25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve

Anne Marie Z. Jukic, Donna D. Baird, Allen J. Wilcox, Clarice R. Weinberg, Anne Z Steiner

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of the study was to examine the associations between 25-hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve in a large community-based sample of women. Methods: In 2010 to 2016, women aged 30 to 44 years without any known fertility problems were recruited from the Chapel Hill, NC area for a prospective time-to-pregnancy cohort study. At enrollment 561 women provided a blood sample that was used to measure 25(OH)D, anti-Müllerian hormone (AMH), follicle-stimulating hormone, and inhibin-B. Unadjusted associations were estimated with Spearman correlation coefficients. Multivariable linear regression was used to estimate associations of 25(OH)D with ovarian reserve biomarkers, after adjusting for age, race, body mass index, smoking history, and recent use of hormonal birth control. Results: The mean 25(OH)D was 36ng/mL (SD=11ng/mL). 25(OH)D was not correlated with AMH, follicle-stimulating hormone, or inhibin-B (all r<0.03). Multivariable results with continuous hormonal outcomes were also null. For dichotomous outcomes, there was a tendency for insufficient 25(OH)D (<30ng/mL) to be associated with low AMH (<0.7ng/mL) (odds ratio [95% CI]: 1.8 [0.9-4]). Conclusions: For the most part, 25(OH)D was not associated with ovarian reserve biomarkers in a group of women trying to become pregnant. We found some evidence that low 25(OH)D (<30ng/mL) was associated with low AMH, but this should be confirmed in studies with a higher prevalence of low 25(OH)D.

LanguageEnglish (US)
Pages811-816
Number of pages6
JournalMenopause
Volume25
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Anti-Mullerian Hormone
Biomarkers
Follicle Stimulating Hormone
Time-to-Pregnancy
Contraception
Fertility
Linear Models
Body Mass Index
Cohort Studies
Smoking
History
Odds Ratio
Ovarian Reserve
25-hydroxyvitamin D
inhibin B

Keywords

  • Fertility
  • Follicle-stimulating hormone
  • Inhibins
  • Ovary
  • Vitamin D
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Jukic, A. M. Z., Baird, D. D., Wilcox, A. J., Weinberg, C. R., & Steiner, A. Z. (2018). 25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve. Menopause, 25(7), 811-816. https://doi.org/10.1097/GME.0000000000001075

25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve. / Jukic, Anne Marie Z.; Baird, Donna D.; Wilcox, Allen J.; Weinberg, Clarice R.; Steiner, Anne Z.

In: Menopause, Vol. 25, No. 7, 01.07.2018, p. 811-816.

Research output: Contribution to journalArticle

Jukic, AMZ, Baird, DD, Wilcox, AJ, Weinberg, CR & Steiner, AZ 2018, '25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve' Menopause, vol. 25, no. 7, pp. 811-816. https://doi.org/10.1097/GME.0000000000001075
Jukic, Anne Marie Z. ; Baird, Donna D. ; Wilcox, Allen J. ; Weinberg, Clarice R. ; Steiner, Anne Z. / 25-Hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve. In: Menopause. 2018 ; Vol. 25, No. 7. pp. 811-816.
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