Quantification of 3D Bony Changes in Temporomandibular Joint Osteoarthritis

Research project

Description

TMJ disorders affect approximately 10% of the population, causing significant functional limitations and facial pain. Of these, approximately 40% are due to or related to the presence of osteoarthritis. Current osteoarthritis (OA) treatments target only clinical manifestations such as significant functional limitations and facial pain and changes in jaw relation with anterior open bite and impaired chewing ability. In severe cases of bone resorption, surgery might be needed, cutting completely one or both TMJs and replacing them with proteses. Developing fully effective medical treatments is hampered by: 1.The lack of robust quantifiable diagnostic imaging markers that underlie the relatioship between anatomical and clinical markers of the disease; 2. Limitations in the ability of current imaging and statistical techniques to quantify the extent of bone damage and assess the effect of treatment interventions; 3. The lack of clinical software for the usage in the clinical orthodontic practices. The intent of this proposal is to establish robust imaging shape biomarkers for the diagnosis and assessment of the progression of Temporomandibular Joint (TMJ) in diseases of arthritic origin.
The statistical modeling framework we previously developed and validated has allowed us to precisely localize and accurately quantify the extent of degenerative changes in the TMJ. Various clinical parameters were also correlated with specific imaging criteria. The novel quantification methodology included in this proposal will provide specific analytical tools for the detection, pathology characterization and treatment monitoring of diseases of arthritic origin. The proposed mapping of the architecture of the osteoarthritic TMJ using imaging criteria (such as joint space narrowing and condylar flatenning and erosions) is an excellent model to facilitate detection of TMJ OA, to monitor treatment outcome, and to provide the foundation for the development of joint deterioration prevention strategies.
StatusFinished
Effective start/end date10/4/138/31/15

Funding

  • University of Michigan (UMICH)

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Temporomandibular Joint
Osteoarthritis
Therapeutics
Temporomandibular Joint Disorders
Facial Pain
Arthritis
Joints
Biomarkers
Open Bite
Mastication
Diagnostic Imaging
Bone Resorption
Orthodontics
Jaw
Software
Pathology
Bone and Bones
Population