Atherosclerosis, the major cause of coronary artery disease, is the result of a series of complex genetic, cellular and biochemical interactions. Although numerous risk factors for atherosclerosis, such as elevated blood pressure and hypercholesterolemia, have been recognized, we have an incomplete understanding of the genetic architecture of this complex disease. GWAS results have identified dozens of variants affecting atherosclerosis but the cumulative effect of these variants accounts for less than 50% of all the genetic risk. Identification of novel genes and pathways is critical to the development of additional therapies. Towards this goal, we have identified the specific choline metabolite trimethylamine N-oxide (TMAO) as being predictive of atherosclerosis and cardiovascular disease.
|Effective start/end date||7/14/15 → 4/30/20|
- NIH National Heart, Lung, and Blood Institute (NHLBI)
Genome-Wide Association Study
Coronary Artery Disease