• 1000 Citations
  • 15 h-Index
20032017
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Research Output 2003 2017

  • 1000 Citations
  • 15 h-Index
  • 18 Article
  • 2 Review article
  • 1 Chapter
2017
5 Citations

Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program

Wang, P., Wander, C. M., Yuan, C. X., Bereman, M. S. & Cohen, T. J., Dec 1 2017, In : Nature Communications. 8, 1, 82

Research output: Contribution to journalArticle

9 Citations

A dual pathogenic mechanism links tau acetylation to sporadic tauopathy

Trzeciakiewicz, H., Tseng, J. H., Wander, C. M., Madden, V., Tripathy, A., Yuan, C. X. & Cohen, T. J., Mar 13 2017, In : Scientific Reports. 7, 44102

Research output: Contribution to journalArticle

Tauopathies
Acetylation
Microtubules
Alzheimer Disease
Pathology
2 Citations

The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology

Tseng, J. H., Xie, L., Song, S., Xie, Y., Allen, L., Ajit, D., Hong, J. S., Chen, X., Meeker, R. B. & Cohen, T. J., Aug 29 2017, In : Cell Reports. 20, 9, p. 2169-2183 15 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Neurons
Matrix Metalloproteinase 9
Mass Spectrometry
2016
4 Citations

Conserved lysine acetylation within the microtubule-binding domain regulates MAP2/tau family members

Hwang, A. W., Trzeciakiewicz, H., Friedmann, D., Yuan, C. X., Marmorstein, R., Lee, V. M. Y. & Cohen, T. J., Dec 1 2016, In : PloS one. 11, 12, e0168913

Research output: Contribution to journalArticle

Acetylation
acetylation
Microtubules
microtubules
Lysine
8 Citations

Intrinsic tau acetylation is coupled to auto-proteolytic tau fragmentation

Cohen, T. J., Constance, B. H., Hwang, A. W., James, M. & Yuan, C. X., Jul 1 2016, In : PloS one. 11, 7, e0158470

Research output: Contribution to journalArticle

Acetylation
acetylation
automobiles
Tauopathies
Lysine
2015
42 Citations

An acetylation switch controls TDP-43 function and aggregation propensity

Cohen, T. J., Hwang, A. W., Restrepo, C. R., Yuan, C. X., Trojanowski, J. Q. & Lee, V. M. Y., Jan 5 2015, In : Nature Communications. 6, 5845

Research output: Contribution to journalArticle

acetylation
Acetylation
TDP-43 Proteinopathies
Amyotrophic Lateral Sclerosis
Agglomeration
2013
35 Citations

Acetylated tau neuropathology in sporadic and hereditary tauopathies

Irwin, D. J., Cohen, T. J., Grossman, M., Arnold, S. E., McCarty-Wood, E., Van Deerlin, V. M., Lee, V. M. Y. & Trojanowski, J. Q., Aug 1 2013, In : American Journal of Pathology. 183, 2, p. 344-351 8 p.

Research output: Contribution to journalArticle

Tauopathies
Frontotemporal Dementia
Flavin-Adenine Dinucleotide
Pick Disease of the Brain
Amyloid
46 Citations

The microtubule-associated tau protein has intrinsic acetyltransferase activity

Cohen, T. J., Friedmann, D., Hwang, A. W., Marmorstein, R. & Lee, V. M. Y., Jun 1 2013, In : Nature Structural and Molecular Biology. 20, 6, p. 756-762 7 p.

Research output: Contribution to journalArticle

tau Proteins
Acetyltransferases
Microtubule-Associated Proteins
Acetylation
Lysine
2012
102 Citations

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

Irwin, D. J., Cohen, T. J., Grossman, M., Arnold, S. E., Xie, S. X., Lee, V. M. Y. & Trojanowski, J. Q., Jan 1 2012, In : Brain. 135, 3, p. 807-818 12 p.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Acetylation
Pathology
Lysine
40 Citations

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

Choi, M. C., Cohen, T. J., Barrientos, T., Wang, B., Li, M., Simmons, B. J., Yang, J. S., Cox, G. A., Zhao, Y. & Yao, T. P., Jul 13 2012, In : Molecular Cell. 47, 1, p. 122-132 11 p.

Research output: Contribution to journalArticle

Muscular Atrophy
Phosphotransferases
Atrophy
Muscles
MEF2 Transcription Factors
70 Citations

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

Cohen, T. J., Hwang, A. W., Unger, T., Trojanowski, J. Q. & Lee, V. M. Y., Mar 7 2012, In : EMBO Journal. 31, 5, p. 1241-1252 12 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Disulfides
Oxidation-Reduction
Cysteine
Oxidative stress
2011
6 Citations

HDACs in skeletal muscle remodeling and neuromuscular disease

Simmons, B. J., Cohen, T. J., Bedlack, R. & Yao, T. P., Oct 24 2011, Histone Deacetylases: the Biology and Clinical Implication. Vol. 206, p. 79-101 23 p. (Handbook of Experimental Pharmacology; vol. 206)

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuromuscular Diseases
Muscle
Skeletal Muscle
Muscles
Metabolic Diseases
66 Citations

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

Cohen, T. J., Lee, V. M. Y. & Trojanowski, J. Q., Nov 1 2011, In : Trends in Molecular Medicine. 17, 11, p. 659-667 9 p.

Research output: Contribution to journalReview article

TDP-43 Proteinopathies
Frontotemporal Dementia
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Neurodegenerative Diseases
255 Citations

The acetylation of tau inhibits its function and promotes pathological tau aggregation

Cohen, T. J., Guo, J. L., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q. & Lee, V. M. Y., Mar 31 2011, In : Nature Communications. 2, 1, 252

Research output: Contribution to journalArticle

acetylation
Acetylation
Tauopathies
Agglomeration
Microtubules
2009
66 Citations

Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway

Kozhemyakina, E., Cohen, T., Yao, T. P. & Lassar, A. B., Nov 2009, In : Molecular and Cellular Biology. 29, 21, p. 5751-5762 12 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Protein Phosphatase 2
Histone Deacetylases
Colforsin
Chondrocytes
51 Citations

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity

Cohen, T. J., Barrientos, T., Hartman, Z. C., Garvey, S. M., Cox, G. A. & Yao, T. P., Jan 2009, In : FASEB Journal. 23, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Histone Deacetylases
Gene expression
Muscle Cells
Gene Expression
2008
21 Citations

Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway

Cohen, T. J., Mallory, M. J., Strich, R. & Yao, T. P., Jul 2008, In : Eukaryotic Cell. 7, 7, p. 1191-1199 9 p.

Research output: Contribution to journalArticle

Secretory Component
Unfolded Protein Response
Cyclin C
stress response
unfolded protein response
2007
91 Citations

The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming

Cohen, T. J., Waddell, D. S., Barrientos, T., Lu, Z., Feng, G., Cox, G. A., Bodine, S. C. & Yao, T. P., Nov 16 2007, In : Journal of Biological Chemistry. 282, 46, p. 33752-33759 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Muscle
Denervation
Transcription
Muscles
23 Citations

The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2

Bolger, T. A., Zhao, X., Cohen, T. J., Tsai, C. C. & Yao, T. P., Oct 5 2007, In : Journal of Biological Chemistry. 282, 40, p. 29186-29192 7 p.

Research output: Contribution to journalArticle

MEF2 Transcription Factors
Neurodegenerative diseases
Neurodegenerative Diseases
Histone Deacetylases
Cytotoxicity
2004
35 Citations

AcK-knowledge reversible acetylation.

Cohen, T. & Yao, T. P. 2004 In : Science's STKE : signal transduction knowledge environment. 2004, 245

Research output: Contribution to journalReview article

Acetylation
Histones
Chromatin
Chromatin Assembly and Disassembly
Transcription
2003
23 Citations

Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p

Cohen, T. J., Lee, K., Rutkowski, L. H. & Strich, R., Oct 2003, In : Eukaryotic Cell. 2, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Cyclin C
Saccharomyces cerevisiae
Oxidative Stress
Mitogen-Activated Protein Kinases
Holoenzymes