1-Dimensional quantitative micro-architecture mapping of multiple scattering media using backscattering of ultrasound in the near-field: Application to nodule imaging in the lungs

Kaustav Mohanty, John Blackwell, S. Behrooz Masuodi, Mir Hasnain Ali, Thomas M Egan, Marie Muller

Research output: Contribution to journalArticle

Abstract

In this letter, we present a near-field method for mapping the micro-architecture of complex media based on the measurement of the diffusion constant D using multiple backscattering of ultrasound waves. Simulation results are reported and validated with experiments. For both simulations and experiments, a linear array of ultrasound transducers is used. The coherent and incoherent intensities are separated using a matrix manipulation of the inter-element response matrix. We demonstrate that no beamforming is necessary to extract the diffusion constant. Acquiring sub-inter-element response matrices by using subsets of elements and calculating the growth of the diffusive halo for each sub-matrix provides an estimate of a semi-local diffusion constant, enabling a 1-D mapping of the scatterer density or volume fraction in a strongly heterogeneous medium. This methodology is then applied to quantitatively characterize the lung parenchyma and detect the presence of solitary pulmonary nodules. The semi-local diffusion constant is mapped along the transducer axis to search for high D values, which correspond to the nodule/lesion location.

LanguageEnglish (US)
Article number033704
JournalApplied Physics Letters
Volume113
Issue number3
DOIs
StatePublished - Jul 16 2018

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nodules
lungs
backscattering
near fields
matrices
scattering
transducers
beamforming
linear arrays
lesions
set theory
manipulators
halos
simulation
methodology
estimates

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

1-Dimensional quantitative micro-architecture mapping of multiple scattering media using backscattering of ultrasound in the near-field : Application to nodule imaging in the lungs. / Mohanty, Kaustav; Blackwell, John; Masuodi, S. Behrooz; Ali, Mir Hasnain; Egan, Thomas M; Muller, Marie.

In: Applied Physics Letters, Vol. 113, No. 3, 033704, 16.07.2018.

Research output: Contribution to journalArticle

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