Nitric oxide-releasing dendrimers for the treatment of periodontal disease

Project: Research project

Description

The goal of this proposal is to develop nitric oxide-­--releasing dendrimers to inhibit biofilm-­--based
periodontopathogens and associated periodontal disease. The rationale for pursuing this work is based on
nitric oxide’s broad-­--spectrum antimicrobial activity, rapid diffusion through biofilms, short half-­--life (thus
imparting local action) and physiological role in the immune response to pathogens. The use of a
macromolecular NO-­--release scaffold enables us to maximize bactericidal activity while minimizing the
cytotoxic impact on healthy oral cells and tissue. We will study the influence of dendrimer size/molecular
weight, charge, exterior functionality, and NO-­--release properties on pathogenic plaque bacteria killing. We
will systematically study both dendrimer and nitric oxide penetration into in vitro models of oral plaque
biofilms as a function of biofilm composition, maturity and mass. An established murine model for
periodontal infection will be employed to evaluate how dendrimer composition and nitric oxide release
influence inflammation, host-­--immune response, and biofilm eradication.
StatusActive
Effective start/end date7/2/154/30/20

Funding

  • NIH National Institute of Dental and Craniofacial Research (NIDCR)

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Dendrimers
Periodontal Diseases
Biofilms
Nitric Oxide
Therapeutics
Oxides
Half-Life
Inflammation
Bacteria
Infection