Find Research Outputs

Search concepts
Selected Filters
2018

Bioresponsive Microneedles with a Sheath Structure for H2O2 and pH Cascade-Triggered Insulin Delivery

Zhang, Y., Wang, J., Yu, J., Wen, D., Kahkoska, A. R., Lu, Y., Zhang, X., Buse, J. B. & Gu, Z. Apr 5 2018 In : Small. 14, 14, 1704181

Research output: Contribution to journalArticle

Controlled drug delivery
Glucose sensors
Glucose Oxidase
Glucose oxidase
Insulin
4 Citations

Cardiovascular outcomes trials in type 2 diabetes: Where Do We Go From Here? Ref lections From a Diabetes Care Editors' Expert Forum

Cefalu, W. T., Kaul, S., Gerstein, H. C., Holman, R. R., Zinman, B., Skyler, J. S., Green, J. B., Buse, J. B., Inzucchi, S. E., Leiter, L. A., Raz, I., Rosenstock, J. & Riddle, M. C. Jan 1 2018 In : Diabetes care. 41, 1, p. 14-31 18 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Drug Approval
Drug Industry
United States Food and Drug Administration
Pharmaceutical Preparations
10 Citations

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis

EXSCEL Study Group Feb 1 2018 (Accepted/In press) In : The Lancet Diabetes and Endocrinology. p. 105-113 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Meta-Analysis
Mortality
Safety
Pharmaceutical Preparations
1 Citations
pioglitazone
Thiazolidinediones
Dipeptidyl-Peptidase IV Inhibitors
Hypoglycemic Agents
Urinary Bladder Neoplasms

Core-Shell Microneedle Gel for Self-Regulated Insulin Delivery

Wang, J., Ye, Y., Yu, J., Kahkoska, A. R., Zhang, X., Wang, C., Sun, W., Corder, R. D., Chen, Z., Khan, S. A., Buse, J. B. & Gu, Z. Mar 27 2018 In : ACS Nano. 12, 3, p. 2466-2473 8 p.

Research output: Contribution to journalArticle

Sulfur hexafluoride circuit breakers
insulin
Insulin
glucose
Glucose
3 Citations

Efficacy and safety of ITCA 650, a novel drug-Device GLP-1 receptor agonist, in type 2 diabetes uncontrolled with oral antidiabetes drugs: The FREEDOM-1 trial

Rosenstock, J., Buse, J. B., Azeem, R., Prabhakar, P., Kjems, L., Huang, H. & Baron, M. A. Feb 1 2018 In : Diabetes care. 41, 2, p. 333-340 8 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Safety
Equipment and Supplies
Placebos
Pharmaceutical Preparations
1 Citations

Increased risk of severe hypoglycemic events before and after cardiovascular outcomes in TECOSSuggests an at-risk type 2 diabetes frail patient phenotype

Standl, E., Stevens, S. R., Armstrong, P. W., Buse, J. B., Chan, J. C. N., Green, J. B., Lachin, J. M., Scheen, A., Travert, F., Van De Werf, F., Peterson, E. D. & Holman, R. R. Mar 1 2018 In : Diabetes care. 41, 3, p. 596-603 8 p.

Research output: Contribution to journalArticle

Hypoglycemic Agents
Type 2 Diabetes Mellitus
Phenotype
Hospitalization
Heart Failure
2 Citations

Modulation of GLP-1 levels by a genetic variant that regulates the cardiovascular effects of intensive glycemic control in ACCORD

Shah, H. S., Morieri, M. L., Marcovina, S. M., Sigal, R. J., Gerstein, H. C., Wagner, M. J., Motsinger-Reif, A. A., Buse, J. B., Kraft, P., Mychaleckyj, J. C. & Doria, A. Feb 1 2018 In : Diabetes care. 41, 2, p. 348-355 8 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Homozygote
Linear Models
Biomarkers
Mortality

Myocardial Infarction Subtypes in Patients With Type 2 Diabetes Mellitus and the Effect of Liraglutide Therapy (from the LEADER Trial)

LEADER Publication Committee on behalf of the LEADER Trial Investigators Jun 15 2018 In : American Journal of Cardiology. 121, 12, p. 1467-1470 4 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Myocardial Infarction
Placebos
Therapeutics
Troponin
6 Citations

Synthetic beta cells for fusion-mediated dynamic insulin secretion

Chen, Z., Wang, J., Sun, W., Archibong, E., Kahkoska, A. R., Zhang, X., Lu, Y., Ligler, F. S., Buse, J. B. & Gu, Z. Jan 1 2018 In : Nature Chemical Biology. 14, 1, p. 86-93 8 p.

Research output: Contribution to journalArticle

Biomimetic Materials
Cell Engineering
Artificial Cells
Membrane Fusion
Experimental Diabetes Mellitus
Dipeptidyl-Peptidase IV Inhibitors
Pancreatitis
Cardiovascular Diseases
Pancreatic Diseases
Medicare
2017
3 Citations

Amylase, lipase, and acute pancreatitis in people with type 2 diabetes treatedwith liraglutide: Results from the LEADER randomized trial

the LEADER Steering Committee, on behalf of the LEADER Trial Investigators Jul 1 2017 In : Diabetes care. 40, 7, p. 966-972 7 p.

Research output: Contribution to journalArticle

Amylases
Lipase
Pancreatitis
Type 2 Diabetes Mellitus
Placebos
19 Citations

Association of fenofibrate therapy with long-term cardiovascular risk in statin-treated patients with type 2 diabetes

ACCORDION Study Investigators Apr 1 2017 In : JAMA Cardiology. 2, 4, p. 370-380 11 p.

Research output: Contribution to journalArticle

Fenofibrate
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Type 2 Diabetes Mellitus
Cardiovascular Diseases
HDL Cholesterol
8 Citations

Baseline characteristics of patients enrolled in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL)

Mentz, R. J., Bethel, M. A., Gustavson, S., Thompson, V. P., Pagidipati, N. J., Buse, J. B., Chan, J. C., Iqbal, N., Maggioni, A. P., Marso, S. P., Ohman, P., Poulter, N., Ramachandran, A., Zinman, B., Hernandez, A. F. & Holman, R. R. May 1 2017 In : American Heart Journal. 187, p. 1-9 9 p.

Research output: Contribution to journalArticle

Placebos
Dipeptidyl-Peptidase IV Inhibitors
Cerebrovascular Disorders
Latin America
Peripheral Arterial Disease

Causes of death in a contemporary cohort of patients with type 2 diabetes and atherosclerotic cardiovascular disease: Insights from the TECOS trial

TECOS Study Group Dec 1 2017 In : Diabetes care. 40, 12, p. 1763-1770 8 p.

Research output: Contribution to journalArticle

Proportional Hazards Models
Double-Blind Method
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Cause of Death
3 Citations

Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

The ACCORD/ACCORDion Investigators Jan 1 2017 In : PeerJ. 2017, 5, e3187

Research output: Contribution to journalArticle

Water recycling
Exome
Genomics
Genetic Markers
noninsulin-dependent diabetes mellitus

Differential Use of Screening Mammography in Older Women Initiating Metformin versus Sulfonylurea

Hong, J. L., Henderson, L. M., Jonsson Funk, M., Lund, J. L., Buse, J. B., Pate, V. & Stürmer, T. Jun 1 2017 In : Pharmacoepidemiology and drug safety. 26, 6, p. 666-675 10 p.

Research output: Contribution to journalArticle

Metformin
Mammography
Breast Neoplasms
Incidence
Medicare
93 Citations

Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

EXSCEL Study Group Sep 28 2017 In : New England Journal of Medicine. 377, 13, p. 1228-1239 12 p.

Research output: Contribution to journalArticle

21 Citations

Effects of sotagliflozin added to insulin in patients with type 1 diabetes

Garg, S. K., Henry, R. R., Banks, P., Buse, J. B., Davies, M. J., Fulcher, G. R., Pozzilli, P., Gesty-Palmer, D., Lapuerta, P., Simó, R., Danne, T., McGuire, D. K., Kushner, J. A., Peters, A. & Strumph, P. Dec 14 2017 In : New England Journal of Medicine. 377, 24, p. 2337-2348 12 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Diabetic Ketoacidosis
Intention to Treat Analysis
Glycosides
Combination Drug Therapy
61 Citations

Efficacy and safety of degludec versus Glargine in Type 2 Diabetes

Marso, S. P., Mcguire, D. K., Zinman, B., Poulter, N. R., Emerson, S. S., Pieber, T. R., Pratley, R. E., Haahr, P. M., Lange, M., Brown-Frandsen, K., Moses, A., Skibsted, S., Kvist, K. & Buse, J. B. Aug 24 2017 In : New England Journal of Medicine. 377, 8, p. 723-732 10 p.

Research output: Contribution to journalArticle

Long-Acting Insulin
Kaplan-Meier Estimate
Hypoglycemia
Double-Blind Method
Hypoglycemic Agents
15 Citations

Glucose self-monitoring in non-insulin-treated patients with type 2 diabetes in primary care settings: A randomized trial

Young, L. A., Buse, J. B., Weaver, M. A., Vu, M. B., Mitchell, C. M., Blakeney, T., Grimm, K., Rees, J., Niblock, F. & Donahue, K. E. Jul 1 2017 In : JAMA Internal Medicine. 177, 7, p. 920-929 10 p.

Research output: Contribution to journalArticle

Outcome and Process Assessment (Health Care)
Blood Glucose Self-Monitoring
Disease Management
Hypoglycemic Agents
Type 2 Diabetes Mellitus
32 Citations

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

Hu, X., Yu, J., Qian, C., Lu, Y., Kahkoska, A. R., Xie, Z., Jing, X., Buse, J. B. & Gu, Z. Jan 24 2017 In : ACS Nano. 11, 1, p. 613-620 8 p.

Research output: Contribution to journalArticle

3 Citations

Hypertension Control in Adults with Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results from the Trial Evaluating Cardiovascular Outcomes with Sitagliptin

Navar, A. M., Gallup, D. S., Lokhnygina, Y., Green, J. B., McGuire, D. K., Armstrong, P. W., Buse, J. B., Engel, S. S., Lachin, J. M., Standl, E., Van De Werf, F., Holman, R. R. & Peterson, E. D. Nov 1 2017 In : Hypertension. 70, 5, p. 907-914 8 p.

Research output: Contribution to journalArticle

29 Citations

Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery

Yu, J., Qian, C., Zhang, Y., Cui, Z., Zhu, Y., Shen, Q., Ligler, F. S., Buse, J. B. & Gu, Z. Feb 8 2017 In : Nano Letters. 17, 2, p. 733-739 7 p.

Research output: Contribution to journalArticle

insulin
Insulin
hypoxia
glucose
Glucose

In reply

Young, L. A., Buse, J. B. & Donahue, K. E. Dec 1 2017 In : JAMA Internal Medicine. 177, 12, p. 1874-1875 2 p.

Research output: Contribution to journalLetter

2 Citations

Insulin-Responsive Glucagon Delivery for Prevention of Hypoglycemia

Yu, J., Zhang, Y., Sun, W., Kahkoska, A. R., Wang, J., Buse, J. B. & Gu, Z. May 17 2017 In : Small. 13, 19, 1603028

Research output: Contribution to journalArticle

Insulin
Glucagon
Hypoglycemia
Needles
Glucose
3 Citations

Metformin use may moderate the effect of DPP-4 inhibitors on cardiovascular outcomes

Crowley, M. J., Williams, J. W., Kosinski, A. S., D'Alessio, D. A. & Buse, J. B. Dec 1 2017 In : Diabetes care. 40, 12, p. 1787-1789 3 p.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Metformin
Drug Interactions
Proportional Hazards Models
Type 2 Diabetes Mellitus
5 Citations
Dipeptidyl-Peptidase IV Inhibitors
Incretins
Hypoglycemic Agents
Observational Studies
Thiazolidinediones
13 Citations

Pancreatic safety of sitagliptin in the TECOS study

for the TECOS Study Group Feb 1 2017 In : Diabetes care. 40, 2, p. 164-170 7 p.

Research output: Contribution to journalArticle

Pancreatitis
Pancreatic Neoplasms
Safety
Dipeptidyl-Peptidase IV Inhibitors
Placebos
14 Citations

Red Blood Cells for Glucose-Responsive Insulin Delivery

Wang, C., Ye, Y., Sun, W., Yu, J., Wang, J., Lawrence, D. S., Buse, J. B. & Gu, Z. May 10 2017 In : Advanced Materials. 29, 18, 1606617

Research output: Contribution to journalArticle

Insulin
Glucose
Blood
Cells
Cell membranes

Safety of degludec versus glargine in type 2 diabetes

Marso, S. P. & Buse, J. B. Nov 16 2017 In : New England Journal of Medicine. 377, 20, p. 1995-1996 2 p.

Research output: Contribution to journalLetter

Type 2 Diabetes Mellitus
Safety
Insulin Glargine
insulin degludec
3 Citations

Sodium-glucose cotransporter 2 inhibitors and diabetic ketoacidosis: A case series from three academic institutions

Misaghian-Xanthos, N., Shariff, A. I., Mekala, K., Fearrington, L. R., Setji, T. L., Aloi, J. A. & Buse, J. B. Jun 1 2017 In : Diabetes care. 40, 6, p. e65-e66

Research output: Contribution to journalShort survey

The war is not yet won

Young, L. A. & Buse, J. B. Sep 1 2017 In : Diabetes care. 40, 9, p. 1152-1153 2 p.

Research output: Contribution to journalComment/debate

Warfare

Three approaches to glucose monitoring in non-insulin treated diabetes: A pragmatic randomized clinical trial protocol

Young, L. A., Buse, J. B., Weaver, M. A., Vu, M. B., Reese, A., Mitchell, C. M., Blakeney, T., Grimm, K., Rees, J. & Donahue, K. E. May 25 2017 In : BMC health services research. 17, 1, 369

Research output: Contribution to journalArticle

Pragmatic Clinical Trials
Blood Glucose Self-Monitoring
Clinical Protocols
Type 2 Diabetes Mellitus
Randomized Controlled Trials

Update and next steps for real-world translation of interventions for type 2 diabetes prevention: Reflections from a diabetes care editors' expert forum. Diabetes care 2016;39:1186-1201

Cefalu, W. T., Buse, J. B., Tuomilehto, J., Fleming, G. A., Ferrannini, E., Gerstein, H. C., Bennett, P. H., Ramachandran, A., Raz, I., Rosenstock, J. & Kahn, S. E. Feb 1 2017 In : Diabetes care. 40, 2, p. e23-e24

Research output: Contribution to journalComment/debate

2016
70 Citations

Association between sitagliptin use and heart failure hospitalization and related outcomes in type 2 diabetes mellitus: Secondary analysis of a randomized clinical trial

McGuire, D. K., Van De Werf, F., Armstrong, P. W., Standl, E., Koglin, J., Green, J. B., Bethel, M. A., Cornel, J. H., Lopes, R. D., Halvorsen, S., Ambrosio, G., Buse, J. B., Josse, R. G., Lachin, J. M., Pencina, M. J., Garg, J., Lokhnygina, Y., Holman, R. R. & Peterson, E. D. May 1 2016 In : JAMA Cardiology. 1, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Hospitalization
Randomized Controlled Trials
Heart Failure
Placebos
15 Citations

Benefits of combination of insulin degludec and liraglutide are independent of baseline glycated haemoglobin level and duration of type 2 diabetes

Rodbard, H. W., Buse, J. B., Woo, V., Vilsbøll, T., Langbakke, I. H., Kvist, K. & Gough, S. C. L. Jan 1 2016 In : Diabetes, Obesity and Metabolism. 18, 1, p. 40-48 9 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Insulin
Hypoglycemia
Hypoglycemic Agents
23 Citations

Chronic exposure to arsenic and markers of cardiometabolic risk: A cross-sectional study in Chihuahua, Mexico

Mendez, M. A., González-Horta, C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Cerón, R. H., Morales, D. V., Baeza Terrazas, F. A., Ishida, M. C., Gutiérrez-Torres, D. S., Saunders, R. J., Drobná, Z., Fry, R. C., Buse, J. B., Loomis, D., García-Vargas, G. G., Del Razo, L. M. & Stýblo, M. Jan 1 2016 In : Environmental Health Perspectives. 124, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

Arsenic
Mexico
Cross-Sectional Studies
Drinking Water
HDL Cholesterol
13 Citations

Design of DEVOTE (Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients With Type 2 Diabetes at High Risk of Cardiovascular Events) – DEVOTE 1

Marso, S. P., McGuire, D. K., Zinman, B., Poulter, N. R., Emerson, S. S., Pieber, T. R., Pratley, R. E., Haahr, P. M., Lange, M., Frandsen, K. B., Rabøl, R. & Buse, J. B. Sep 1 2016 In : American Heart Journal. 179, p. 175-183 9 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Safety
Random Allocation
Chronic Renal Insufficiency
Cardiovascular Diseases
2 Citations

Effect of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors on colorectal cancer incidence and its precursors

Htoo, P. T., Buse, J. B., Gokhale, M., Marquis, M. A., Pate, V. & Stürmer, T. Aug 1 2016 In : European Journal of Clinical Pharmacology. 72, 8, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Colorectal Neoplasms
Long-Acting Insulin
Incidence
Confidence Intervals
63 Citations

Effect of insulin glargine up-titration vs insulin degludec/liraglutide on glycated hemoglobin levels in patients with uncontrolled type 2 diabetes: The DUAL v randomized clinical trial

Lingvay, I., Manghi, F. P., García-Hernández, P., Norwood, P., Lehmann, L., Tarp-Johansen, M. J. & Buse, J. B. Mar 1 2016 In : JAMA - Journal of the American Medical Association. 315, 9, p. 898-907 10 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Insulin
Metformin
32 Citations

Effect of naltrexone-bupropion on major adverse cardiovascular events in overweight and obese patients with cardiovascular risk factors: A randomized clinical trial

Nissen, S. E., Wolski, K. E., Prcela, L., Wadden, T., Buse, J. B., Bakris, G., Perez, A. & Smith, S. R. Mar 8 2016 In : JAMA - Journal of the American Medical Association. 315, 10, p. 990-1004 15 p.

Research output: Contribution to journalArticle

Bupropion
Naltrexone
Randomized Controlled Trials
Placebos
Obesity
13 Citations

Efficacy and safety of liraglutide added to capped insulin treatment in subjects with type 1 diabetes: The adjunct two randomized trial

Ahren, B., Hirsch, I. B., Pieber, T. R., Mathieu, C., Gomez-Peralta, F., Hansen, T. K., Philotheou, A., Birch, S., Christiansen, E., Jensen, T. J. & Buse, J. B. Oct 1 2016 In : Diabetes Care. 39, 10, p. 1693-1701 9 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Insulin
Safety
Placebos
Therapeutics
7 Citations

Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial

Shah, H. S., Gao, H., Morieri, M. L., Skupien, J., Marvel, S., Paré, G., Mannino, G. C., Buranasupkajorn, P., Mendonca, C., Hastings, T., Marcovina, S. M., Sigal, R. J., Gerstein, H. C., Wagner, M. J., Motsinger-Reif, A. A., Buse, J. B., Kraft, P., Mychaleckyj, J. C. & Doria, A. Nov 1 2016 In : Diabetes care. 39, 11, p. 1915-1924 10 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Clinical Trials
Mortality
Genome
Diabetes Complications
9 Citations

IDegLira Improves Both Fasting and Postprandial Glucose Control as Demonstrated Using Continuous Glucose Monitoring and a Standardized Meal Test

Holst, J. J., Buse, J. B., Rodbard, H. W., Linjawi, S., Woo, V. C., Boesgaard, T. W., Kvist, K. & Gough, S. C. Mar 1 2016 In : Journal of Diabetes Science and Technology. 10, 2, p. 389-397 9 p.

Research output: Contribution to journalArticle

Insulin
Glucose
Meals
Fasting
Monitoring
1 Citations

Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response

The ACCORD/ACCORDion Investigators Aug 17 2016 In : Frontiers in Genetics. 7, AUG, 138

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Genome-Wide Association Study
Genome
Pharmaceutical Preparations
Linear Models
2 Citations

LEADER 7: Cardiovascular risk profiles of US and European participants in the LEADER diabetes trial differ

Rutten, G. E. H. M., Tack, C. J., Pieber, T. R., Comlekci, A., Ørsted, D. D., Baeres, F. M. M., Marso, S. P. & Buse, J. B. Jun 2 2016 In : Diabetology and Metabolic Syndrome. 8, 1, 37

Research output: Contribution to journalArticle

Cardiovascular Diseases
Blood Pressure
LDL Cholesterol
Glycosylated Hemoglobin A
Risk Management
1 Citations

Maria gordon buse, MD: A family affair through six decades of diabetes discovery

Burant, C. F., Buse, C. R., Robinson, K. A. & Buse, J. B. Jun 1 2016 In : Diabetes Care. 39, 6, p. 852-856 5 p.

Research output: Contribution to journalArticle

1 Citations

Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

Yu, J., Zhang, Y., Ye, Y., DiSanto, R., Sun, W., Ranson, D., Ligler, F. S., Buse, J. B. & Gu, Z. Feb 1 2016 In : Diabetes Technology and Therapeutics. 18, p. S54-S55

Research output: Contribution to journalComment/debate

Insulin
Glucose
Hypoxia
28 Citations

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery

Ye, Y., Yu, J., Wang, C., Nguyen, N. Y., Walker, G. M., Buse, J. B. & Gu, Z. Apr 27 2016 In : Advanced Materials. 28, 16, p. 3115-3121 7 p.

Research output: Contribution to journalArticle

Insulin
Sugars
Glucose
Blood Glucose
Blood