• 10228 Citations
  • 39 h-Index
19952018
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1995 2018

Filter
Article
2018

Consequences of VHL Loss on Global DNA Methylome

Robinson, C. M., Lefebvre, F., Poon, B. P., Bousard, A., Fan, X., Lathrop, M., Tost, J., Kim, W. Y., Riazalhosseini, Y. & Ohh, M., Dec 1 2018, In : Scientific Reports. 8, 1, 3313.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
DNA Methylation
DNA
Methylation
Gene Expression
2 Citations

Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma

Smith, C. C., Beckermann, K. E., Bortone, D. S., Cubas, A. A., Bixby, L. M., Lee, S. J., Panda, A., Ganesan, S., Bhanot, G., Wallen, E. M., Milowsky, M. I., Kim, W. Y., Rathmell, W. K., Swanstrom, R. I., Parker, J., Serody, J. S., Selitsky, S. R. & Vincent, B. G., Nov 1 2018, In : Journal of Clinical Investigation. 128, 11, p. 4804-4820 17 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Renal Cell Carcinoma
Immunotherapy
Tumor Microenvironment
Neoplasms
4 Citations

Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing

Patel, N. M., Michelini, V. V., Snell, J. M., Balu, S., Hoyle, A. P., Parker, J., Hayward, M. C., Eberhard, D. A., Salazar, A. H., McNeillie, P., Xu, J., Huettner, C. S., Koyama, T., Utro, F., Rhrissorrakrai, K., Norel, R., Bilal, E., Royyuru, A., Parida, L., Earp, H. S. & 5 othersGrilley-Olson, J. E., Hayes, D. N., Harvey, S. J., Sharpless, N. E. & Kim, W. Y., Feb 1 2018, In : Oncologist. 23, 2, p. 179-185 7 p.

Research output: Contribution to journalArticle

Genomics
Clinical Trials
Neoplasms
Patient Care
Precision Medicine
3 Citations

Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors

Beckford Vera, D. R., Smith, C. C., Bixby, L. M., Glatt, D. M., Dunn, S. S., Saito, R., Kim, W. Y., Serody, J. S., Vincent, B. G. & Parrott, M. C., Mar 1 2018, In : PloS one. 13, 3, e0193832.

Research output: Contribution to journalArticle

Bearings (structural)
Tumor-Infiltrating Lymphocytes
positron-emission tomography
Positron emission tomography
T-cells
1 Citations

Molecular subtype-specific immunocompetent models of high-grade urothelial carcinoma reveal differential neoantigen expression and response to immunotherapy

Saito, R., Smith, C. C., Utsumi, T., Bixby, L. M., Kardos, J., Wobker, S. E., Stewart, K. G., Chai, S., Manocha, U., Byrd, K. M., Damrauer, J. S., Williams, S. E., Vincent, B. G. & Kim, W. Y., Jul 15 2018, In : Cancer Research. 78, 14, p. 3954-3968 15 p.

Research output: Contribution to journalArticle

Immunotherapy
Carcinoma
Urinary Bladder Neoplasms
Neoplasms
CD4-CD8 Ratio

Phase II trial of palbociclib in patients with metastatic urothelial cancer after failure of first-line chemotherapy

Rose, T. L., Chism, D. D., Alva, A. S., Deal, A. M., Maygarden, S. J., Whang, Y. E., Kardos, J., Drier, A., Basch, E. M., Godley, P. A., Dunn, M. W., Kim, W. Y. & Milowsky, M. I., Oct 2 2018, In : British journal of cancer. 119, 7, p. 801-807 7 p.

Research output: Contribution to journalArticle

Retinoblastoma
Drug Therapy
Neoplasms
Platinum
Disease-Free Survival

The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells

Gao, Y., Kardos, J., Yang, Y., Tamir, T. Y., Mutter-Rottmayer, E., Weissman, B. E., Major, M. B., Kim, W. Y. & Vaziri, C., Dec 1 2018, In : Scientific Reports. 8, 1, 15304.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Testicular Neoplasms
Homologous Recombination
Antigens
Ionizing Radiation
2017
4 Citations

Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer

Sun, X., Hoadley, K. A., Kim, W. Y., Furberg, H., Olshan, A. F. & Troester, M. A., Jun 1 2017, In : Cancer Causes and Control. 28, 6, p. 539-544 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Obesity
Smoking
Muscles
Atlases
1 Citations
Atlases
Cytosine
Guanine
Urinary Bladder Neoplasms
Methylation
9 Citations

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

Bailey, S. T., Smith, A. M., Kardos, J., Wobker, S. E., Wilson, H. L., Krishnan, B., Saito, R., Lee, H. J., Zhang, J., Eaton, S. C., Williams, L. A., Manocha, U., Peters, D. J., Pan, X., Carroll, T. J., Felsher, D. W., Walter, V., Zhang, Q., Parker, J., Yeh, J. J. & 3 othersMoffitt, R. A., Leung, Y. M. & Kim, W. Y., Jun 8 2017, In : Nature communications. 8, 15770.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Tumors
tumors
cancer
Chemical activation
6 Citations

Sav1 loss induces senescence and Stat3 activation coinciding with tubulointerstitial fibrosis

Leung, Y. M., Wilson, H. L., Voltzke, K. J., Williams, L. A., Lee, H. J., Wobker, S. E. & Kim, W. Y., Jun 1 2017, In : Molecular and Cellular Biology. 37, 12, e00565-16.

Research output: Contribution to journalArticle

Fibrosis
Chronic Renal Insufficiency
Transcriptional Activation
Chronic Kidney Failure
Epithelium
2016
53 Citations

Bladder cancer molecular taxonomy: Summary from a consensus meeting

Lerner, S. P., McConkey, D. J., Hoadley, K. A., Chan, K. S., Kim, W. Y., Radvanyi, F., Höglund, M. & Real, F. X., Jan 1 2016, In : Bladder Cancer. 2, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Neoplasms
Technology
Research
11 Citations

Intrinsic genomic differences between african American and white patients with clear cell renal cell carcinoma

Krishnan, B., Rose, T. L., Kardos, J., Milowsky, M. I. & Kim, W. Y., May 1 2016, In : JAMA Oncology. 2, 5, p. 664-667 4 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
African Americans
Mutation Rate
Neoplasms
RNA
5 Citations

Racial disparities in survival among patients with advanced renal cell carcinoma in the targeted therapy era

Rose, T. L., Deal, A. M., Krishnan, B., Nielsen, M. E., Smith, A. M., Kim, W. Y. & Milowsky, M. I., Jun 24 2016, In : Cancer. 122, 19, p. 2988-2995 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
African Americans
Survival
Therapeutics
Confidence Intervals
2015
98 Citations

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

Chandler, R. L., Damrauer, J. S., Raab, J. R., Schisler, J. C., Wilkerson, M. D., Didion, J. P., Starmer, J. D., Serber, D., Yee, D., Xiong, J., Darr, D. B., Pardo Manuel De Villena, F. P., Kim, W. Y. & Magnuson, T. R., Jan 1 2015, In : Nature communications. 6, 6118.

Research output: Contribution to journalArticle

mutations
Tumors
Carcinogenesis
cancer
Cytokines
8 Citations

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Rager, J. E., Tilley, S. K., Tulenko, S. E., Smeester, L., Ray, P. D., Yosim, A., Currier, J. M., Ishida, M. C., González-Horta, M. D. C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Gutiérrez-Torres, D. S., Drobná, Z., Del Razo, L. M., García-Vargas, G. G., Kim, W. Y., Zhou, Y. H., Wright, F. A., Styblo, M. & Fry, R. C., Jun 15 2015, In : Chemical Research in Toxicology. 28, 6, p. 1144-1155 12 p.

Research output: Contribution to journalArticle

Arsenic
DNA Methylation
Urinary Bladder Neoplasms
Genes
Methylation
33 Citations

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

Miao, L., Wang, Y., Lin, C. M., Xiong, Y., Chen, N., Zhang, L., Kim, W. Y. & Huang, L., Nov 10 2015, In : Journal of Controlled Release. 217, p. 27-41 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Nanoparticles
Cisplatin
Therapeutics
Phenotype
16 Citations

Targeting tumor hypoxia with hypoxia-activated prodrugs

Yeh, J. J. & Kim, W. Y., May 1 2015, In : Journal of Clinical Oncology. 33, 13, p. 1505-1508 4 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Prodrugs
Pancreatic Neoplasms
Hypoxia
Tumor Hypoxia
2014
1139 Citations

Comprehensive molecular characterization of urothelial bladder carcinoma

Weinstein, J. N., Akbani, R., Broom, B. M., Wang, W., Verhaak, R. G. W., McConkey, D., Lerner, S., Morgan, M., Creighton, C. J., Smith, C., Cherniack, A. D., Kim, J., Pedamallu, C. S., Noble, M. S., Al-Ahmadie, H. A., Reuter, V. E., Rosenberg, J. E., F.Bajorin, D., Bochner, B. H., Solit, D. B. & 273 othersKoppie, T., Robinson, B., Gordenin, D. A., Fargo, D., Klimczak, L. J., Roberts, S. A., Au, J., Laird, P. W., Hinoue, T., Schultz, N., Ramirez, R., Hansel, D., Hoadley, K. A., Kim, W. Y., Damrauer, J. S., Baylin, S. B., Mungall, A. J., Robertson, A. G., Chu, A., Kwiatkowski, D. J., Sougnez, C., Cibulskis, K., Lichtenstein, L., Sivachenko, A., Stewart, C., Lawrence, M. S., Getz, G., Lander, E., Gabrie, S. B., Donehower, L., Carter, S. L., Saksena, G., Schumacher, S. E., Freeman, S. S., Jung, J., Bhatt, A. S., Pugh, T., Beroukhim, R., Meyerson, M., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Dhalla, N., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Wong, T., Wye, N., Bowlby, R., Chuah, E., Guin, R., Shen, H., Bootwalla, M. S., Triche, T., Lai, P. H., Van Den Berg, D. J., Weisenberger, D. J., Balu, S., Bodenheimer, T., Hoyle, A. P., Jefferys, S. R., Meng, S., Mose, L. E., Simons, J. V., Soloway, M. G., Wu, J., Parker, J., Hayes, D. N., Roach, J., Buda, E., Jones, C. D., Mieczkowski, P. A., Tan, D., Veluvolu, U., Waring, S., Auman, J. T., Perou, C. M., Wilkerson, M. D., Santoso, N., Parfenov, M., Ren, X., Pantazi, A., Hadjipanayis, A., Seidman, J., Kucherlapati, R., Lee, S., Yang, L., Park, P. J., Xu, A. W., Protopopov, A., Zhang, J., Bristow, C., Mahadeshwar, H. S., Seth, S., Song, X., Tang, J., Zeng, D., Chin, L., Guo, C., Casasent, T. D., Liu, W., Ju, Z., Motter, T., Peng, B., Ryan, M., Su, X., Yang, J. Y., Lorenzi, P. L., Yao, H., Zhang, N., Zhang, J., Mills, G. B., Cho, J., DiCara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Lin, P., Liu, Y., Stojanov, P., Voet, D., Zhang, H., Zou, L., Bernard, B., Kreisberg, D., Reynolds, S., Rovira, H., Shmulevich, I., Gao, J., Jacobsen, A., Aksoy, B. A., Antipin, Y., Ciriello, G., Dresdner, G., Gross, B., Lee, W., Reva, B., Shen, R., Sinha, R., Sumer, S. O., Weinhold, N., Ladanyi, M., Sander, C., Benz, C., Carlin, D., Haussler, D., Ng, S., Paull, E., Stuart, J., Zhu, J., Liu, Y., Zhang, W., Taylor, B. S., Lichtenberg, T. M., Zmuda, E., Barr, T., Black, A. D., George, M., Hanf, B., Helsel, C., McAllister, C., Ramirez, N. C., Tabler, T. R., Weaver, S., Wise, L., Bowen, J., Gastier-Foster, J. M., Jian, W., Tello, S., Ittman, M., Castro, P., McClenden, W. D., Gibbs, R., Saller, C., Tarvin, K., DiPiero, J. M., Owens, J., Bollag, R., Li, Q., Weinberger, P., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Swanson, P., Shelton, T., Curley, E., Gardner, J., Mallery, D., Penny, R., Van Bang, N., Hanh, P. T., Kohl, B., Van Le, X., Phu, B. D., Thorp, R., Tien, N. V., Vinh, L. Q., Sandusky, G., Burks, E., Christ, K., Gee, J., Holway, A., Moinzadeh, A., Sorcini, A., Sullivan, T., Garcia-Grossman, I. R., Regazzi, A. M., Boice, L., Rathmell, W. K., Thorne, L. B., Bastacky, S., Davies, B., Dhir, R., Gingrich, J., Hrebinko, R., Maranchie, J., Nelson, J., Parwani, A., Bshara, W., Gaudioso, C., Morrison, C., Alexopoulou, V., Bartlett, J., Engel, J., Kodeeswaran, S., Antic, T., O'Donnell, P. H., Smith, N. D., Steinberg, G. D., Egea, S., Gomez-Fernandez, C., Herbert, L., Jorda, M., Soloway, M., Beaver, A., Carter, S., Kapur, P., Lewis, C., Lotan, Y., Bondaruk, J., Czerniak, B., Skinner, E., Aldape, K., Jensen, M. A., Kahn, A. B., Pihl, T. D., Pot, D. A., Srinivasan, D., Wan, Y., Ferguson, M. L., Zenklusen, J. C., Davidsen, T., Demchok, J. A., Shaw, K. R. M., Sheth, M., Tarnuzzer, R., Wang, Z., Yang, L., Hutter, C., Ozenberger, B. A., Sofia, H. J. & Eley, G., Jan 1 2014, In : Nature. 507, 7492, p. 315-322 8 p.

Research output: Contribution to journalArticle

Urinary Bladder
Carcinoma
Chromatin
RNA Sequence Analysis
Neoplasms
29 Citations

Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal

Zhou, B., Damrauer, J. S., Bailey, S. T., Hadzic, T., Jeong, Y., Clark, K., Fan, C., Murphy, L., Lee, C. Y., Troester, M. A., Miller, C. R., Jin, J., Darr, D., Perou, C. M., Levine, R. L., Diehn, M. & Kim, W. Y., Feb 3 2014, In : Journal of Clinical Investigation. 124, 2, p. 553-563 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Erythropoietin
Carcinogenesis
Breast
Breast Neoplasms
8 Citations

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

Couvé, S., Ladroue, C., Laine, E., Mahtouk, K., Guégan, J., Gad, S., Le Jeune, H., Le Gentil, M., Nuel, G., Kim, W. Y., Lecomte, B., Pagès, J. C., Collin, C., Lasne, F., Benusiglio, P. R., Bressac-De Paillerets, B., Feunteun, J., Lazar, V., Gimenez-Roqueplo, A. P., Mazure, N. M. & 7 othersDessen, P., Tchertanov, L., Mole, D. R., Kaelin, W., Ratcliffe, P., Richard, S. & Gardie, B., Nov 15 2014, In : Cancer Research. 74, 22, p. 6554-6564 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
von Hippel-Lindau Disease
Mutation
Tumor Suppressor Genes
Hemangioblastoma
273 Citations

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

Damrauer, J. S., Hoadley, K. A., Chism, D. D., Fan, C., Tignanelli, C. J., Wobker, S. E., Yeh, J. J., Milowsky, M. I., Iyer, G., Parker, J. & Kim, W. Y., Feb 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3110-3115 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Breast Neoplasms
Gene Expression
Microarray Analysis
Standard of Care
12 Citations

mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma

Bailey, S. T., Zhou, B., Damrauer, J. S., Krishnan, B., Wilson, H. L., Smith, A. M., Li, M., Yeh, J. J. & Kim, W. Y., Jan 1 2014, In : PLoS One. 9, 9, e104413.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
kidney cells
Renal Cell Carcinoma
carcinoma
Chemical activation
54 Citations

Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model

Zhang, J., Miao, L., Guo, S., Zhang, Y., Zhang, L., Satterlee, A., Kim, W. Y. & Huang, L., May 28 2014, In : Journal of Controlled Release. 182, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

gemcitabine
Nanoparticles
Cisplatin
Urinary Bladder
Carcinoma
52 Citations

Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States: 1988 to 2006

Nielsen, M. E., Smith, A. M., Meyer, A. M., Kuo, T. M., Tyree, S., Kim, W. Y., Milowsky, M. I., Pruthi, R. S. & Millikan, R. C., Jan 1 2014, In : Cancer. 120, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

Urinary Bladder
Carcinoma
Urinary Bladder Neoplasms
Incidence
Population
2013
42 Citations

A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer

Whang, Y. E., Armstrong, A. J., Rathmell, W. K., Godley, P. A., Kim, W. Y., Pruthi, R. S., Wallen, E. M., Crane, J. M., Moore, D. T., Grigson, G., Morris, K., Watkins, C. P. & George, D. J., Jan 1 2013, In : Urologic Oncology: Seminars and Original Investigations. 31, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Castration
Epidermal Growth Factor Receptor
Prostatic Neoplasms
Therapeutics
69 Citations

Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC

Zhang, Y., Schwerbrock, N. M. J., Rogers, A. B., Kim, W. Y. & Huang, L., Jan 1 2013, In : Molecular Therapy. 21, 8, p. 1559-1569 11 p.

Research output: Contribution to journalArticle

gemcitabine
Non-Small Cell Lung Carcinoma
Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA
82 Citations

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

Hanna, S. C., Krishnan, B., Bailey, S. T., Moschos, S. J., Kuan, P. F., Shimamura, T., Osborne, L. D., Siegel, M. B., Duncan, L. M., O'Brien, E. T., Superfine, R., Miller, C. R., Simon, M. C., Wong, K. K. & Kim, W. Y., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 2078-2093 16 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Neoplasms
Matrix Metalloproteinase 14
Focal Adhesion Protein-Tyrosine Kinases
56 Citations

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1 -mutant lung cancer

Liu, Y., Marks, K., Cowley, G. S., Carretero, J., Liu, Q., Niel, T. J. F., Xu, C., Cohoon, T. J., Gao, P., Zhang, Y., Chen, Z., Altabef, A. B., Tchaicha, J. H., Wang, X., Choe, S., Driggers, E. M., Zhang, J., Bailey, S. T., Sharpless, N. E., Hayes, D. N. & 20 othersPatel, N. M., Janne, P. A., Bardeesy, N., Engelman, J. A., Manning, B. D., Shaw, R. J., Asara, J. M., Scully, R., Kimmelman, A., Byers, L. A., Gibbons, D. L., Wistuba, I. I., Heymach, J. V., Kwiatkowski, D. J., Kim, W. Y., Kung, A. L., Gray, N. S., Root, D. E., Cantley, L. C. & Wong, K. K., Aug 1 2013, In : Cancer Discovery. 3, 8, p. 870-879 10 p.

Research output: Contribution to journalArticle

Thymidine Monophosphate
Lung Neoplasms
Phosphotransferases
Cations
Nucleotides
4 Citations

Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier

Ding, M., Coward, R. J., Jeansson, M., Kim, W. Y. & Quaggin, S. E., Jan 1 2013, In : American Journal of Physiology - Renal Physiology. 304, 1

Research output: Contribution to journalArticle

Podocytes
Knockout Mice
Glomerulonephritis
Kidney
Phenotype
3 Citations

Stearoyl co-a desaturase 1 as a ccRCC therapeutic target: Death by stress

Leung, Y. M. & Kim, W. Y., Jun 15 2013, In : Clinical Cancer Research. 19, 12, p. 3111-3113 3 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Therapeutics
54 Citations

Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy

Zhang, Y., Kim, W. Y. & Huang, L., Apr 1 2013, In : Biomaterials. 34, 13, p. 3447-3458 12 p.

Research output: Contribution to journalArticle

Calcium phosphate
Pancreatic Neoplasms
Non-Small Cell Lung Carcinoma
Nanoparticles
Lipids
2012
119 Citations

Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer

Choueiri, T. K., Ross, R. W., Jacobus, S., Vaishampayan, U., Yu, E. Y., Quinn, D. I., Hahn, N. M., Hutson, T. E., Sonpavde, G., Morrissey, S. C., Buckle, G. C., Kim, W. Y., Petrylak, D. P., Ryan, C. W., Eisenberger, M. A., Mortazavi, A., Bubley, G. J., Taplin, M. E., Rosenberg, J. E. & Kantoff, P. W., Feb 10 2012, In : Journal of Clinical Oncology. 30, 5, p. 507-512 6 p.

Research output: Contribution to journalArticle

docetaxel
Platinum
Placebos
Disease-Free Survival
Neoplasms
348 Citations

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

Duncan, J. S., Whittle, M. C., Nakamura, K., Abell, A. N., Midland, A. A., Zawistowski, J. S., Johnson, N. L., Granger, D. A., Jordan, N. V., Darr, D. B., Usary, J., Kuan, P. F., Smalley, D. M., Major, M. B., He, X., Hoadley, K. A., Zhou, B., Sharpless, N. E., Perou, C. M., Kim, W. Y. & 7 othersGomez, S. M., Chen, X., Jin, J., Frye, S. V., Earp, H. S., Graves, L. M. & Johnson, G. L., Apr 13 2012, In : Cell. 149, 2, p. 307-321 15 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Mitogen-Activated Protein Kinase Kinases
Receptor Protein-Tyrosine Kinases
Corrosion inhibitors
Drug Resistance
11 Citations
docetaxel
Androgens
Prostatic Neoplasms
Cohort Studies
Radiotherapy
2011
42 Citations
Neoplasms
Therapeutics
Urinary Bladder Neoplasms
Prostatic Neoplasms
Urinary Bladder
10 Citations

A phase I trial of sorafenib combined with cisplatin/etoposide or carboplatin/pemetrexed in refractory solid tumor patients

Davies, J. M., Dhruva, N. S., Walko, C. M., Socinski, M. A., Bernard, S. A., Hayes, D. N., Kim, W. Y., Ivanova, A., Keller, K., Hilbun, L. R., Chiu, M., Dees, E. C. & Stinchcombe, T. E., Feb 1 2011, In : Lung Cancer. 71, 2, p. 151-155 5 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Etoposide
Cisplatin
Neoplasms
43 Citations

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

Russell, R. C., Sufan, R. I., Zhou, B., Heir, P., Bunda, S., Sybingco, S. S., Greer, S. N., Roche, O., Heathcote, S. A., Chow, V. W. K., Boba, L. M., Richmond, T. D., Hickey, M. M., Barber, D. L., Cheresh, D. A., Simon, M. C., Irwin, M. S., Kim, W. Y. & Ohh, M., Jul 1 2011, In : Nature Medicine. 17, 7, p. 845-853 9 p.

Research output: Contribution to journalArticle

Polycythemia
Ubiquitin-Protein Ligases
Cytokines
Genes
Erythropoietin
14 Citations
docetaxel
Estramustine
Prostatectomy
Prostatic Neoplasms
Radiotherapy
2010
72 Citations
Cystectomy
Urinary Bladder Neoplasms
Muscles
Surgical Pathology
Neoadjuvant Therapy
162 Citations

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Carretero, J., Shimamura, T., Rikova, K., Jackson, A. L., Wilkerson, M. D., Borgman, C. L., Buttarazzi, M. S., Sanofsky, B. A., McNamara, K. L., Brandstetter, K. A., Walton, Z. E., Gu, T. L., Silva, J. C., Crosby, K., Shapiro, G. I., Maira, S. M., Ji, H., Castrillon, D. H., Kim, C. F., García-Echeverría, C. & 6 othersBardeesy, N., Sharpless, N. E., Hayes, D. N., Kim, W. Y., Engelman, J. A. & Wong, K. K., Jun 15 2010, In : Cancer Cell. 17, 6, p. 547-559 13 p.

Research output: Contribution to journalArticle

Proteomics
Lung
Neoplasms
Penetrance
Phosphoproteins
145 Citations

Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma

Cowey, C. L., Amin, C., Pruthi, R. S., Wallen, E. M., Nielsen, M. E., Grigson, G., Watkins, C., Nance, K. V., Crane, J., Jalkut, M., Moore, D. T., Kim, W. Y., Godley, P. A., Whang, Y. E., Fielding, J. R. & Rathmell, W. K., Mar 20 2010, In : Journal of Clinical Oncology. 28, 9, p. 1502-1507 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Clinical Trials
Nephrectomy
Neoplasms
Therapeutics
2009
98 Citations

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Kim, W. Y., Perera, S., Zhou, B., Carretero, J., Jen, J. Y., Heathcote, S. A., Jackson, A. L., Nikolinakos, P., Ospina, B., Naumov, G., Brandstetter, K. A., Weigman, V. J., Zaghlul, S., Hayes, D. N., Padera, R. F., Heymach, J. V., Kung, A. L., Sharpless, N. E., Kaelin, W. G. & Wong, K. K., Aug 3 2009, In : Journal of Clinical Investigation. 119, 8, p. 2160-2170 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Lung
Epithelial-Mesenchymal Transition
Non-Small Cell Lung Carcinoma
Neoplasms
122 Citations

Regulation of endocytosis via the oxygen-sensing pathway

Wang, Y., Roche, O., Yan, M. S., Finak, G., Evans, A. J., Metcalf, J. L., Hast, B. E., Hanna, S. C., Wondergem, B., Furge, K. A., Irwin, M. S., Kim, W. Y., Teh, B. T., Grinstein, S., Park, M., Marsden, P. A. & Ohh, M., Mar 1 2009, In : Nature Medicine. 15, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

Endocytosis
Tumors
Receptor Protein-Tyrosine Kinases
Oxygen
Chemical activation
2007
61 Citations

CD200 is induced by ERK and is a potential therapeutic target in melanoma

Petermann, K. B., Rozenberg, G. I., Zedek, D. C., Groben, P. A., Mckinnon, K. P., Buehler, C., Kim, W. Y., Shields, J. M., Penland, S., Bear, J. E., Thomas, N. E., Serody, J. S. & Sharpless, N. E., Dec 1 2007, In : Journal of Clinical Investigation. 117, 12, p. 3922-3929 8 p.

Research output: Contribution to journalArticle

Melanoma
Therapeutics
Immunomodulation
Mitogen-Activated Protein Kinase Kinases
Microarray Analysis
44 Citations

Dexamethasone-induced posterior reversible encephalopathy syndrome

Irvin, W., MacDonald, G., Smith, J. K. & Kim, W. Y., Jun 10 2007, In : Journal of Clinical Oncology. 25, 17, p. 2484-2486 3 p.

Research output: Contribution to journalArticle

Hypertensive Encephalopathy
Posterior Leukoencephalopathy Syndrome
Trazodone
Pyridines
X Ray Computed Tomography
58 Citations

Dominant-negative HIF-3α4 suppresses VHL-null renal cell carcinoma progression

Maynard, M. A., Evans, A. J., Shi, W., Kim, W. Y., Liu, F. F. & Ohh, M., Nov 15 2007, In : Cell Cycle. 6, 22, p. 2810-2816 7 p.

Research output: Contribution to journalArticle

Null Lymphocytes
Renal Cell Carcinoma
Mutation
Neoplasms
Ubiquitin-Protein Ligases
108 Citations

pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2

Yang, H., Minamishima, Y. A., Yan, Q., Schlisio, S., Ebert, B. L., Zhang, X., Zhang, L., Kim, W. Y., Olumi, A. F. & Kaelin, W. G., Oct 12 2007, In : Molecular Cell. 28, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Von Hippel-Lindau Tumor Suppressor Protein
Carcinogenesis
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligases
181 Citations

VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

Evans, A. J., Russell, R. C., Roche, O., Burry, T. N., Fish, J. E., Chow, V. W. K., Kim, W. Y., Saravanan, A., Maynard, M. A., Gervais, M. L., Sufan, R. I., Roberts, A. M., Wilson, L. A., Betten, M., Vandewalle, C., Berx, G., Marsden, P. A., Irwin, M. S., Teh, B. T., Jewett, M. A. S. & 1 othersOhh, M., Jan 1 2007, In : Molecular and cellular biology. 27, 1, p. 157-169 13 p.

Research output: Contribution to journalArticle

Snails
Cadherins
Renal Cell Carcinoma
Genes
Kidney