Systems Genetic Studies of TMAO regulation and Atherosclerosis

Project: Research project

Description

Atherosclerosis, the major cause of coronary artery disease, is the result of a series of complex genetic, cellular and biochemical interactions. Although numerous risk factors for atherosclerosis, such as elevated blood pressure and hypercholesterolemia, have been recognized, we have an incomplete understanding of the genetic architecture of this complex disease. GWAS results have identified dozens of variants affecting atherosclerosis but the cumulative effect of these variants accounts for less than 50% of all the genetic risk. Identification of novel genes and pathways is critical to the development of additional therapies. Towards this goal, we have identified the specific choline metabolite trimethylamine N-oxide (TMAO) as being predictive of atherosclerosis and cardiovascular disease.
StatusActive
Effective start/end date7/14/154/30/20

Funding

  • NIH National Heart, Lung, and Blood Institute (NHLBI)

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Atherosclerosis
Critical Pathways
Genome-Wide Association Study
Choline
Hypercholesterolemia
Coronary Artery Disease
Molecular Biology
Cardiovascular Diseases
Blood Pressure
trimethyloxamine
Genes
Therapeutics