Research and Development Program Component II: Epithelial Function in Cystic Fibrosis

Project: Research project


The UNC CF Center has two major goals: 1) to cure CF lung disease; and 2) to identify approaches to make the abnormal CFTR protein functional. Our strategy is to promote and support high quality basic CF research and provide the tools to rapidly transfer new basic science insights into clinical CF therapies, a process called “translational” research. The mechanism we use to achieve these goals is called a “Core-support” system. Our strategy is to create and support “Cores” that provide to CF investigators the “tools” (e.g., CF cells, from the Cell Culture Core; measurements of CFTR activity in the CFTR Functional Analysis Core; CF mice, from the Molecular Biology and Mouse Core) to perform their research in a timely and quality-controlled fashion. Other Cores support information transfer within the Center (the Administrative/Program Enhancement Core) and foster national and international collaborations. Finally, we support a Core designed to train the CF investigators of the future (the Training Core). Thus, the Core support mechanism is the vital infrastructure that allows CF research on the UNC-CH campus to proceed with the utmost speed possible.
Effective start/end date7/1/156/30/19


  • Cystic Fibrosis Foundation


Cystic Fibrosis
Research Personnel
Cystic Fibrosis Transmembrane Conductance Regulator
Translational Medical Research
Lung Diseases
Molecular Biology
Cell Culture Techniques