• 50281 Citations
  • 99 h-Index
1984 …2018
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Research Output 1984 2018

1 Citations

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors

Asquith, C. R. M., Godoi, P. H., Cou ago, R. M., Laitinen, T., Scott, J. W., Langendorf, C. G., Oakhill, J. S., Drewry, D. H., Zuercher, W. J., Koutentis, P. A., Willson, T. M. & Kalogirou, A. S., Jan 1 2018, In : Molecules. 23, 5, 1221.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Kinase
Thiadiazoles
X ray crystallography
Protein Kinase Inhibitors
Molecular structure

Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth

Krulikas, L. J., McDonald, I. M., Lee, B., Okumu, D. O., East, M. P., Gilbert, T. S. K., Herring, L. E., Golitz, B. T., Wells, C. I., Axtman, A. D., Zuercher, W. J., Willson, T. M., Kireev, D., Yeh, J. J., Johnson, G. L., Baines, A. T. & Graves, L. M., Sep 1 2018, In : SLAS Discovery. 23, 8, p. 850-861 12 p.

Research output: Contribution to journalArticle

gemcitabine
Preclinical Drug Evaluations
Cell growth
Pancreatic Neoplasms
Screening
2 Citations

Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase

Asquith, C. R. M., Laitinen, T., Bennett, J. M., Godoi, P. H., East, M. P., Tizzard, G. J., Graves, L. M., Johnson, G. L., Dornsife, R. E., Wells, C. I., Elkins, J. M., Willson, T. M. & Zuercher, W. J., Jan 8 2018, In : ChemMedChem. 13, 1, p. 48-66 19 p.

Research output: Contribution to journalArticle

Cyclin G
Phosphotransferases
Anti-Bacterial Agents
Amines
14 Citations

Progress towards a public chemogenomic set for protein kinases and a call for contributions

Drewry, D. H., Wells, C. I., Andrews, D. M., Angell, R., Al-Ali, H., Axtman, A. D., Capuzzi, S. J., Elkins, J. M., Ettmayer, P., Frederiksen, M., Gileadi, O., Gray, N., Hooper, A., Knapp, S., Laufer, S., Luecking, U., Michaelides, M., Müller, S., Muratov, E., Denny, R. A. & 4 othersSaikatendu, K. S., Treiber, D. K., Zuercher, W. J. & Willson, T. M., Aug 1 2017, In : PloS one. 12, 8, e0181585.

Research output: Contribution to journalArticle

protein kinases
Protein Kinases
phosphotransferases (kinases)
Phosphotransferases
Drug Discovery
14 Citations

Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., Rajpal, D. K., Creech, K., Furst, S., Lee, J., Wu, D., Rastinejad, F., Willson, T. M., Viviani, F., Morris, D. C., Moore, J. T. & 1 othersCote-Sierra, J., Oct 1 2017, In : Journal of Investigative Dermatology. 137, 10, p. 2110-2119 10 p.

Research output: Contribution to journalArticle

Resorcinols
Basic Helix-Loop-Helix Transcription Factors
Animal Disease Models
Topical Administration
Aryl Hydrocarbon Receptors