• 6549 Citations
  • 49 h-Index
1986 …2019
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  • 20 Similar Profiles
Hemophilia B Medicine & Life Sciences
Dogs Medicine & Life Sciences
Factor IX Medicine & Life Sciences
Hemophilia A Medicine & Life Sciences
Canidae Medicine & Life Sciences
Swine Medicine & Life Sciences
von Willebrand Diseases Medicine & Life Sciences
Genetic Therapy Medicine & Life Sciences

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Projects 1995 2019

Dependovirus
Hemophilia A
Neutralizing Antibodies
Canidae
Hepatocytes
Miniature Swine
Patents
LDL Receptors
Feasibility Studies
Blood Vessels

FIX tolerance induction in HB dogs

Nichols, T. C.

Industry Sponsor

6/17/157/16/16

Project: Research project

Hemophilia B
Factor IX
Dogs

Research Output 1986 2018

An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs

Sun, J., Shao, W., Chen, X., Merricks, E. P., Wimsey, L., Abajas, Y. L., Niemeyer, G. P., Lothrop, C. D., Monahan, P. E., Samulski, R. J., Nichols, T. C. & Li, C., Sep 21 2018, In : Molecular Therapy - Methods and Clinical Development. 10, p. 257-267 11 p.

Research output: Contribution to journalArticle

Dependovirus
Hemophilia A
Observational Studies
Dogs
Cytokines
1 Citations

Influence of diabetes on the foreign body response to nitric oxide-releasing implants

Soto, R. J., Merricks, E. P., Bellinger, D. A., Nichols, T. C. & Schoenfisch, M. H., Mar 1 2018, In : Biomaterials. 157, p. 76-85 10 p.

Research output: Contribution to journalArticle

Glucose sensors
Polyurethanes
Endothelial cells
Blood vessels
Pathology

Mechanical Anisotropy Assessment in Kidney Cortex Using ARFI Peak Displacement: Preclinical Validation and Pilot In Vivo Clinical Results in Kidney Allografts

Hossain, M. M., Detwiler, R. K., Chang, E. H., Caughey, M. C., Fisher, M. W., Nichols, T. C., Merricks, E., Raymer, R., Whitford, M., Dwight, B. A., Wimsey, L. E. & Gallippi, C. M., Aug 11 2018, (Accepted/In press) In : IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

Research output: Contribution to journalArticle

cortexes
kidneys
sound waves
Anisotropy
Acoustics
3 Citations

Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models

Markusic, D. M., Nichols, T. C., Merricks, E. P., Palaschak, B., Zolotukhin, I., Marsic, D., Zolotukhin, S., Srivastava, A. & Herzog, R. W., May 1 2017, In : Journal of Translational Medicine. 15, 1, 94.

Research output: Contribution to journalArticle

Gene transfer
Genetic engineering
Gene therapy
Genetic Vectors
Factor IX

Global measurement of coagulation in plasma from normal and haemophilia dogs using a novel modified thrombin generation test - Demonstrated in vitro and ex vivo

Madsen, D. E., Nichols, T. C., Merricks, E. P., Waters, E. K. & Wiinberg, B., Apr 1 2017, In : PloS one. 12, 4, e0175030.

Research output: Contribution to journalArticle

hemophilia
thrombin
Hemophilia A
Coagulation
coagulation