• 8212 Citations
  • 51 h-Index
1975 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1975 2018

2018

Nutritional control of gastrointestinal hormone gene expression

Lund, P. K., Jan 1 2018, Nutrition and Gene Expression. CRC Press, p. 91-116 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gastrointestinal Hormones
Gene Expression
2017
4 Citations
Fluorescent Dyes
Epidermal Growth Factor Receptor
Optical Imaging
Colon
Carcinogenesis
2 Citations

Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation

Kechele, D. O., Blue, R. E., Zwarycz, B., Espenschied, S. T., Mah, A. T., Siegel, M. B., Perou, C. M., Ding, S., Magness, S. T., Lund, P. K. & Caron, K. M., Feb 1 2017, In : Journal of Clinical Investigation. 127, 2, p. 593-607 15 p.

Research output: Contribution to journalArticle

Orphaned Children
Adenoma
Regeneration
Stem Cells
Organoids
2016
9 Citations

Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis

Rigby, R. J., Carr, J., Orgel, K., King, S. L., Lund, P. K. & Dekaney, C. M., Sep 2 2016, In : Gut microbes. 7, 5, p. 414-423 10 p.

Research output: Contribution to journalArticle

Doxorubicin
Enterobacteriaceae
Apoptosis
Bacteria
Paneth Cells
9 Citations

miR-30 family controls proliferation and differentiation of intestinal epithelial cell models by directing a broad gene expression program that includes SOX9 and the ubiquitin ligase pathway

Peck, B. C. E., Sincavage, J., Feinstein, S., Mah, A. T., Simmons, J. G., Lund, P. K. & Sethupathy, P., Jul 29 2016, In : Journal of Biological Chemistry. 291, 31, p. 15975-15984 10 p.

Research output: Contribution to journalArticle

Ligases
Ubiquitin
Gene expression
Epithelial Cells
Gene Expression
20 Citations

The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

Koblansky, A. A., Truax, A. D., Liu, R., Montgomery, S. A., Ding, S., Wilson, J. E., Brickey, W. J., Mühlbauer, M., McFadden, R. M. T., Hu, P., Li, Z., Jobin, C., Lund, P. K. & Ting, J. P. Y., Mar 22 2016, In : Cell Reports. 14, 11, p. 2562-2575 14 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Tumors
Colon
Carcinogenesis
Colonic Neoplasms
2015
10 Citations

Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and paneth cell mRNAs

Andres, S. F., Agostina Santoro, M., Mah, A. T., Adeola Keku, J., Bortvedt, A. E., Eric Blue, R. & Kay Lund, P., Jan 15 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 2, p. G100-G111

Research output: Contribution to journalArticle

Paneth Cells
Enteroendocrine Cells
Insulin Receptor
High Fat Diet
Stem Cells
25 Citations

IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations

Van Landeghem, L., Santoro, M. A., Mah, A. T., Krebs, A. E., Dehmer, J. J., McNaughton, K. K., Helmrath, M. A., Magness, S. T. & Lund, P. K., Jul 1 2015, In : FASEB Journal. 29, 7, p. 2828-2842 15 p.

Research output: Contribution to journalArticle

Somatomedins
Stem cells
Stem Cells
Chemical activation
Population
4 Citations

Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon

Santoro, M. A., Blue, R. E., Andres, S. F., Mah, A. T., Van Landeghem, L. & Lund, P. K., Sep 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 7, p. G578-G589

Research output: Contribution to journalArticle

Somatomedin Receptors
Insulin Receptor
Colon
Obesity
Radiation
7 Citations

Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury

Poindexter, S. V., Reddy, V. K., Mittal, M. K., Williams, A. M., Washington, M. K., Harris, E., Mah, A., Hiebert, S. W., Singh, K., Chaturvedi, R., Wilson, K. T., Lund, P. K. & Williams, C. S., Jan 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 6, p. G562-G571

Research output: Contribution to journalArticle

Co-Repressor Proteins
Radiation Injuries
Regeneration
Apoptosis
Goblet Cells
2014
5 Citations
Molecular Probes
Colitis
Fluorescent Dyes
Dextran Sulfate
Inflammation
27 Citations

Impact of diet-induced obesity on intestinal stem cells: Hyperproliferation but impaired intrinsic function that requires insulin/IGF1

Mah, A. T., Landeghem, L. V., Gavin, H. E., Magness, S. T. & Lund, P. K., Jan 1 2014, In : Endocrinology. 155, 9, p. 3302-3314 13 p.

Research output: Contribution to journalArticle

Somatomedins
Stem Cells
Obesity
Insulin
Diet
47 Citations

MicroRNA-29 fine-tunes the expression of key foxa2- Activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes

Kurtz, C. L., Peck, B. C. E., Fannin, E. E., Beysen, C., Miao, J., Landstreet, S. R., Ding, S., Turaga, V., Lund, P. K., Turner, S., Biddinger, S. B., Vickers, K. C. & Sethupathy, P., Jan 1 2014, In : Diabetes. 63, 9, p. 3141-3148 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Lipid Metabolism
Insulin Resistance
Animal Models
pioglitazone
9 Citations
RNA Isoforms
Somatomedin Receptors
Insulin Receptor
Adenoma
Mucous Membrane
2013
26 Citations

Impact of Ileocecal Resection and Concomitant Antibiotics on the Microbiome of the Murine Jejunum and Colon

Devine, A. A., Gonzalez, A., Speck, K. E., Knight, R., Helmrath, M., Lund, P. K. & Azcarate-Peril, M. A., Aug 27 2013, In : PloS one. 8, 8, e73140.

Research output: Contribution to journalArticle

Microbiota
resection
Jejunum
jejunum
colon
27 Citations

Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: Evidence that IR-B limits proliferation

Andres, S. F., Simmons, J. G., Mah, A. T., Santoro, M. A., Van Landeghem, L. & Lund, P. K., Dec 15 2013, In : Journal of Cell Science. 126, 24, p. 5645-5656 12 p.

Research output: Contribution to journalArticle

Insulin Receptor
Protein Isoforms
Stem Cells
Neoplasms
Epithelial Cells
2 Citations

Opportunities and challenges for women phd investigators in gastrointestinal research

Hamilton, K. E., Tétreault, M. P. & Lund, P. K., Jan 1 2013, In : Gastroenterology. 145, 2, p. 266-271 6 p.

Research output: Contribution to journalArticle

Sexism
Gastroenterology
Research Personnel
Research
2012
88 Citations

Activation of two distinct Sox9-EGFP-expressing intestinal stem cell populations during crypt regeneration after irradiation.

Van Landeghem, L., Santoro, M. A., Krebs, A. E., Mah, A. T., Dehmer, J. J., Gracz, A. D., Scull, B. P., McNaughton, K., Magness, S. T. & Lund, P. K., May 15 2012, In : American journal of physiology. Gastrointestinal and liver physiology. 302, 10

Research output: Contribution to journalArticle

Regeneration
Stem Cells
Population
Epithelial Cells
Organoids
11 Citations

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa

Vidal, A. C., Lund, P. K., Hoyo, C., Galanko, J., Burcal, L., Holston, R., Massa, B., Omofoye, O., Sandler, R. S. & Keku, T. O., Sep 5 2012, In : BMC cancer. 12, 389.

Research output: Contribution to journalArticle

C-Peptide
Adenoma
Insulin-Like Growth Factor Binding Protein 1
Mucous Membrane
Insulin
11 Citations

Fixing the breaks in intestinal stem cells after radiation: A matter of DNA damage and death or DNA repair and regeneration

Lund, P. K., Jan 1 2012, In : Gastroenterology. 143, 5, p. 1144-1147 4 p.

Research output: Contribution to journalReview article

Adult Stem Cells
Double-Stranded DNA Breaks
Radiation Tolerance
Jejunum
DNA Repair
46 Citations

Insulin-like growth factor 1: Common mediator of multiple enterotrophic hormones and growth factors

Bortvedt, S. F. & Lund, P. K., Mar 1 2012, In : Current Opinion in Gastroenterology. 28, 2, p. 89-98 10 p.

Research output: Contribution to journalReview article

Somatomedins
Intercellular Signaling Peptides and Proteins
Hormones
Glucagon-Like Peptide 2
Growth
9 Citations

Localized Intestinal Radiation and Liquid Diet Enhance Survival and Permit Evaluation of Long-Term Intestinal Responses to High Dose Radiation in Mice

van Landeghem, L., Blue, R. E., Dehmer, J. J., Henning, S. J., Helmrath, M. A. & Lund, P. K., Dec 7 2012, In : PLoS One. 7, 12, e51310.

Research output: Contribution to journalArticle

liquid diet
Nutrition
Dosimetry
Radiation
Diet
10 Citations

Molecular imaging of gastric neoplasia with near-infrared fluorescent activatable probes

Ding, S., Blue, R. E., Chen, Y., Scull, B., Lund, P. K. & Morgan, D., Nov 1 2012, In : Molecular imaging. 11, 6, p. 507-515 9 p.

Research output: Contribution to journalArticle

Molecular imaging
Cathepsins
Molecular Probes
Molecular Imaging
Matrix Metalloproteinases
18 Citations

Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice

Ding, S., Walton, K. L. W., Blue, R. E., MacNaughton, K., Magness, S. T. & Lund, P. K., Aug 3 2012, In : PLoS One. 7, 8, e42568.

Research output: Contribution to journalArticle

Procollagen
fibrosis
Fibrosis
inflammation
promoter regions
2011
24 Citations

Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells

Hamilton, K. E., Simmons, J. G., Ding, S., Van Landeghem, L. & Lund, P. K., Dec 2011, In : Molecular Cancer Research. 9, 12, p. 1718-1731 14 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type II
Colonic Neoplasms
Cytokines
Interleukin-6
Response Elements
9 Citations

Inflammation enhances resection-induced intestinal adaptive growth in IL-10 null mice

Speck, K. E., Garrison, A. P., Rigby, R. J., Von Allmen, D. C., Lund, P. K. & Helmrath, M. A., Jun 1 2011, In : Journal of Surgical Research. 168, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Interleukin-10
Inflammation
Growth
Small Intestine
Colon
30 Citations

Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts

Leen, J. L. S., Izzo, A., Upadhyay, C., Rowland, K. J., Dubé, P. E., Gu, S., Heximer, S. P., Rhodes, C. J., Storm, D. R., Lund, P. K. & Brubaker, P. L., Feb 1 2011, In : Endocrinology. 152, 2, p. 436-446 11 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 2
Insulin-Like Growth Factor I
Fibroblasts
Myofibroblasts
Messenger RNA
11 Citations

Postdoctoral training aligned with the academic professoriate

Rybarczyk, B., Lerea, L., Lund, P. K., Whittington, D. & Dykstra, L., Sep 1 2011, In : BioScience. 61, 9, p. 699-705 7 p.

Research output: Contribution to journalArticle

Research
Teaching
professional development
Biological Science Disciplines
education programs
68 Citations
Insulin Resistance
Obesity
Inflammation
Diet
High Fat Diet
54 Citations

Themes in fibrosis and gastrointestinal inflammation

Fiocchi, C. & Kay Lund, P., May 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 300, 5

Research output: Contribution to journalEditorial

Fibrosis
Inflammation
Wound Healing
Gastrointestinal Diseases
Extracellular Matrix
2010
292 Citations

High-fat diet: Bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse

Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C. & Lund, P. K., Oct 19 2010, In : PLoS One. 5, 8, e12191.

Research output: Contribution to journalArticle

High Fat Diet
high fat diet
Nutrition
insulin resistance
Insulin Resistance
10 Citations

Suppressor of cytokine signaling-2 gene disruption promotes Apc Min/+ tumorigenesis and activator protein-1 activation

Newton, V. A., Ramocki, N. M., Scull, B. P., Simmons, J. G., McNaughton, K. & Lund, P. K., Jan 1 2010, In : American Journal of Pathology. 176, 5, p. 2320-2332 13 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Carcinogenesis
Cytokines
Genes
Small Intestine
1 Citations
Biomarkers
Adenoma
Cytokines
Colorectal Neoplasms
Mucous Membrane
2009
28 Citations

A new animal model of postsurgical bowel inflammation and fibrosis: The effect of commensal microflora

Rigby, R. J., Hunt, M. R., Scull, B. P., Simmons, J. G., Speck, K. E., Helmrath, M. A. & Lund, P. K., Aug 1 2009, In : Gut. 58, 8, p. 1104-1112 9 p.

Research output: Contribution to journalArticle

Interleukin-10
Fibrosis
Animal Models
Inflammation
Small Intestine
48 Citations
Glucagon-Like Peptide 2
Stem Cells
Insulin-Like Growth Factor I
Side-Population Cells
Messenger RNA
2008
31 Citations
Insulin-Like Growth Factor I
Islets of Langerhans
Hypoglycemia
Growth
Metallothionein
16 Citations

Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection

Dekaney, C. M., von Allmen, D. C., Garrison, A. P., Rigby, R. J., Lund, P. K., Henning, S. J. & Helmrath, M. A., Aug 1 2008, In : Surgery. 144, 2, p. 174-181 8 p.

Research output: Contribution to journalArticle

Protein Transport
Bile Acids and Salts
Up-Regulation
Colon
Immunohistochemistry
24 Citations

Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of adenomas of the GI tract

Zhang, H., Morgan, D., Cecil, G., Burkholder, A., Ramocki, N., Scull, B. & Lund, P. K., Sep 1 2008, In : Gastrointestinal endoscopy. 68, 3, p. 520-527 8 p.

Research output: Contribution to journalArticle

Capsule Endoscopy
Molecular Imaging
Adenoma
Gastrointestinal Tract
Fluorescent Dyes
36 Citations

Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9

Ramocki, N. M., Wilkins, H. R., Magness, S. T., Simmons, J. G., Scull, B. P., Lee, G. H., McNaughton, K. K. & Lund, P. K., Jan 2008, In : Endocrinology. 149, 1, p. 261-267 7 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Stem Cells
Apoptosis
Neoplasms
beta Catenin
14 Citations

Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

Keku, T. O., Sandler, R. S., Simmons, J. G., Galanko, J., Woosley, J. T., Proffitt, M., Omofoye, O., McDoom, M. & Lund, P. K., May 22 2008, In : BMC Cancer. 8, 143.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor Binding Protein 3
Adenoma
Apoptosis
Messenger RNA
Blood Proteins
5 Citations

What are the mechanisms of fibrosis in IBD?

Lund, P. K. & Rigby, R. J., Oct 2008, In : Inflammatory Bowel Diseases. 14 Suppl 2

Research output: Contribution to journalArticle

Intestinal Mucosa
Inflammatory Bowel Diseases
Pathologic Constriction
Fibrosis
2007
20 Citations

Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth

Simmons, J. G., Ling, Y., Wilkins, H., Fuller, C. R., D'Ercole, A. J., Fagin, J. & Lund, P. K., Nov 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 5

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor I
Colon
Growth
Myofibroblasts
70 Citations
Stem Cells
Bromodeoxyuridine
Flow Cytometry
Immunohistochemistry
Jejunum
111 Citations

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon

Rigby, R. J., Simmons, J. G., Greenhalgh, C. J., Alexander, W. S. & Lund, P. K., Jul 19 2007, In : Oncogene. 26, 33, p. 4833-4841 9 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Cytokines
Inflammation
Dextran Sulfate
2006
20 Citations

Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic mice

Michaylira, C. Z., Ramocki, N. M., Simmons, J. G., Tanner, C. K., McNaughton, K. K., Woosley, J. T., Greenhalgh, C. J. & Lund, P. K., Apr 1 2006, In : Endocrinology. 147, 4, p. 1632-1641 10 p.

Research output: Contribution to journalArticle

Polyps
Haplotypes
Transgenic Mice
Growth Hormone
Cytokines
1 Citations

SOC-ing It to Tumors: Suppressors of Cytokine Signaling as Tumor Repressors

Lund, P. K. & Rigby, R. J., Jan 1 2006, In : Gastroenterology. 131, 1, p. 317-319 3 p.

Research output: Contribution to journalEditorial

Neoplastic Gene Expression Regulation
Neoplasm DNA
Liver Neoplasms
Tumor Biomarkers
Tumor Cell Line
28 Citations

Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo

Michaylira, C. Z., Simmons, J. G., Ramocki, N. M., Scull, B. P., McNaughton, K. K., Fuller, C. R. & Lund, P. K., Sep 11 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 3

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Insulin-Like Growth Factor I
Cytokines
Growth
Caco-2 Cells
2005

An extraordinary mentor: Judson J. Van Wyk, 1921-2004.

Lund, P. K., Jan 1 2005, In : Gastroenterology. 128, 1, 1 p.

Research output: Contribution to journalArticle

20th Century History
Mentors
Gastroenterology
Insulin-Like Growth Factor I
Research

Comment from the editors

Lund, P. K., Jan 1 2005, In : Gastroenterology. 128, 1, 1 p.

Research output: Contribution to journalComment/debate

78 Citations

Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury

Sanz, S., Pucilowska, J. B., Liu, S., Rodríguez-Ortigosa, C. M., Lund, P. K., Brenner, D. A., Fuller, C. R., Simmons, J. G., Pardo, A., Martínez-Chantar, M. L., Fagin, J. A. & Prieto, J., Jan 1 2005, In : Gut. 54, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Liver Regeneration
Insulin-Like Growth Factor I
Wounds and Injuries
Liver