• 888 Citations
  • 17 h-Index
20042018
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Research Output 2004 2018

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Article
2018

Symptomatic cerebrospinal fluid HIV-1 escape with no resistance-associated mutations following low-level plasma viremia

Trunfio, M., Joseph, S. B., Ghisetti, V., Romito, A., Martini, C., Cusato, J., Audagnotto, S., Pesci Kincer, L., Ferrara, M., Sala, A., Imperiale, D., Di Perri, G. & Calcagno, A., Feb 1 2018, In : Journal of NeuroVirology. 24, 1, p. 132-136 5 p.

Research output: Contribution to journalArticle

Virology
Viremia
Cerebrospinal Fluid
HIV-1
HIV
2017
6 Citations

A comparative phase I study of combination, homologous subtype-C DNA, MVA, and Env gp140 protein/adjuvant HIV vaccines in two immunization regimes

Joseph, S. , Quinn, K. , Greenwood, A. , Cope, A. V. , McKay, P. F. , Hayes, P. J. , Kopycinski, J. T. , Gilmour, J. , Miller, A. N. , Geldmacher, C. , Nadai, Y. , Ahmed, M. I. M. , Montefiori, D. C. , Dally, L. , Bouliotis, G. , Lewis, D. J. M. , Tatoud, R. , Wagner, R. , Esteban, M. , Shattock, R. J. & 2 others McCormack, S. & Weber, J., Feb 22 2017, In : Frontiers in Immunology. 8, FEB, 149

Research output: Contribution to journalArticle

env Gene Products
AIDS Vaccines
Immunization
Combined Vaccines
DNA
6 Citations

A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa

Jespers, V., Kyongo, J., Joseph, S., Hardy, L., Cools, P., Crucitti, T., Mwaura, M., Ndayisaba, G., Delany-Moretlwe, S., Buyze, J., Vanham, G. & Van De Wijgert, J. H. H. M., Dec 1 2017, In : Scientific Reports. 7, 1, 11974

Research output: Contribution to journalArticle

2016
4 Citations

Boosting with subtype C CN54rgp140 protein adjuvanted with glucopyranosyl lipid adjuvant after priming with HIV-DNA and HIV-MVA is safe and enhances immune responses: A phase I trial

Joachim, A. , Bauer, A. , Joseph, S. , Geldmacher, C. , Munseri, P. J. , Aboud, S. , Missanga, M. , Mann, P. , Wahren, B. , Ferrari, G. , Polonis, V. R. , Robb, M. L. , Weber, J. , Tatoud, R. , Maboko, L. , Hoelscher, M. , Lyamuya, E. F. , Biberfeld, G. , Sandström, E. , Kroidl, A. & 3 others Bakari, M., Nilsson, C. & McCormack, S., May 1 2016, In : PloS one. 11, 5, e0155702

Research output: Contribution to journalArticle

Immunization
Protein C
adjuvants
immunization
immune response
7 Citations

CD25+ FoxP3+ memory CD4 T cells are frequent targets of HIV infection in vivo

Chachage, M., Pollakis, G., Kuffour, E. O., Haase, K., Bauer, A., Nadai, Y., Podola, L., Clowes, P., Schiemann, M., Henkel, L., Hoffmann, D., Joseph, S., Bhuju, S., Maboko, L., Sarfo, F. S., Eberhardt, K., Hoelscher, M., Feldt, T., Saathoff, E. & Geldmacher, C., Jan 1 2016, In : Journal of Virology. 90, 20, p. 8954-8967 14 p.

Research output: Contribution to journalArticle

HIV infections
HIV Infections
T-lymphocytes
T-Lymphocytes
HIV
12 Citations

Comparative immunogenicity of HIV-1 gp140 vaccine delivered by parenteral, and mucosal routes in female volunteers; MUCOVAC2, a randomized two centre study

Cosgrove, C. A. , Lacey, C. J. , Cope, A. V. , Bartolf, A. , Morris, G. , Yan, C. , Baden, S. , Cole, T. , Carter, D. , Brodnicki, E. , Shen, X. , Joseph, S. , DeRosa, S. C. , Peng, L. , Yu, X. , Ferrari, G. , Seaman, M. , Montefiori, D. C. , Frahm, N. , Tomaras, G. D. & 3 others Stöhr, W., McCormack, S. & Shattock, R. J., May 1 2016, In : PloS one. 11, 5, e0152038

Research output: Contribution to journalArticle

Immunization
Human immunodeficiency virus 1
volunteers
Volunteers
immunization
2015
61 Citations

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

Sturdevant, C. B., Joseph, S. B., Schnell, G., Price, R. W., Swanstrom, R. & Spudich, S., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-24 24 p., e1004720

Research output: Contribution to journalArticle

HIV-1
Central Nervous System
Cerebrospinal Fluid
T-Lymphocytes
Infection
13 Citations

Correlates of the molecular vaginal microbiota composition of African women

Vaginal Biomarkers Study Group, Feb 11 2015, In : BMC Infectious Diseases. 15, 1, 86

Research output: Contribution to journalArticle

Rwanda
Tanzania
Kenya
Microbiota
South Africa
32 Citations

Cross-sectional analysis of selected genital tract immunological markers and molecular vaginal microbiota in sub-Saharan African women, with relevance to HIV risk and prevention

Kyongo, J. K., Crucitti, T., Menten, J., Hardy, L., Cools, P., Michiels, J., Delany-Moretlwe, S., Mwaura, M., Ndayisaba, G., Joseph, S., Fichorova, R., Van De Wijgert, J., Vanham, G., Ariën, K. K. & Jespers, V., Jan 1 2015, In : Clinical and Vaccine Immunology. 22, 5, p. 526-538 13 p.

Research output: Contribution to journalArticle

Interleukin-1alpha
Microbiota
Bacterial Vaginosis
Cross-Sectional Studies
HIV
36 Citations

HIV-1 target cells in the CNS

Joseph, S. B., Arrildt, K. T., Sturdevant, C. B. & Swanstrom, R., Jun 16 2015, In : Journal of NeuroVirology. 21, 3, p. 276-289 14 p.

Research output: Contribution to journalArticle

HIV-1
Central Nervous System
Macrophages
T-Lymphocytes
Viruses
19 Citations

Phenotypic correlates of HIV-1 macrophage tropism

Arrildt, K. T., LaBranche, C. C., Joseph, S. B., Dukhovlinova, E. N., Graham, W. D., Ping, L. H., Schnell, G., Sturdevant, C. B., Kincer, L. P., Mallewa, M., Heyderman, R. S., Van Rie, A., Cohen, M. S., Spudich, S., Price, R. W., Montefiori, D. C. & Swanstrom, R., Jan 1 2015, In : Journal of Virology. 89, 22, p. 11294-11311 18 p.

Research output: Contribution to journalArticle

tropisms
Tropism
Human immunodeficiency virus 1
HIV-1
tropics
2014
2 Citations

Dominance effects of deleterious and beneficial mutations in a single gene of the RNA virus φ6

Joseph, S. B., Peck, K. M. & Burch, C. L., Jun 19 2014, In : PLoS One. 9, 6, e97717

Research output: Contribution to journalArticle

RNA Viruses
Viruses
dominance (genetics)
Bacteriophages
Genes
12 Citations

Evolving character of chronic central nervous system HIV infection

Price, R. W., Spudich, S. S., Peterson, J., Joseph, S., Fuchs, D., Zetterberg, H., Gisslén, M. & Swanstrom, R., Jan 1 2014, In : Seminars in Neurology. 34, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

AIDS Dementia Complex
Central Nervous System Infections
HIV Infections
Central Nervous System
Nervous System Trauma
24 Citations

Glucopyranosyl lipid a adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen

McKay, P. F., Cope, A. V., Mann, J. F. S., Joseph, S., Esteban, M., Tatoud, R., Carter, D., Reed, S. G., Weber, J. & Shattock, R. J., Jan 23 2014, In : PLoS One. 9, 1, e84707

Research output: Contribution to journalArticle

adjuvants
B-lymphocytes
Human Immunodeficiency Virus Proteins
B-Lymphocytes
Vaccines
26 Citations

Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-Saharan Africa: A cross-sectional study

Vaginal Biomarkers Study Group, Oct 7 2014, In : PloS one. 9, 10, e109670

Research output: Contribution to journalArticle

Bacterial Vaginosis
Africa South of the Sahara
Sub-Saharan Africa
cross-sectional studies
Screening
41 Citations

Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities

Joseph, S. B., Arrildt, K. T., Swanstrom, A. E., Schnell, G., Lee, B., Hoxie, J. A. & Swanstrom, R., Feb 2014, In : Journal of Virology. 88, 4, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
HIV-1
tropics
macrophages
Macrophages
2013
63 Citations

Comparison of viral env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

Ping, L. H. , Joseph, S. B. , Anderson, J. A. , Abrahams, M. R. , Salazar-Gonzalez, J. F. , Kincer, L. P. , Treurnicht, F. K. , Arney, L. , Ojeda, S. , Zhang, M. , Keys, J. , Lake Potter, E. , Chu, H. , Moore, P. , Salazar, M. G. , Iyer, S. , Jabara, C. , Kirchherr, J. , Mapanje, C. , Ngandu, N. & 19 others Seoighe, C., Hoffman, I., Gao, F., Tang, Y., Labranche, C., Lee, B., Saville, A., Vermeulen, M., Fiscus, S., Morris, L., Karim, S. A., Haynes, B. F., Shaw, G. M., Korber, B. T., Hahn, B. H., Cohen, M. S., Montefiori, D., Williamson, C. & Swanstrom, R., Jul 1 2013, In : Journal of Virology. 87, 13, p. 7218-7233 16 p.

Research output: Contribution to journalArticle

env Gene Products
viral proteins
Viral Proteins
glycosylation
Human immunodeficiency virus 1
52 Citations

The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells

Gupta, S., Gach, J. S., Becerra, J. C., Phan, T. B., Pudney, J., Moldoveanu, Z., Joseph, S. B., Landucci, G., Supnet, M. J., Ping, L. H., Corti, D., Moldt, B., Hel, Z., Lanzavecchia, A., Ruprecht, R. M., Burton, D. R., Mestecky, J., Anderson, D. J. & Forthal, D. N., Nov 1 2013, In : PLoS pathogens. 9, 11, e1003776

Research output: Contribution to journalArticle

Transcytosis
HIV-1
Epithelial Cells
Immunoglobulin G
Viruses
2012
36 Citations

Central Nervous System Compartmentalization of HIV-1 Subtype C Variants Early and Late in Infection in Young Children

Sturdevant, C. B., Dow, A., Jabara, C. B., Joseph, S. B., Schnell, G., Takamune, N., Mallewa, M., Heyderman, R. S., Van Rie, A. & Swanstrom, R., Dec 1 2012, In : PLoS pathogens. 8, 12, e1003094

Research output: Contribution to journalArticle

HIV-1
Central Nervous System
Viruses
Infection
Macrophages
7 Citations

The Implementation and Appraisal of a Novel Confirmatory HIV-1 Testing Algorithm in the Microbicides Development Programme 301 Trial (MDP301)

Jentsch, U., Lunga, P., Lacey, C., Weber, J., Cairns, J., Pinheiro, G., Joseph, S., Stevens, W. & McCormack, S., Sep 11 2012, In : PLoS One. 7, 9, e42322

Research output: Contribution to journalArticle

program planning
Anti-Infective Agents
Human immunodeficiency virus 1
HIV-1
anti-infective agents
2011
104 Citations

HIV-1 replication in the central nervous system occurs in two distinct cell types

Schnell, G., Joseph, S., Spudich, S., Price, R. W. & Swanstrom, R., Oct 1 2011, In : PLoS pathogens. 7, 10, e1002286

Research output: Contribution to journalArticle

Virus Replication
HIV-1
Central Nervous System
Cerebrospinal Fluid
Viruses
2010
18 Citations

A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae

Hall, D. W. & Joseph, S. B., Aug 1 2010, In : Genetics. 185, 4, p. 1397-1409 13 p.

Research output: Contribution to journalArticle

Mutation Rate
Saccharomyces cerevisiae
Mutation
Haploidy
Growth
2009
5 Citations

Coinfection rates in φ6 bacteriophage are enhanced by virus-induced changes in host cells

Joseph, S. B., Hanley, K. A., Chao, L. & Burch, C. L., Feb 2009, In : Evolutionary Applications. 2, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

bacteriophage
Coinfection
mixed infection
bacteriophages
Bacteriophages
2008
14 Citations

Effects of the [PSI+] prion on rates of adaptation in yeast

Joseph, S. B. & Kirkpatrick, M., May 2008, In : Journal of Evolutionary Biology. 21, 3, p. 773-780 8 p.

Research output: Contribution to journalArticle

Prions
prions
yeast
Yeasts
yeasts
31 Citations

Spontaneous mutations in diploid Saccharomyces cerevisiae: Another thousand cell generations

Hall, D. W., Mahmoudizad, R., Hurd, A. W. & Joseph, S. B., Jun 2008, In : Genetics Research. 90, 3, p. 229-241 13 p.

Research output: Contribution to journalArticle

Diploidy
Saccharomyces cerevisiae
Mutation
Selection Bias
Genome
2004
92 Citations

Spontaneous mutations in diploid Saccharomyces cerevisiae: More beneficial than expected

Joseph, S. B. & Hall, D. W., Dec 2004, In : Genetics. 168, 4, p. 1817-1825 9 p.

Research output: Contribution to journalArticle

Diploidy
Saccharomyces cerevisiae
Mutation
Yeasts
Haploidy