Research Output 2003 2017

  • 858 Citations
  • 15 h-Index
  • 16 Article
  • 2 Review article
  • 1 Chapter
2017
2 Citations

A dual pathogenic mechanism links tau acetylation to sporadic tauopathy

Trzeciakiewicz, H., Tseng, J. H., Wander, C. M., Madden, V., Tripathy, A., Yuan, C. X. & Cohen, T. J. Mar 13 2017 In : Scientific Reports. 7, 44102

Research output: Research - peer-reviewArticle

Tauopathies
Acetylation
Microtubules
Alzheimer Disease
Pathology
2016
3 Citations

Conserved lysine acetylation within the microtubule-binding domain regulates MAP2/tau family members

Hwang, A. W., Trzeciakiewicz, H., Friedmann, D., Yuan, C. X., Marmorstein, R., Lee, V. M. Y. & Cohen, T. J. Dec 1 2016 In : PLoS ONE. 11, 12, e0168913

Research output: Research - peer-reviewArticle

Acetylation
Microtubules
Lysine
acetylation
microtubules
3 Citations

Intrinsic tau acetylation is coupled to auto-proteolytic tau fragmentation

Cohen, T. J., Constance, B. H., Hwang, A. W., James, M. & Yuan, C. X. Jul 1 2016 In : PLoS One. 11, 7, e0158470

Research output: Research - peer-reviewArticle

Acetylation
acetylation
automobiles
Lysine
Tauopathies
2015
30 Citations

An acetylation switch controls TDP-43 function and aggregation propensity

Cohen, T. J., Hwang, A. W., Restrepo, C. R., Yuan, C. X., Trojanowski, J. Q. & Lee, V. M. Y. Jan 5 2015 In : Nature Communications. 6, 5845

Research output: Research - peer-reviewArticle

Acetylation
Agglomeration
Switches
acetylation
switches
2013
27 Citations

Acetylated tau neuropathology in sporadic and hereditary tauopathies

Irwin, D. J., Cohen, T. J., Grossman, M., Arnold, S. E., McCarty-Wood, E., Van Deerlin, V. M., Lee, V. M. Y. & Trojanowski, J. Q. Aug 1 2013 In : American Journal of Pathology. 183, 2, p. 344-351 8 p.

Research output: Research - peer-reviewArticle

Tauopathies
Frontotemporal Dementia
Neuropathology
Flavin-Adenine Dinucleotide
Pick Disease of the Brain
34 Citations

The microtubule-associated tau protein has intrinsic acetyltransferase activity

Cohen, T. J., Friedmann, D., Hwang, A. W., Marmorstein, R. & Lee, V. M. Y. Jun 1 2013 In : Nature Structural and Molecular Biology. 20, 6, p. 756-762 7 p.

Research output: Research - peer-reviewArticle

tau Proteins
Acetyltransferases
Microtubule-Associated Proteins
Acetylation
Lysine
2012
92 Citations

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

Irwin, D. J., Cohen, T. J., Grossman, M., Arnold, S. E., Xie, S. X., Lee, V. M. Y. & Trojanowski, J. Q. 2012 In : Brain. 135, 3, p. 807-818 12 p.

Research output: Research - peer-reviewArticle

Tauopathies
Alzheimer Disease
Pathology
Acetylation
Lysine
34 Citations

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

Choi, M. C., Cohen, T. J., Barrientos, T., Wang, B., Li, M., Simmons, B. J., Yang, J. S., Cox, G. A., Zhao, Y. & Yao, T. P. Jul 13 2012 In : Molecular Cell. 47, 1, p. 122-132 11 p.

Research output: Research - peer-reviewArticle

Muscular Atrophy
Phosphotransferases
Muscles
Atrophy
MEF2 Transcription Factors
61 Citations

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

Cohen, T. J., Hwang, A. W., Unger, T., Trojanowski, J. Q. & Lee, V. M. Y. Mar 7 2012 In : EMBO Journal. 31, 5, p. 1241-1252 12 p.

Research output: Research - peer-reviewArticle

Disulfides
Cysteine
Oxidation
Oxidation-Reduction
Oxidative stress
2011
6 Citations

HDACs in skeletal muscle remodeling and neuromuscular disease

Simmons, B. J., Cohen, T. J., Bedlack, R. & Yao, T. P. Oct 24 2011 Histone Deacetylases: the Biology and Clinical Implication. Vol. 206, p. 79-101 23 p. (Handbook of Experimental Pharmacology; vol. 206)

Research output: ResearchChapter

Neuromuscular Diseases
Skeletal Muscle
Muscle
Muscles
Metabolic Diseases
59 Citations

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

Cohen, T. J., Lee, V. M. Y. & Trojanowski, J. Q. Nov 1 2011 In : Trends in Molecular Medicine. 17, 11, p. 659-667 9 p.

Research output: Research - peer-reviewReview article

TDP-43 Proteinopathies
Frontotemporal Dementia
Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Neurodegenerative Diseases
219 Citations

The acetylation of tau inhibits its function and promotes pathological tau aggregation

Cohen, T. J., Guo, J. L., Hurtado, D. E., Kwong, L. K., Mills, I. P., Trojanowski, J. Q. & Lee, V. M. Y. 2011 In : Nature Communications. 2, 1, 252

Research output: Research - peer-reviewArticle

Acetylation
Agglomeration
acetylation
Tauopathies
Microtubules
2009
60 Citations

Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway

Kozhemyakina, E., Cohen, T., Yao, T. P. & Lassar, A. B. Nov 2009 In : Molecular and Cellular Biology. 29, 21, p. 5751-5762 12 p.

Research output: Research - peer-reviewArticle

Parathyroid Hormone-Related Protein
Protein Phosphatase 2
Histone Deacetylases
Colforsin
Chondrocytes
48 Citations

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity

Cohen, T. J., Barrientos, T., Hartman, Z. C., Garvey, S. M., Cox, G. A. & Yao, T. P. Jan 2009 In : FASEB Journal. 23, 1, p. 99-106 8 p.

Research output: Research - peer-reviewArticle

Histone Deacetylases
Muscle Cells
Gene Expression
Gene expression
MEF2 Transcription Factors
2008
20 Citations

Hos2p/Set3p deacetylase complex signals secretory stress through the Mpk1p cell integrity pathway

Cohen, T. J., Mallory, M. J., Strich, R. & Yao, T. P. Jul 2008 In : Eukaryotic Cell. 7, 7, p. 1191-1199 9 p.

Research output: Research - peer-reviewArticle

Secretory Component
Unfolded Protein Response
Genes
stress response
cells
2007
80 Citations

The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming

Cohen, T. J., Waddell, D. S., Barrientos, T., Lu, Z., Feng, G., Cox, G. A., Bodine, S. C. & Yao, T. P. Nov 16 2007 In : Journal of Biological Chemistry. 282, 46, p. 33752-33759 8 p.

Research output: Research - peer-reviewArticle

Histone Deacetylases
Muscles
Muscle
Denervation
Transcription
23 Citations

The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2

Bolger, T. A., Zhao, X., Cohen, T. J., Tsai, C. C. & Yao, T. P. Oct 5 2007 In : Journal of Biological Chemistry. 282, 40, p. 29186-29192 7 p.

Research output: Research - peer-reviewArticle

MEF2 Transcription Factors
Neurodegenerative diseases
Ataxin-1
Neurodegenerative Diseases
Histone Deacetylases
2004
34 Citations

AcK-knowledge reversible acetylation.

Cohen, T. & Yao, T. P. 2004 In : Science's STKE : signal transduction knowledge environment. 2004, 245

Research output: Research - peer-reviewReview article

Acetylation
Histones
Chromatin
Proteins
Transcription
2003
23 Citations

Ask10p mediates the oxidative stress-induced destruction of the Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p

Cohen, T. J., Lee, K., Rutkowski, L. H. & Strich, R. Oct 2003 In : Eukaryotic Cell. 2, 5, p. 962-970 9 p.

Research output: Research - peer-reviewArticle

Cyclin C
Saccharomyces cerevisiae
Oxidative Stress
Mitogen-Activated Protein Kinases
Holoenzymes