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2018

Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1

Hoesel, B., Mussbacher, M., Dikorman, B., Salzmann, M., Assinger, A., Hell, L., Thaler, J., Basílio, J., Moser, B., Resch, U., Paar, H., Mackman, N. & Schmid, J. A. Apr 1 2018 In : Journal of Thrombosis and Haemostasis. 16, 4, p. 749-758 10 p.

Research output: Contribution to journalArticle

Early Growth Response Protein 1
Venous Thromboembolism
Androgen Receptors
Thromboplastin
Prostatic Neoplasms

Caspase inhibition reduces hepatic tissue factor-driven coagulation in vitro and in vivo

Kopec, A. K., Spada, A. P., Contreras, P. C., Mackman, N. & Luyendyk, J. P. Apr 1 2018 In : Toxicological Sciences. 162, 2, p. 396-405 10 p.

Research output: Contribution to journalArticle

Thromboplastin
Caspases
Liver
Hepatocytes
Caspase 3

Comparison of microvesicle tissue factor activity in non-cancer severely ill patients and cancer patients

Hisada, Y., Thålin, C., Lundström, S., Wallén, H. & Mackman, N. May 1 2018 In : Thrombosis research. 165, p. 1-5 5 p.

Research output: Contribution to journalArticle

Thromboplastin
Neoplasms
Adenocarcinoma
Population
Survival
2 Citations

Distinct Pathogenesis of Pancreatic Cancer Microvesicle-Associated Venous Thrombosis Identifies New Antithrombotic Targets in Vivo

Stark, K. , Schubert, I. , Joshi, U. , Kilani, B. , Hoseinpour, P. , Thakur, M. , Grünauer, P. , Pfeiler, S. , Schmidergall, T. , Stockhausen, S. , Bäumer, M. , Chandraratne, S. , Von Brühl, M. L. , Lorenz, M. , Coletti, R. , Reese, S. , Laitinen, I. , Wörmann, S. M. , Algül, H. , Bruns, C. J. & 4 others Ware, J., Mackman, N., Engelmann, B. & Massberg, S. Apr 1 2018 In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. 772-786 15 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Venous Thrombosis
Neoplasms
Thrombosis
Factor X

Dual Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease and Peripheral Artery Disease Patients

Mackman, N., Spronk, H. M. H., Stouffer, G. A. & Ten Cate, H. Apr 1 2018 In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. 726-732 7 p.

Research output: Contribution to journalReview article

Peripheral Arterial Disease
Anticoagulants
Coronary Artery Disease
Therapeutics

Extracellular vesicles exposing tissue factor for the prediction of venous thromboembolism in patients with cancer: A prospective cohort study

van Es, N., Hisada, Y., Di Nisio, M., Cesarman, G., Kleinjan, A., Mahé, I., Otten, H. M., Kamphuisen, P. W., Berckmans, R. J., Büller, H. R., Mackman, N. & Nieuwland, R. Jun 1 2018 In : Thrombosis research. 166, p. 54-59 6 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Thromboplastin
Cohort Studies
Prospective Studies
Fibrin

Mouse models of cancer-associated thrombosis

Hisada, Y. & Mackman, N. Apr 1 2018 In : Thrombosis research. 164, p. S48-S53

Research output: Contribution to journalArticle

Thromboplastin
Venous Thrombosis
Thrombosis
Neoplasms
Extracellular Traps

Platelet Signaling Pathways and New Inhibitors

Grover, S. P., Bergmeier, W. & Mackman, N. Apr 1 2018 In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. e28-e35

Research output: Contribution to journalArticle

Platelet Aggregation Inhibitors
Blood Platelets
Platelet Activation
Hemostatics
Thrombosis

The factor Xa inhibitor rivaroxaban reduces cardiac dysfunction in a mouse model of myocardial infarction

Bode, M. F., Auriemma, A. C., Grover, S. P., Hisada, Y., Rennie, A., Bode, W. D., Vora, R., Subramaniam, S., Cooley, B., Andrade-Gordon, P., Antoniak, S. & Mackman, N. Jul 1 2018 In : Thrombosis research. 167, p. 128-134 7 p.

Research output: Contribution to journalArticle

Myocardial Infarction
PAR-2 Receptor
Ligation
Arteries
Factor Xa
2 Citations

Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis

Grover, S. P. & Mackman, N. Apr 1 2018 In : Arteriosclerosis, thrombosis, and vascular biology. 38, 4, p. 709-725 17 p.

Research output: Contribution to journalArticle

Thromboplastin
Hemostasis
Thrombosis
Hemostatics
Venous Thrombosis

Tissue factor and oxidative stress

Mackman, N. & Antoniak, S. May 10 2018 In : Blood. 131, 19, p. 2094-2095 2 p.

Research output: Contribution to journalReview article

Marine biology
Aryldialkylphosphatase
Thromboplastin
Endothelium
Oxidative Stress
2017
1 Citations

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade

Solovey, A., Somani, A., Belcher, J. D., Milbauer, L., Vincent, L., Pawlinski, R., Nath, K. A., Kelm, R. J., Mackman, N., O'Sullivan, M. G., Gupta, K., Vercellotti, G. M. & Hebbel, R. P. Nov 1 2017 In : American journal of hematology. 92, 11, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

10 Citations

Cancer-associated pathways and biomarkers of venous thrombosis

Hisada, Y. & Mackman, N. Sep 28 2017 In : Blood. 130, 13, p. 1499-1506 8 p.

Research output: Contribution to journalReview article

Venous Thromboembolism
Metabolic Networks and Pathways
Venous Thrombosis
Biomarkers
Neoplasms
1 Citations

Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy

Hisada, Y., Auriemma, A. C., Alexander, W., Ay, C. & Mackman, N. Feb 1 2017 In : Thrombosis Research. 150, p. 65-72 8 p.

Research output: Contribution to journalArticle

Annexin A5
Thromboplastin
Confocal Microscopy
Anti-Idiotypic Antibodies
Pancreatic Neoplasms
Thromboplastin
Emotions
Hemorrhage
Lung
4 Citations

Evaluation of venous thrombosis and tissue factor in epithelial ovarian cancer

Cohen, J. G., Prendergast, E., Geddings, J. E., Walts, A. E., Agadjanian, H., Hisada, Y., Karlan, B. Y., Mackman, N. & Walsh, C. S. Jul 1 2017 In : Gynecologic Oncology. 146, 1, p. 146-152 7 p.

Research output: Contribution to journalArticle

Enzyme Multiplied Immunoassay Technique
Glandular and Epithelial Neoplasms
Neoplasm Staging
Venous Thromboembolism
Thromboplastin
1 Citations

Factor XI-deficient mice exhibit increased bleeding after injury to the saphenous vein

Ay, C., Hisada, Y., Cooley, B. C. & Mackman, N. Sep 1 2017 In : Journal of Thrombosis and Haemostasis. 15, 9, p. 1829-1833 5 p.

Research output: Contribution to journalArticle

Factor XI
Saphenous Vein
Hemophilia A
Hemostasis
Hemorrhage
6 Citations

Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size

Hisada, Y., Ay, C., Auriemma, A. C., Cooley, B. C. & Mackman, N. Nov 1 2017 In : Journal of Thrombosis and Haemostasis. 15, 11, p. 2208-2217 10 p.

Research output: Contribution to journalArticle

Insight into Editor

MacKman, N. Jan 1 2017 In : Arteriosclerosis, thrombosis, and vascular biology. 37, 11, p. e172-e173

Research output: Contribution to journalComment/debate

1 Citations

Letter to Editor response: Endothelial cell tissue factor and coagulation

Antoniak, S. & Mackman, N. Feb 1 2017 In : Trends in Cardiovascular Medicine. 27, 2, p. 157 1 p.

Research output: Contribution to journalLetter

Thromboplastin
Endothelium
Endothelial Cells
39 Citations

Methodological guidelines to study extracellular vesicles

Coumans, F. A. W. , Brisson, A. R. , Buzas, E. I. , Dignat-George, F. , Drees, E. E. E. , El-Andaloussi, S. , Emanueli, C. , Gasecka, A. , Hendrix, A. , Hill, A. F. , Lacroix, R. , Lee, Y. , Van Leeuwen, T. G. , Mackman, N. , Mäger, I. , Nolan, J. P. , Van Der Pol, E. , Pegtel, D. M. , Sahoo, S. , Siljander, P. R. M. & 3 others Sturk, G., De Wever, O. & Nieuwland, R. May 12 2017 In : Circulation research. 120, 10, p. 1632-1648 17 p.

Research output: Contribution to journalReview article

Blood Specimen Collection
Exosomes
Flow Cytometry
Cardiovascular Diseases
Biomarkers
1 Citations

Myeloid but not epithelial tissue factor exerts protective anti-inflammatory effects in acid aspiration-induced acute lung injury

Kral-Pointner, J. B., Schrottmaier, W. C., Horvath, V., Datler, H., Hell, L., Ay, C., Niederreiter, B., Jilma, B., Schmid, J. A., Assinger, A., Mackman, N., Knapp, S. & Schabbauer, G. Aug 1 2017 In : Journal of Thrombosis and Haemostasis. 15, 8, p. 1625-1639 15 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Thromboplastin
Blood Coagulation
Anti-Inflammatory Agents
Epithelium
3 Citations

Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation

Antoniak, S., Cardenas, J. C., Buczek, L. J., Church, F. C., Mackman, N. & Pawlinski, R. Mar 1 2017 In : Cardiology (Switzerland). 136, 4, p. 258-268 11 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Angiotensin II
Inflammation
Aorta
Fibrosis
2 Citations

Protease-Activated Receptor 1 Enhances Poly I: C Induction of the Antiviral Response in Macrophages and Mice

Antoniak, S., Tatsumi, K., Bode, M., Vanja, S., Williams, J. C. & Mackman, N. Feb 1 2017 In : Journal of Innate Immunity. 9, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Poly I-C
Antiviral Agents
Macrophages
Thrombin
5 Citations

Thrombin promotes diet-induced obesity through fibrin-driven inflammation

Kopec, A. K., Abrahams, S. R., Thornton, S., Palumbo, J. S., Mullins, E. S., Divanovic, S., Weiler, H., Owens, A. P., Mackman, N., Goss, A., Van Ryn, J., Luyendyk, J. P. & Flick, M. J. Aug 1 2017 In : Journal of Clinical Investigation. 127, 8, p. 3152-3166 15 p.

Research output: Contribution to journalArticle

2 Citations

Tissue factor: Catch me if you can!

Ay, C. & Mackman, N. Apr 1 2017 In : Journal of Clinical Oncology. 35, 10, p. 1128-1130 3 p.

Research output: Contribution to journalArticle

Thromboplastin
2016
1 Citations

A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice

Bode, M. F. & Mackman, N. Oct 1 2016 In : Thrombosis Research. 146, p. 46-50 5 p.

Research output: Contribution to journalArticle

Thromboplastin
Hemorrhage
Lung
Hemostasis
protease-activated receptor 4
5 Citations
Zebrafish
Primates
Thrombosis
Animal Models
Pharmaceutical Preparations
3 Citations

Antibody-based targeting of alternatively spliced tissue factor: A new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

Unruh, D., Ünlü, B., Lewis, C. S., Qi, X., Chu, Z., Sturm, R., Keil, R., Ahmad, S. A., Sovershaev, T., Adam, M., Van Dreden, P., Woodhams, B. J., Ramchandani, D., Weber, G. F., Rak, J. W., Wolberg, A. S., Mackman, N., Versteeg, H. H. & Bogdanov, V. Y. May 1 2016 In : Oncotarget. 7, 18, p. 25264-25275 12 p.

Research output: Contribution to journalArticle

Thromboplastin
Adenocarcinoma
Antibodies
Growth
Neoplasms
1 Citations

Anticoagulation increases alveolar hemorrhage in mice infected with influenza A

Tatsumi, K., Antoniak, S., Subramaniam, S., Gondouin, B., Neidich, S. D., Beck, M. A., Mickelson, J., Monroe, D. M., Bastarache, J. A. & Mackman, N. Dec 1 2016 In : Physiological Reports. 4, 24, e13071

Research output: Contribution to journalArticle

Human Influenza
Hemorrhage
Bronchoalveolar Lavage Fluid
Influenza A virus
Warfarin
8 Citations

Anti phospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4

Laplante, P., Fuentes, R., Salem, D., Subang, R., Gillis, M. A., Hachem, A., Farhat, N., Qureshi, S. T., Fletcher, C. A., Roubey, R. A. S., Merhi, Y., Thorin, Levine, J. S., Mackman, N. & Rauch, J. Feb 1 2016 In : Lupus. 25, 2, p. 162-176 15 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Antiphospholipid Antibodies
Anti-Idiotypic Antibodies
Phospholipids
Thrombosis
6 Citations

CalDAG-GEFI deficiency reduces atherosclerotic lesion development in mice

Boulaftali, Y., Owens, A. P., Beale, A., Piatt, R., Casari, C., Lee, R. H., Conley, P. B., Paul, D. S., Mackman, N. & Bergmeier, W. May 1 2016 In : Arteriosclerosis, thrombosis, and vascular biology. 36, 5, p. 792-799 8 p.

Research output: Contribution to journalArticle

Blood Platelets
Sinus of Valsalva
Leukocytes
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
3 Citations

Complying with the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations

Daugherty, A., Hegele, R. A., Mackman, N., Rader, D. J., Schmidt, A. M. & Weber, C. Jul 1 2016 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 7, p. 1303-1304 2 p.

Research output: Contribution to journalShort survey

National Institutes of Health (U.S.)
Guidelines
9 Citations

Editorial Commentary: Tissue factor expression by the endothelium: Coagulation or inflammation?

Antoniak, S. & Mackman, N. May 1 2016 In : Trends in Cardiovascular Medicine. 26, 4, p. 304-305 2 p.

Research output: Contribution to journalEditorial

Vascular Endothelium
Thromboplastin
Blood Coagulation
Endothelium
Inflammation

Erratum: Corrigendum to “Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays” (Thrombosis Research (2016) 139 (90–97))

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., McNamara, C., Wallen, H., MarcoWitkowski, Key, N. S., Rauch, U. & Mackman, N. Nov 1 2016 In : Thrombosis Research. 147, 1 p.

Research output: Contribution to journalComment/debate

S 0139
Thromboplastin
Norway
Emotions
Thrombosis

Erratum: Corrigendum to ‘Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer”, (Thrombosis Research (2016) 141 (39–48)(S0049384816300615)(10.1016/j.thromres.2016.03.002))

Claussen, C., Rausch, A. V., Lezius, S., Amirkhosravi, A., Davila, M., Francis, J. L., Hisada, Y. M., Mackman, N., Bokemeyer, C., Schmalfeldt, B., Mahner, S. & Langer, F. Oct 1 2016 In : Thrombosis research. 146, 1 p.

Research output: Contribution to journalComment/debate

Thromboplastin
Norway
Ovarian Neoplasms
Emotions
Thrombosis
1 Citations

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells

Simmers, M. B., Cole, B. K., Ogletree, M. L., Chen, Z., Xu, Y., Kong, L. J., Mackman, N., Blackman, B. R. & Wamhoff, B. R. Jul 1 2016 In : Thrombosis research. 143, p. 34-39 6 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Endothelial Cells
Hemodynamics
Fibrin
Atrial Appendage
12 Citations

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury

Rautou, P. E., Tatsumi, K., Antoniak, S., Owens, A. P., Sparkenbaugh, E., Holle, L. A., Wolberg, A. S., Kopec, A. K., Pawlinski, R., Luyendyk, J. P. & MacKman, N. Jan 1 2016 In : Journal of Hepatology. 64, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Thromboplastin
Hepatocytes
Liver
Wounds and Injuries
Leukocytes
1 Citations

IL-13 augments compressive stress-induced tissue factor expression in human airway epithelial cells

Mitchel, J. A., Antoniak, S., Lee, J. H., Kim, S. H., McGill, M., Kasahara, D. I., Randell, S. H., Israel, E., Shore, S. A., Mackman, N. & Park, J. A. Apr 1 2016 In : American journal of respiratory cell and molecular biology. 54, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

Interleukin-13
Thromboplastin
Compressive stress
Epithelial Cells
Asthma
1 Citations

Is leukocyte tissue factor the key to venous thrombosis in antiphospholipid syndrome?

Mackman, N. & Roubey, R. A. S. May 1 2016 In : Journal of Thrombosis and Haemostasis. 14, 5, p. 1008-1010 3 p.

Research output: Contribution to journalComment/debate

23 Citations

Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., McNamara, C., Wallen, H., Witkowski, M., Key, N. S., Rauch, U. & MacKman, N. Mar 1 2016 In : Thrombosis research. 139, p. 90-97 8 p.

Research output: Contribution to journalArticle

Thromboplastin
Thrombosis
Biomarkers
Endotoxemia
Venous Thromboembolism
10 Citations

Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer

Claussen, C., Rausch, A. V., Lezius, S., Amirkhosravi, A., Davila, M., Francis, J. L., Hisada, Y. M., MacKman, N., Bokemeyer, C., Schmalfeldt, B., Mahner, S. & Langer, F. May 1 2016 In : Thrombosis Research. 141, p. 39-48 10 p.

Research output: Contribution to journalArticle

Thromboplastin
Ovarian Neoplasms
Venous Thromboembolism
Neoplasms
Antigens
9 Citations

Microvesicle tissue factor activity and interleukin-8 levels are associated with mortality in patients with influenza A/H1N1 infection

Rondina, M. T., Tatsumi, K., Bastarache, J. A. & Mackman, N. Jul 1 2016 In : Critical care medicine. 44, 7, p. e574-e578

Research output: Contribution to journalArticle

Thromboplastin
Interleukin-8
Human Influenza
Mortality
Infection

Mouse models of venous thrombosis are not equal

Mackman, N. May 26 2016 In : Blood. 127, 21, p. 2510-2511 2 p.

Research output: Contribution to journalComment/debate

Factor XII
Platelets
Venous Thrombosis
Neutrophils
Blood
3 Citations

Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury

Shaver, C. M., Grove, B. S., Clune, J. K., Mackman, N., Ware, L. B. & Bastarache, J. A. Feb 29 2016 In : Scientific Reports. 6, 22249

Research output: Contribution to journalArticle

Acute Lung Injury
Thromboplastin
Permeability
Pneumonia
Myeloid Cells
1 Citations

The clot thickens in atherosclerosis

MacKman, N. Mar 1 2016 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 3, p. 425-426 2 p.

Research output: Contribution to journalEditorial

Factor XI Deficiency
Factor XI
Aortic Diseases
Apolipoproteins E
Aorta
2 Citations

Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease

Sparkenbaugh, E. M., Chantrathammachart, P., Chandarajoti, K., Mackman, N., Key, N. S. & Pawlinski, R. Mar 10 2016 In : Blood. 127, 10, p. 1371-1373 3 p.

Research output: Contribution to journalLetter

Animal Disease Models
Cardiomegaly
Sickle Cell Anemia
Thromboplastin
Thrombin
13 Citations

Thrombosis in cancer: Research priorities identified by a national cancer institute/national heart, lung, and blood institute strategic working group

Key, N. S., Khorana, A. A., Mackman, N., McCarty, O. J. T., White, G. C., Francis, C. W., McCrae, K. R., Palumbo, J. S., Raskob, G. E., Chan, A. T. & Sood, A. K. Jul 1 2016 In : Cancer Research. 76, 13, p. 3671-3675 5 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
National Cancer Institute (U.S.)
Venous Thromboembolism
Thrombosis
Research
9 Citations

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice

Antoniak, S., Tatsumi, K., Hisada, Y., Milner, J. J., Neidich, S. D., Shaver, C. M., Pawlinski, R., Beck, M. A., Bastarache, J. A. & Mackman, N. Jun 1 2016 In : Journal of Thrombosis and Haemostasis. 14, 6, p. 1238-1248 11 p.

Research output: Contribution to journalArticle

Influenza A virus
Thromboplastin
Hemorrhage
Virus Diseases
Lung
29 Citations

Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice

Geddings, J. E., Hisada, Y., Boulaftali, Y., Getz, T. M., Whelihan, M., Fuentes, R., Dee, R., Cooley, B. C., Key, N. S., Wolberg, A. S., Bergmeier, W. & Mackman, N. Jan 1 2016 In : Journal of Thrombosis and Haemostasis. 14, 1, p. 153-166 14 p.

Research output: Contribution to journalArticle

Thromboplastin
Thrombosis
Blood Platelets
Neoplasms
Platelet Activation