Optimization of TNBS-induced experimental IBD for therapeutic intervention

Research project

Description

Animal models of inflammatory bowel diseases (IBD) offer useful systems for preclinical testing of therapies that promote mucosal healing. This proposal will utilize an animal model of injury and IBD-like disease induced by trinitrobenzene sulfonic acid (TNBS) to optimize timing and analyses for evaluation of mucosal repair.

Phase 1 will evaluate 2 days and 4 days after TNBS to establish variability in disease and healing across animals.

Phase 2 will test a preclinical therapy (anti-IL-12) that has proved effective in other (longer-term) and more challenging models.

Phase 3 will test a long acting form of growth hormone for efficacy in promoting mucosal healing.

Body weights, plasma and tissue samples (colon and liver) will be collected to monitor disease and treatment outcomes.
StatusFinished
Effective start/end date6/6/143/5/15

Funding

  • Industry Sponsor

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Trinitrobenzenes
Sulfonic Acids
Inflammatory Bowel Diseases
Therapeutics
Animal Models
Interleukin-12
Growth Hormone
Colon
Body Weight
Liver
Wounds and Injuries