Sarah BETH Joseph – Publications — University of North Carolina at Chapel Hill

2018

Symptomatic cerebrospinal fluid HIV-1 escape with no resistance-associated mutations following low-level plasma viremia

Trunfio, M., Joseph, S. B., Ghisetti, V., Romito, A., Martini, C., Cusato, J., Audagnotto, S., Pesci Kincer, L., Ferrara, M., Sala, A., Imperiale, D., Di Perri, G. & Calcagno, A., Feb 1 2018, In : Journal of NeuroVirology. 24, 1, p. 132-136 5 p.

Research output: Contribution to journal › Article

Virology

Viremia

Cerebrospinal Fluid

HIV-1

HIV

2017

6 Citations

A comparative phase I study of combination, homologous subtype-C DNA, MVA, and Env gp140 protein/adjuvant HIV vaccines in two immunization regimes

Joseph, S. , Quinn, K. , Greenwood, A. , Cope, A. V. , McKay, P. F. , Hayes, P. J. , Kopycinski, J. T. , Gilmour, J. , Miller, A. N. , Geldmacher, C. , Nadai, Y. , Ahmed, M. I. M. , Montefiori, D. C. , Dally, L. , Bouliotis, G. , Lewis, D. J. M. , Tatoud, R. , Wagner, R. , Esteban, M. , Shattock, R. J. & 2 others McCormack, S. & Weber, J., Feb 22 2017, In : Frontiers in Immunology. 8, FEB, 149

Research output: Contribution to journal › Article

env Gene Products

AIDS Vaccines

Immunization

Combined Vaccines

DNA

6 Citations

A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa

Jespers, V., Kyongo, J., Joseph, S., Hardy, L., Cools, P., Crucitti, T., Mwaura, M., Ndayisaba, G., Delany-Moretlwe, S., Buyze, J., Vanham, G. & Van De Wijgert, J. H. H. M., Dec 1 2017, In : Scientific Reports. 7, 1, 11974

Research output: Contribution to journal › Article

2016

4 Citations

Boosting with subtype C CN54rgp140 protein adjuvanted with glucopyranosyl lipid adjuvant after priming with HIV-DNA and HIV-MVA is safe and enhances immune responses: A phase I trial

Joachim, A. , Bauer, A. , Joseph, S. , Geldmacher, C. , Munseri, P. J. , Aboud, S. , Missanga, M. , Mann, P. , Wahren, B. , Ferrari, G. , Polonis, V. R. , Robb, M. L. , Weber, J. , Tatoud, R. , Maboko, L. , Hoelscher, M. , Lyamuya, E. F. , Biberfeld, G. , Sandström, E. , Kroidl, A. & 3 others Bakari, M., Nilsson, C. & McCormack, S., May 1 2016, In : PloS one. 11, 5, e0155702

Research output: Contribution to journal › Article

Immunization

Protein C

adjuvants

immunization

immune response

7 Citations

CD25⁺ FoxP3⁺ memory CD4 T cells are frequent targets of HIV infection in vivo

Chachage, M., Pollakis, G., Kuffour, E. O., Haase, K., Bauer, A., Nadai, Y., Podola, L., Clowes, P., Schiemann, M., Henkel, L., Hoffmann, D., Joseph, S., Bhuju, S., Maboko, L., Sarfo, F. S., Eberhardt, K., Hoelscher, M., Feldt, T., Saathoff, E. & Geldmacher, C., Jan 1 2016, In : Journal of Virology. 90, 20, p. 8954-8967 14 p.

Research output: Contribution to journal › Article

HIV infections

HIV Infections

T-lymphocytes

T-Lymphocytes

HIV

12 Citations

Comparative immunogenicity of HIV-1 gp140 vaccine delivered by parenteral, and mucosal routes in female volunteers; MUCOVAC2, a randomized two centre study

Cosgrove, C. A. , Lacey, C. J. , Cope, A. V. , Bartolf, A. , Morris, G. , Yan, C. , Baden, S. , Cole, T. , Carter, D. , Brodnicki, E. , Shen, X. , Joseph, S. , DeRosa, S. C. , Peng, L. , Yu, X. , Ferrari, G. , Seaman, M. , Montefiori, D. C. , Frahm, N. , Tomaras, G. D. & 3 others Stöhr, W., McCormack, S. & Shattock, R. J., May 1 2016, In : PloS one. 11, 5, e0152038

Research output: Contribution to journal › Article

Immunization

Human immunodeficiency virus 1

volunteers

Volunteers

immunization

2015

61 Citations

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

Sturdevant, C. B., Joseph, S. B., Schnell, G., Price, R. W., Swanstrom, R. & Spudich, S., Mar 1 2015, In : PLoS pathogens. 11, 3, p. 1-24 24 p., e1004720

Research output: Contribution to journal › Article

HIV-1

Central Nervous System

Cerebrospinal Fluid

T-Lymphocytes

Infection

13 Citations

Correlates of the molecular vaginal microbiota composition of African women

Vaginal Biomarkers Study Group, Feb 11 2015, In : BMC Infectious Diseases. 15, 1, 86

Research output: Contribution to journal › Article

Rwanda

Tanzania

Kenya

Microbiota

South Africa

32 Citations

Cross-sectional analysis of selected genital tract immunological markers and molecular vaginal microbiota in sub-Saharan African women, with relevance to HIV risk and prevention

Kyongo, J. K., Crucitti, T., Menten, J., Hardy, L., Cools, P., Michiels, J., Delany-Moretlwe, S., Mwaura, M., Ndayisaba, G., Joseph, S., Fichorova, R., Van De Wijgert, J., Vanham, G., Ariën, K. K. & Jespers, V., Jan 1 2015, In : Clinical and Vaccine Immunology. 22, 5, p. 526-538 13 p.

Research output: Contribution to journal › Article

Interleukin-1alpha

Microbiota

Bacterial Vaginosis

Cross-Sectional Studies

HIV

36 Citations

HIV-1 target cells in the CNS

Joseph, S. B., Arrildt, K. T., Sturdevant, C. B. & Swanstrom, R., Jun 16 2015, In : Journal of NeuroVirology. 21, 3, p. 276-289 14 p.

Research output: Contribution to journal › Article

HIV-1

Central Nervous System

Macrophages

T-Lymphocytes

Viruses

19 Citations

Phenotypic correlates of HIV-1 macrophage tropism

Arrildt, K. T., LaBranche, C. C., Joseph, S. B., Dukhovlinova, E. N., Graham, W. D., Ping, L. H., Schnell, G., Sturdevant, C. B., Kincer, L. P., Mallewa, M., Heyderman, R. S., Van Rie, A., Cohen, M. S., Spudich, S., Price, R. W., Montefiori, D. C. & Swanstrom, R., Jan 1 2015, In : Journal of Virology. 89, 22, p. 11294-11311 18 p.

Research output: Contribution to journal › Article

tropisms

Tropism

Human immunodeficiency virus 1

HIV-1

tropics

2014

2 Citations

Dominance effects of deleterious and beneficial mutations in a single gene of the RNA virus φ6

Joseph, S. B., Peck, K. M. & Burch, C. L., Jun 19 2014, In : PLoS One. 9, 6, e97717

Research output: Contribution to journal › Article

RNA Viruses

Viruses

dominance (genetics)

Bacteriophages

Genes

12 Citations

Evolving character of chronic central nervous system HIV infection

Price, R. W., Spudich, S. S., Peterson, J., Joseph, S., Fuchs, D., Zetterberg, H., Gisslén, M. & Swanstrom, R., Jan 1 2014, In : Seminars in Neurology. 34, 1, p. 7-13 7 p.

Research output: Contribution to journal › Article

AIDS Dementia Complex

Central Nervous System Infections

HIV Infections

Central Nervous System

Nervous System Trauma

24 Citations

Glucopyranosyl lipid a adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen

McKay, P. F., Cope, A. V., Mann, J. F. S., Joseph, S., Esteban, M., Tatoud, R., Carter, D., Reed, S. G., Weber, J. & Shattock, R. J., Jan 23 2014, In : PLoS One. 9, 1, e84707

Research output: Contribution to journal › Article

adjuvants

B-lymphocytes

Human Immunodeficiency Virus Proteins

B-Lymphocytes

Vaccines

26 Citations

Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-Saharan Africa: A cross-sectional study

Vaginal Biomarkers Study Group, Oct 7 2014, In : PloS one. 9, 10, e109670

Research output: Contribution to journal › Article

Bacterial Vaginosis

Africa South of the Sahara

Sub-Saharan Africa

cross-sectional studies

Screening

41 Citations

Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities

Joseph, S. B., Arrildt, K. T., Swanstrom, A. E., Schnell, G., Lee, B., Hoxie, J. A. & Swanstrom, R., Feb 2014, In : Journal of Virology. 88, 4, p. 1858-1869 12 p.

Research output: Contribution to journal › Article

Human immunodeficiency virus 1

HIV-1

tropics

macrophages

Macrophages

2013

63 Citations

Comparison of viral env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

Ping, L. H. , Joseph, S. B. , Anderson, J. A. , Abrahams, M. R. , Salazar-Gonzalez, J. F. , Kincer, L. P. , Treurnicht, F. K. , Arney, L. , Ojeda, S. , Zhang, M. , Keys, J. , Lake Potter, E. , Chu, H. , Moore, P. , Salazar, M. G. , Iyer, S. , Jabara, C. , Kirchherr, J. , Mapanje, C. , Ngandu, N. & 19 others Seoighe, C., Hoffman, I., Gao, F., Tang, Y., Labranche, C., Lee, B., Saville, A., Vermeulen, M., Fiscus, S., Morris, L., Karim, S. A., Haynes, B. F., Shaw, G. M., Korber, B. T., Hahn, B. H., Cohen, M. S., Montefiori, D., Williamson, C. & Swanstrom, R., Jul 1 2013, In : Journal of Virology. 87, 13, p. 7218-7233 16 p.

Research output: Contribution to journal › Article

env Gene Products

viral proteins

Viral Proteins

glycosylation

Human immunodeficiency virus 1

52 Citations

The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells

Gupta, S., Gach, J. S., Becerra, J. C., Phan, T. B., Pudney, J., Moldoveanu, Z., Joseph, S. B., Landucci, G., Supnet, M. J., Ping, L. H., Corti, D., Moldt, B., Hel, Z., Lanzavecchia, A., Ruprecht, R. M., Burton, D. R., Mestecky, J., Anderson, D. J. & Forthal, D. N., Nov 1 2013, In : PLoS pathogens. 9, 11, e1003776

Research output: Contribution to journal › Article

Transcytosis

HIV-1

Epithelial Cells

Immunoglobulin G

Viruses

2012

36 Citations

Central Nervous System Compartmentalization of HIV-1 Subtype C Variants Early and Late in Infection in Young Children

Sturdevant, C. B., Dow, A., Jabara, C. B., Joseph, S. B., Schnell, G., Takamune, N., Mallewa, M., Heyderman, R. S., Van Rie, A. & Swanstrom, R., Dec 1 2012, In : PLoS pathogens. 8, 12, e1003094

Research output: Contribution to journal › Article

HIV-1

Central Nervous System

Viruses

Infection

Macrophages

7 Citations

The Implementation and Appraisal of a Novel Confirmatory HIV-1 Testing Algorithm in the Microbicides Development Programme 301 Trial (MDP301)

Jentsch, U., Lunga, P., Lacey, C., Weber, J., Cairns, J., Pinheiro, G., Joseph, S., Stevens, W. & McCormack, S., Sep 11 2012, In : PLoS One. 7, 9, e42322

Research output: Contribution to journal › Article

program planning

Anti-Infective Agents

Human immunodeficiency virus 1

HIV-1

anti-infective agents

2011

104 Citations

HIV-1 replication in the central nervous system occurs in two distinct cell types

Schnell, G., Joseph, S., Spudich, S., Price, R. W. & Swanstrom, R., Oct 1 2011, In : PLoS pathogens. 7, 10, e1002286

Research output: Contribution to journal › Article

Virus Replication

HIV-1

Central Nervous System

Cerebrospinal Fluid

Viruses

2010

18 Citations

A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae

Hall, D. W. & Joseph, S. B., Aug 1 2010, In : Genetics. 185, 4, p. 1397-1409 13 p.

Research output: Contribution to journal › Article

Mutation Rate

Saccharomyces cerevisiae

Mutation

Haploidy

Growth

2009

5 Citations

Coinfection rates in φ6 bacteriophage are enhanced by virus-induced changes in host cells

Joseph, S. B., Hanley, K. A., Chao, L. & Burch, C. L., Feb 2009, In : Evolutionary Applications. 2, 1, p. 24-31 8 p.

Research output: Contribution to journal › Article

bacteriophage

Coinfection

mixed infection

bacteriophages

Bacteriophages

2008

14 Citations

Effects of the [PSI+] prion on rates of adaptation in yeast

Joseph, S. B. & Kirkpatrick, M., May 2008, In : Journal of Evolutionary Biology. 21, 3, p. 773-780 8 p.

Research output: Contribution to journal › Article

Prions

prions

yeast

Yeasts

yeasts

31 Citations

Spontaneous mutations in diploid Saccharomyces cerevisiae: Another thousand cell generations

Hall, D. W., Mahmoudizad, R., Hurd, A. W. & Joseph, S. B., Jun 2008, In : Genetics Research. 90, 3, p. 229-241 13 p.

Research output: Contribution to journal › Article

Diploidy

Saccharomyces cerevisiae

Mutation

Selection Bias

Genome

2004

92 Citations

Spontaneous mutations in diploid Saccharomyces cerevisiae: More beneficial than expected

Joseph, S. B. & Hall, D. W., Dec 2004, In : Genetics. 168, 4, p. 1817-1825 9 p.

Research output: Contribution to journal › Article

Diploidy

Saccharomyces cerevisiae

Mutation

Yeasts

Haploidy