Center for Gastrointestinal Biology and Disease

Project: Research project


Members of the Center for Gastrointestinal Biology and Disease (CGIBD) are basic and clinical scientists from diverse disciplines dedicated to
advancing our understanding of gastrointestinal biology, physiology and epidemiology with a special emphasis on inflammatory bowel diseases.
The overarching hypothesis that integrates the scientific activities of CGIBD members is that most digestive and hepatic diseases are the result
of complex interactions between host genetic susceptibility, and environmental stimuli. The theme that links the research of center members is
gene-environment interactions in gastrointestinal and liver disease. The goal of the Center is to promote and enhance multidisciplinary and
translational digestive disease research. The Center achieves this goal through: 1) core facilities that provide training, technical support,
laboratory animals, biostatistical and data management support, assays, imaging, and vectors; 2) a pilot feasibility program that offers startup
funds to junior investigators, or to established investigators who wish to pursue a new research direction; 3) a scientific enrichment program
consisting of seminars, symposia and workshops to improve the intellectual climate for digestive disease research and to promote cooperation,
collaboration and communication among involved personnel; 4) a professional development and training program that fosters the careers of
junior faculty. To support the research of members, the center proposes the following cores: 1) Biostatistics and Data Management; 2)
Proteomics/lmmunotechnologies 3) Imaging (small animal imaging’, histology); 4) Vector; and 5) Gnotobiotic Animal. These cores have evolved
in response to new scientific directions of center members and new investigative opportunities. Gastrointestinal diseases and their complications
have a significant health and economic impact. Research by members of this center has led to fundamental breakthroughs in our understanding
of mechanisms responsible for inflammatory bowel diseases, cirrhosis, irritable bowel syndrome, and gastrointestinal cancer.
Effective start/end date12/1/96 → 11/30/19


  • NIH National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDKD)


Gastrointestinal Diseases
Inflammatory Bowel Diseases
Research Personnel
Germ-Free Life
Training Support
Gastrointestinal Neoplasms
Irritable Bowel Syndrome
Laboratory Animals
Genetic Predisposition to Disease
Liver Diseases