In this joint project between the University of North Carolina at Chapel Hill (UNC) and Penn State University Hershey Medical Center (PSUHMC) we propose to study welders and matched controls to assess the functional consequences of manganese (Mn) and iron (Fe) accumulation in various regions of the brain. Aim 1 will determine if state of the art MRI measures in humans can provide biomarkers of regional brain accumulation of Mn from airborne Mn exposures. Aim 2 will delineate the functional consequences of region-specific Mn accumulation in brain, and Aim 3 will explore Fe-Mn interactions and their functional consequences. Under this research proposal UNC will provide expertise in designing and interpreting exposure assessment questionnaires for the welders and control subjects using existing exposure measurements; as well as provide analysis of blood samples for Manganese and Fe.
|Effective start/end date||5/1/14 → 4/30/16|
- Pennsylvania State University