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2017
1 Citations

Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy

Hisada, Y., Auriemma, A. C., Alexander, W., Ay, C. & Mackman, N. Feb 1 2017 In : Thrombosis Research. 150, p. 65-72 8 p.

Research output: Research - peer-reviewArticle

Annexin A5
Thromboplastin
Confocal Microscopy
Extracellular Vesicles
Anti-Idiotypic Antibodies
Thromboplastin
Emotions
Hemorrhage
Lung

Letter to Editor response: Endothelial cell tissue factor and coagulation

Antoniak, S. & Mackman, N. Feb 1 2017 In : Trends in Cardiovascular Medicine. 27, 2, p. 157 1 p.

Research output: Research - peer-reviewLetter

Thromboplastin
Endothelium
Endothelial Cells
1 Citations

Protease-Activated Receptor 1 Contributes to Angiotensin II-Induced Cardiovascular Remodeling and Inflammation

Antoniak, S., Cardenas, J. C., Buczek, L. J., Church, F. C., Mackman, N. & Pawlinski, R. Mar 1 2017 In : Cardiology (Switzerland). 136, 4, p. 258-268 11 p.

Research output: Research - peer-reviewArticle

PAR-1 Receptor
Angiotensin II
Inflammation
Aorta
Fibrosis
1 Citations

Protease-Activated Receptor 1 Enhances Poly I: C Induction of the Antiviral Response in Macrophages and Mice

Antoniak, S., Tatsumi, K., Bode, M., Vanja, S., Williams, J. C. & Mackman, N. Feb 1 2017 In : Journal of Innate Immunity. 9, 2, p. 181-192 12 p.

Research output: Research - peer-reviewArticle

PAR-1 Receptor
Poly I-C
Antiviral Agents
Macrophages
Thrombin
1 Citations

Tissue factor: Catch me if you can!

Ay, C. & Mackman, N. Apr 1 2017 In : Journal of Clinical Oncology. 35, 10, p. 1128-1130 3 p.

Research output: Research - peer-reviewArticle

Thromboplastin
2016

A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice

Bode, M. F. & Mackman, N. Oct 1 2016 In : Thrombosis Research. 146, p. 46-50 5 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Hemorrhage
Lung
protease-activated receptor 4
Hemostasis
3 Citations
Zebrafish
Primates
Thrombosis
Animal Models
Pharmaceutical Preparations
3 Citations

Antibody-based targeting of alternatively spliced tissue factor: A new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma

Unruh, D., Ünlü, B., Lewis, C. S., Qi, X., Chu, Z., Sturm, R., Keil, R., Ahmad, S. A., Sovershaev, T., Adam, M., Van Dreden, P., Woodhams, B. J., Ramchandani, D., Weber, G. F., Rak, J. W., Wolberg, A. S., Mackman, N., Versteeg, H. H. & Bogdanov, V. Y. May 1 2016 In : Oncotarget. 7, 18, p. 25264-25275 12 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Adenocarcinoma
Antibodies
Growth
Neoplasms

Anticoagulation increases alveolar hemorrhage in mice infected with influenza A

Tatsumi, K., Antoniak, S., Subramaniam, S., Gondouin, B., Neidich, S. D., Beck, M. A., Mickelson, J., Monroe, D. M., Bastarache, J. A. & Mackman, N. Dec 1 2016 In : Physiological Reports. 4, 24, e13071

Research output: Research - peer-reviewArticle

Human Influenza
Hemorrhage
Bronchoalveolar Lavage Fluid
Influenza A virus
Warfarin
6 Citations

Anti phospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4

Laplante, P., Fuentes, R., Salem, D., Subang, R., Gillis, M. A., Hachem, A., Farhat, N., Qureshi, S. T., Fletcher, C. A., Roubey, R. A. S., Merhi, Y., Thorin, Levine, J. S., Mackman, N. & Rauch, J. Feb 1 2016 In : Lupus. 25, 2, p. 162-176 15 p.

Research output: Research - peer-reviewArticle

Toll-Like Receptor 4
Antiphospholipid Antibodies
Anti-Idiotypic Antibodies
Phospholipids
Thrombosis
3 Citations

CalDAG-GEFI deficiency reduces atherosclerotic lesion development in mice

Boulaftali, Y., Owens, A. P., Beale, A., Piatt, R., Casari, C., Lee, R. H., Conley, P. B., Paul, D. S., Mackman, N. & Bergmeier, W. May 1 2016 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 5, p. 792-799 8 p.

Research output: Research - peer-reviewArticle

Blood Platelets
Leukocytes
Sinus of Valsalva
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
2 Citations

Complying with the National Institutes of Health Guidelines and Principles for Rigor and Reproducibility: Refutations

Daugherty, A., Hegele, R. A., Mackman, N., Rader, D. J., Schmidt, A. M. & Weber, C. Jul 1 2016 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 7, p. 1303-1304 2 p.

Research output: Research - peer-reviewShort survey

National Institutes of Health (U.S.)
Guidelines
6 Citations

Editorial Commentary: Tissue factor expression by the endothelium: Coagulation or inflammation?

Antoniak, S. & Mackman, N. May 1 2016 In : Trends in Cardiovascular Medicine. 26, 4, p. 304-305 2 p.

Research output: Research - peer-reviewEditorial

Vascular Endothelium
Thromboplastin
Blood Coagulation
Endothelium
Inflammation

Erratum: Corrigendum to “Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays” (Thrombosis Research (2016) 139 (90–97))

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., McNamara, C., Wallen, H., MarcoWitkowski, Key, N. S., Rauch, U. & Mackman, N. Nov 1 2016 In : Thrombosis Research. 147, 1 p.

Research output: Research - peer-reviewComment/debate

S 0139
Thromboplastin
Norway
Emotions
Thrombosis

Erratum: Corrigendum to ‘Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer”, (Thrombosis Research (2016) 141 (39–48)(S0049384816300615)(10.1016/j.thromres.2016.03.002))

Claussen, C., Rausch, A. V., Lezius, S., Amirkhosravi, A., Davila, M., Francis, J. L., Hisada, Y. M., Mackman, N., Bokemeyer, C., Schmalfeldt, B., Mahner, S. & Langer, F. Oct 1 2016 In : Thrombosis Research. 146, 1 p.

Research output: Research - peer-reviewComment/debate

Thromboplastin
Norway
Ovarian Neoplasms
Emotions
Thrombosis
1 Citations

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells

Simmers, M. B., Cole, B. K., Ogletree, M. L., Chen, Z., Xu, Y., Kong, L. J., Mackman, N., Blackman, B. R. & Wamhoff, B. R. Jul 1 2016 In : Thrombosis Research. 143, p. 34-39 6 p.

Research output: Research - peer-reviewArticle

Atrial Fibrillation
Endothelial Cells
Hemodynamics
Fibrin
Atrial Appendage
9 Citations

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury

Rautou, P. E., Tatsumi, K., Antoniak, S., Owens, A. P., Sparkenbaugh, E., Holle, L. A., Wolberg, A. S., Kopec, A. K., Pawlinski, R., Luyendyk, J. P. & MacKman, N. Jan 1 2016 In : Journal of Hepatology. 64, 1, p. 53-59 7 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Hepatocytes
Liver
Wounds and Injuries
Leukocytes
1 Citations

IL-13 augments compressive stress-induced tissue factor expression in human airway epithelial cells

Mitchel, J. A., Antoniak, S., Lee, J. H., Kim, S. H., McGill, M., Kasahara, D. I., Randell, S. H., Israel, E., Shore, S. A., Mackman, N. & Park, J. A. Apr 1 2016 In : American Journal of Respiratory Cell and Molecular Biology. 54, 4, p. 524-531 8 p.

Research output: Research - peer-reviewArticle

Interleukin-13
Thromboplastin
Compressive stress
Epithelial Cells
Asthma

Is leukocyte tissue factor the key to venous thrombosis in antiphospholipid syndrome?

Mackman, N. & Roubey, R. A. S. May 1 2016 In : Journal of Thrombosis and Haemostasis. 14, 5, p. 1008-1010 3 p.

Research output: Research - peer-reviewComment/debate

15 Citations

Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., McNamara, C., Wallen, H., Witkowski, M., Key, N. S., Rauch, U. & MacKman, N. Mar 1 2016 In : Thrombosis Research. 139, p. 90-97 8 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Thrombosis
Biomarkers
Endotoxemia
Venous Thromboembolism
7 Citations

Microvesicle-associated tissue factor procoagulant activity for the preoperative diagnosis of ovarian cancer

Claussen, C., Rausch, A. V., Lezius, S., Amirkhosravi, A., Davila, M., Francis, J. L., Hisada, Y. M., MacKman, N., Bokemeyer, C., Schmalfeldt, B., Mahner, S. & Langer, F. May 1 2016 In : Thrombosis Research. 141, p. 39-48 10 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Ovarian Neoplasms
Neoplasms
fibrin fragment D
Venous Thromboembolism
5 Citations

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

Rondina, M. T., Tatsumi, K., Bastarache, J. A. & Mackman, N. Jan 8 2016 (Accepted/In press) In : Critical Care Medicine.

Research output: Research - peer-reviewArticle

Thromboplastin
Interleukin-8
Human Influenza
Mortality
Infection

Mouse models of venous thrombosis are not equal

Mackman, N. May 26 2016 In : Blood. 127, 21, p. 2510-2511 2 p.

Research output: Research - peer-reviewComment/debate

Factor XII
Venous Thrombosis
Neutrophils
Blood Platelets
Platelets
2 Citations

Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury

Shaver, C. M., Grove, B. S., Clune, J. K., Mackman, N., Ware, L. B. & Bastarache, J. A. Feb 29 2016 In : Scientific Reports. 6, 22249

Research output: Research - peer-reviewArticle

Acute Lung Injury
Thromboplastin
Permeability
Pneumonia
Myeloid Cells
1 Citations

The clot thickens in atherosclerosis

MacKman, N. Mar 1 2016 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 3, p. 425-426 2 p.

Research output: Research - peer-reviewEditorial

Factor XI Deficiency
Factor XI
Aortic Diseases
Apolipoproteins E
Aorta
1 Citations

Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease

Sparkenbaugh, E. M., Chantrathammachart, P., Chandarajoti, K., Mackman, N., Key, N. S. & Pawlinski, R. Mar 10 2016 In : Blood. 127, 10, p. 1371-1373 3 p.

Research output: Research - peer-reviewLetter

Animal Disease Models
Cardiomegaly
Sickle Cell Anemia
Thromboplastin
Thrombin
9 Citations

Thrombosis in cancer: Research priorities identified by a national cancer institute/national heart, lung, and blood institute strategic working group

Key, N. S., Khorana, A. A., Mackman, N., McCarty, O. J. T., White, G. C., Francis, C. W., McCrae, K. R., Palumbo, J. S., Raskob, G. E., Chan, A. T. & Sood, A. K. Jul 1 2016 In : Cancer Research. 76, 13, p. 3671-3675 5 p.

Research output: Research - peer-reviewArticle

National Heart, Lung, and Blood Institute (U.S.)
National Cancer Institute (U.S.)
Thrombosis
Research
Neoplasms
7 Citations

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice

Antoniak, S., Tatsumi, K., Hisada, Y., Milner, J. J., Neidich, S. D., Shaver, C. M., Pawlinski, R., Beck, M. A., Bastarache, J. A. & Mackman, N. Jun 1 2016 In : Journal of Thrombosis and Haemostasis. 14, 6, p. 1238-1248 11 p.

Research output: Research - peer-reviewArticle

Influenza A virus
Thromboplastin
Hemorrhage
Virus Diseases
Lung
19 Citations

Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice

Geddings, J. E., Hisada, Y., Boulaftali, Y., Getz, T. M., Whelihan, M., Fuentes, R., Dee, R., Cooley, B. C., Key, N. S., Wolberg, A. S., Bergmeier, W. & Mackman, N. Jan 1 2016 In : Journal of Thrombosis and Haemostasis. 14, 1, p. 153-166 14 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Thrombosis
Blood Platelets
Neoplasms
Platelet Activation
2015
6 Citations

A matched cross-sectional study of the association between circulating tissue factor activity, immune activation and advanced liver fibrosis in hepatitis C infection

Hodowanec, A. C., Lee, R. D., Brady, K. E., Gao, W., Kincaid, S., Plants, J., Bahk, M., Mackman, N., Landay, A. L. & Huhn, G. D. Dec 12 2015 In : BMC Infectious Diseases. 15, 1, 190

Research output: Research - peer-reviewArticle

Thromboplastin
Hepatitis C
Hepacivirus
Liver Cirrhosis
Cross-Sectional Studies
17 Citations

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Sparkenbaugh, E. M., Chantrathammachart, P., Wang, S., Jonas, W., Kirchhofer, D., Gailani, D., Gruber, A., Kasthuri, R., Key, N. S., Mackman, N. & Pawlinski, R. Jan 1 2015 In : Haematologica. 100, 3, p. 308-313 6 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Heme
Factor XI
Leukocytes
Endothelial Cells
21 Citations

Extracellular vesicles, tissue factor, cancer and thrombosis - discussion themes of the ISEV 2014 educational day

Gardiner, C., Harrison, P., Belting, M., Böing, A., Campello, E., Carter, B. S., Collier, M. E., Coumans, F., Ettelaie, C., Van Es, N., Hochberg, F. H., Mackman, N., Rennert, R. C., Thaler, J., Rak, J. & Nieuwland, R. Jan 1 2015 In : Journal of Extracellular Vesicles. 4, 2015, p. 1-14 14 p.

Research output: Research - peer-reviewReview article

Thromboplastin
Thrombosis
Neoplasms
Extracellular Vesicles
Venous Thromboembolism
10 Citations

Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition

Getz, T. M., Piatt, R., Petrich, B. G., Monroe, D., Mackman, N. & Bergmeier, W. Mar 1 2015 In : Journal of Thrombosis and Haemostasis. 13, 3, p. 417-425 9 p.

Research output: Research - peer-reviewArticle

Bleeding Time
Hemostatics
Hemostasis
Blood Platelets
Fibrin
14 Citations

Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm

Owens, A. P., Edwards, T. L., Antoniak, S., Geddings, J. E., Jahangir, E., Wei, W. Q., Denny, J. C., Boulaftali, Y., Bergmeier, W., Daugherty, A., Sampson, U. K. A. & MacKman, N. Sep 28 2015 In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 9, p. 2032-2041 10 p.

Research output: Research - peer-reviewArticle

Platelet Aggregation Inhibitors
Abdominal Aortic Aneurysm
Rupture
Blood Platelets
Aneurysm
2 Citations

Procoagulant Microparticles in Dogs with Immune-Mediated Hemolytic Anemia

Kidd, L., Geddings, J., Hisada, Y., Sueda, M., Concannon, T., Nichols, T., Merricks, E. & Mackman, N. May 1 2015 In : Journal of Veterinary Internal Medicine. 29, 3, p. 908-916 9 p.

Research output: Research - peer-reviewArticle

hemolytic anemia
dogs
Hemolytic Anemia
Dogs
thrombosis
6 Citations

Protective and pathological roles of tissue factor in the heart

Bode, M. F. & Mackman, N. 2015 In : Hamostaseologie. 35, 1, p. 37-46 10 p.

Research output: Research - peer-reviewReview article

Thromboplastin
PAR-1 Receptor
Proteinase-Activated Receptors
Myocarditis
Thrombin
24 Citations

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

Stefanini, L., Paul, D. S., Robledo, R. F., Chan, E. R., Getz, T. M., Campbell, R. A., Kechele, D. O., Casari, C., Piatt, R., Caron, K. M., Mackman, N., Weyrich, A. S., Parrott, M. C., Boulaftali, Y., Adams, M. D., Peters, L. L. & Bergmeier, W. Apr 1 2015 In : Journal of Clinical Investigation. 125, 4, p. 1419-1432 14 p.

Research output: Research - peer-reviewArticle

Platelet Activation
Blood Platelets
Adenosine Diphosphate
Thrombosis
Purinergic P1 Receptors
20 Citations

Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor

Stavrou, E. X., Fang, C., Merkulova, A., Alhalabi, O., Grobe, N., Antoniak, S., Mackman, N. & Schmaier, A. H. Jan 22 2015 In : Blood. 125, 4, p. 710-719 10 p.

Research output: Research - peer-reviewArticle

Epoprostenol Receptors
Thromboplastin
Epoprostenol
Plasmas
Thrombosis
6 Citations

Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor

Shaver, C. M., Grove, B. S., Putz, N. D., Clune, J. K., Lawson, W. E., Carnahan, R. H., Mackman, N., Ware, L. B. & Bastarache, J. A. Nov 1 2015 In : American Journal of Respiratory Cell and Molecular Biology. 53, 5, p. 719-727 9 p.

Research output: Research - peer-reviewArticle

Acute Lung Injury
Thromboplastin
Permeability
Epithelium
Lung
5 Citations

Theme 2: Epidemiology, Biomarkers, and Imaging of Venous Thromboembolism (and postthrombotic syndrome)

Spronk, H. M. H., Cannegieter, S., Morange, P., Hackeng, T., Huisman, M., Nagler, M., Posthuma, J., Ninivaggi, M., Zwaveling, S., Van Der Hulle, T., Scheres, L. J. J., Van Mens, T. E. & Mackman, N. Jan 1 2015 In : Thrombosis Research. 136, p. S8-S12

Research output: Research - peer-reviewArticle

Postthrombotic Syndrome
Venous Thromboembolism
Epidemiology
Biomarkers
33 Citations

The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Nickel, K. F., Ronquist, G., Langer, F., Labberton, L., Fuchs, T. A., Bokemeyer, C., Sauter, G., Graefen, M., Mackman, N., Stavrou, E. X., Ronquist, G. & Renné, T. Sep 10 2015 In : Blood. 126, 11, p. 1379-1389 11 p.

Research output: Research - peer-reviewArticle

Factor XII
Polyphosphates
Prostatic Neoplasms
Thrombosis
Coagulation
19 Citations

Tissue factor and atherothrombosis

Tatsumi, K. & Mackman, N. May 27 2015 In : Journal of Atherosclerosis and Thrombosis. 22, 6, p. 543-549 7 p.

Research output: Research - peer-reviewReview article

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Factor VIIa
Macrophages
Thromboplastin
Medical problems
9 Citations

Venous thrombosis

Wolberg, A. S., Rosendaal, F. R., Weitz, J. I., Jaffer, I. H., Agnelli, G., Baglin, T. & MacKman, N. May 7 2015 In : Nature Reviews Disease Primers. 1, 15006

Research output: Research - peer-reviewArticle

Venous Thromboembolism
Venous Thrombosis
Thrombosis
Pulmonary Embolism
Anticoagulants
30 Citations

Venous thrombosis and cancer: From mouse models to clinical trials

Hisada, Y., Geddings, J. E., Ay, C. & Mackman, N. Aug 1 2015 In : Journal of Thrombosis and Haemostasis. 13, 8, p. 1372-1382 11 p.

Research output: Research - peer-reviewReview article

Venous Thrombosis
Clinical Trials
Neoplasms
Venous Thromboembolism
Thrombosis
3 Citations

Δ9-Tetrahydrocannabinol (THC) enhances lipopolysaccharide-stimulated tissue factor in human monocytes and monocyte-derived microvesicles

Williams, J. C., Klein, T. W., Goldberger, B. A., Sleasman, J. W., Mackman, N. & Goodenow, M. M. Jun 12 2015 In : Journal of Inflammation (United Kingdom). 12, 1, 39

Research output: Research - peer-reviewArticle

Dronabinol
Thromboplastin
Lipopolysaccharides
Monocytes
Cannabis
2014
5 Citations

Circulating microparticle tissue factor activity is increased in patients with cirrhosis

Rautou, P. E., Vion, A. C., Luyendyk, J. P. & Mackman, N. Nov 1 2014 In : Hepatology (Baltimore, Md.). 60, 5, p. 1793-1795 3 p.

Research output: Research - peer-reviewLetter

Cell-Derived Microparticles
Thromboplastin
Liver Cirrhosis
Case-Control Studies
Fibrosis
15 Citations

Coagulation, protease-activated receptors, and viral myocarditis

Antoniak, S. & Mackman, N. 2014 In : Journal of Cardiovascular Translational Research. 7, 2, p. 203-211 9 p.

Research output: Research - peer-reviewReview article

Proteinase-Activated Receptors
Myocarditis
PAR-2 Receptor
Thromboplastin
Virus Diseases
14 Citations

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

Yokota, N., Zarpellon, A., Chakrabarty, S., Bogdanov, V. Y., Gruber, A., Castellino, F. J., Mackman, N., Ellies, L. G., Weiler, H., Ruggeri, Z. M. & Ruf, W. Jan 2014 In : Journal of Thrombosis and Haemostasis. 12, 1, p. 71-81 11 p.

Research output: Research - peer-reviewArticle

Thromboplastin
Thrombin
Neoplasm Metastasis
Blood Platelets
Neoplasms
31 Citations

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease

Sparkenbaugh, E. M., Chantrathammachart, P., Mickelson, J., Van Ryn, J., Hebbel, R. P., Monroe, D. M., Mackman, N., Key, N. S. & Pawlinski, R. Mar 13 2014 In : Blood. 123, 11, p. 1747-1756 10 p.

Research output: Research - peer-reviewArticle

Sickle Cell Anemia
Thrombin
Blood Vessels
Inflammation
PAR-1 Receptor