Research Output 1975 2017

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2017

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

Kechele, D. O., Blue, R. E., Zwarycz, B., Espenschied, S. T., Mah, A. T., Siegel, M. B., Perou, C. M., Ding, S., Magness, S. T., Lund, P. K. & Caron, K. M. Feb 1 2017 In : Journal of Clinical Investigation. 127, 2, p. 593-607 15 p.

Research output: Research - peer-reviewArticle

Orphaned Children
Adenoma
Regeneration
Stem Cells
Organoids
2016
4 Citations

Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis

Rigby, R. J., Carr, J., Orgel, K., King, S. L., Lund, P. K. & Dekaney, C. M. Sep 2 2016 In : Gut Microbes. 7, 5, p. 414-423 10 p.

Research output: Research - peer-reviewArticle

Doxorubicin
Apoptosis
Bacteria
Enterobacteriaceae
Therapeutics
8 Citations

miR-30 family controls proliferation and differentiation of intestinal epithelial cell models by directing a broad gene expression program that includes SOX9 and the ubiquitin ligase pathway

Peck, B. C. E., Sincavage, J., Feinstein, S., Mah, A. T., Simmons, J. G., Lund, P. K. & Sethupathy, P. Jul 29 2016 In : Journal of Biological Chemistry. 291, 31, p. 15975-15984 10 p.

Research output: Research - peer-reviewArticle

Ligases
Ubiquitin
Epithelial Cells
Gene Expression
Gene expression
7 Citations

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

Koblansky, A. A., Truax, A. D., Liu, R., Montgomery, S. A., Ding, S., Wilson, J. E., Brickey, W. J., Mühlbauer, M., McFadden, R. M. T., Hu, P., Li, Z., Jobin, C., Lund, P. K. & Ting, J. P. Y. Mar 22 2016 In : Cell Reports. 14, 11, p. 2562-2575 14 p.

Research output: Research - peer-reviewArticle

Colon
Carcinogenesis
Neoplasms
Tumors
Colonic Neoplasms
2015
7 Citations

Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and paneth cell mRNAs

Andres, S. F., Agostina Santoro, M., Mah, A. T., Adeola Keku, J., Bortvedt, A. E., Eric Blue, R. & Kay Lund, P. Jan 15 2015 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 2, p. G100-G111

Research output: Research - peer-reviewArticle

Paneth Cells
Enteroendocrine Cells
Insulin Receptor
High Fat Diet
Stem Cells
15 Citations

IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations

Van Landeghem, L., Santoro, M. A., Mah, A. T., Krebs, A. E., Dehmer, J. J., McNaughton, K. K., Helmrath, M. A., Magness, S. T. & Lund, P. K. Jul 1 2015 In : FASEB Journal. 29, 7, p. 2828-2842 15 p.

Research output: Research - peer-reviewArticle

Somatomedins
Stem Cells
Population
Stem cells
Chemical activation
3 Citations

Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon

Santoro, M. A., Blue, R. E., Andres, S. F., Mah, A. T., Van Landeghem, L. & Lund, P. K. Sep 1 2015 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 7, p. G578-G589

Research output: Research - peer-reviewArticle

Somatomedin Receptors
Insulin Receptor
Colon
Obesity
Radiation
6 Citations

Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury

Poindexter, S. V., Reddy, V. K., Mittal, M. K., Williams, A. M., Washington, M. K., Harris, E., Mah, A., Hiebert, S. W., Singh, K., Chaturvedi, R., Wilson, K. T., Lund, P. K. & Williams, C. S. 2015 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 6, p. G562-G571

Research output: Research - peer-reviewArticle

Co-Repressor Proteins
Radiation Injuries
Regeneration
Apoptosis
Goblet Cells
2014
2 Citations
Molecular Probes
Colitis
Fluorescent Dyes
Inflammation
Enzymes
16 Citations

Impact of diet-induced obesity on intestinal stem cells: Hyperproliferation but impaired intrinsic function that requires insulin/IGF1

Mah, A. T., Landeghem, L. V., Gavin, H. E., Magness, S. T. & Lund, P. K. Sep 1 2014 In : Endocrinology. 155, 9, p. 3302-3314 13 p.

Research output: Research - peer-reviewArticle

Somatomedins
Stem Cells
Obesity
Insulin
Diet
36 Citations

MicroRNA-29 fine-tunes the expression of key foxa2- Activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes

Kurtz, C. L., Peck, B. C. E., Fannin, E. E., Beysen, C., Miao, J., Landstreet, S. R., Ding, S., Turaga, V., Lund, P. K., Turner, S., Biddinger, S. B., Vickers, K. C. & Sethupathy, P. 2014 In : Diabetes. 63, 9, p. 3141-3148 8 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Lipid Metabolism
Insulin Resistance
Animal Models
Liver
8 Citations
RNA Isoforms
Somatomedin Receptors
Insulin Receptor
Adenoma
Mucous Membrane
2013
22 Citations

Impact of Ileocecal Resection and Concomitant Antibiotics on the Microbiome of the Murine Jejunum and Colon

Devine, A. A., Gonzalez, A., Speck, K. E., Knight, R., Helmrath, M., Lund, P. K. & Azcarate-Peril, M. A. Aug 27 2013 In : PLoS One. 8, 8, e73140

Research output: Research - peer-reviewArticle

resection
jejunum
colon
antibiotics
mice
24 Citations

Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: Evidence that IR-B limits proliferation

Andres, S. F., Simmons, J. G., Mah, A. T., Santoro, M. A., Van Landeghem, L. & Lund, P. K. Dec 15 2013 In : Journal of Cell Science. 126, 24, p. 5645-5656 12 p.

Research output: Research - peer-reviewArticle

Insulin Receptor
Protein Isoforms
Stem Cells
Neoplasms
Epithelial Cells
2 Citations

Opportunities and challenges for women phd investigators in gastrointestinal research

Hamilton, K. E., Tétreault, M. P. & Lund, P. K. Aug 2013 In : Gastroenterology. 145, 2, p. 266-271 6 p.

Research output: Research - peer-reviewArticle

2012
78 Citations

Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

Van Landeghem, L., Santoro, M. A., Krebs, A. E., Mah, A. T., Dehmer, J. J., Gracz, A. D., Scull, B. P., McNaughton, K., Magness, S. T. & Lund, P. K. May 15 2012 In : American journal of physiology. Gastrointestinal and liver physiology. 302, 10

Research output: Research - peer-reviewArticle

Regeneration
Stem Cells
Population
Epithelial Cells
Radiation
11 Citations

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa

Vidal, A. C., Lund, P. K., Hoyo, C., Galanko, J., Burcal, L., Holston, R., Massa, B., Omofoye, O., Sandler, R. S. & Keku, T. O. Sep 5 2012 In : BMC Cancer. 12, 389

Research output: Research - peer-reviewArticle

C-Peptide
Adenoma
Mucous Membrane
Insulin
Insulin-Like Growth Factor Binding Protein 1
8 Citations

Localized Intestinal Radiation and Liquid Diet Enhance Survival and Permit Evaluation of Long-Term Intestinal Responses to High Dose Radiation in Mice

van Landeghem, L., Blue, R. E., Dehmer, J. J., Henning, S. J., Helmrath, M. A. & Lund, P. K. Dec 7 2012 In : PLoS One. 7, 12, e51310

Research output: Research - peer-reviewArticle

liquid diet
mice
dosage
Nutrition
Dosimetry
8 Citations

Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes

Ding, S., Blue, R. E., Chen, Y., Scull, B., Lund, P. K. & Morgan, D. Nov 2012 In : Molecular Imaging. 11, 6, p. 507-515 9 p.

Research output: Research - peer-reviewArticle

Cathepsins
Molecular Probes
Molecular Imaging
Matrix Metalloproteinases
Fluorescent Dyes
15 Citations

Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice

Ding, S., Walton, K. L. W., Blue, R. E., MacNaughton, K., Magness, S. T. & Lund, P. K. Aug 3 2012 In : PLoS One. 7, 8, e42568

Research output: Research - peer-reviewArticle

fibrosis
inflammation
promoter regions
mice
Procollagen
2011
16 Citations

Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells

Hamilton, K. E., Simmons, J. G., Ding, S., Van Landeghem, L. & Lund, P. K. Dec 2011 In : Molecular Cancer Research. 9, 12, p. 1718-1731 14 p.

Research output: Research - peer-reviewArticle

Receptors, Tumor Necrosis Factor, Type II
Colonic Neoplasms
Cytokines
Interleukin-6
Neoplasms
7 Citations

Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice

Speck, K. E., Garrison, A. P., Rigby, R. J., Von Allmen, D. C., Lund, P. K. & Helmrath, M. A. Jun 1 2011 In : Journal of Surgical Research. 168, 1, p. 62-69 8 p.

Research output: Research - peer-reviewArticle

Interleukin-10
Inflammation
Growth
Small Intestine
Colon
25 Citations

Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts

Leen, J. L. S., Izzo, A., Upadhyay, C., Rowland, K. J., Dubé, P. E., Gu, S., Heximer, S. P., Rhodes, C. J., Storm, D. R., Lund, P. K. & Brubaker, P. L. Feb 2011 In : Endocrinology. 152, 2, p. 436-446 11 p.

Research output: Research - peer-reviewArticle

Glucagon-Like Peptide 2
Insulin-Like Growth Factor I
Fibroblasts
Messenger RNA
Myofibroblasts
8 Citations

Postdoctoral training aligned with the academic professoriate

Rybarczyk, B., Lerea, L., Lund, P. K., Whittington, D. & Dykstra, L. Sep 2011 In : BioScience. 61, 9, p. 699-705 7 p.

Research output: Research - peer-reviewArticle

Research
Teaching
Biological Science Disciplines
Students
Education
2010
250 Citations

High-fat diet: Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse

Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C. & Lund, P. K. 2010 In : PLoS One. 5, 8, e12191

Research output: Research - peer-reviewArticle

high fat diet
insulin resistance
obesity
inflammation
bacteria
10 Citations

Suppressor of cytokine signaling-2 gene disruption promotes Apc Min/+ tumorigenesis and activator protein-1 activation

Newton, V. A., Ramocki, N. M., Scull, B. P., Simmons, J. G., McNaughton, K. & Lund, P. K. 2010 In : American Journal of Pathology. 176, 5, p. 2320-2332 13 p.

Research output: Research - peer-reviewArticle

Transcription Factor AP-1
Carcinogenesis
Cytokines
Genes
Neoplasms
1 Citations
Adenoma
Biomarkers
Cytokines
Colorectal Neoplasms
Mucous Membrane
2009
28 Citations

A new animal model of postsurgical bowel inflammation and fibrosis: The effect of commensal microflora

Rigby, R. J., Hunt, M. R., Scull, B. P., Simmons, J. G., Speck, K. E., Helmrath, M. A. & Lund, P. K. Aug 2009 In : Gut. 58, 8, p. 1104-1112 9 p.

Research output: Research - peer-reviewArticle

Interleukin-10
Fibrosis
Animal Models
Inflammation
Small Intestine
45 Citations
Glucagon-Like Peptide 2
Stem Cells
Insulin-Like Growth Factor I
Messenger RNA
Side-Population Cells
2008
29 Citations
Insulin-Like Growth Factor I
Islets of Langerhans
Hypoglycemia
Growth
Cell growth
14 Citations

Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection

Dekaney, C. M., von Allmen, D. C., Garrison, A. P., Rigby, R. J., Lund, P. K., Henning, S. J. & Helmrath, M. A. Aug 2008 In : Surgery. 144, 2, p. 174-181 8 p.

Research output: Research - peer-reviewArticle

Protein Transport
Bile Acids and Salts
Up-Regulation
bile acid binding proteins
Colon
23 Citations

Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of adenomas of the GI tract

Zhang, H., Morgan, D., Cecil, G., Burkholder, A., Ramocki, N., Scull, B. & Lund, P. K. Sep 2008 In : Gastrointestinal Endoscopy. 68, 3, p. 520-527 8 p.

Research output: Research - peer-reviewArticle

Capsule Endoscopy
Molecular Imaging
Adenoma
Gastrointestinal Tract
Fluorescent Dyes
32 Citations

Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9

Ramocki, N. M., Wilkins, H. R., Magness, S. T., Simmons, J. G., Scull, B. P., Lee, G. H., McNaughton, K. K. & Lund, P. K. Jan 2008 In : Endocrinology. 149, 1, p. 261-267 7 p.

Research output: Research - peer-reviewArticle

Insulin Receptor Substrate Proteins
Stem Cells
Apoptosis
Neoplasms
beta Catenin
13 Citations

Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

Keku, T. O., Sandler, R. S., Simmons, J. G., Galanko, J., Woosley, J. T., Proffitt, M., Omofoye, O., McDoom, M. & Lund, P. K. May 22 2008 In : BMC Cancer. 8, 143

Research output: Research - peer-reviewArticle

Insulin-Like Growth Factor Binding Protein 3
Adenoma
Apoptosis
Messenger RNA
Blood Proteins
5 Citations

What are the mechanisms of fibrosis in IBD?

Lund, P. K. & Rigby, R. J. Oct 2008 In : Inflammatory Bowel Diseases. 14 Suppl 2

Research output: Research - peer-reviewArticle

2007
19 Citations

Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth

Simmons, J. G., Ling, Y., Wilkins, H., Fuller, C. R., D'Ercole, A. J., Fagin, J. & Lund, P. K. Nov 2007 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 5

Research output: Research - peer-reviewArticle

Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor I
Colon
Growth
Myofibroblasts
61 Citations
Stem Cells
Bromodeoxyuridine
Flow Cytometry
Immunohistochemistry
Jejunum
105 Citations

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon

Rigby, R. J., Simmons, J. G., Greenhalgh, C. J., Alexander, W. S. & Lund, P. K. Jul 19 2007 In : Oncogene. 26, 33, p. 4833-4841 9 p.

Research output: Research - peer-reviewArticle

Colon
Carcinogenesis
Cytokines
Inflammation
Cre recombinase
2006
19 Citations

Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic mice

Michaylira, C. Z., Ramocki, N. M., Simmons, J. G., Tanner, C. K., McNaughton, K. K., Woosley, J. T., Greenhalgh, C. J. & Lund, P. K. Apr 2006 In : Endocrinology. 147, 4, p. 1632-1641 10 p.

Research output: Research - peer-reviewArticle

Polyps
Haplotypes
Transgenic Mice
Growth Hormone
Cytokines
25 Citations

Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo

Michaylira, C. Z., Simmons, J. G., Ramocki, N. M., Scull, B. P., McNaughton, K. K., Fuller, C. R. & Lund, P. K. 2006 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 3

Research output: Research - peer-reviewArticle

Insulin-Like Growth Factor I
Cytokines
Growth
IGF Type 1 Receptor
Caco-2 Cells
2005

An extraordinary mentor: Judson J. Van Wyk, 1921-2004.

Lund, P. K. 2005 In : Gastroenterology. 128, 1, p. 7 1 p.

Research output: Research - peer-reviewArticle

73 Citations

Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury

Sanz, S., Pucilowska, J. B., Liu, S., Rodríguez-Ortigosa, C. M., Lund, P. K., Brenner, D. A., Fuller, C. R., Simmons, J. G., Pardo, A., Martínez-Chantar, M. L., Fagin, J. A. & Prieto, J. Jan 2005 In : Gut. 54, 1, p. 134-141 8 p.

Research output: Research - peer-reviewArticle

Hepatic Stellate Cells
Liver Regeneration
Insulin-Like Growth Factor I
Wounds and Injuries
Liver
66 Citations

GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus

Helm, K. A., Haberman, R. P., Dean, S. L., Hoyt, E. C., Melcher, T., Lund, P. K. & Gallagher, M. 2005 In : Neuropharmacology. 48, 7, p. 956-964 9 p.

Research output: Research - peer-reviewArticle

Cyclic AMP Response Element-Binding Protein
gamma-Aminobutyric Acid
Hippocampus
(3-aminopropyl)(n-butyl)phosphinic acid
Spatial Memory
31 Citations

Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation

Theiss, A. L., Fuller, C. R., Simmons, J. G., Liu, B., Sartor, R. B. & Lund, P. K. Jul 2005 In : Gastroenterology. 129, 1, p. 204-219 16 p.

Research output: Research - peer-reviewArticle

Growth Hormone
Fibrosis
Cytokines
Inflammation
Peptidoglycan
80 Citations

Insulin resistance, apoptosis, and colorectal adenoma risk

Keku, T. O., Lund, P. K., Galanko, J., Simmons, J. G., Woosley, J. T. & Sandler, R. S. Sep 2005 In : Cancer Epidemiology Biomarkers and Prevention. 14, 9, p. 2076-2081 6 p.

Research output: Research - peer-reviewArticle

Adenoma
Insulin Resistance
Insulin
Apoptosis
Glucose
31 Citations

Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells

Fruchtman, S., Simmons, J. G., Michaylira, C. Z., Miller, M. E., Greenhalgh, C. J., Ney, D. M. & Lund, P. K. Aug 2005 In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 2 52-2

Research output: Research - peer-reviewArticle

Insulin-Like Growth Factor I
Growth Hormone
Cytokines
Collagen
Myofibroblasts
115 Citations

Tumor necrosis factor (TNF) α increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2

Theiss, A. L., Simmons, J. G., Jobin, C. & Lund, P. K. Oct 28 2005 In : Journal of Biological Chemistry. 280, 43, p. 36099-36109 11 p.

Research output: Research - peer-reviewArticle

Receptors, Tumor Necrosis Factor, Type II
Receptors, Tumor Necrosis Factor, Type I
Myofibroblasts
Collagen
Tumor Necrosis Factor-alpha
2004
7 Citations

Differential inhibition of postnatal brain, spinal cord and body growth by a growth hormone antagonist

McIlwain, D. L., Hoke, V. B., Kopchick, J. J., Fuller, C. R. & Lund, P. K. Feb 23 2004 In : BMC Neuroscience. 5, 6

Research output: Research - peer-reviewArticle

Hormone Antagonists
Growth Hormone
Spinal Cord
Brain
Growth
13 Citations

Postreceptor Resistance to Exogenous Growth Hormone Exists in the Jejunal Mucosa of Parenterally Fed Rats

Dahly, E. M., Miller, M. E., Lund, P. K. & Ney, D. M. Mar 2004 In : Journal of Nutrition. 134, 3, p. 530-537 8 p.

Research output: Research - peer-reviewArticle

somatotropin
mucosa
rats
Growth Hormone
Mucous Membrane
41 Citations

Suppressor of cytokine signaling-2: A growth hormone-inducible inhibitor of intestinal epithelial cell proliferation

Miller, M. E., Michaylira, C. Z., Simmons, J. G., Ney, D. M., Dahly, E. M., Heath, J. K. & Lund, P. K. Aug 2004 In : Gastroenterology. 127, 2, p. 570-581 12 p.

Research output: Research - peer-reviewArticle

Growth Hormone
Epithelial Cells
Cell Proliferation
Cytokines
Insulin-Like Growth Factor I