• 9539 Citations
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19952018
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Research Output 1995 2018

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Article
2018

Consequences of VHL Loss on Global DNA Methylome

Robinson, C. M., Lefebvre, F., Poon, B. P., Bousard, A., Fan, X., Lathrop, M., Tost, J., Kim, W. Y., Riazalhosseini, Y. & Ohh, M. Dec 1 2018 In : Scientific Reports. 8, 1, 3313

Research output: Contribution to journalArticle

Renal Cell Carcinoma
DNA Methylation
DNA
Methylation
Gene Expression
3 Citations

Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing

Patel, N. M. , Michelini, V. V. , Snell, J. M. , Balu, S. , Hoyle, A. P. , Parker, J. S. , Hayward, M. C. , Eberhard, D. A. , Salazar, A. H. , McNeillie, P. , Xu, J. , Huettner, C. S. , Koyama, T. , Utro, F. , Rhrissorrakrai, K. , Norel, R. , Bilal, E. , Royyuru, A. , Parida, L. , Earp, H. S. & 5 others Grilley-Olson, J. E., Hayes, D. N., Harvey, S. J., Sharpless, N. E. & Kim, W. Y. Feb 1 2018 In : Oncologist. 23, 2, p. 179-185 7 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Precision Medicine
Artificial Intelligence
Genomics
Clinical Trials

Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors

Beckford Vera, D. R., Smith, C. C., Bixby, L. M., Glatt, D. M., Dunn, S. S., Saito, R., Kim, W. Y., Serody, J. S., Vincent, B. G. & Parrott, M. C. Mar 1 2018 In : PloS one. 13, 3, e0193832

Research output: Contribution to journalArticle

Hydrophobic chromatography
Tumor-Infiltrating Lymphocytes
positron-emission tomography
Positron-Emission Tomography
Anti-Idiotypic Antibodies
2017
3 Citations

Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer

Sun, X., Hoadley, K. A., Kim, W. Y., Furberg, H., Olshan, A. F. & Troester, M. A. Jun 1 2017 In : Cancer Causes and Control. 28, 6, p. 539-544 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Obesity
Smoking
Muscles
Atlases
1 Citations
Atlases
Cytosine
Glutamate Receptors
Guanine
Urinary Bladder Neoplasms
6 Citations

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

Bailey, S. T. , Smith, A. M. , Kardos, J. , Wobker, S. E. , Wilson, H. L. , Krishnan, B. , Saito, R. , Lee, H. J. , Zhang, J. , Eaton, S. C. , Williams, L. A. , Manocha, U. , Peters, D. J. , Pan, X. , Carroll, T. J. , Felsher, D. W. , Walter, V. , Zhang, Q. , Parker, J. S. , Yeh, J. J. & 3 others Moffitt, R. A., Leung, J. Y. & Kim, W. Y. Jun 8 2017 In : Nature Communications. 8, 15770

Research output: Contribution to journalArticle

cells and cell components
disease treatment
genetic engineering
rodents
bioactivity
3 Citations

Sav1 loss induces senescence and Stat3 activation coinciding with tubulointerstitial fibrosis

Leung, J. Y., Wilson, H. L., Voltzke, K. J., Williams, L. A., Lee, H. J., Wobker, S. E. & Kim, W. Y. Jun 1 2017 In : Molecular and cellular biology. 37, 12, e00565-16

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Aristolochic Acids
Kidney Tubules
STAT3 Transcription Factor
Cell Cycle Proteins
2016
7 Citations

Intrinsic genomic differences between african American and white patients with clear cell renal cell carcinoma

Krishnan, B., Rose, T. L., Kardos, J., Milowsky, M. I. & Kim, W. Y. May 1 2016 In : JAMA Oncology. 2, 5, p. 664-667 4 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
African Americans
Mutation Rate
Neoplasms
RNA
5 Citations

Racial disparities in survival among patients with advanced renal cell carcinoma in the targeted therapy era

Rose, T. L., Deal, A. M., Krishnan, B., Nielsen, M. E., Smith, A. B., Kim, W. Y. & Milowsky, M. I. Jan 1 2016 (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
African Americans
Survival
Therapeutics
Confidence Intervals
2015
79 Citations

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

Chandler, R. L., Damrauer, J. S., Raab, J. R., Schisler, J. C., Wilkerson, M. D., Didion, J. P., Starmer, J., Serber, D., Yee, D., Xiong, J., Darr, D. B., De Villena, F. P. M., Kim, W. Y. & Magnuson, T. Jan 1 2015 In : Nature Communications. 6, 6118

Research output: Contribution to journalArticle

mutations
Tumors
Carcinogenesis
cancer
Cytokines
8 Citations

Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer

Rager, J. E., Tilley, S. K., Tulenko, S. E., Smeester, L., Ray, P. D., Yosim, A., Currier, J. M., Ishida, M. C., González-Horta, M. D. C., Sánchez-Ramírez, B., Ballinas-Casarrubias, L., Gutiérrez-Torres, D. S., Drobná, Z., Del Razo, L. M., García-Vargas, G. G., Kim, W. Y., Zhou, Y. H., Wright, F. A., Stýblo, M. & Fry, R. C. Jun 15 2015 In : Chemical Research in Toxicology. 28, 6, p. 1144-1155 12 p.

Research output: Contribution to journalArticle

Arsenic
DNA Methylation
Urinary Bladder Neoplasms
Genes
Methylation
27 Citations

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

Miao, L., Wang, Y., Lin, C. M., Xiong, Y., Chen, N., Zhang, L., Kim, W. Y. & Huang, L. Nov 10 2015 In : Journal of Controlled Release. 217, p. 27-41 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Nanoparticles
Cisplatin
Therapeutics
Phenotype
4 Citations
Cystectomy
Urinary Bladder Neoplasms
Drug Therapy
Muscles
Patient Transfer
13 Citations

Targeting tumor hypoxia with hypoxia-activated prodrugs

Yeh, J. J. & Kim, W. Y. May 1 2015 In : Journal of Clinical Oncology. 33, 13, p. 1505-1508 4 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Prodrugs
Pancreatic Neoplasms
Hypoxia
Tumor Hypoxia
2014
967 Citations

Comprehensive molecular characterization of urothelial bladder carcinoma

Weinstein, J. N. , Akbani, R. , Broom, B. M. , Wang, W. , Verhaak, R. G. W. , McConkey, D. , Lerner, S. , Morgan, M. , Creighton, C. J. , Smith, C. , Cherniack, A. D. , Kim, J. , Pedamallu, C. S. , Noble, M. S. , Al-Ahmadie, H. A. , Reuter, V. E. , Rosenberg, J. E. , F.Bajorin, D. , Bochner, B. H. , Solit, D. B. & 273 others Koppie, T., Robinson, B., Gordenin, D. A., Fargo, D., Klimczak, L. J., Roberts, S. A., Au, J., Laird, P. W., Hinoue, T., Schultz, N., Ramirez, R., Hansel, D., Hoadley, K. A., Kim, W. Y., Damrauer, J. S., Baylin, S. B., Mungall, A. J., Robertson, A. G., Chu, A., Kwiatkowski, D. J., Sougnez, C., Cibulskis, K., Lichtenstein, L., Sivachenko, A., Stewart, C., Lawrence, M. S., Getz, G., Lander, E., Gabrie, S. B., Donehower, L., Carter, S. L., Saksena, G., Schumacher, S. E., Freeman, S. S., Jung, J., Bhatt, A. S., Pugh, T., Beroukhim, R., Meyerson, M., Ally, A., Balasundaram, M., Butterfield, Y. S. N., Dhalla, N., Hirst, C., Holt, R. A., Jones, S. J. M., Lee, D., Li, H. I., Marra, M. A., Mayo, M., Moore, R. A., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Wong, T., Wye, N., Bowlby, R., Chuah, E., Guin, R., Shen, H., Bootwalla, M. S., Triche, T., Lai, P. H., Van Den Berg, D. J., Weisenberger, D. J., Balu, S., Bodenheimer, T., Hoyle, A. P., Jefferys, S. R., Meng, S., Mose, L. E., Simons, J. V., Soloway, M. G., Wu, J., Parker, J. S., Hayes, D. N., Roach, J., Buda, E., Jones, C. D., Mieczkowski, P. A., Tan, D., Veluvolu, U., Waring, S., Auman, J. T., Perou, C. M., Wilkerson, M. D., Santoso, N., Parfenov, M., Ren, X., Pantazi, A., Hadjipanayis, A., Seidman, J., Kucherlapati, R., Lee, S., Yang, L., Park, P. J., Xu, A. W., Protopopov, A., Zhang, J., Bristow, C., Mahadeshwar, H. S., Seth, S., Song, X., Tang, J., Zeng, D., Chin, L., Guo, C., Casasent, T. D., Liu, W., Ju, Z., Motter, T., Peng, B., Ryan, M., Su, X., Yang, J. Y., Lorenzi, P. L., Yao, H., Zhang, N., Zhang, J., Mills, G. B., Cho, J., DiCara, D., Frazer, S., Gehlenborg, N., Heiman, D. I., Lin, P., Liu, Y., Stojanov, P., Voet, D., Zhang, H., Zou, L., Bernard, B., Kreisberg, D., Reynolds, S., Rovira, H., Shmulevich, I., Gao, J., Jacobsen, A., Aksoy, B. A., Antipin, Y., Ciriello, G., Dresdner, G., Gross, B., Lee, W., Reva, B., Shen, R., Sinha, R., Sumer, S. O., Weinhold, N., Ladanyi, M., Sander, C., Benz, C., Carlin, D., Haussler, D., Ng, S., Paull, E., Stuart, J., Zhu, J., Liu, Y., Zhang, W., Taylor, B. S., Lichtenberg, T. M., Zmuda, E., Barr, T., Black, A. D., George, M., Hanf, B., Helsel, C., McAllister, C., Ramirez, N. C., Tabler, T. R., Weaver, S., Wise, L., Bowen, J., Gastier-Foster, J. M., Jian, W., Tello, S., Ittman, M., Castro, P., McClenden, W. D., Gibbs, R., Saller, C., Tarvin, K., DiPiero, J. M., Owens, J., Bollag, R., Li, Q., Weinberger, P., Czerwinski, C., Huelsenbeck-Dill, L., Iacocca, M., Petrelli, N., Rabeno, B., Swanson, P., Shelton, T., Curley, E., Gardner, J., Mallery, D., Penny, R., Van Bang, N., Hanh, P. T., Kohl, B., Van Le, X., Phu, B. D., Thorp, R., Tien, N. V., Vinh, L. Q., Sandusky, G., Burks, E., Christ, K., Gee, J., Holway, A., Moinzadeh, A., Sorcini, A., Sullivan, T., Garcia-Grossman, I. R., Regazzi, A. M., Boice, L., Rathmell, W. K., Thorne, L., Bastacky, S., Davies, B., Dhir, R., Gingrich, J., Hrebinko, R., Maranchie, J., Nelson, J., Parwani, A., Bshara, W., Gaudioso, C., Morrison, C., Alexopoulou, V., Bartlett, J., Engel, J., Kodeeswaran, S., Antic, T., O'Donnell, P. H., Smith, N. D., Steinberg, G. D., Egea, S., Gomez-Fernandez, C., Herbert, L., Jorda, M., Soloway, M., Beaver, A., Carter, S., Kapur, P., Lewis, C., Lotan, Y., Bondaruk, J., Czerniak, B., Skinner, E., Aldape, K., Jensen, M. A., Kahn, A. B., Pihl, T. D., Pot, D. A., Srinivasan, D., Wan, Y., Ferguson, M. L., Zenklusen, J. C., Davidsen, T., Demchok, J. A., Shaw, K. R. M., Sheth, M., Tarnuzzer, R., Wang, Z., Yang, L., Hutter, C., Ozenberger, B. A., Sofia, H. J. & Eley, G. Jan 1 2014 In : Nature. 507, 7492, p. 315-322 8 p.

Research output: Contribution to journalArticle

Urinary Bladder
Carcinoma
Chromatin
RNA Sequence Analysis
Neoplasms
27 Citations

Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal

Zhou, B., Damrauer, J. S., Bailey, S. T., Hadzic, T., Jeong, Y., Clark, K., Fan, C., Murphy, L., Lee, C. Y., Troester, M. A., Miller, C. R., Jin, J., Darr, D., Perou, C. M., Levine, R. L., Diehn, M. & Kim, W. Y. Feb 3 2014 In : Journal of Clinical Investigation. 124, 2, p. 553-563 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Erythropoietin
Carcinogenesis
Breast
Breast Neoplasms
4 Citations

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis

Couvé, S. , Ladroue, C. , Laine, E. , Mahtouk, K. , Guégan, J. , Gad, S. , Le Jeune, H. , Le Gentil, M. , Nuel, G. , Kim, W. Y. , Lecomte, B. , Pagès, J. C. , Collin, C. , Lasne, F. , Benusiglio, P. R. , Bressac-De Paillerets, B. , Feunteun, J. , Lazar, V. , Gimenez-Roqueplo, A. P. , Mazure, N. M. & 7 others Dessen, P., Tchertanov, L., Mole, D. R., Kaelin, W., Ratcliffe, P., Richard, S. & Gardie, B. Nov 15 2014 In : Cancer Research. 74, 22, p. 6554-6564 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
von Hippel-Lindau Disease
Mutation
Tumor Suppressor Genes
Hemangioblastoma
218 Citations

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

Damrauer, J. S., Hoadley, K. A., Chism, D. D., Fan, C., Tignanelli, C. J., Wobker, S. E., Yeh, J. J., Milowsky, M. I., Iyer, G., Parker, J. S. & Kim, W. Y. Feb 25 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3110-3115 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Breast Neoplasms
Gene Expression
Microarray Analysis
Standard of Care
12 Citations

mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma

Bailey, S. T., Zhou, B., Damrauer, J. S., Krishnan, B., Wilson, H. L., Smith, A. M., Li, M., Yeh, J. J. & Kim, W. Y. Jan 1 2014 In : PLoS ONE. 9, 9, e104413

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
kidney cells
Renal Cell Carcinoma
carcinoma
Chemical activation
47 Citations

Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model

Zhang, J., Miao, L., Guo, S., Zhang, Y., Zhang, L., Satterlee, A., Kim, W. Y. & Huang, L. May 28 2014 In : Journal of Controlled Release. 182, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

gemcitabine
Nanoparticles
Cisplatin
Urinary Bladder
Carcinoma
36 Citations

Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States: 1988 to 2006

Nielsen, M. E., Smith, A. B., Meyer, A. M., Kuo, T. M., Tyree, S., Kim, W. Y., Milowsky, M. I., Pruthi, R. S. & Millikan, R. C. Jan 1 2014 In : Cancer. 120, 1, p. 86-95 10 p.

Research output: Contribution to journalArticle

Urinary Bladder
Carcinoma
Urinary Bladder Neoplasms
Incidence
Population
2013
40 Citations

A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer

Whang, Y. E., Armstrong, A. J., Rathmell, W. K., Godley, P. A., Kim, W. Y., Pruthi, R. S., Wallen, E. M., Crane, J. M., Moore, D. T., Grigson, G., Morris, K., Watkins, C. P. & George, D. J. Jan 1 2013 In : Urologic Oncology: Seminars and Original Investigations. 31, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Castration
Epidermal Growth Factor Receptor
Prostatic Neoplasms
Therapeutics
62 Citations

Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC

Zhang, Y., Schwerbrock, N. M. J., Rogers, A. B., Kim, W. Y. & Huang, L. Jan 1 2013 In : Molecular Therapy. 21, 8, p. 1559-1569 11 p.

Research output: Contribution to journalArticle

gemcitabine
Non-Small Cell Lung Carcinoma
Nanoparticles
Vascular Endothelial Growth Factor A
Small Interfering RNA
74 Citations

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

Hanna, S. C., Krishnan, B., Bailey, S. T., Moschos, S. J., Kuan, P. F., Shimamura, T., Osborne, L. D., Siegel, M. B., Duncan, L. M., O'Brien, E. T., Superfine, R., Miller, C. R., Simon, M. C., Wong, K. K. & Kim, W. Y. May 1 2013 In : Journal of Clinical Investigation. 123, 5, p. 2078-2093 16 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Neoplasms
Matrix Metalloproteinase 14
Focal Adhesion Protein-Tyrosine Kinases
49 Citations

Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1 -mutant lung cancer

Liu, Y. , Marks, K. , Cowley, G. S. , Carretero, J. , Liu, Q. , Niel, T. J. F. , Xu, C. , Cohoon, T. J. , Gao, P. , Zhang, Y. , Chen, Z. , Altabef, A. B. , Tchaicha, J. H. , Wang, X. , Choe, S. , Driggers, E. M. , Zhang, J. , Bailey, S. T. , Sharpless, N. E. , Neil Hayes, D. & 20 others Patel, N. M., Janne, P. A., Bardeesy, N., Engelman, J. A., Manning, B. D., Shaw, R. J., Asara, J. M., Scully, R., Kimmelman, A., Byers, L. A., Gibbons, D. L., Wistuba, I. I., Heymach, J. V., Kwiatkowski, D. J., Kim, W. Y., Kung, A. L., Gray, N. S., Root, D. E., Cantley, L. C. & Wong, K. K. Aug 1 2013 In : Cancer Discovery. 3, 8, p. 870-879 10 p.

Research output: Contribution to journalArticle

Thymidine Monophosphate
Lung Neoplasms
Phosphotransferases
Cations
Nucleotides
4 Citations

Regulation of hypoxia-inducible factor 2-a is essential for integrity of the glomerular barrier

Ding, M., Coward, R. J., Jeansson, M., Kim, W. & Quaggin, S. E. Jan 1 2013 In : American Journal of Physiology - Renal Physiology. 304, 1

Research output: Contribution to journalArticle

Podocytes
Knockout Mice
Glomerulonephritis
Kidney
Phenotype
3 Citations

Stearoyl co-a desaturase 1 as a ccRCC therapeutic target: Death by stress

Leung, J. Y. & Kim, W. Y. Jun 15 2013 In : Clinical Cancer Research. 19, 12, p. 3111-3113 3 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Therapeutics
50 Citations

Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy

Zhang, Y., Kim, W. Y. & Huang, L. Apr 1 2013 In : Biomaterials. 34, 13, p. 3447-3458 12 p.

Research output: Contribution to journalArticle

Calcium phosphate
Pancreatic Neoplasms
Non-Small Cell Lung Carcinoma
Nanoparticles
Lipids
2012
109 Citations

Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinum-pretreated metastatic urothelial cancer

Choueiri, T. K., Ross, R. W., Jacobus, S., Vaishampayan, U., Yu, E. Y., Quinn, D. I., Hahn, N. M., Hutson, T. E., Sonpavde, G., Morrissey, S. C., Buckle, G. C., Kim, W. Y., Petrylak, D. P., Ryan, C. W., Eisenberger, M. A., Mortazavi, A., Bubley, G. J., Taplin, M. E., Rosenberg, J. E. & Kantoff, P. W. Feb 10 2012 In : Journal of Clinical Oncology. 30, 5, p. 507-512 6 p.

Research output: Contribution to journalArticle

docetaxel
Platinum
Placebos
Disease-Free Survival
Neoplasms
310 Citations

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

Duncan, J. S. , Whittle, M. C. , Nakamura, K. , Abell, A. N. , Midland, A. A. , Zawistowski, J. S. , Johnson, N. L. , Granger, D. A. , Jordan, N. V. , Darr, D. B. , Usary, J. , Kuan, P. F. , Smalley, D. M. , Major, B. , He, X. , Hoadley, K. A. , Zhou, B. , Sharpless, N. E. , Perou, C. M. , Kim, W. Y. & 7 others Gomez, S. M., Chen, X., Jin, J., Frye, S. V., Earp, H. S., Graves, L. M. & Johnson, G. L. Apr 13 2012 In : Cell. 149, 2, p. 307-321 15 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Mitogen-Activated Protein Kinase Kinases
Receptor Protein-Tyrosine Kinases
Corrosion inhibitors
Drug Resistance
8 Citations
docetaxel
Androgens
Prostatic Neoplasms
Cohort Studies
Radiotherapy
2011
37 Citations
Neoplasms
Therapeutics
Urinary Bladder Neoplasms
Prostatic Neoplasms
Urinary Bladder
10 Citations

A phase I trial of sorafenib combined with cisplatin/etoposide or carboplatin/pemetrexed in refractory solid tumor patients

Davies, J. M., Dhruva, N. S., Walko, C. M., Socinski, M. A., Bernard, S., Hayes, D. N., Kim, W. Y., Ivanova, A., Keller, K., Hilbun, L. R., Chiu, M., Dees, E. C. & Stinchcombe, T. E. Feb 1 2011 In : Lung Cancer. 71, 2, p. 151-155 5 p.

Research output: Contribution to journalArticle

Pemetrexed
Carboplatin
Etoposide
Cisplatin
Neoplasms
41 Citations

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

Russell, R. C., Sufan, R. I., Zhou, B., Heir, P., Bunda, S., Sybingco, S. S., Greer, S. N., Roche, O., Heathcote, S. A., Chow, V. W. K., Boba, L. M., Richmond, T. D., Hickey, M. M., Barber, D. L., Cheresh, D. A., Simon, M. C., Irwin, M. S., Kim, W. Y. & Ohh, M. Jul 1 2011 In : Nature Medicine. 17, 7, p. 845-853 9 p.

Research output: Contribution to journalArticle

Polycythemia
Ubiquitin-Protein Ligases
Cytokines
Genes
Erythropoietin
14 Citations
docetaxel
Estramustine
Prostatectomy
Prostatic Neoplasms
Radiotherapy
2010
68 Citations
Cystectomy
Urinary Bladder Neoplasms
Muscles
Surgical Pathology
Neoadjuvant Therapy
157 Citations

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Carretero, J. , Shimamura, T. , Rikova, K. , Jackson, A. L. , Wilkerson, M. D. , Borgman, C. L. , Buttarazzi, M. S. , Sanofsky, B. A. , McNamara, K. L. , Brandstetter, K. A. , Walton, Z. E. , Gu, T. L. , Silva, J. C. , Crosby, K. , Shapiro, G. I. , Maira, S. M. , Ji, H. , Castrillon, D. H. , Kim, C. F. , García-Echeverría, C. & 6 others Bardeesy, N., Sharpless, N. E., Hayes, N. D., Kim, W. Y., Engelman, J. A. & Wong, K. K. Jun 15 2010 In : Cancer Cell. 17, 6, p. 547-559 13 p.

Research output: Contribution to journalArticle

Proteomics
Lung
Neoplasms
Penetrance
Phosphoproteins
141 Citations

Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma

Cowey, C. L., Amin, C., Pruthi, R. S., Wallen, E. M., Nielsen, M. E., Grigson, G., Watkins, C., Nance, K. V., Crane, J., Jalkut, M., Moore, D. T., Kim, W. Y., Godley, P. A., Whang, Y. E., Fielding, J. R. & Rathmell, W. K. Mar 20 2010 In : Journal of Clinical Oncology. 28, 9, p. 1502-1507 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Clinical Trials
Nephrectomy
Neoplasms
Therapeutics
2009
94 Citations

HIF2α cooperates with RAS to promote lung tumorigenesis in mice

Kim, W. Y., Perera, S., Zhou, B., Carretero, J., Jen, J. Y., Heathcote, S. A., Jackson, A. L., Nikolinakos, P., Ospina, B., Naumov, G., Brandstetter, K. A., Weigman, V. J., Zaghlul, S., Hayes, D. N., Padera, R. F., Heymach, J. V., Kung, A. L., Sharpless, N. E., Kaelin, W. G. & Wong, K. K. Aug 3 2009 In : Journal of Clinical Investigation. 119, 8, p. 2160-2170 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Lung
Epithelial-Mesenchymal Transition
Non-Small Cell Lung Carcinoma
Neoplasms
119 Citations

Regulation of endocytosis via the oxygen-sensing pathway

Wang, Y., Roche, O., Yan, M. S., Finak, G., Evans, A. J., Metcalf, J. L., Hast, B. E., Hanna, S. C., Wondergem, B., Furge, K. A., Irwin, M. S., Kim, W. Y., Teh, B. T., Grinstein, S., Park, M., Marsden, P. A. & Ohh, M. Mar 1 2009 In : Nature Medicine. 15, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

Endocytosis
Tumors
Receptor Protein-Tyrosine Kinases
Oxygen
Chemical activation
2007
60 Citations

CD200 is induced by ERK and is a potential therapeutic target in melanoma

Petermann, K. B., Rozenberg, G. I., Zedek, D., Groben, P., McKinnon, K., Buehler, C., Kim, W. Y., Shields, J. M., Penland, S., Bear, J. E., Thomas, N. E., Serody, J. S. & Sharpless, N. E. Dec 2007 In : Journal of Clinical Investigation. 117, 12, p. 3922-3929 8 p.

Research output: Contribution to journalArticle

Melanoma
Therapeutics
Immunomodulation
Mitogen-Activated Protein Kinase Kinases
Microarray Analysis
43 Citations

Dexamethasone-induced posterior reversible encephalopathy syndrome

Irvin, W., MacDonald, G., Smith, J. K. & Kim, W. Y. Jun 10 2007 In : Journal of Clinical Oncology. 25, 17, p. 2484-2486 3 p.

Research output: Contribution to journalArticle

Hypertensive Encephalopathy
Posterior Leukoencephalopathy Syndrome
Trazodone
Pyridines
X Ray Computed Tomography
56 Citations

Dominant-negative HIF-3α4 suppresses VHL-null renal cell carcinoma progression

Maynard, M. A., Evans, A. J., Shi, W., Kim, W. Y., Liu, F. F. & Ohh, M. Nov 15 2007 In : Cell Cycle. 6, 22, p. 2810-2816 7 p.

Research output: Contribution to journalArticle

Null Lymphocytes
Renal Cell Carcinoma
Tumors
Cells
Mutation
103 Citations

pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2

Yang, H., Minamishima, Y. A., Yan, Q., Schlisio, S., Ebert, B. L., Zhang, X., Zhang, L., Kim, W. Y., Olumi, A. F. & Kaelin, W. G. Oct 12 2007 In : Molecular Cell. 28, 1, p. 15-27 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Von Hippel-Lindau Tumor Suppressor Protein
Carcinogenesis
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligases
179 Citations

VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail

Evans, A. J. , Russell, R. C. , Roche, O. , Burry, T. N. , Fish, J. E. , Chow, V. W. K. , Kim, W. Y. , Saravanan, A. , Maynard, M. A. , Gervais, M. L. , Sufan, R. I. , Roberts, A. M. , Wilson, L. A. , Betten, M. , Vandewalle, C. , Berx, G. , Marsden, P. A. , Irwin, M. S. , Teh, B. T. , Jewett, M. A. S. & 1 others Ohh, M. Jan 1 2007 In : Molecular and Cellular Biology. 27, 1, p. 157-169 13 p.

Research output: Contribution to journalArticle

Snails
Cadherins
Renal Cell Carcinoma
Genes
Kidney
2006
136 Citations

Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo

Kim, W. Y., Safran, M., Buckley, M. R. M., Ebert, B. L., Glickman, J., Bosenberg, M., Regan, M. & Kaelin, W. G. Oct 4 2006 In : EMBO Journal. 25, 19, p. 4650-4662 13 p.

Research output: Contribution to journalArticle

Liver
Genes
Skin
Gene Expression Profiling
Tumor Suppressor Genes
55 Citations

Molecular Pathways in Renal Cell Carcinoma-Rationale for Targeted Treatment

Kim, W. Y. & Kaelin, W. G. Oct 1 2006 In : Seminars in Oncology. 33, 5, p. 588-595 8 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Kidney Neoplasms
Platelet-Derived Growth Factor
Sirolimus
Tumor Suppressor Genes
183 Citations

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production

Safran, M., Kim, W. Y., O'Connell, F., Flippin, L., Günzler, V., Horner, J. W., DePinho, R. A. & Kaelin, W. G. Jan 3 2006 In : Proceedings of the National Academy of Sciences of the United States of America. 103, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Erythropoietin
Oxygen
Prolyl-Hydroxylase Inhibitors
Firefly Luciferases
323 Citations

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

Ji, H. , Li, D. , Chen, L. , Shimamura, T. , Kobayashi, S. , McNamara, K. , Mahmood, U. , Mitchell, A. , Sun, Y. , Al-Hashem, R. , Chirieac, L. R. , Padera, R. , Bronson, R. T. , Kim, W. , Jänne, P. A. , Shapiro, G. I. , Tenen, D. , Johnson, B. E. , Weissleder, R. , Sharpless, N. E. & 1 others Wong, K. K. Jun 13 2006 In : Cancer Cell. 9, 6, p. 485-495 11 p.

Research output: Contribution to journalArticle

Carcinogenesis
Phosphotransferases
Epidermal Growth Factor Receptor
Lung
Mutation
2004
7 Citations

Analysis of von Hippel-Lindau Hereditary Cancer Syndrome: Implications of Oxygen Sensing

Yang, H., Ivan, M., Min, J. H., Kim, W. Y. & Kaelin, W. G. Jan 1 2004 In : Methods in enzymology. 381, p. 320-335 16 p.

Research output: Contribution to journalArticle

Hereditary Neoplastic Syndromes
Oxygen
Paper bearings