• 6747 Citations
  • 48 h-Index
1972 …2018
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  • 5 Similar Profiles
Pentamidine Medicine & Life Sciences
Amidines Medicine & Life Sciences
Prodrugs Medicine & Life Sciences
Pneumocystis Pneumonia Medicine & Life Sciences
Pneumocystis carinii Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
DNA Medicine & Life Sciences
Inhibitory Concentration 50 Medicine & Life Sciences

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Projects 2000 2016

Scaffolds
Molecules
Screening
Testing
Drug Discovery

Bayer Cryptosporidium Project

Tidwell, R. R.

Industry Sponsor

4/1/1212/10/13

Project: Research project

Cryptosporidium
chemistry
testing
synthesis
animals
Pentamidine
African Trypanosomiasis
Kidney
Liver
Pneumocystis Pneumonia
Pharmaceutical Preparations
Workflow
Libraries
Joints
Professional Competence

Research Output 1972 2018

In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi

Santos, C. C., Lionel, J. R., Peres, R. B., Batista, M. M., Da Silva, P. B., De Oliveira, G. M., Da Silva, C. F., Batista, D. G. J., Souza, S. M. O., Andrade, C. H., Neves, B. J., Braga, R. C., Patrick, D. A., Bakunova, S. M., Tidwell, R. R. & Soeiro, M. D. N. C., Feb 1 2018, In : Antimicrobial agents and chemotherapy. 62, 2, e02205-17.

Research output: Contribution to journalArticle

Amidines
Trypanosoma cruzi
Computer Simulation
Parasitemia
Pharmacokinetics
5 Citations

In vitro, ex vivo, and in vivo activities of diamidines against Trypanosoma congolense and Trypanosoma vivax

Gillingwater, K., Kunz, C., Braghiroli, C., Boykin, D. W., Tidwell, R. R. & Brun, R., May 1 2017, In : Antimicrobial Agents and Chemotherapy. 61, 5, e02356.

Research output: Contribution to journalArticle

Trypanosoma vivax
Trypanosoma congolense
Pentamidine
African Trypanosomiasis
Pharmaceutical Preparations

Role of suppression of the inward rectifier current in terminal action potential repolarization in the failing heart

Klein, M. G., Shou, M., Stohlman, J., Solhjoo, S., Haigney, M., Tidwell, R. R., Goldstein, R. E., Flagg, T. P. & Haigney, M. C., Aug 1 2017, In : Heart Rhythm. 14, 8, p. 1217-1223 7 p.

Research output: Contribution to journalArticle

Action Potentials
Heart Failure
Muscle Cells
Pentamidine
Ion Channels
4 Citations

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

Burri, C., Yeramian, P. D., Allen, J. L., Merolle, A., Serge, K. K., Mpanya, A., Lutumba, P., Mesu, V. K. B. K., Bilenge, C. M. M., Lubaki, J. P. F., Mpoto, A. M., Thompson, M., Munungu, B. F., Manuel, F., Josenando, T., Bernhard, S. C., Olson, C. A., Blum, J., Tidwell, R. R. & Pohlig, G., Feb 16 2016, In : PLoS Neglected Tropical Diseases. 10, 2, e0004362.

Research output: Contribution to journalArticle

Safety
Pentamidine
Pharmaceutical Preparations
African Trypanosomiasis
Democratic Republic of the Congo
7 Citations

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig, G., Bernhard, S. C., Blum, J., Burri, C., Mpanya, A., Lubaki, J. P. F., Mpoto, A. M., Munungu, B. F., N’tombe, P. M., Deo, G. K. M., Mutantu, P. N., Kuikumbi, F. M., Mintwo, A. F., Munungi, A. K., Dala, A., Macharia, S., Bilenge, C. M. M., Mesu, V. K. B. K., Franco, J. R., Dituvanga, N. D. & 2 othersTidwell, R. R. & Olson, C. A., Feb 16 2016, In : PLoS Neglected Tropical Diseases. 10, 2, e0004363.

Research output: Contribution to journalArticle

Pentamidine
Phase III Clinical Trials
Safety
African Trypanosomiasis
Therapeutics