DeHoff, R. M. & Arnett, D. K., Jan 1 2014, In : Current Hypertension Reports. 16, 8, 461

Research output: Contribution to journalReview article

Antihypertensive Agents
Blood Pressure
Hypertension
Genome-Wide Association Study
Therapeutics
14 Citations

Genetics of hypertension: Discoveries from the bench to human populations

Franceschini, N. & Le, T. H., Jan 1 2014, In : American Journal of Physiology - Renal Physiology. 306, 1

Research output: Contribution to journalReview article

Hypertension
Population
Genome-Wide Association Study
Genetic Models
Medical Genetics
2 Citations

Genetic variants in nicotinic acetylcholine receptor genes jointly contribute to kidney function in American Indians: The Strong Heart Family Study

Zhu, Y., Yang, J., Li, S., Cole, S. A., Haack, K., Umans, J. G., Franceschini, N., Howard, B. V., Lee, E. T. & Zhao, J., Jan 1 2014, In : Journal of Hypertension. 32, 5, p. 1042-1049 8 p.

Research output: Contribution to journalArticle

North American Indians
Nicotinic Receptors
Kidney
Genes
Smoking
51 Citations

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Loth, D. W. , Artigas, M. S. , Gharib, S. A. , Wain, L. V. , Franceschini, N. , Koch, B. , Pottinger, T. D. , Smith, A. V. , Duan, Q. , Oldmeadow, C. , Lee, M. K. , Strachan, D. P. , James, A. L. , Huffman, J. E. , Vitart, V. , Ramasamy, A. , Wareham, N. J. , Kaprio, J. , Wang, X. Q. , Trochet, H. & 140 others Kähönen, M., Flexeder, C., Albrecht, E., Lopez, L. M., De Jong, K., Thyagarajan, B., Alves, A. C., Enroth, S., Omenaas, E., Joshi, P. K., Fall, T., Viñuela, A., Launer, L. J., Loehr, L. R., Fornage, M., Li, G., Wilk, J. B., Tang, W., Manichaikul, A., Lahousse, L., Harris, T. B., North, K. E., Rudnicka, A. R., Hui, J., Gu, X., Lumley, T., Wright, A. F., Hastie, N. D., Campbell, S., Kumar, R., Pin, I., Scott, R. A., Pietiläinen, K. H., Surakka, I., Liu, Y., Holliday, E. G., Schulz, H., Heinrich, J., Davies, G., Vonk, J. M., Wojczynski, M., Pouta, A., Johansson, A., Wild, S. H., Ingelsson, E., Rivadeneira, F., Völzke, H., Hysi, P. G., Eiriksdottir, G., Morrison, A. C., Rotter, J. I., Gao, W., Postma, D. S., White, W. B., Rich, S. S., Hofman, A., Aspelund, T., Couper, D., Smith, L. J., Psaty, B. M., Lohman, K., Burchard, E. G., Uitterlinden, A. G., Garcia, M., Joubert, B. R., McArdle, W. L., Musk, A. B., Hansel, N., Heckbert, S. R., Zgaga, L., Van Meurs, J. B. J., Navarro, P., Rudan, I., Oh, Y. M., Redline, S., Jarvis, D. L., Zhao, J. H., Rantanen, T., O'Connor, G. T., Ripatti, S., Scott, R. J., Karrasch, S., Grallert, H., Gaddis, N. C., Starr, J. M., Wijmenga, C., Minster, R. L., Lederer, D. J., Pekkanen, J., Gyllensten, U., Campbell, H., Morris, A. P., Gläser, S., Hammond, C. J., Burkart, K. M., Beilby, J., Kritchevsky, S. B., Gudnason, V., Hancock, D. B., Williams, O. D., Polasek, O., Zemunik, T., Kolcic, I., Petrini, M. F., Wjst, M., Kim, W. J., Porteous, D. J., Scotland, G., Smith, B. H., Viljanen, A., Heliövaara, M., Attia, J. R., Sayers, I., Hampel, R., Gieger, C., Deary, I. J., Boezen, H. M., Newman, A., Jarvelin, M. R., Wilson, J. F., Lind, L., Stricker, B. H., Teumer, A., Spector, T. D., Melén, E., Peters, M. J., Lange, L. A., Barr, R. G., Bracke, K. R., Verhamme, F. M., Sung, J., Hiemstra, P. S., Cassano, P. A., Sood, A., Hayward, C., Dupuis, J., Hall, I. P., Brusselle, G. G., Tobin, M. D. & London, S. J., Jan 1 2014, In : Nature Genetics. 46, 7, p. 669-677 9 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Vital Capacity
Lung
Lung Diseases
Hispanic Americans
28 Citations

Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

Tang, W. , Kowgier, M. , Loth, D. W. , Soler Artigas, M. , Joubert, B. R. , Hodge, E. , Gharib, S. A. , Smith, A. V. , Ruczinski, I. , Gudnason, V. , Mathias, R. A. , Harris, T. B. , Hansel, N. N. , Launer, L. J. , Barnes, K. C. , Hansen, J. G. , Albrecht, E. , Aldrich, M. C. , Allerhand, M. , Barr, R. G. & 61 others Brusselle, G. G., Couper, D. J., Curjuric, I., Davies, G., Deary, I. J., Dupuis, J., Fall, T., Foy, M., Franceschini, N., Gao, W., Gläser, S., Gu, X., Hancock, D. B., Heinrich, J., Hofman, A., Imboden, M., Ingelsson, E., James, A., Karrasch, S., Koch, B., Kritchevsky, S. B., Kumar, A., Lahousse, L., Li, G., Lind, L., Lindgren, C., Liu, Y., Lohman, K., Lumley, T., McArdle, W. L., Meibohm, B., Morris, A. P., Morrison, A. C., Musk, B., North, K. E., Palmer, L. J., Probst-Hensch, N. M., Psaty, B. M., Rivadeneira, F., Rotter, J. I., Schulz, H., Smith, L. J., Sood, A., Starr, J. M., Strachan, D. P., Teumer, A., Uitterlinden, A. G., Völzke, H., Voorman, A., Wain, L. V., Wells, M. T., Wilk, J. B., Williams, O. D., Heckbert, S. R., Stricker, B. H., London, S. J., Fornage, M., Tobin, M. D., O'Connor, G. T., Hall, I. P. & Cassano, P. A., Jul 1 2014, In : PloS one. 9, 7, e100776

Research output: Contribution to journalArticle

Genome-Wide Association Study
lung function
Meta-Analysis
Genes
Lung