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  • 4 Similar Profiles
Pentamidine Medicine & Life Sciences
Amidines Medicine & Life Sciences
Prodrugs Medicine & Life Sciences
Pneumocystis Pneumonia Medicine & Life Sciences
Pneumocystis carinii Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
DNA Medicine & Life Sciences
Trypanosoma brucei rhodesiense Medicine & Life Sciences

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Projects 2000 2016

Scaffolds
Molecules
Screening
Testing
Drug Discovery

Bayer Cryptosporidium Project

Tidwell, R. R.

Industry Sponsor

4/1/1212/10/13

Project: Research project

Cryptosporidium
chemistry
testing
synthesis
animals
Pentamidine
African Trypanosomiasis
Kidney
Liver
Pneumocystis Pneumonia
Pharmaceutical Preparations
Workflow
Libraries
Joints
Professional Competence

Research Output 1972 2016

3 Citations

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

Burri, C., Yeramian, P. D., Allen, J. L., Merolle, A., Serge, K. K., Mpanya, A., Lutumba, P., Mesu, V. K. B. K., Bilenge, C. M. M., Lubaki, J. P. F., Mpoto, A. M., Thompson, M., Munungu, B. F., Manuel, F., Josenando, T., Bernhard, S. C., Olson, C. A., Blum, J., Tidwell, R. R. & Pohlig, G. Feb 16 2016 In : PLoS Neglected Tropical Diseases. 10, 2, e0004362

Research output: Contribution to journalArticle

Safety
Pentamidine
Pharmaceutical Preparations
African Trypanosomiasis
Democratic Republic of the Congo
4 Citations

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig, G. , Bernhard, S. C. , Blum, J. , Burri, C. , Mpanya, A. , Lubaki, J. P. F. , Mpoto, A. M. , Munungu, B. F. , N’tombe, P. M. , Deo, G. K. M. , Mutantu, P. N. , Kuikumbi, F. M. , Mintwo, A. F. , Munungi, A. K. , Dala, A. , Macharia, S. , Bilenge, C. M. M. , Mesu, V. K. B. K. , Franco, J. R. , Dituvanga, N. D. & 2 others Tidwell, R. R. & Olson, C. A. Feb 16 2016 In : PLoS Neglected Tropical Diseases. 10, 2, e0004363

Research output: Contribution to journalArticle

Pentamidine
Phase III Clinical Trials
Safety
African Trypanosomiasis
Therapeutics
5 Citations

In vitro and in vivo trypanosomicidal action of novel arylimidamides against trypanosoma cruzi

Guedes-Da-Silva, F. H., Batista, D. G. J., Meuser, M. B., Demarque, K. C., Fulco, T. O., Araújo, J. S., Da Silva, P. B., Da Silva, C. F., Patrick, D. A., Bakunova, S. M., Bakunov, S. A., Tidwell, R. R., Oliveira, G. M., Britto, C., Moreira, O. C. & Soeiro, M. N. C. Apr 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2425-2434 10 p.

Research output: Contribution to journalArticle

Parasitemia
Chagas Disease
Trypanosoma cruzi
Amidines
Parasite Load
10 Citations

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense

Patrick, D. A., Wenzler, T., Yang, S., Weiser, P. T., Wang, M. Z., Brun, R. & Tidwell, R. R. Jun 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2451-2465 15 p.

Research output: Contribution to journalArticle

Ethylamines
Trypanosoma brucei rhodesiense
Amides
Urea
Parasites
5 Citations

Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys

Thuita, J. K., Wolf, K. K., Murilla, G. A., Bridges, A. S., Boykin, D. W., Mutuku, J. N., Liu, Q., Jones, S. K., Gem, C. O., Ching, S., Tidwell, R. R., Wang, M. Z., Paine, M. F. & Brun, R. Jan 1 2015 In : PLoS Neglected Tropical Diseases. 9, 2, e0003409

Research output: Contribution to journalArticle

African Trypanosomiasis
Pentamidine
Cercopithecus aethiops
Prodrugs
Haplorhini