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  • 4 Similar Profiles
Pentamidine Medicine & Life Sciences
In Vitro Techniques Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
DNA Medicine & Life Sciences
Prodrugs Medicine & Life Sciences
Pneumocystis Pneumonia Medicine & Life Sciences
Amidines Medicine & Life Sciences
Pneumocystis carinii Medicine & Life Sciences

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Projects 2000 2016

Scaffolds
Drug Discovery
Molecules
Screening
Testing

Bayer Cryptosporidium Project

Tidwell, R. R.

Industry Sponsor

4/1/1212/10/13

Project: Research project

Cryptosporidium
testing
chemistry
synthesis
animals
Kidney
Liver
pafuramidine
Pentamidine
African Trypanosomiasis
Pharmaceutical Preparations
Workflow
Libraries
Joints
In Vitro Techniques

Research Output 1972 2016

3 Citations

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

Burri, C., Yeramian, P. D., Allen, J. L., Merolle, A., Serge, K. K., Mpanya, A., Lutumba, P., Mesu, V. K. B. K., Bilenge, C. M. M., Lubaki, J. P. F., Mpoto, A. M., Thompson, M., Munungu, B. F., Manuel, F., Josenando, T., Bernhard, S. C., Olson, C. A., Blum, J., Tidwell, R. R. & Pohlig, G. Feb 16 2016 In : PLoS Neglected Tropical Diseases. 10, 2, e0004362

Research output: Research - peer-reviewArticle

Safety
Pharmaceutical Preparations
Therapeutics
pafuramidine
Clinical Studies
4 Citations

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial

Pohlig, G. , Bernhard, S. C. , Blum, J. , Burri, C. , Mpanya, A. , Lubaki, J. P. F. , Mpoto, A. M. , Munungu, B. F. , N’tombe, P. M. , Deo, G. K. M. , Mutantu, P. N. , Kuikumbi, F. M. , Mintwo, A. F. , Munungi, A. K. , Dala, A. , Macharia, S. , Bilenge, C. M. M. , Mesu, V. K. B. K. , Franco, J. R. , Dituvanga, N. D. & 2 others Tidwell, R. R. & Olson, C. A. Feb 16 2016 In : PLoS Neglected Tropical Diseases. 10, 2, e0004363

Research output: Research - peer-reviewArticle

Pentamidine
Phase III Clinical Trials
Safety
Therapeutics
maleic acid
4 Citations

In vitro and in vivo trypanosomicidal action of novel arylimidamides against trypanosoma cruzi

Guedes-Da-Silva, F. H., Batista, D. G. J., Meuser, M. B., Demarque, K. C., Fulco, T. O., Araújo, J. S., Da Silva, P. B., Da Silva, C. F., Patrick, D. A., Bakunova, S. M., Bakunov, S. A., Tidwell, R. R., Oliveira, G. M., Britto, C., Moreira, O. C. & Soeiro, M. N. C. Apr 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2425-2434 10 p.

Research output: Research - peer-reviewArticle

Parasitemia
Chagas Disease
Trypanosoma cruzi
In Vitro Techniques
Amidines
9 Citations

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense

Patrick, D. A., Wenzler, T., Yang, S., Weiser, P. T., Wang, M. Z., Brun, R. & Tidwell, R. R. Jun 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2451-2465 15 p.

Research output: Research - peer-reviewArticle

Ethylamines
Amides
Urea
Derivatives
Parasites
5 Citations

Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys

Thuita, J. K., Wolf, K. K., Murilla, G. A., Bridges, A. S., Boykin, D. W., Mutuku, J. N., Liu, Q., Jones, S. K., Gem, C. O., Ching, S., Tidwell, R. R., Wang, M. Z., Paine, M. F. & Brun, R. 2015 In : PLoS Neglected Tropical Diseases. 9, 2, e0003409

Research output: Research - peer-reviewArticle

African Trypanosomiasis
Pentamidine
Cercopithecus aethiops
Prodrugs
Haplorhini