• 12194 Citations
  • 55 h-Index
1974 …2018
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  • 7 Similar Profiles
Ligands Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Drug Receptors Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Adrenergic Receptors Medicine & Life Sciences
GTP-Binding Proteins Medicine & Life Sciences

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Projects 2007 2017

Research Output 1974 2018

Equilibrium assays are required to accurately characterize the activity profiles of drugs modulating Gq-protein-coupled receptors

Bdioui, S., Verdi, J., Pierre, N., Trinquet, E., Roux, T. & Kenakin, T., Sep 1 2018, In : Molecular pharmacology. 94, 3, p. 992-1006 15 p.

Research output: Contribution to journalArticle

Gq-G11 GTP-Binding Protein alpha Subunits
Pharmacology
Calcium
Pharmaceutical Preparations
Ghrelin Receptor

Is the quest for signaling bias worth the effort?

Kenakin, T., Apr 1 2018, In : Molecular Pharmacology. 93, 4, p. 266-269 4 p.

Research output: Contribution to journalArticle

Pharmacology
Health Expenditures
Drug Therapy
In Vitro Techniques
Therapeutics
1 Citations

PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?

Kenakin, T. & Strachan, R. T., Jan 1 2018, (Accepted/In press) In : Trends in Pharmacological Sciences.

Research output: Contribution to journalArticle

Endothelins
Vasoconstriction
Ligands
Therapeutics
10 Citations

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor

Nguyen, T., Li, J. X., Thomas, B. F., Wiley, J. L., Kenakin, T. P. & Zhang, Y., May 1 2017, In : Medicinal Research Reviews. 37, 3, p. 441-474 34 p.

Research output: Contribution to journalReview article

Cannabinoid Receptor CB1
Pharmacology
Allosteric Site
Ligands
Biological Phenomena
2 Citations

A new molecular mechanism to engineer protean agonism at a G protein-coupled receptor

De Min, A., Matera, C., Bock, A., Holze, J., Kloeckner, J., Muth, M., Traenkle, C., De Amici, M., Kenakin, T., Holzgrabe, U., Dallanoce, C., Kostenis, E., Mohr, K. & Schrage, R., Apr 1 2017, In : Molecular pharmacology. 91, 4, p. 348-356 9 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Cholinergic Receptors
Cholinergic Agents
Ligands
Molecular Probes