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2017

Bayesian clinical trial design using Markov models with applications to autoimmune disease

Eggleston, B. S., Ibrahim, J. G. & Catellier, D. Dec 1 2017 In : Contemporary Clinical Trials. 63, p. 73-83 11 p.

Research output: Research - peer-reviewArticle

Platelet Count
Autoimmune Diseases
Clinical Trials
Hemorrhage
Recurrence
1 Citations

Bayesian longitudinal low-rank regression models for imaging genetic data from longitudinal studies

Lu, Z. H., Khondker, Z., Ibrahim, J. G., Wang, Y. & Zhu, H. Apr 1 2017 In : NeuroImage. 149, p. 305-322 18 p.

Research output: Research - peer-reviewArticle

Genetic Models
Longitudinal Studies
Neuroimaging
Single Nucleotide Polymorphism
Alzheimer Disease
1 Citations

Bayesian Model Assessment in Joint Modeling of Longitudinal and Survival Data With Applications to Cancer Clinical Trials

Zhang, D., Chen, M. H., Ibrahim, J. G., Boye, M. E. & Shen, W. Jan 2 2017 In : Journal of Computational and Graphical Statistics. 26, 1, p. 121-133 13 p.

Research output: Research - peer-reviewArticle

Joint Modeling
Joint Model
Survival Data
Bayesian Model
Longitudinal Data

LCN: A random graph mixture model for community detection in functional brain networks

Bryant, C., Zhu, H., Ahn, M. & Ibrahim, J. 2017 In : Statistics and its Interface. 10, 3, p. 369-378 10 p.

Research output: Research - peer-reviewArticle

Latent Class
Community Detection
Community Structure
Graph Model
Mixture Model

On inference of control-based imputation for analysis of repeated binary outcomes with missing data

Gao, F., Liu, G., Zeng, D., Diao, G., Heyse, J. F. & Ibrahim, J. G. May 4 2017 In : Journal of Biopharmaceutical Statistics. 27, 3, p. 358-372 15 p.

Research output: Research - peer-reviewArticle

Binary Outcomes
Imputation
Missing Data
Clinical Trials
Biased
3 Citations

Regression models on Riemannian symmetric spaces

Cornea, E., Zhu, H., Kim, P., Ibrahim, J. G. & the Alzheimer's Disease Neuroimaging Initiative Mar 1 2017 In : Journal of the Royal Statistical Society. Series B: Statistical Methodology. 79, 2, p. 463-482 20 p.

Research output: Research - peer-reviewArticle

Riemannian Symmetric Space
Regression Model
Regression model
Test Statistic
Euclidean space

Statistical design of noninferiority multiple region clinical trials to assess global and consistent treatment effects

Diao, G., Zeng, D., Ibrahim, J. G., Rong, A., Lee, O., Zhang, K. & Chen, Q. Mar 17 2017 (Accepted/In press) In : Journal of Biopharmaceutical Statistics. p. 1-12 12 p.

Research output: Research - peer-reviewArticle

Non-inferiority
Treatment Effects
Clinical Trials
Design
Guidelines
2016
1 Citations

An Automated High-throughput Array Microscope for Cancer Cell Mechanics

Cribb, J. A., Osborne, L. D., Beicker, K., Psioda, M., Chen, J., O'Brien, E. T., Taylor, R. M., Vicci, L., Hsiao, J. P. L., Shao, C., Falvo, M., Ibrahim, J. G., Wood, K. C., Blobe, G. C. & Superfine, R. Jun 6 2016 In : Scientific Reports. 6, 27371

Research output: Research - peer-reviewArticle

Epithelial-Mesenchymal Transition
Mechanics
Compliance
Epithelial Cells
Neoplasms
Sequencing
Statistical Model
Gene Expression
Gene expression
Statistical Models
2 Citations

Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines

Cordeiro-Stone, M., Mcnulty, J. J., Sproul, C. D., Chastain, P. D., Gibbs-Flournoy, E., Zhou, Y., Carson, C., Rao, S., Mitchell, D. L., Simpson, D. A., Thomas, N. E., Ibrahim, J. G. & Kaufmann, W. K. Jan 1 2016 In : Pigment Cell and Melanoma Research. 29, 1, p. 68-80 13 p.

Research output: Research - peer-reviewArticle

S Phase Cell Cycle Checkpoints
Melanocytes
Melanoma
Cell Line
Fibroblasts

Estimating Treatment Effects for Recurrent Events in the Presence of Rescue Medications: An Application to the Immune Thrombocytopenia Study

Gao, F., Zeng, D., Wei, H., Wang, X. & Ibrahim, J. G. Aug 29 2016 (Accepted/In press) In : Statistics in Biosciences. p. 1-17 17 p.

Research output: Research - peer-reviewArticle

Recurrent Events
Treatment Effects
Idiopathic Thrombocytopenic Purpura
Therapeutics
Platelets
2 Citations

JMFit: A SAS macro for joint models of longitudinal and survival data

Zhang, D., Chen, M. H., Ibrahim, J. G., Boye, M. E. & Shen, W. Jan 1 2016 In : Journal of Statistical Software. 71, p. 1-24 24 p.

Research output: Research - peer-reviewArticle

Joint Model
Survival Data
Longitudinal Data
Macros
Model

Reply to Comments

Zeng, D., Gao, F., Ibrahim, J. G., Hu, K. & Jia, C. Apr 30 2016 In : Statistics in Medicine. 35, 9, p. 1560 1 p.

Research output: Research - peer-reviewLetter

Sample Size
Human

SR-HARDI: Spatially Regularizing High Angular Resolution Diffusion Imaging

Rao, S., Ibrahim, J. G., Cheng, J., Yap, P. T. & Zhu, H. Oct 1 2016 In : Journal of Computational and Graphical Statistics. 25, 4, p. 1195-1211 17 p.

Research output: Research - peer-reviewArticle

High Angular Resolution
Regression Model
Imaging
Regression model
Voxel
7 Citations

Tamoxifen dose escalation in patients with diminished CYP2D6 activity normalizes endoxifen concentrations without increasing toxicity

Hertz, D. L. , Deal, A. , Ibrahim, J. G. , Walko, C. M. , Weck, K. E. , Anderson, S. , Magrinat, G. , Olajide, O. , Moore, S. , Raab, R. , Carrizosa, D. R. , Corso, S. , Schwartz, G. , Graham, M. , Peppercorn, J. M. , Jones, D. R. , Desta, Z. , Flockhart, D. A. , Evans, J. P. , McLeod, H. L. & 2 others Carey, L. A. & Irvin, W. J. Jul 1 2016 In : Oncologist. 21, 7, p. 795-803 9 p.

Research output: Research - peer-reviewArticle

Cytochrome P-450 CYP2D6
Tamoxifen
4-hydroxy-N-desmethyltamoxifen
Breast Neoplasms
Quality of Life
2015
1 Citations

A counterfactual P -Value approach for benefit-risk assessment in clinical trials

Zeng, D., Chen, M. H., Ibrahim, J. G., Wei, R., Ding, B., Ke, C. & Jiang, Q. Jan 1 2015 In : Journal of Biopharmaceutical Statistics. 25, 3, p. 508-524 17 p.

Research output: Research - peer-reviewArticle

Risk Assessment
Clinical Trials
Weights and Measures
Therapeutics
p-Value

Bayesian Inference for Multivariate Meta-Regression With a Partially Observed Within-Study Sample Covariance Matrix

Yao, H., Kim, S., Chen, M. H., Ibrahim, J. G., Shah, A. K. & Lin, J. Apr 3 2015 In : Journal of the American Statistical Association. 110, 510, p. 528-544 17 p.

Research output: Research - peer-reviewArticle

Sample Covariance Matrix
Cholesterol
Bayesian inference
Regression
Covariance matrix

Bayesian probability of success for clinical trials using historical data

Ibrahim, J. G., Chen, M. H., Lakshminarayanan, M., Liu, G. F. & Heyse, J. F. Jan 1 2015 In : Statistics in Medicine. 34, 2, p. 249-264 16 p.

Research output: Research - peer-reviewArticle

Historical Data
Clinical Trials
Therapeutics
Covariates
Methodology
1 Citations

Bflcrm: A bayesian functional linear cox regression model for predicting time to conversion to alzheimer’s disease

Lee, E., Zhu, H., Kong, D., Wang, Y., Giovanello, K. S. & Ibrahim, J. G. Dec 1 2015 In : Annals of Applied Statistics. 9, 4, p. 2153-2178 26 p.

Research output: Research - peer-reviewArticle

Cox Regression Model
Alzheimer's Disease
Linear Regression Model
Regression model
Alzheimer's disease

Diagnostic measures for the Cox regression model with missing covariates

Zhu, H., Ibrahim, J. G. & Chen, M. H. Dec 1 2015 In : Biometrika. 102, 4, p. 907-923 17 p.

Research output: Research - peer-reviewArticle

Martingale Residuals
Cox Regression Model
Missing Covariates
Goodness of fit
Diagnostics
2 Citations

DNA damage checkpoint responses in the S phase of synchronized diploid human fibroblasts

Chastain, P. D., Brylawski, B. P., Zhou, Y. C., Rao, S., Chu, H., Ibrahim, J. G., Kaufmann, W. K. & Cordeiro-Stone, M. 2015 In : Photochemistry and Photobiology. 91, 1, p. 109-116 8 p.

Research output: Research - peer-reviewArticle

Diploidy
S Phase
DNA Damage
Fibroblasts
DNA

Homology cluster differential expression analysis for interspecies mRNA-Seq experiments

Gelfond, J. A., Ibrahim, J. G., Chen, M. H., Sun, W., Lewis, K., Kinahan, S., Hibbs, M. & Buffenstein, R. Dec 1 2015 In : Statistical Applications in Genetics and Molecular Biology. 14, 6, p. 507-516 10 p.

Research output: Research - peer-reviewArticle

Differential Expression
Messenger RNA
Homology
Experiment
Mole Rats
2 Citations

Hypothesis testing for two-stage designs with over or under enrollment

Zeng, D., Gao, F., Hu, K., Jia, C. & Ibrahim, J. G. Jul 20 2015 In : Statistics in Medicine. 34, 16, p. 2417-2426 10 p.

Research output: Research - peer-reviewArticle

Two-stage Design
Hypothesis Testing
Sample Size
Type I error
Normal Approximation
3 Citations

Identifiability of PBPK models with applications to dimethylarsinic acid exposure

Garcia, R. I., Ibrahim, J. G., Wambaugh, J. F., Kenyon, E. M. & Setzer, R. W. Jul 21 2015 In : Journal of Pharmacokinetics and Pharmacodynamics. 42, 6, p. 591-609 19 p.

Research output: Research - peer-reviewArticle

Cacodylic Acid
Pharmacokinetics
Statistical Models
Bayes Theorem
Datasets
13 Citations

In vivo assessment of the metabolic activity of CYP2D6 diplotypes and alleles

Hertz, D. L. , Snavely, A. C. , McLeod, H. L. , Walko, C. M. , Ibrahim, J. G. , Anderson, S. , Weck, K. E. , Magrinat, G. , Olajide, O. , Moore, S. , Raab, R. , Carrizosa, D. R. , Corso, S. , Schwartz, G. , Peppercorn, J. M. , Evans, J. P. , Jones, D. R. , Desta, Z. , Flockhart, D. A. , Carey, L. A. & 1 others Irvin, W. J. Nov 1 2015 In : British Journal of Clinical Pharmacology. 80, 5, p. 1122-1130 9 p.

Research output: Research - peer-reviewArticle

Cytochrome P-450 CYP2D6
Alleles
Phenotype
Tamoxifen
Genotype
17 Citations

Joint modeling of survival and longitudinal non-survival data: Current methods and issues. Report of the DIA Bayesian joint modeling working group

Lawrence Gould, A., Boye, M. E., Crowther, M. J., Ibrahim, J. G., Quartey, G., Micallef, S. & Bois, F. Y. Jan 1 2015 In : Statistics in Medicine. 34, 14, p. 2181-2195 15 p.

Research output: Research - peer-reviewArticle

Joint Modeling
Bayesian Modeling
Bayes Theorem
Software
Joints

Quantifying the average of the time-varying hazard ratio via a class of transformations

Chen, Q., Zeng, D., Ibrahim, J. G., Chen, M. H., Pan, Z. & Xue, X. 2015 In : Lifetime Data Analysis. 21, 2, p. 259-279 21 p.

Research output: Research - peer-reviewArticle

Hazard
Time-varying
Estimate
Class
Hazards
2 Citations

Responses to discussants of 'Joint modeling of survival and longitudinal non-survival data: Current methods and issues. report of the DIA Bayesian joint modeling working group'

Gould, A. L., Boye, M. E., Crowther, M. J., Ibrahim, J. G., Quartey, G., Micallef, S. & Bois, F. Y. Jan 1 2015 In : Statistics in Medicine. 34, 14, p. 2202-2203 2 p.

Research output: Research - peer-reviewComment/debate

Joint Modeling
Bayesian Modeling
Survival Analysis
Statistical Model
Human
5 Citations

SPReM: Sparse Projection Regression Model For High-Dimensional Linear Regression

Sun, Q., Zhu, H., Liu, Y. & Ibrahim, J. G. Jan 2 2015 In : Journal of the American Statistical Association. 110, 509, p. 289-302 14 p.

Research output: Research - peer-reviewArticle

Linear regression
Regression Model
High-dimensional
Regression
Projection
7 Citations

The power prior: Theory and applications

Ibrahim, J. G., Chen, M. H., Gwon, Y. & Chen, F. Dec 10 2015 In : Statistics in Medicine. 34, 28, p. 3724-3749 26 p.

Research output: Research - peer-reviewArticle

Review
Power (Psychology)
Experimental design
Clinical Trials
Model
2 Citations

The use of bayesian hierarchical models for adaptive randomization in biomarker-driven phase II studies

Barry, W. T., Perou, C. M., Marcom, P. K., Carey, L. A. & Ibrahim, J. G. Jan 2 2015 In : Journal of Biopharmaceutical Statistics. 25, 1, p. 66-88 23 p.

Research output: Research - peer-reviewArticle

Bayesian Hierarchical Model
Biomarkers
Randomisation
Random Allocation
Subgroup
2014
6 Citations

A community-based multicenter trial of pharmacokinetically guided 5-fluorouracil dosing for personalized colorectal cancer therapy

Patel, J. N., O'neil, B. H., Deal, A. M., Ibrahim, J. G., Sherrill, G. B., Olajide, O. A., Atluri, P. M., Inzerillo, J. J., Chay, C. H., McLeod, H. L. & Walko, C. M. 2014 In : Oncologist. 19, 9, p. 959-965 7 p.

Research output: Research - peer-reviewArticle

Fluorouracil
Multicenter Studies
Colorectal Neoplasms
Therapeutics
Odds Ratio
6 Citations

Assessing model fit in joint models of longitudinal and survival data with applications to cancer clinical trials

Zhang, D., Chen, M. H., Ibrahim, J. G., Boye, M. E., Wang, P. & Shen, W. Jan 1 2014 In : Statistics in Medicine. 33, 27, p. 4715-4733 19 p.

Research output: Research - peer-reviewArticle

Joint Model
Survival Data
Longitudinal Data
Clinical Trials
Cancer

Assessing temporal agreement between central and local progression-free survival times

Zeng, D., Cornea, E., Dong, J., Pan, J. & Ibrahim, J. G. Feb 28 2014 In : Statistics in Medicine. 34, 5, p. 844-858 15 p.

Research output: Research - peer-reviewArticle

Survival Time
Progression
Disease-Free Survival
Evaluation
Censoring
1 Citations

Bayesian case-deletion model complexity and information criterion

Zhu, H., Ibrahim, J. G. & Chen, Q. 2014 In : Statistics and its Interface. 7, 4, p. 531-542 12 p.

Research output: Research - peer-reviewArticle

Case Deletion
Model Complexity
Information Criterion
Model
Influence
1 Citations

Bayesian design of superiority clinical trials for recurrent events data with applications to bleeding and transfusion events in myelodyplastic syndrome

Chen, M. H., Ibrahim, J. G., Zeng, D., Hu, K. & Jia, C. Dec 1 2014 In : Biometrics. 70, 4, p. 1003-1013 11 p.

Research output: Research - peer-reviewArticle

Bayesian Design
Recurrent Events
Clinical Trials
Myelodysplastic Syndromes
Hemorrhage
9 Citations

Bayesian gamma frailty models for survival data with semi-competing risks and treatment switching

Zhang, Y., Chen, M. H., Ibrahim, J. G., Zeng, D., Chen, Q., Pan, Z. & Xue, X. Jan 2014 In : Lifetime Data Analysis. 20, 1, p. 76-105 30 p.

Research output: Research - peer-reviewArticle

Deviance Information Criterion
Colorectal Cancer
Frailty Model
Competing Risks
Survival Data
20 Citations

Bayesian Generalized Low Rank Regression Models for Neuroimaging Phenotypes and Genetic Markers

Zhu, H., Khondker, Z., Lu, Z. & Ibrahim, J. G. Jul 3 2014 In : Journal of the American Statistical Association. 109, 507, p. 977-990 14 p.

Research output: Research - peer-reviewArticle

Rank Regression
Neuroimaging
Phenotype
Regression Model
Regression model
6 Citations

Bayesian sensitivity analysis of statistical models with missing data

Zhu, H., Ibrahim, J. G. & Tang, N. Apr 1 2014 In : Statistica Sinica. 24, 2, p. 871-896 26 p.

Research output: Research - peer-reviewArticle

Bayesian Analysis
Missing Data
Statistical Model
Sensitivity Analysis
Perturbation
4 Citations

Bayesian sequential meta-analysis design in evaluating cardiovascular risk in a new antidiabetic drug development program

Chen, M. H., Ibrahim, J. G., Amy Xia, H., Liu, T. & Hennessey, V. Apr 30 2014 In : Statistics in Medicine. 33, 9, p. 1600-1618 19 p.

Research output: Research - peer-reviewArticle

Drugs
Design
Hypoglycemic Agents
Meta-Analysis
Guidance
1 Citations

Bayesian transformation models for multivariate survival data

De Castro, M., Chen, M. H., Ibrahim, J. G. & Klein, J. P. Mar 1 2014 In : Scandinavian Journal of Statistics. 41, 1, p. 187-199 13 p.

Research output: Research - peer-reviewArticle

Multivariate Survival Data
Transformation Model
Bayesian Model
Class
Transformation model
3 Citations
cyclobutane
biological effects
biomarkers
fibroblasts
pyrimidines
7 Citations

Development of DNA Damage Response Signaling Biomarkers using Automated, Quantitative Image Analysis

Nikolaishvilli-Feinberg, N., Cohen, S. M., Midkiff, B., Zhou, Y., Olorvida, M., Ibrahim, J. G., Omolo, B., Shields, J. M., Thomas, N. E., Groben, P. A., Kaufmann, W. K. & Miller, C. R. Mar 1 2014 In : Journal of Histochemistry and Cytochemistry. 62, 3, p. 185-196 12 p.

Research output: Research - peer-reviewArticle

DNA Damage
Melanoma
Biomarkers
Cell Line
Neoplasms
50 Citations

Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer

Sanoff, H. K., Deal, A. M., Krishnamurthy, J., Torrice, C., Dillon, P., Sorrentino, J., Ibrahim, J. G., Jolly, T. A., Williams, G., Carey, L. A., Drobish, A., Gordon, B. B., Alston, S., Hurria, A., Kleinhans, K., Rudolph, K. L., Sharpless, N. E. & Muss, H. B. 2014 In : Journal of the National Cancer Institute. 106, 4, dju057

Research output: Research - peer-reviewArticle

Breast Neoplasms
Drug Therapy
Anthracyclines
Adjuvant Chemotherapy
Therapeutics
1 Citations

Flexible stopping boundaries when changing primary endpoints after unblinded interim analyses

Chen, L. M., Ibrahim, J. G. & Chu, H. Jul 4 2014 In : Journal of Biopharmaceutical Statistics. 24, 4, p. 817-833 17 p.

Research output: Research - peer-reviewArticle

Group Sequential
Type I error
Group Sequential Design
Clinical Trials
Testing
4 Citations

Functional-mixed effects models for candidate genetic mapping in imaging genetic studies

Lin, J. A., Zhu, H., Mihye, A., Sun, W. & Ibrahim, J. G. Dec 1 2014 In : Genetic Epidemiology. 38, 8, p. 680-691 12 p.

Research output: Research - peer-reviewArticle

Genetic Models
Genetic Markers
Genes
Brain
Phenotype
4 Citations

Joint modeling of longitudinal and survival data with missing and left-censored time-varying covariates

Chen, Q., May, R. C., Ibrahim, J. G., Chu, H. & Cole, S. R. Nov 20 2014 In : Statistics in Medicine. 33, 26, p. 4560-4576 17 p.

Research output: Research - peer-reviewArticle

Time-varying Covariates
Joint Modeling
Joint Model
Survival Data
Longitudinal Data
5 Citations

Mechanisms of chromosomal instability in melanoma

Kaufmann, W. K., Carson, C. C., Omolo, B., Filgo, A. J., Sambade, M. J., Simpson, D. A., Shields, J. M., Ibrahim, J. G. & Thomas, N. E. Jan 1 2014 In : Environmental and Molecular Mutagenesis. 55, 6, p. 457-471 15 p.

Research output: Research - peer-reviewArticle

Chromosomal Instability
Melanoma
DNA Damage
Cell Line
Chromosome Duplication
2 Citations
Informative Censoring
Recurrent Events
Myelodysplastic Syndromes
Joints
Hemorrhage

Patients' understanding of how genotype variation affects benefits of tamoxifen therapy for breast cancer

Brewer, N. T., Defrank, J. T., Chiu, W. K., Ibrahim, J. G., Walko, C. M., Rubin, P., Olajide, O. A., Moore, S. G., Raab, R. E., Carrizosa, D. R., Corso, S. W., Schwartz, G., Peppercorn, J. M., McLeod, H. L., Carey, L. A. & Irvin, W. J. 2014 In : Public Health Genomics. 17, 1, p. 43-47 5 p.

Research output: Research - peer-reviewArticle

Tamoxifen
Genotype
Breast Neoplasms
Therapeutics
Cytochrome P-450 CYP2D6