• 21398 Citations
  • 75 h-Index
1984 …2018
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Projects 1986 2018

Patient Care
Costs and Cost Analysis
Research

North Carolina Translational & Clinical Sciences Institute (NC TraCS)

Fraser, M. W., Wohl, D. A., Weber, D. J., Bangdiwala, S. I., Carey, T. S., Phillips, C. L., Miller, W. C., Jonsson-Funk, M. L., Jones, S. W., Beck, J. D., Mauriello, S. M., Retsch-Bogart, G. Z., Falk, R. J., Jordan, J. M., Ammerman, A. S., Carpenter, W. R., Edwards, L. J., Garrett, J. M., Coyne-Beasley, T., Henderson, G. E., Stewart, P. W., Davis, A. M., Evans, J. P., Gilmore, J. H., Gaynes, B. N., Brookhart, M. A., Sleath, B. L., Offenbacher, S., Marzluff, W. F., Topal, M. D., Orringer, E. P., Qaqish, B. F., Leigh, M. W., Peden, D. B., Buse, J. B., Tolleson-Rinehart, S., Ransohoff, D. F., Funkhouser, W. K., Egan, T. M., Cai, J., Truong, K. N., Brouwer, K. L., Boucher, R. C., Sen, P. K., Reuland, D. S., Donahue, K. E., Weiner, B. J., Watkins, P. B., Lin, W., Perrin, E. M., Magnuson, T. R., Corbie-Smith, G. M., Duncan, J. A., Weinberger, M., Zeng, D., Meshnick, S. R., Ibrahim, J. G., Dilworth-Anderson, P., Johnson, G. L., Walker, R. L., Viera, A. J., Glickman, S. W., Halladay, J. R., Rennie, S. M., Key, N. S., Rubin, J. E., Kosorok, M. R., Zhu, H., Bair, E., Henning, S. J., Mackman, N., Fine, J. P., Mayer-Davis, E. J., Stuermer, T. H. R., Davis, R. M., Park, S. I., Wu, M. C., Carpenter, D. M., Fang, G., Weaver, M. A., Lin, F., Davis, S. M., Shea, C. M., Carter-Edwards, L., Dennis, A. M., Fisher, J. A., Golightly, Y. M., Hingtgen, S. D., Smith, A. M., Tan, J. T., Asher, G. N., Barritt, A. S., Blouin, R., Buchbinder, M., Hurt, C., Juengst, E. T., Mendoza, L. C., Reeve, B., Roman Isler, M. D., Wood, W. A., Ahalt, S., Agans, R. P., Dave, G. J., Zhou, H., Skinner, A. C., Wilhelmsen, K. C., Song, L., Fischer, W. A., Peery, A. F., Powers, K. A., Sims, C. E., Mostafa, J., Lightfoot, A. F., Ryan, A. E., Otey, C. A., Donaldson, S. H., Leeman, J., Kashuba, A. D., Gomez, S. M., Chung, A. E., Meyer, A. M., Parrott, M. C., Toles, M. P., Schmitt, C., Nichols, H. B. & Moran, T. P.

NIH National Center for Advancing Translational Sciences (NCATS)

9/26/134/30/18

Project: Research project

Annual Reports

North Carolina Translational & Clinical Sciences Institute (NC TraCS)

Fraser, M. W., Sims, C. E., Mostafa, J., Wohl, D. A., Weber, D. J., Bangdiwala, S. I., Carey, T. S., Phillips, C. L., Miller, W. C., Jonsson-Funk, M. L., Jones, S. W., Beck, J. D., Mauriello, S. M., Retsch-Bogart, G. Z., Falk, R. J., Jordan, J. M., Ammerman, A. S., Carpenter, W. R., Edwards, L. J., Garrett, J. M., Coyne-Beasley, T., Henderson, G. E., Stewart, P. W., Davis, A. M., Evans, J. P., Gilmore, J. H., Gaynes, B. N., Brookhart, M. A., Sleath, B. L., Offenbacher, S., Marzluff, W. F., Topal, M. D., Orringer, E. P., Qaqish, B. F., Leigh, M. W., Peden, D. B., Buse, J. B., Tolleson-Rinehart, S., Ransohoff, D. F., Funkhouser, W. K., Egan, T. M., Cai, J., Truong, K. N., Brouwer, K. L., Boucher, R. C., Sen, P. K., Reuland, D. S., Donahue, K. E., Weiner, B. J., Watkins, P. B., Lin, W., Perrin, E. M., Magnuson, T. R., Corbie-Smith, G. M., Duncan, J. A., Weinberger, M., Zeng, D., Meshnick, S. R., Ibrahim, J. G., Dilworth-Anderson, P., Johnson, G. L., Walker, R. L., Viera, A. J., Glickman, S. W., Halladay, J. R., Rennie, S. M., Key, N. S., Rubin, J. E., Kosorok, M. R., Zhu, H., Bair, E., Henning, S. J., Mackman, N., Fine, J. P., Mayer-Davis, E. J., Stuermer, T. H. R., Davis, R. M., Park, S. I., Wu, M. C., Carpenter, D. M., Fang, G., Weaver, M. A., Lin, F., Davis, S. M., Shea, C. M., Carter-Edwards, L., Dennis, A. M., Fisher, J. A., Golightly, Y. M., Hingtgen, S. D., Smith, A. M., Tan, J. T., Asher, G. N., Barritt, A. S., Blouin, R., Buchbinder, M., Hurt, C., Juengst, E. T., Mendoza, L. C., Reeve, B., Roman Isler, M. D., Wood, W. A., Ahalt, S., Agans, R. P., Dave, G. J., Lightfoot, A. F., Zhou, H., Skinner, A. C., Wilhelmsen, K. C., Song, L., Fischer, W. A., Peery, A. F., Powers, K. A., Ryan, A. E., Otey, C. A., Donaldson, S. H., Leeman, J., Kashuba, A. D., Gomez, S. M., Chung, A. E., Meyer, A. M., Parrott, M. C., Toles, M. P., Schmitt, C., Nichols, H. B. & Moran, T. P.

NIH National Center for Advancing Translational Sciences (NCATS)

9/26/134/30/18

Project: Research project

Annual Reports

Research Output 1984 2018

An introduction to DILIsym® software, a mechanistic mathematical representation of drug-induced liver injury

Battista, C., Howell, B. A., Siler, S. Q. & Watkins, P. B. Jan 1 2018 Methods in Pharmacology and Toxicology. 9781493976768 ed. Humana Press Inc., p. 101-121 21 p. (Methods in Pharmacology and Toxicology; no. 9781493976768)

Research output: Chapter in Book/Report/Conference proceedingChapter

Chemical and Drug Induced Liver Injury
Software
Biomarkers
Public-Private Sector Partnerships
Safety
Chemical and Drug Induced Liver Injury
Biomarkers
Acetaminophen
Clinical Trials
Liver

In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials

Church, R. J. & Watkins, P. B. Feb 1 2018 In : Experimental Biology and Medicine. 243, 3, p. 300-307 8 p.

Research output: Contribution to journalArticle

Slip forming
Chemical and Drug Induced Liver Injury
Computer Simulation
Biomarkers
Clinical Trials

Liver Safety of Fasiglifam (TAK-875) in Patients with Type 2 Diabetes: Review of the Global Clinical Trial Experience

Marcinak, J. F., Munsaka, M. S., Watkins, P. B., Ohira, T. & Smith, N. Jun 1 2018 In : Drug Safety. 41, 6, p. 625-640 16 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Clinical Trials
Safety
Liver
Intelligent control

Optimized methods to explore the mechanistic and biomarker potential of hepatocyte-derived exosomes in drug-induced liver injury

Thacker, S. E., Nautiyal, M., Otieno, M. A., Watkins, P. B. & Mosedale, M. May 1 2018 In : Toxicological Sciences. 163, 1, p. 92-100 9 p.

Research output: Contribution to journalArticle

Slip forming
Exosomes
Chemical and Drug Induced Liver Injury
Hepatocytes
Biomarkers