Chromatin based strategies to target Ewing sarcoma

Project: Research project

Description

Biologically targeted agents have the possibility to change the way that we treat pediatric cancers. The discovery of new classes of medications is needed to make this a reality. Focusing on a class of molecules that act on the way that DNA and its associated proteins interact to turn genes on and off, we have discovered a novel compound with biological activity against Ewing sarcoma. However, much more work needs to be done to figure out why. We will:

• Explore the proteins and pathways that associate with this molecule.
• Identify the effects of this compound using integrated genome-wide approaches.
By understanding the function of this molecule we may gain a better understanding of Ewing sarcoma and discover novel strategies for the treatment of Ewing sarcoma and other similar diseases.
StatusActive
Effective start/end date10/1/159/30/18

Funding

  • Hyundai Hope on Wheels

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Ewing's Sarcoma
Chromatin
Proteins
Genome
Pediatrics
DNA
Genes
Neoplasms