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Sarah BETH Joseph

    • 844 Citations
    • 17 h-Index
    20042018
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    Research Output 2004 2018

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    Article
    2018

    Symptomatic cerebrospinal fluid HIV-1 escape with no resistance-associated mutations following low-level plasma viremia

    Trunfio, M., Joseph, S. B., Ghisetti, V., Romito, A., Martini, C., Cusato, J., Audagnotto, S., Pesci Kincer, L., Ferrara, M., Sala, A., Imperiale, D., Di Perri, G. & Calcagno, A. Feb 1 2018 In : Journal of NeuroVirology. 24, 1, p. 132-136 5 p.

    Research output: Contribution to journal › Article

    Virology
    Viremia
    Cerebrospinal Fluid
    HIV-1
    HIV
    2017
    4 Citations

    A comparative phase I study of combination, homologous subtype-C DNA, MVA, and Env gp140 protein/adjuvant HIV vaccines in two immunization regimes

    Joseph, S. , Quinn, K. , Greenwood, A. , Cope, A. V. , McKay, P. F. , Hayes, P. J. , Kopycinski, J. T. , Gilmour, J. , Miller, A. N. , Geldmacher, C. , Nadai, Y. , Ahmed, M. I. M. , Montefiori, D. C. , Dally, L. , Bouliotis, G. , Lewis, D. J. M. , Tatoud, R. , Wagner, R. , Esteban, M. , Shattock, R. J. & 2 others McCormack, S. & Weber, J. Feb 22 2017 In : Frontiers in Immunology. 8, FEB, 149

    Research output: Contribution to journal › Article

    env Gene Products
    AIDS Vaccines
    Immunization
    Combined Vaccines
    DNA
    4 Citations

    A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa

    Jespers, V., Kyongo, J., Joseph, S., Hardy, L., Cools, P., Crucitti, T., Mwaura, M., Ndayisaba, G., Delany-Moretlwe, S., Buyze, J., Vanham, G. & Van De Wijgert, J. H. H. M. Dec 1 2017 In : Scientific Reports. 7, 1, 11974

    Research output: Contribution to journal › Article

    2016
    4 Citations

    Boosting with subtype C CN54rgp140 protein adjuvanted with glucopyranosyl lipid adjuvant after priming with HIV-DNA and HIV-MVA is safe and enhances immune responses: A phase I trial

    Joachim, A. , Bauer, A. , Joseph, S. , Geldmacher, C. , Munseri, P. J. , Aboud, S. , Missanga, M. , Mann, P. , Wahren, B. , Ferrari, G. , Polonis, V. R. , Robb, M. L. , Weber, J. , Tatoud, R. , Maboko, L. , Hoelscher, M. , Lyamuya, E. F. , Biberfeld, G. , Sandstr�m, E. , Kroidl, A. & 3 others Bakari, M., Nilsson, C. & McCormack, S. May 1 2016 In : PloS one. 11, 5, e0155702

    Research output: Contribution to journal › Article

    Immunization
    Protein C
    adjuvants
    immunization
    immune response
    7 Citations

    CD25+ FoxP3+ memory CD4 T cells are frequent targets of HIV infection in vivo

    Chachage, M., Pollakis, G., Kuffour, E. O., Haase, K., Bauer, A., Nadai, Y., Podola, L., Clowes, P., Schiemann, M., Henkel, L., Hoffmann, D., Joseph, S., Bhuju, S., Maboko, L., Sarfo, F. S., Eberhardt, K., Hoelscher, M., Feldt, T., Saathoff, E. & Geldmacher, C. Jan 1 2016 In : Journal of Virology. 90, 20, p. 8954-8967 14 p.

    Research output: Contribution to journal › Article

    HIV infections
    HIV Infections
    T-lymphocytes
    T-Lymphocytes
    HIV
    11 Citations

    Comparative immunogenicity of HIV-1 gp140 vaccine delivered by parenteral, and mucosal routes in female volunteers; MUCOVAC2, a randomized two centre study

    Cosgrove, C. A. , Lacey, C. J. , Cope, A. V. , Bartolf, A. , Morris, G. , Yan, C. , Baden, S. , Cole, T. , Carter, D. , Brodnicki, E. , Shen, X. , Joseph, S. , DeRosa, S. C. , Peng, L. , Yu, X. , Ferrari, G. , Seaman, M. , Montefiori, D. C. , Frahm, N. , Tomaras, G. D. & 3 others St�hr, W., McCormack, S. & Shattock, R. J. May 1 2016 In : PloS one. 11, 5, e0152038

    Research output: Contribution to journal › Article

    Immunization
    Human immunodeficiency virus 1
    volunteers
    Volunteers
    immunization
    2015
    56 Citations

    Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

    Sturdevant, C. B., Joseph, S. B., Schnell, G., Price, R. W., Swanstrom, R. & Spudich, S. Mar 1 2015 In : PLoS Pathogens. 11, 3, p. 1-24 24 p., e1004720

    Research output: Contribution to journal › Article

    HIV-1
    Central Nervous System
    Cerebrospinal Fluid
    T-Lymphocytes
    Infection
    12 Citations

    Correlates of the molecular vaginal microbiota composition of African women

    Gautam, R. , Borgdorff, H. , Jespers, V. , Francis, S. C. , Verhelst, R. , Mwaura, M. , Delany-Moretlwe, S. , Ndayisaba, G. , Kyongo, J. K. , Hardy, L. , Menten, J. , Crucitti, T. , Tsivtsivadze, E. , Schuren, F. , van de Wijgert, J. H. H. M. , Mandaliya, K. , Dierick, L. , Mwaura, M. , Jaoko, W. , Irungu, E. & 31 others Katingima, C., Maina, M., Mazera, J. W., Gichuru, J., Onuki, G. A., Kiambi, M., Thiong'o, M., Wanjiku, S., Nduku, P., Njeru, C., Mbogho, B., Wambua, S., Baya, R. S., Onduko, E. M., Kombo, P. K., Masha, S. C., Ndinda, M., Odeyo, J. K., Ngala, D., Odero, C., Delany-Moretlwe, S., Edward, V. A., Reddy, K., Von Knorring, N., Mahabeer, I., Mashilo, J. N., Mnyandu, N., Mokoatle, K., Nani, S., Joseph, S. & Vaginal Biomarkers Study Group Feb 11 2015 In : BMC Infectious Diseases. 15, 1, 86

    Research output: Contribution to journal › Article

    Rwanda
    Tanzania
    Kenya
    Microbiota
    South Africa
    30 Citations

    Cross-sectional analysis of selected genital tract immunological markers and molecular vaginal microbiota in sub-Saharan African women, with relevance to HIV risk and prevention

    Kyongo, J. K., Crucitti, T., Menten, J., Hardy, L., Cools, P., Michiels, J., Delany-Moretlwe, S., Mwaura, M., Ndayisaba, G., Joseph, S., Fichorova, R., Van De Wijgert, J., Vanham, G., Ariën, K. K. & Jespers, V. Jan 1 2015 In : Clinical and Vaccine Immunology. 22, 5, p. 526-538 13 p.

    Research output: Contribution to journal › Article

    Interleukin-1alpha
    Microbiota
    Bacterial Vaginosis
    Cross-Sectional Studies
    HIV
    19 Citations

    Phenotypic correlates of HIV-1 macrophage tropism

    Arrildt, K. T., LaBranche, C. C., Joseph, S. B., Dukhovlinova, E. N., Graham, W. D., Ping, L. H., Schnell, G., Sturdevant, C. B., Kincer, L. P., Mallewa, M., Heyderman, R. S., Van Rie, A., Cohen, M. S., Spudich, S., Price, R. W., Montefiori, D. C. & Swanstrom, R. Jan 1 2015 In : Journal of Virology. 89, 22, p. 11294-11311 18 p.

    Research output: Contribution to journal › Article

    tropisms
    Tropism
    Human immunodeficiency virus 1
    HIV-1
    tropics
    2014
    2 Citations

    Dominance effects of deleterious and beneficial mutations in a single gene of the RNA virus φ6

    Joseph, S. B., Peck, K. M. & Burch, C. L. Jun 19 2014 In : PLoS ONE. 9, 6, e97717

    Research output: Contribution to journal › Article

    RNA Viruses
    Viruses
    dominance (genetics)
    Bacteriophages
    Genes
    10 Citations

    Evolving character of chronic central nervous system HIV infection

    Price, R. W., Spudich, S. S., Peterson, J., Joseph, S., Fuchs, D., Zetterberg, H., Gisslén, M. & Swanstrom, R. Jan 1 2014 In : Seminars in Neurology. 34, 1, p. 7-13 7 p.

    Research output: Contribution to journal › Article

    AIDS Dementia Complex
    Central Nervous System Infections
    HIV Infections
    Central Nervous System
    Nervous System Trauma
    23 Citations

    Glucopyranosyl lipid a adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen

    McKay, P. F., Cope, A. V., Mann, J. F. S., Joseph, S., Esteban, M., Tatoud, R., Carter, D., Reed, S. G., Weber, J. & Shattock, R. J. Jan 23 2014 In : PLoS ONE. 9, 1, e84707

    Research output: Contribution to journal › Article

    adjuvants
    B-lymphocytes
    Human Immunodeficiency Virus Proteins
    B-Lymphocytes
    Vaccines
    32 Citations

    HIV-1 target cells in the CNS

    Joseph, S. B., Arrildt, K. T., Sturdevant, C. B. & Swanstrom, R. Sep 19 2014 In : Journal of NeuroVirology. 21, 3, p. 276-289 14 p.

    Research output: Contribution to journal › Article

    HIV-1
    Central Nervous System
    Macrophages
    T-Lymphocytes
    Viruses
    24 Citations

    Prevalence and correlates of bacterial vaginosis in different sub-populations of women in sub-Saharan Africa: A cross-sectional study

    Vaginal Biomarkers Study Group Oct 7 2014 In : PloS one. 9, 10, e109670

    Research output: Contribution to journal › Article

    Bacterial Vaginosis
    Africa South of the Sahara
    Sub-Saharan Africa
    cross-sectional studies
    Screening
    39 Citations

    Quantification of entry phenotypes of macrophage-tropic HIV-1 across a wide range of CD4 densities

    Joseph, S. B., Arrildt, K. T., Swanstrom, A. E., Schnell, G., Lee, B., Hoxie, J. A. & Swanstrom, R. Feb 2014 In : Journal of Virology. 88, 4, p. 1858-1869 12 p.

    Research output: Contribution to journal › Article

    Human immunodeficiency virus 1
    HIV-1
    tropics
    macrophages
    Macrophages
    2013
    63 Citations

    Comparison of viral env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design

    Ping, L. H. , Joseph, S. B. , Anderson, J. A. , Abrahams, M. R. , Salazar-Gonzalez, J. F. , Kincer, L. P. , Treurnicht, F. K. , Arney, L. , Ojeda, S. , Zhang, M. , Keys, J. , Lake Potter, E. , Chu, H. , Moore, P. , Salazar, M. G. , Iyer, S. , Jabara, C. , Kirchherr, J. , Mapanje, C. , Ngandu, N. & 19 others Seoighe, C., Hoffman, I., Gao, F., Tang, Y., Labranche, C., Lee, B., Saville, A., Vermeulen, M., Fiscus, S., Morris, L., Karim, S. A., Haynes, B. F., Shaw, G. M., Korber, B. T., Hahn, B. H., Cohen, M. S., Montefiori, D., Williamson, C. & Swanstrom, R. Jul 1 2013 In : Journal of Virology. 87, 13, p. 7218-7233 16 p.

    Research output: Contribution to journal › Article

    env Gene Products
    viral proteins
    Viral Proteins
    glycosylation
    Human immunodeficiency virus 1
    52 Citations

    The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells

    Gupta, S., Gach, J. S., Becerra, J. C., Phan, T. B., Pudney, J., Moldoveanu, Z., Joseph, S. B., Landucci, G., Supnet, M. J., Ping, L. H., Corti, D., Moldt, B., Hel, Z., Lanzavecchia, A., Ruprecht, R. M., Burton, D. R., Mestecky, J., Anderson, D. J. & Forthal, D. N. Nov 1 2013 In : PLoS Pathogens. 9, 11, e1003776

    Research output: Contribution to journal › Article

    Transcytosis
    HIV-1
    Epithelial Cells
    Immunoglobulin G
    Viruses
    2012
    32 Citations

    Central Nervous System Compartmentalization of HIV-1 Subtype C Variants Early and Late in Infection in Young Children

    Sturdevant, C. B., Dow, A., Jabara, C. B., Joseph, S. B., Schnell, G., Takamune, N., Mallewa, M., Heyderman, R. S., Van Rie, A. & Swanstrom, R. Dec 1 2012 In : PLoS Pathogens. 8, 12, e1003094

    Research output: Contribution to journal › Article

    HIV-1
    Central Nervous System
    Viruses
    Infection
    Macrophages
    7 Citations

    The Implementation and Appraisal of a Novel Confirmatory HIV-1 Testing Algorithm in the Microbicides Development Programme 301 Trial (MDP301)

    Jentsch, U., Lunga, P., Lacey, C., Weber, J., Cairns, J., Pinheiro, G., Joseph, S., Stevens, W. & McCormack, S. Sep 11 2012 In : PLoS ONE. 7, 9, e42322

    Research output: Contribution to journal › Article

    program planning
    Anti-Infective Agents
    Human immunodeficiency virus 1
    HIV-1
    anti-infective agents
    2011
    100 Citations

    HIV-1 replication in the central nervous system occurs in two distinct cell types

    Schnell, G., Joseph, S., Spudich, S., Price, R. W. & Swanstrom, R. Oct 1 2011 In : PLoS Pathogens. 7, 10, e1002286

    Research output: Contribution to journal › Article

    Virus Replication
    HIV-1
    Central Nervous System
    Cerebrospinal Fluid
    Viruses
    2010
    18 Citations

    A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae

    Hall, D. W. & Joseph, S. B. Aug 1 2010 In : Genetics. 185, 4, p. 1397-1409 13 p.

    Research output: Contribution to journal › Article

    Mutation Rate
    Saccharomyces cerevisiae
    Mutation
    Haploidy
    Growth
    2009
    4 Citations

    Coinfection rates in φ6 bacteriophage are enhanced by virus-induced changes in host cells

    Joseph, S. B., Hanley, K. A., Chao, L. & Burch, C. L. Feb 2009 In : Evolutionary Applications. 2, 1, p. 24-31 8 p.

    Research output: Contribution to journal › Article

    bacteriophage
    Coinfection
    mixed infection
    bacteriophages
    Bacteriophages
    2008
    14 Citations

    Effects of the [PSI+] prion on rates of adaptation in yeast

    Joseph, S. B. & Kirkpatrick, M. May 2008 In : Journal of Evolutionary Biology. 21, 3, p. 773-780 8 p.

    Research output: Contribution to journal › Article

    Prions
    prions
    yeast
    Yeasts
    yeasts
    31 Citations

    Spontaneous mutations in diploid Saccharomyces cerevisiae: Another thousand cell generations

    Hall, D. W., Mahmoudizad, R., Hurd, A. W. & Joseph, S. B. Jun 2008 In : Genetics Research. 90, 3, p. 229-241 13 p.

    Research output: Contribution to journal › Article

    Diploidy
    Saccharomyces cerevisiae
    Mutation
    Selection Bias
    Genome
    2004
    91 Citations

    Spontaneous mutations in diploid Saccharomyces cerevisiae: More beneficial than expected

    Joseph, S. B. & Hall, D. W. Dec 2004 In : Genetics. 168, 4, p. 1817-1825 9 p.

    Research output: Contribution to journal › Article

    Diploidy
    Saccharomyces cerevisiae
    Mutation
    Yeasts
    Haploidy