• 6264 Citations
  • 39 h-Index
1985 …2019
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  • 8 Similar Profiles
Lysine Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Structure-Activity Relationship Medicine & Life Sciences
Histones Medicine & Life Sciences
Ligands Medicine & Life Sciences
Drug Discovery Medicine & Life Sciences
Proteins Medicine & Life Sciences
Epigenomics Medicine & Life Sciences

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Projects 1997 2019

Research Output 1985 2018

1 Citations

MerTK as a therapeutic target in glioblastoma: Neuro Oncol

Wu, J., Frady, L. N., Bash, R. E., Cohen, S. M., Schorzman, A. N., Su, Y. T., Irvin, D. M., Zamboni, W. C., Wang, X., Frye, S. V., Ewend, M. G., Sulman, E. P., Gilbert, M. R., Earp, H. S. & Miller, C. R., Jun 13 2018, In : Neuro-Oncology. 20, 1, p. 92-102 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Macrophages
Neoplasms
Therapeutics
UNC2025

Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1

Suh, J. L., Watts, B., Stuckey, J. I., Norris-Drouin, J. L., Cholensky, S. H., Dickson, B. M., An, Y., Mathea, S., Salah, E., Knapp, S., Khan, A., Adams, A. T., Strahl, B. D., Sagum, C. A., Bedford, M. T., James, L. I., Kireev, D. B. & Frye, S. V., Apr 10 2018, In : Biochemistry. 57, 14, p. 2140-2149 10 p.

Research output: Contribution to journalArticle

Transcription Factor TFIID
Peptide Initiation Factors
Transcription
Ligands
Proteins

Use of Protein Kinase–Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors

Puhl-Rubio, A. C., Stashko, M. A., Wang, H., Hardy, P. B., Tyagi, V., Li, B., Wang, X., Kireev, D., Jessen, H. J., Frye, S. V., Shears, S. B. & Pearce, K. H., May 1 2018, (Accepted/In press) In : SLAS Discovery.

Research output: Contribution to journalArticle

Reactor startup
Inositol Phosphates
Natural gas well logging
Biofilms
Inositol
4 Citations

Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors

McIver, A. L., Zhang, W., Liu, Q., Jiang, X., Stashko, M. A., Nichols, J., Miley, M. J., Norris-Drouin, J., Machius, M., DeRyckere, D., Wood, E., Graham, D. K., Earp, H. S., Kireev, D., Frye, S. V. & Wang, X., Jan 1 2017, In : ChemMedChem. 12, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

Pyrimidines
Protein-Tyrosine Kinases
Assays
Immunosorbents
Enzyme-Linked Immunosorbent Assay
5 Citations

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2

Barnash, K. D., The, J., Norris-Drouin, J. L., Cholensky, S. H., Worley, B. M., Li, F., Stuckey, J. I., Brown, P. J., Vedadi, M., Arrowsmith, C. H., Frye, S. V. & James, L. I. Mar 13 2017 In : ACS Combinatorial Science. 19, 3, p. 161-172 12 p.

Research output: Contribution to journalArticle