Chromatin based strategies to target Ewing sarcoma

Research project

Description

Biologically targeted agents have the possibility to change the way that we treat pediatric cancers. The discovery of new classes of medications is needed to make this a reality. Focusing on a class of molecules that act on the way that DNA and its associated proteins interact to turn genes on and off, we have discovered a novel compound with biological activity against Ewing sarcoma. However, much more work needs to be done to figure out why. We will:

• Explore the proteins and pathways that associate with this molecule.
• Identify the effects of this compound using integrated genome-wide approaches.
By understanding the function of this molecule we may gain a better understanding of Ewing sarcoma and discover novel strategies for the treatment of Ewing sarcoma and other similar diseases.
StatusActive
Effective start/end date10/1/159/30/18

Funding

  • Hyundai Hope on Wheels

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Ewing's Sarcoma
Chromatin
Proteins
Genome
Pediatrics
DNA
Genes
Neoplasms