• 9577 Citations
  • 55 h-Index
1976 …2018
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  • 9 Similar Profiles
Molecular Dynamics Simulation Medicine & Life Sciences
Proteins Medicine & Life Sciences
Protein Folding Medicine & Life Sciences
Mutation Medicine & Life Sciences
RNA Medicine & Life Sciences
Molecular dynamics Chemical Compounds
Cystic Fibrosis Transmembrane Conductance Regulator Medicine & Life Sciences
Thermodynamics Medicine & Life Sciences

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Projects 1976 2017

Research Output 1994 2018

Ca2-mediated activation of the skeletal-muscle ryanodine receptor ion channel

Xu, L., Chirasani, V. R., Carter, J. S., Pasek, D. A., Dokholyan, N. V., Yamaguchi, N. & Meissner, G. W., Jan 1 2018, In : Journal of Biological Chemistry. 293, 50, p. 19501-19509 9 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Ion Channels
Muscle
Skeletal Muscle
Chemical activation

Computational design of chemogenetic and optogenetic split proteins

Dagliyan, O., Krokhotin, A., Ozkan-Dagliyan, I., Deiters, A., Der, C. J., Hahn, K. M. & Dokholyan, N. V., Dec 1 2018, In : Nature communications. 9, 1, 4042.

Research output: Contribution to journalArticle

Optogenetics
proteins
Proteins
assembly
Biological Phenomena
1 Citations

G4941K substitution in the pore-lining S6 helix of the skeletal muscle ryanodine receptor increases RyR1 sensitivity to ytosolic and luminal Ca2+

Xu, L., Mowrey, D. D., Chirasani, V. R., Wang, Y., Pasek, D. A., Dokholyan, N. V. & Meissner, G. W., Jan 1 2018, In : Journal of Biological Chemistry. 293, 6, p. 2015-2028 14 p.

Research output: Contribution to journalArticle

S 6
Ryanodine Receptor Calcium Release Channel
Linings
Muscle
Skeletal Muscle
3 Citations

High-speed atomic force microscopy reveals structural dynamics of α -synuclein monomers and dimers

Zhang, Y., Hashemi, M., Lv, Z., Williams, B., Popov, K. I., Dokholyan, N. V. & Lyubchenko, Y. L., Mar 28 2018, In : Journal of Chemical Physics. 148, 12, 123322.

Research output: Contribution to journalArticle

alpha-Synuclein
dynamic structural analysis
Structural dynamics
Dimers
Atomic force microscopy
1 Citations
Amyotrophic Lateral Sclerosis
Cell Survival
Motor Neurons
Poisons
Neurodegenerative Diseases