Autonomous Treatment of Opioid Abuse AARA

Research project

Description

One emerging option for autonomous assessment of abstinence from opioid use and delivery of buprenorphine and other opioid addiction treatment agents involves the use of microneedles. A microneedle-based “smart” patch will provide sustained delivery of buprenorphine if needed; however, it will also be programmed to provide gradual elimination of the drug in order to accelerate opioid detoxification if a dose reduction is possible. A comprehensive program is needed to fully and systematically assess the structural and functional properties of microneedle-based “smart” patches created using two photon induced polymerization. The proposed research plan contains three overlapping phases. Phase I will involve chemical and mechanical characterization of Ormocer® materials created using two photon induced polymerization. Phase II will involve biological and functional characterization of Ormocer® microneedles. Phase III will involve integrating microneedles with pumping devices in autonomous “smart” patch devices.
StatusFinished
Effective start/end date8/1/097/31/12

Funding

  • NIH National Institute on Drug Abuse (NIDA)

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Opioid Analgesics
Organically Modified Ceramics
Buprenorphine
Photons
Polymerization
Equipment and Supplies
Research
Pharmaceutical Preparations