Research Output 2000 2017

  • 373 Citations
  • 12 h-Index
  • 37 Article
  • 1 Comment/debate
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Article
2017

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Jan 27 2017 In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Double-Stranded DNA Breaks
Alkaloids
Tumor Cell Line
Tumors

A novel clerodane diterpene from Vitex cofassus

Rasyid, F. A., Fukuyoshi, S., Ando, H., Miyake, K., Atsumi, T., Fujie, T., Saito, Y., Goto, M., Shinya, T., Mikage, M., Sasaki, Y. & Nakagawa-Goto, K. 2017 In : Chemical and Pharmaceutical Bulletin. 65, 1, p. 116-120 5 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes
Vitex
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cells
2 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxicity
Derivatives
irinotecan
lissamine rhodamine B
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y. Mar 1 2016 In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
alkaloids
1 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Contribution to journalArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Monomers
Cells
7 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H. Mar 1 2016 In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Contribution to journalArticle

Oxytropis
Alkaloids
Cells
Derivatives
Cell Line
5 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H. Jun 10 2016 In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
irinotecan
Structure-Activity Relationship
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H. Sep 1 2016 In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J. Nov 16 2016 In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction
1 Citations

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria

Suzuki, A., Miyake, K., Saito, Y., Rasyid, F. A., Tokuda, H., Takeuchi, M., Suzuki, N., Ichiishi, E., Fujie, T., Goto, M., Sasaki, Y. & Nakagawa-Goto, K. Jun 15 2016 (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Thymelaeaceae
Chromones
Tumor Cell Line
Tumors
Cells
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Jul 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tumor Cell Line
Tumors
Cells
Quinazolines
3 Citations

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Nakagawa-Goto, K., Taniguchi, Y., Watanabe, Y., Oda, A., Ohkoshi, E., Hamel, E., Lee, K. H. & Goto, M. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 22, p. 6048-6057 10 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Naphthalenes
Chromones
Tubulin
Colchicine
2015
10 Citations

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J. Jan 1 2015 In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Endoplasmic Reticulum Stress
Cyclin A2
Growth
Neoplasm Metastasis
14 Citations

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

Song, Z. L., Chen, H. L., Wang, Y. H., Goto, M., Gao, W. J., Cheng, P. L., Morris-Natschke, S. L., Liu, Y. Q., Zhu, G. X., Wang, M. J. & Lee, K. H. May 30 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 13, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

irinotecan
Camptothecin
Tumor Cell Line
Polyethylene glycols
Cells
24 Citations

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

Nakagawa-Goto, K., Oda, A., Hamel, E., Ohkoshi, E., Lee, K. H. & Goto, M. Mar 12 2015 In : Journal of Medicinal Chemistry. 58, 5, p. 2378-2389 12 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Tubulin
Microtubules
Interphase
Hydrogen
8 Citations

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

Wada, K., Ohkoshi, E., Zhao, Y., Goto, M., Morris-Natschke, S. L. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 7, p. 1525-1531 7 p.

Research output: Contribution to journalArticle

Aconitum
Diterpenes
Alkaloids
Vincristine
Tumors
10 Citations

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Pharmaceutical Preparations
Phosphorylation
9 Citations

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

Wang, S. B., Wang, X. F., Qin, B., Ohkoshi, E., Hsieh, K. Y., Hamel, E., Cui, M. T., Zhu, D. Q., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5740-5747 8 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Colchicine
Tubulin
Antineoplastic Agents
Assays
3 Citations

Six new norditerpenoid alkaloids from Delphinium elatum

Wada, K., Chiba, R., Kanazawa, R., Matsuoka, K., Suzuki, M., Ikuta, M., Goto, M., Yamashita, H. & Lee, K. H. Jan 1 2015 In : Phytochemistry Letters. 12, p. 79-83 5 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
2014
26 Citations

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J. , Liu, Y. Q. , Chang, L. C. , Wang, C. Y. , Zhao, Y. L. , Zhao, X. B. , Qian, K. , Nan, X. , Yang, L. , Yang, X. M. , Hung, H. Y. , Yang, J. S. , Kuo, D. H. , Goto, M. , Morris-Natschke, S. L. , Pan, S. L. , Teng, C. M. , Kuo, S. C. , Wu, T. S. , Wu, Y. C. & 1 others Lee, K. H. Jul 24 2014 In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
irinotecan
Antineoplastic Agents
DNA Damage
7 Citations

Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Goto, M., Song, Z. L., Morris-Natschke, S. L., Zhao, Y., Wu, D., Yang, L., Li, S. G., Liu, Y. Q., Zhu, G. X., Wu, X. B. & Lee, K. H. Aug 15 2014 In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3850-3853 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Topotecan
Derivatives
7 Citations

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Wu, D., Wang, M. J., Goto, M., Morris-Natschke, S. L., Liu, Y. Q., Wu, X. B., Song, Z. L., Zhu, G. X. & Lee, K. H. Nov 15 2014 In : Bioorganic and Medicinal Chemistry. 22, 22, p. 6453-6458 6 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Cells
Cytotoxicity
10 Citations

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

Wang, Y. H., Goto, M., Wang, L. T., Hsieh, K. Y., Morris-Natschke, S. L., Tang, G. H., Long, C. L. & Lee, K. H. Oct 15 2014 In : Bioorganic and Medicinal Chemistry Letters. 24, 20, p. 4818-4821 4 p.

Research output: Contribution to journalArticle

Piper
Multiple Drug Resistance
Alkaloids
Amides
Tumors
3 Citations

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

Yang, L., Wang, M. J., Zhang, Z. J., Morris-Natschke, S. L., Goto, M., Tian, J., Liu, Y. Q., Wang, C. Y., Tian, X., Yang, X. M. & Lee, K. H. Jan 1 2014 In : Medicinal Chemistry Research. 23, 7, p. 3269-3273 5 p.

Research output: Contribution to journalArticle

Fluorouracil
Antineoplastic Agents
Lung Neoplasms
Cells
Derivatives
2013
15 Citations

Discovery of novel andrographolide derivatives as cytotoxic agents

Wei, S., Tang, Y. B., Hua, H., Ohkoshi, E., Goto, M., Wang, L. T., Lee, K. H. & Xiao, Z. Jul 15 2013 In : Bioorganic and Medicinal Chemistry Letters. 23, 14, p. 4056-4060 5 p.

Research output: Contribution to journalArticle

Cytotoxins
Tumors
Cells
Derivatives
Diterpenes
12 Citations

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

Zhao, Y., Su, J., Goto, M., Morris-Natschke, S. L., Li, Y., Zhao, Q. S., Yao, Z. J. & Lee, K. H. Jun 13 2013 In : Journal of Medicinal Chemistry. 56, 11, p. 4749-4757 9 p.

Research output: Contribution to journalArticle

Taxoids
Tumor Cell Line
Microtubules
Taxus
Antimitotic Agents
2012
1 Citations

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

Hung, H. Y., Ohkoshi, E., Goto, M., Nakagawa-Goto, K. & Lee, K. H. Dec 15 2012 In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7726-7729 4 p.

Research output: Contribution to journalArticle

Ethane
Vincristine
Verapamil
Esters
Chromones
22 Citations
Vincristine
Antineoplastic Agents
P-Glycoprotein
Verapamil
Doxorubicin
19 Citations

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

Shi, Q., Wada, K., Ohkoshi, E., Lin, L., Huang, R., Morris-Natschke, S. L., Goto, M. & Lee, K. H. Jul 1 2012 In : Bioorganic and Medicinal Chemistry. 20, 13, p. 4020-4031 12 p.

Research output: Contribution to journalArticle

Curcumin
Antineoplastic Agents
Androgens
Pseudopodia
Prostatic Neoplasms
2011
17 Citations

Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

Nakagawa-Goto, K., Wu, P. C., Lai, C. Y., Hamel, E., Zhu, H., Zhang, L., Kozaka, T., Ohkoshi, E., Goto, M., Bastow, K. F. & Lee, K. H. Mar 10 2011 In : Journal of Medicinal Chemistry. 54, 5, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Cytotoxins
Antineoplastic Agents
P-Glycoprotein
Cell Line
Colchicine
12 Citations

Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action

Nakagawa-Goto, K., Wu, P. C., Bastow, K. F., Yang, S. C., Yu, S. L., Chen, H. Y., Lin, J. C., Goto, M., Morris-Natschke, S. L., Yang, P. C. & Lee, K. H. Mar 1 2011 In : Bioorganic and Medicinal Chemistry. 19, 5, p. 1816-1822 7 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Tumor Cell Line
Antineoplastic Agents
Tumors
Chemical activation
2010
13 Citations

Antitumor agents. 282. 2′-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent

Usami, Y., Nakagawa-Goto, K., Lang, J. Y., Kim, Y., Lai, C. Y., Goto, M., Sakurai, N., Taniguchi, M., Akiyama, T., Morris-Natschke, S. L., Bastow, K. F., Cragg, G., Newman, D. J., Fujitake, M., Takeya, K., Hung, M. C., Lee, E. Y. H. P. & Lee, K. H. Sep 24 2010 In : Journal of Natural Products. 73, 9, p. 1553-1558 6 p.

Research output: Contribution to journalArticle

Quassins
Antineoplastic Agents
Ovarian Neoplasms
Quassia
Breast
23 Citations

Speriolin is a novel human and mouse sperm centrosome protein

Goto, M., O'Brien, D. A. & Eddy, E. M. Aug 1 2010 In : Human Reproduction. 25, 8, p. 1884-1894 11 p.

Research output: Contribution to journalArticle

Centrosome
Centrioles
Spermatozoa
Proteins
Zygote
2005
54 Citations

Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p

Izawa, D., Goto, M., Yamashita, A., Yamano, H. & Yamamoto, M. Mar 24 2005 In : Nature. 434, 7032, p. 529-533 5 p.

Research output: Contribution to journalArticle

Cyclins
Schizosaccharomyces
Meiosis
Mitosis
Anaphase-Promoting Complex-Cyclosome
2004
25 Citations

Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20

Goto, M. & Eddy, E. M. Oct 1 2004 In : Journal of Biological Chemistry. 279, 40, p. 42128-42138 11 p.

Research output: Contribution to journalArticle

Centrosome
Anaphase-Promoting Complex-Cyclosome
Cdc20 Proteins
Spermatocytes
Meiosis
2001

Arabidopsis cDNA clones isolated by transcomplementation of the fission yeast cAMP phosphodiesterase mutant

Oshitani-Okamoto, S., Kuromori, T., Goto, M. & Yamamoto, M. Jan 1 2001 In : DNA Research. 8, 4, p. 189-192 4 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
3',5'-Cyclic-AMP Phosphodiesterases
Fungal Genes
Genetic Complementation Test
Plant DNA
2000
3 Citations

Molecular cloning and characterization of mouse testis poly(A) binding protein II encoded by the Pabp3 gene, which transcomplements meiotic mutant sme2 of S. pombe

Okamura, T., Imai, Y., Kon, Y., Goto, M., Yamamoto, M. & Watanabe, T. Jun 22 2000 In : Biochemical Genetics. 38, 1-2, p. 1-11 11 p.

Research output: Contribution to journalArticle

Poly(A)-Binding Protein II
Schizosaccharomyces
Cloning
Molecular Cloning
Testis