• 12415 Citations
  • 55 h-Index
1974 …2018
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  • 4 Similar Profiles
Ligands Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Drug Receptors Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
GTP-Binding Proteins Medicine & Life Sciences
Adrenergic Receptors Medicine & Life Sciences

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Projects 2007 2017

Research Output 1974 2018

Diarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation

Nguyen, T., Gamage, T. F., Decker, A. M., German, N., Langston, T. L., Farquhar, C. E., Kenakin, T. P., Wiley, J. L., Thomas, B. F. & Zhang, Y., Jan 1 2018, (Accepted/In press) In : ACS Chemical Neuroscience.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Structure-Activity Relationship
Guanosine 5'-O-(3-Thiotriphosphate)

Equilibrium assays are required to accurately characterize the activity profiles of drugs modulating Gq-protein-coupled receptors

Bdioui, S., Verdi, J., Pierre, N., Trinquet, E., Roux, T. & Kenakin, T., Sep 1 2018, In : Molecular pharmacology. 94, 3, p. 992-1006 15 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Pharmaceutical Preparations
Ghrelin Receptor
2 Citations

Is the quest for signaling bias worth the effort?

Kenakin, T., Apr 1 2018, In : Molecular Pharmacology. 93, 4, p. 266-269 4 p.

Research output: Contribution to journalArticle

Health Expenditures
Drug Therapy
In Vitro Techniques

Neutrophil priming that turns natural FFA2R agonists into potent activators of the superoxide generating NADPH-oxidase

Mårtensson, J., Holdfeldt, A., Sundqvist, M., Gabl, M., Kenakin, T. P., Björkman, L., Forsman, H. & Dahlgren, C., Dec 1 2018, In : Journal of Leukocyte Biology. 104, 6, p. 1117-1132 16 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Tumor Necrosis Factor-alpha
Formyl Peptide Receptor
2 Citations

PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?

Kenakin, T. P. & Strachan, R. T., Aug 1 2018, In : Trends in pharmacological sciences. 39, 8, p. 748-765 18 p.

Research output: Contribution to journalReview article