Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 4 Similar Profiles
Lysine Medicine & Life Sciences
Proteins Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Ligands Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Histones Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1997 2019

Research Output 1985 2017

1 Citations

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

McIver, A. L., Zhang, W., Liu, Q., Jiang, X., Stashko, M. A., Nichols, J., Miley, M. J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D. K., Earp, H. S., Kireev, D., Frye, S. V. & Wang, X. 2017 In : ChemMedChem. 12, 3, p. 207-213 7 p.

Research output: Research - peer-reviewArticle

Pyrimidines
Protein-Tyrosine Kinases
Assays
Immunosorbents
Enzymes
3 Citations

UNC2025, a MERTK small-molecule inhibitor, is therapeutically effective alone and in combination with methotrexate in leukemia models

DeRyckere, D., Lee-Sherick, A. B., Huey, M. G., Hill, A. A., Tyner, J. W., Jacobsen, K. M., Page, L. S., Kirkpatrick, G. G., Eryildiz, F., Montgomery, S. A., Zhang, W., Wang, X., Frye, S. V., Earp, H. S. & Graham, D. K. Mar 15 2017 In : Clinical Cancer Research. 23, 6, p. 1481-1492 12 p.

Research output: Research - peer-reviewArticle

Methotrexate
Leukemia
UNC2025
Acute Myeloid Leukemia
Therapeutics
2 Citations

A high-throughput screening-compatible strategy for the identification of inositol pyrophosphate kinase inhibitors

Baughman, B. M., Wang, H., An, Y., Kireev, D., Stashko, M. A., Jessen, H. J., Pearce, K. H., Frye, S. V. & Shears, S. B. Oct 1 2016 In : PLoS ONE. 11, 10, e0164378

Research output: Research - peer-reviewArticle

Inositol
Screening
Phosphotransferases
Throughput
diphosphoric acid
6 Citations

Chemical probes for methyl lysine reader domains

James, L. I. & Frye, S. V. Jan 1 2016 In : Current Opinion in Chemical Biology. 33, p. 135-141 7 p.

Research output: Research - peer-reviewReview article

Lysine
Proteins
Modulation
7 Citations

Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing

Barnash, K. D., Lamb, K. N., Stuckey, J. I., Norris, J. L., Cholensky, S. H., Kireev, D. B., Frye, S. V. & James, L. I. Sep 16 2016 In : ACS Chemical Biology. 11, 9, p. 2475-2483 9 p.

Research output: Research - peer-reviewArticle

Ligands
Proteins
UNC3866
Peptidomimetics
Molecules