Find Research Outputs

Search concepts
Selected Filters
2018

Frequency of breast cancer subtypes among African American women in the AMBER consortium: Breast Cancer Res

Allott, E. H. , Geradts, J. , Cohen, S. M. , Khoury, T. , Zirpoli, G. R. , Bshara, W. , Davis, W. , Omilian, A. , Nair, P. , Ondracek, R. P. , Cheng, T. D. , Miller, C. R. , Hwang, H. , Thorne, L. B. , O'Connor, S. , Bethea, T. N. , Bell, M. E. , Hu, Z. , Li, Y. , Kirk, E. L. & 7 others Sun, X., Ruiz-Narvaez, E. A., Perou, C. M., Palmer, J. R., Olshan, A. F., Ambrosone, C. B. & Troester, M. A. Feb 8 2018 In : Breast cancer research : BCR. 20, 1

Research output: Contribution to journalArticle

African Americans
Epidemiology
Breast Neoplasms
Estrogen Receptors
Neoplasms
2017

Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer

Mehta, G. A., Parker, J. S., Silva, G. O., Hoadley, K. A., Perou, C. M. & Gatza, M. L. Apr 1 2017 In : Breast Cancer Research and Treatment. 162, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Family Therapy
Genomic Instability
RNA Interference
1 Citations

Docetaxel-loaded PLGA nanoparticles improve efficacy in taxane-resistant triple-negative breast cancer

Bowerman, C. J., Byrne, J. D., Chu, K. S., Schorzman, A. N., Keeler, A. W., Sherwood, C. A., Perry, J. L., Luft, J. C., Darr, D. B., Deal, A. M., Napier, M. E., Zamboni, W. C., Sharpless, N. E., Perou, C. M. & DeSimone, J. M. 2017 In : Nano Letters. 17, 1, p. 242-248 7 p.

Research output: Contribution to journalArticle

docetaxel
breast
cancer
Nanoparticles
nanoparticles
17 Citations

Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex

Zawistowski, J. S. , Bevill, S. M. , Goulet, D. R. , Stuhlmiller, T. J. , Beltran, A. S. , Olivares-Quintero, J. F. , Singh, D. , Sciaky, N. , Parker, J. S. , Rashid, N. U. , Chen, X. , Duncan, J. S. , Whittle, M. C. , Angus, S. P. , Velarde, S. H. , Golitz, B. T. , He, X. , Santos, C. , Darr, D. B. , Gallagher, K. & 5 others Graves, L. M., Perou, C. M., Carey, L. A., Shelton Earp, H. & Johnson, G. L. Mar 1 2017 In : Cancer Discovery. 7, 3, p. 302-321 20 p.

Research output: Contribution to journalArticle

Positive Transcriptional Elongation Factor B
Mitogen-Activated Protein Kinase Kinases
Triple Negative Breast Neoplasms
Receptor Protein-Tyrosine Kinases
Neoplasms
3 Citations

Nuclear localized LSR: A novel regulator of breast cancer behavior and tumorigenesis

Reaves, D. K., Hoadley, K. A., Fagan-Solis, K. D., Jima, D. D., Bereman, M., Thorpe, L., Hicks, J., McDonald, D., Troester, M. A., Perou, C. M. & Fleming, J. M. Feb 1 2017 In : Molecular Cancer Research. 15, 2, p. 165-178 14 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Carcinogenesis
Breast Neoplasms
Neoplasms
Post Translational Protein Processing
1 Citations

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

Kechele, D. O., Blue, R. E., Zwarycz, B., Espenschied, S. T., Mah, A. T., Siegel, M. B., Perou, C. M., Ding, S., Magness, S. T., Lund, P. K. & Caron, K. M. Feb 1 2017 In : Journal of Clinical Investigation. 127, 2, p. 593-607 15 p.

Research output: Contribution to journalArticle

Orphaned Children
Adenoma
Regeneration
Stem Cells
Organoids
3 Citations

Pentraxin-3 is a PI3K signaling target that promotes stem cell-like traits in basal-like breast cancers

Thomas, C., Henry, W., Cuiffo, B. G., Collmann, A. Y., Marangoni, E., Benhamo, V., Bhasin, M. K., Fan, C., Fuhrmann, L., Baldwin, A. S., Perou, C., Vincent-Salomon, A., Toker, A. & Karnoub, A. E. Feb 21 2017 In : Science Signaling. 10, 467, eaah4674

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Stem cells
Phosphotransferases
Stem Cells
2 Citations

Progesterone Receptor Isoform Ratio: A Breast Cancer Prognostic and Predictive Factor for Antiprogestin Responsiveness

Rojas, P. A., May, M., Sequeira, G. R., Elia, A., Alvarez, M., Martínez, P., Gonzalez, P., Hewitt, S., He, X., Perou, C. M., Molinolo, A., Gibbons, L., Abba, M. C., Gass, H. & Lanari, C. Jul 1 2017 In : Journal of the National Cancer Institute. 109, 7, djw317

Research output: Contribution to journalArticle

Progesterone Receptors
Protein Isoforms
Breast Neoplasms
Neoplasms
Mifepristone
2016
20 Citations

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

He, Z., Wan, X., Schulz, A., Bludau, H., Dobrovolskaia, M. A., Stern, S. T., Montgomery, S. A., Yuan, H., Li, Z., Alakhova, D., Sokolsky, M., Darr, D. B., Perou, C. M., Jordan, R., Luxenhofer, R. & Kabanov, A. V. Sep 1 2016 In : Biomaterials. 101, p. 296-309 14 p.

Research output: Contribution to journalArticle

Drug therapy
Micelles
Paclitaxel
Tumors
Solubility
31 Citations
B-Lymphocytes
Confidence Intervals
Neoplasms
Melanoma
Survival
5 Citations

Genomic profiling of murine mammary tumors identifies potential personalized drug targets for p53-deficient mammary cancers

Pfefferle, A. D., Agrawal, Y. N., Koboldt, D. C., Kanchi, K. L., Herschkowitz, J. I., Mardis, E. R., Rosen, J. M. & Perou, C. M. Jul 1 2016 In : DMM Disease Models and Mechanisms. 9, 7, p. 749-757 9 p.

Research output: Contribution to journalArticle

Tumors
Breast Neoplasms
Pharmaceutical Preparations
Neoplasms
Triple Negative Breast Neoplasms
4 Citations

High intratumoral stromal content defines reactive breast cancer as a low-risk breast cancer subtype

Dennison, J. B., Shahmoradgoli, M., Liu, W., Ju, Z., Meric-Bernstam, F., Perou, C. M., Sahin, A. A., Welm, A., Oesterreich, S., Sikora, M. J., Brown, R. E. & Mills, G. B. Oct 15 2016 In : Clinical Cancer Research. 22, 20, p. 5068-5078 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogen Receptors
Protein Array Analysis
Neoplasms
Proteins
2 Citations

Identification of mRNA isoform switching in breast cancer

Zhao, W., Hoadley, K. A., Parker, J. S. & Perou, C. M. 2016 In : BMC Genomics. 17, 1, 181

Research output: Contribution to journalArticle

RNA Isoforms
Protein Isoforms
Breast Neoplasms
Genes
Neoplasms
3 Citations

Insulin receptor substrate adaptor proteins mediate prognostic gene expression profiles in breast cancer

Becker, M. A., Ibrahim, Y. H., Oh, A. S., Fagan, D. H., Byron, S. A., Sarver, A. L., Lee, A. V., Shaw, L. M., Fan, C., Perou, C. M. & Yee, D. Mar 1 2016 In : PLoS One. 11, 3, e0150564

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin Receptor
Transcriptome
Gene expression
breast neoplasms
61 Citations

Molecular heterogeneity and response to neoadjuvant human epidermal growth factor receptor 2 targeting in CALGB 40601, a randomized phase III trial of paclitaxel plus trastuzumab with or without lapatinib

Carey, L. A., Berry, D. A., Cirrincione, C. T., Barry, W. T., Pitcher, B. N., Harris, L. N., Ollila, D. W., Krop, I. E., Henry, N. L., Weckstein, D. J., Anders, C. K., Singh, B., Hoadley, K. A., Iglesia, M., Cheang, M. C. U., Perou, C. M., Winer, E. P. & Hudis, C. A. Feb 20 2016 In : Journal of Clinical Oncology. 34, 6, p. 542-549 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Tumor Microenvironment
Gene Expression
Arm
Hormones
34 Citations

MR imaging radiomics signatures for predicting the risk of breast cancer recurrence as given by research versions of MammaPrint, oncotype DX, and PAM50 gene assays

Li, H., Zhu, Y., Burnside, E. S., Drukker, K., Hoadley, K. A., Fan, C., Conzen, S. D., Whitman, G. J., Sutton, E. J., Net, J. M., Ganott, M., Huang, E., Morris, E. A., Perou, C. M., Ji, Y. & Giger, M. L. Jan 1 2016 In : Radiology. 281, 2, p. 382-391 10 p.

Research output: Contribution to journalReview article

Magnetic Resonance Imaging
Breast Neoplasms
Recurrence
Research
Genes
2 Citations

Overview of genetically engineered mouse models of distinct breast cancer subtypes

Usary, J., Darr, D. B., Pfefferle, A. D. & Perou, C. M. Mar 1 2016 In : Current Protocols in Pharmacology. 2016, p. 14.38.1-14.38.11

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Drug Discovery
Heterografts
Cause of Death
14 Citations

Performance of three-biomarker immunohistochemistry for intrinsic breast cancer subtyping in the AMBER consortium

Allott, E. H. , Cohen, S. M. , Geradts, J. , Sun, X. , Khoury, T. , Bshara, W. , Zirpoli, G. R. , Miller, C. R. , Hwang, H. , Thorne, L. B. , O'Connor, S. , Tse, C. K. , Bell, M. B. , Hu, Z. , Li, Y. , Kirk, E. L. , Bethea, T. N. , Perou, C. M. , Palmer, J. R. , Ambrosone, C. B. & 2 others Olshan, A. F. & Troester, M. A. Mar 1 2016 In : Cancer Epidemiology Biomarkers and Prevention. 25, 3, p. 470-478 9 p.

Research output: Contribution to journalArticle

Epidemiology
Biomarkers
Immunohistochemistry
Breast Neoplasms
Progesterone Receptors
14 Citations

Prognostic ability of EndoPredict compared to research-based versions of the PAM50 risk of recurrence (ROR) scores in node-positive, estrogen receptor-positive, and HER2-negative breast cancer. A GEICAM/9906 sub-study

Martin, M., Brase, J. C., Ruiz, A., Prat, A., Kronenwett, R., Calvo, L., Petry, C., Bernard, P. S., Ruiz-Borrego, M., Weber, K. E., Rodriguez, C. A., Alvarez, I. M., Segui, M. A., Perou, C. M., Casas, M., Carrasco, E., Caballero, R. & Rodriguez-Lescure, A. Feb 1 2016 In : Breast Cancer Research and Treatment. 156, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Recurrence
Research
Neoplasm Metastasis
4 Citations

Rho GTPase transcriptome analysis reveals oncogenic roles for rho GTPase-activating proteins in basal-like breast cancers

Lawson, C. D., Fan, C., Mitin, N., Baker, N. M., George, S. D., Graham, D. M., Perou, C. M., Burridge, K., Der, C. J. & Rossman, K. L. Jul 1 2016 In : Cancer Research. 76, 13, p. 3826-3837 12 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Gene Expression Profiling
Breast Neoplasms
Growth
Cell Proliferation
10 Citations

Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases

Hoadley, K. A., Siegel, M. B., Kanchi, K. L., Miller, C. A., Ding, L., Zhao, W., He, X., Parker, J. S., Wendl, M. C., Fulton, R. S., Demeter, R. T., Wilson, R. K., Carey, L. A., Perou, C. M. & Mardis, E. R. Dec 1 2016 In : PLoS Medicine. 13, 12, e1002174

Research output: Contribution to journalArticle

Genomics
Retrospective Studies
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Validation of the lung subtyping panel in multiple fresh-frozen and formalin-fixed, paraffin-embedded lung tumor gene expression data sets

Faruki, H., Mayhew, G. M., Fan, C., Wilkerson, M. D., Parker, S., Kam-Morgan, L., Eisenberg, M., Horten, B., Hayes, D. N., Perou, C. M. & Lai-Goldman, M. Jun 1 2016 In : Archives of Pathology and Laboratory Medicine. 140, 6, p. 536-542 7 p.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Gene Expression
Lung
Neoplasms
2015
12 Citations

Activating PIK3CA mutations induce an epidermal growth factor receptor (EGFR)/extracellular signal-regulated Kinase (ERK) paracrine signaling axis in basal-like breast cancer

Young, C. D. , Zimmerman, L. J. , Hoshino, D. , Formisano, L. , Hanker, A. B. , Gatza, M. L. , Morrison, M. M. , Moore, P. D. , Whitwell, C. A. , Dave, B. , Stricker, T. , Bhola, N. E. , Silva, G. O. , Patel, P. , Brantley-Sieders, D. M. , Levin, M. , Horiates, M. , Palma, N. A. , Wang, K. , Stephens, P. J. & 8 others Perou, C. M., Weaver, A. M., O'Shaughnessy, J. A., Chang, J. C., Park, B. H., Liebler, D. C., Cook, R. S. & Arteaga, C. L. Jan 1 2015 In : Molecular and Cellular Proteomics. 14, 7, p. 1959-1976 18 p.

Research output: Contribution to journalArticle

Paracrine Communication
Extracellular Signal-Regulated MAP Kinases
Epidermal Growth Factor Receptor
Breast Neoplasms
Mutation
84 Citations

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

Wagenblast, E., Soto, M., Gutiérrez-Ángel, S., Hartl, C. A., Gable, A. L., Maceli, A. R., Erard, N., Williams, A. M., Kim, S. Y., Dickopf, S., Harrell, J. C., Smith, A. D., Perou, C. M., Wilkinson, J. E., Hannon, G. J. & Knott, S. R. V. Apr 15 2015 In : Nature. 520, 7547, p. 358-362 5 p.

Research output: Contribution to journalArticle

Blood Vessels
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Clone Cells
17 Citations

Body Mass Index, PAM50 Subtype, and Outcomes in Node-Positive Breast Cancer: CALGB 9741 (Alliance)

Ligibel, J. A., Cirrincione, C. T., Liu, M., Citron, M., Ingle, J. N., Gradishar, W., Martino, S., Sikov, W., Michaelson, R., Mardis, E., Perou, C. M., Ellis, M., Winer, E., Hudis, C. A., Berry, D. & Barry, W. T. Sep 1 2015 In : Journal of the National Cancer Institute. 107, 9, djv179

Research output: Contribution to journalArticle

Body Mass Index
Breast Neoplasms
Confidence Intervals
Weights and Measures
Drug Therapy
7 Citations

CCR 20th anniversary commentary: The development of breast cancer molecular subtyping

Nielsen, T. O. & Perou, C. M. Apr 15 2015 In : Clinical Cancer Research. 21, 8, p. 1779-1781 3 p.

Research output: Contribution to journalComment/debate

Anniversaries and Special Events
Breast Neoplasms
Gene Expression Profiling
Neoplasms
Cohort Studies
7 Citations

CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer

Black, J. L., Harrell, J. C., Leisner, T. M., Fellmeth, M. J., George, S. D., Reinhold, D., Baker, N. M., Jones, C. D., Der, C. J., Perou, C. M. & Parise, L. V. Jun 24 2015 In : Breast Cancer Research and Treatment. 152, 2, p. 337-346 10 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Cell Survival
Growth
Neoplasms
RNA Sequence Analysis
3 Citations

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

Cantrell, M. A., Ebelt, N. D., Pfefferle, A. D., Perou, C. M. & Van Den Berg, C. L. Jan 1 2015 In : Oncotarget. 6, 14, p. 11863-11881 19 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 9
Neoplasm Genes
Human Mammary Glands
Phosphotransferases
Breast Neoplasms
501 Citations

Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas

Brat, D. J. , Verhaak, R. G. W. , Aldape, K. D. , Yung, W. K. A. , Salama, S. R. , Cooper, L. A. D. , Rheinbay, E. , Miller, C. R. , Vitucci, M. , Morozova, O. , Robertson, A. G. , Noushmehr, H. , Laird, P. W. , Cherniack, A. D. , Akbani, R. , Huse, J. T. , Ciriello, G. , Poisson, L. M. , Barnholtz-Sloan, J. S. , Berger, M. S. & 30 others Brennan, C., Colen, R. R., Colman, H., Flanders, A. E., Giannini, C., Grifford, M., Iavarone, A., Jain, R., Joseph, I., Kim, J., Kasaian, K., Mikkelsen, T., Murray, B. A., O'Neill, B. P., Pachter, L., Parsons, D. W., Sougnez, C., Sulman, E. P., Vandenberg, S. R., Van Meir, E. G., Von Deimling, A., Zhang, H., Crain, D., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, T. & Sherman, M. Jun 25 2015 In : New England Journal of Medicine. 372, 26, p. 2481-2498 18 p.

Research output: Contribution to journalArticle

Glioma
Mutation
Glioblastoma
DNA Methylation
Exome
701 Citations

Comprehensive genomic characterization of head and neck squamous cell carcinomas

The Cancer Genome Atlas Network Jan 29 2015 In : Nature. 517, 7536, p. 576-582 7 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
TNF Receptor-Associated Factor 3
cdc Genes
Atlases
272 Citations

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

Ciriello, G. , Gatza, M. L. , Beck, A. H. , Wilkerson, M. D. , Rhie, S. K. , Pastore, A. , Zhang, H. , McLellan, M. , Yau, C. , Kandoth, C. , Bowlby, R. , Shen, H. , Hayat, S. , Fieldhouse, R. , Lester, S. C. , Tse, G. M. K. , Factor, R. E. , Collins, L. C. , Allison, K. H. , Chen, Y. Y. & 30 others Jensen, K., Johnson, N. B., Oesterreich, S., Mills, G. B., Cherniack, A. D., Robertson, G., Benz, C., Sander, C., Laird, P. W., Hoadley, K. A., King, T. A., Akbani, R., Auman, J. T., Balasundaram, M., Balu, S., Barr, T., Benz, S., Berrios, M., Beroukhim, R., Bodenheimer, T., Boice, L., Bootwalla, M. S., Bowen, J., Brooks, D., Chin, L., Cho, J., Chudamani, S., Davidsen, T., Demchok, J. A. & Dennison, J. B. Oct 8 2015 In : Cell. 163, 2, p. 506-519 14 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Breast Neoplasms
Phosphorylation
Cadherins
Tumors
11 Citations

Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer

Silva, G. O., He, X., Parker, J. S., Gatza, M. L., Carey, L. A., Hou, J. P., Moulder, S. L., Marcom, P. K., Ma, J., Rosen, J. M. & Perou, C. M. Jun 25 2015 In : Breast Cancer Research and Treatment. 152, 2, p. 347-356 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
DNA
Genes
Gene Expression
Neoplasm Genes
31 Citations

Defining breast cancer intrinsic subtypes by quantitative receptor expression

Cheang, M. C. U. , Martin, M. , Nielsen, T. O. , Prat, A. , Voduc, D. , Rodriguez-Lescure, A. , Ruiz, A. , Chia, S. , Shepherd, L. , Ruiz-Borrego, M. , Calvo, L. , Alba, E. , Carrasco, E. , Caballero, R. , Tu, D. , Pritchard, K. I. , Levine, M. N. , Bramwell, V. H. , Parker, J. , Bernard, P. S. & 4 others Ellis, M. J., Perou, C. M., Di Leo, A. & Carey, L. A. Jan 1 2015 In : Oncologist. 20, 5, p. 474-482 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Hormones
Neoplasms
Immunohistochemistry
Reverse Transcription
42 Citations

Development and verification of the PAM50-based Prosigna breast cancer gene signature assay

Wallden, B., Storhoff, J., Nielsen, T., Dowidar, N., Schaper, C., Ferree, S., Liu, S., Leung, S., Geiss, G., Snider, J., Vickery, T., Davies, S. R., Mardis, E. R., Gnant, M., Sestak, I., Ellis, M. J., Perou, C. M., Bernard, P. S. & Parker, J. S. Aug 22 2015 In : BMC Medical Genomics. 8, 1, 54

Research output: Contribution to journalArticle

Neoplasm Genes
Breast Neoplasms
Recurrence
Validation Studies
Paraffin
3 Citations

Erratum: Progesterone receptor modulates ERα action in breast cancer (Nature (2015) 523 313-317 DOI:10.1038/nature14583)

Mohammed, H. , Russell, I. A. , Stark, R. , Rueda, O. M. , Hickey, T. E. , Tarulli, G. A. , Serandour, A. A. , Birrell, S. N. , Bruna, A. , Saadi, A. , Menon, S. , Hadfield, J. , Pugh, M. , Raj, G. V. , Brown, G. D. , D'Santos, C. , Robinson, J. L. L. , Silva, G. , Launchbury, R. , Perou, C. M. & 4 others Stingl, J., Caldas, C., Tilley, W. D. & Carroll, J. S. Oct 1 2015 In : Nature. 526, 7571, 1 p.

Research output: Contribution to journalComment/debate

Progesterone Receptors
Breast Neoplasms
6 Citations

Genome medicine in cancer: What's in a name?

Schott, A. F., Perou, C. M. & Hayes, D. F. May 15 2015 In : Cancer Research. 75, 10, p. 1930-1935 6 p.

Research output: Contribution to journalReview article

Names
Medicine
Genome
Technology
Neoplasms
484 Citations

Genomic Classification of Cutaneous Melanoma

The Cancer Genome Atlas Network Jun 20 2015 In : Cell. 161, 7, p. 1681-1696 16 p.

Research output: Contribution to journalArticle

Melanoma
Skin
T-cells
Lymphocytes
Pathology
1 Citations

Hierarchical task-driven feature learning for tumor histology

Couture, H. D., Marron, J. S., Thomas, N. E., Perou, C. M. & Niethammer, M. Jul 21 2015 2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015. IEEE Computer Society, Vol. 2015-July, p. 999-1003 5 p. 7164039

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Histology
Glossaries
Tumors
Learning
Labels
209 Citations

Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance)

Sikov, W. M., Berry, D. A., Perou, C. M., Singh, B., Cirrincione, C. T., Tolaney, S. M., Kuzma, C. S., Pluard, T. J., Somlo, G., Port, E. R., Golshan, M., Bellon, J. R., Collyar, D., Hahn, O. M., Carey, L. A., Hudis, C. A. & Winer, E. P. Jan 1 2015 In : Journal of Clinical Oncology. 33, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Carboplatin
Paclitaxel
Doxorubicin
Cyclophosphamide
25 Citations

Intratumoral heterogeneity in a Trp53-null mouse model of human breast cancer

Zhang, M., Tsimelzon, A., Chang, C. H., Fan, C., Wolff, A., Perou, C. M., Hilsenbeck, S. G. & Rosen, J. M. Jan 1 2015 In : Cancer Discovery. 5, 5, p. 521-533 13 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasms
Neoplastic Stem Cells
Tissue Array Analysis
Gene Knockdown Techniques
16 Citations

Loss of heterozygosity at the CYP2D6 locus in breast cancer: Implications for germline pharmacogenetic studies

Goetz, M. P. , Sun, J. X. , Suman, V. J. , Silva, G. O. , Perou, C. M. , Nakamura, Y. , Cox, N. J. , Stephens, P. J. , Miller, V. A. , Ross, J. S. , Chen, D. , Safgren, S. L. , Kuffel, M. J. , Ames, M. M. , Kalari, K. R. , Gomez, H. L. , Gonzalez-Angulo, A. M. , Burgues, O. , Brauch, H. B. , Ingle, J. N. & 2 others Ratain, M. J. & Yelensky, R. Jan 1 2015 In : Journal of the National Cancer Institute. 107, 2, dju401

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Loss of Heterozygosity
Breast Neoplasms
Genotype
Neoplasms
12 Citations

Luminal progenitor and fetal mammary stem cell expression features predict breast tumor response to neoadjuvant chemotherapy

Pfefferle, A. D., Spike, B. T., Wahl, G. M. & Perou, C. M. Jan 1 2015 In : Breast Cancer Research and Treatment. 149, 2, p. 425-437 13 p.

Research output: Contribution to journalArticle

Fetal Stem Cells
Breast
Breast Neoplasms
Drug Therapy
Neoplasms
24 Citations

Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival

for the TEX Trialists Group Jan 1 2015 In : Annals of Oncology. 26, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Gene Expression
Recurrence
Survival
23 Citations

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

Wang, P., Wu, J., Ma, S., Zhang, L., Yao, J., Hoadley, K. A., Wilkerson, M. D., Perou, C. M., Guan, K. L., Ye, D. & Xiong, Y. Dec 22 2015 In : Cell Reports. 13, 11, p. 2353-2361 9 p.

Research output: Contribution to journalArticle

DNA Repair Enzymes
Alkylating Agents
Lomustine
Glioma
DNA
11 Citations

Palbociclib - Taking breast-cancer cells out of gear

Carey, L. A. & Perou, C. M. Jul 16 2015 In : New England Journal of Medicine. 373, 3, p. 273-274 2 p.

Research output: Contribution to journalEditorial

Antineoplastic Combined Chemotherapy Protocols
Piperazines
Pyridines
Protein Kinase Inhibitors
Breast Neoplasms
27 Citations

Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation

He, Z., Schulz, A., Wan, X., Seitz, J., Bludau, H., Alakhova, D. Y., Darr, D. B., Perou, C. M., Jordan, R., Ojima, I., Kabanov, A. V. & Luxenhofer, R. Jun 28 2015 In : Journal of Controlled Release. 208, p. 67-75 9 p.

Research output: Contribution to journalArticle

Taxoids
Micelles
Paclitaxel
Pharmaceutical Preparations
docetaxel
136 Citations

Progesterone receptor modulates ERα action in breast cancer

Mohammed, H. , Russell, I. A. , Stark, R. , Rueda, O. M. , Hickey, T. E. , Tarulli, G. A. , Serandour, A. A. A. , Birrell, S. N. , Bruna, A. , Saadi, A. , Menon, S. , Hadfield, J. , Pugh, M. , Raj, G. V. , Brown, G. D. , D'Santos, C. , Robinson, J. L. L. , Silva, G. , Launchbury, R. , Perou, C. M. & 4 others Stingl, J., Caldas, C., Tilley, W. D. & Carroll, J. S. Jul 16 2015 In : Nature. 523, 7560, p. 313-317 5 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Breast Neoplasms
Chromatin
Estrogen Receptor alpha
Heterografts
1 Citations

Proper Use of Allele-Specific Expression Improves Statistical Power for cis-eQTL Mapping with RNA-Seq Data

Hu, Y. J., Sun, W., Tzeng, J. Y. & Perou, C. M. Jul 3 2015 In : Journal of the American Statistical Association. 110, 511, p. 962-974 13 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Statistical Power
Gene
Sequencing
Haplotype
20 Citations

Pseudogenes transcribed in breast invasive carcinoma show subtype-specific expression and ceRNA potential

Welch, J. D., Baran-Gale, J., Perou, C. M., Sethupathy, P. & Prins, J. F. Feb 22 2015 In : BMC Genomics. 16, 1, 113

Research output: Contribution to journalArticle

Pseudogenes
Breast Neoplasms
MicroRNAs
RNA
Neoplasms
15 Citations

Race-associated biological differences among Luminal A breast tumors

D’Arcy, M., Fleming, J., Robinson, W. R., Kirk, E. L., Perou, C. M. & Troester, M. A. Jul 1 2015 In : Breast Cancer Research and Treatment. 152, 2, p. 437-448 12 p.

Research output: Contribution to journalArticle

African Americans
Breast Neoplasms
Genes
Survival
Mortality