One emerging option for autonomous assessment of abstinence from opioid use and delivery of buprenorphine and other opioid addiction treatment agents involves the use of microneedles. A microneedle-based “smart” patch will provide sustained delivery of buprenorphine if needed; however, it will also be programmed to provide gradual elimination of the drug in order to accelerate opioid detoxification if a dose reduction is possible. A comprehensive program is needed to fully and systematically assess the structural and functional properties of microneedle-based “smart” patches created using two photon induced polymerization. The proposed research plan contains three overlapping phases. Phase I will involve chemical and mechanical characterization of Ormocer® materials created using two photon induced polymerization. Phase II will involve biological and functional characterization of Ormocer® microneedles. Phase III will involve integrating microneedles with pumping devices in autonomous “smart” patch devices.
|Effective start/end date||8/1/09 → 7/31/12|
- NIH National Institute on Drug Abuse (NIDA)
Organically Modified Ceramics
Equipment and Supplies