• 435 Citations
  • 13 h-Index
20002018
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Research Output 2000 2018

  • 435 Citations
  • 13 h-Index
  • 52 Article
  • 2 Review article
  • 1 Comment/debate
2018
3 Citations

Biologically active quinoline and quinazoline alkaloids part I

Shang, X. F., Morris-Natschke, S. L., Liu, Y. Q., Guo, X., Xu, X. S., Goto, M., Li, J. C., Yang, G. Z. & Lee, K. H., May 1 2018, In : Medicinal Research Reviews. 38, 3, p. 775-828 54 p.

Research output: Contribution to journalReview article

1 Citations

Biologically active quinoline and quinazoline alkaloids part II

Shang, X. F., Morris-Natschke, S. L., Yang, G. Z., Liu, Y. Q., Guo, X., Xu, X. S., Goto, M., Li, J. C., Zhang, J. Y. & Lee, K. H., Sep 1 2018, In : Medicinal Research Reviews. 38, 5, p. 1614-1660 47 p.

Research output: Contribution to journalReview article

Quinazolines
Alkaloids
Antitussive Agents
Antiparasitic Agents
Biological Products

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa

Aimaiti, S., Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Jan 19 2018, In : Journal of Organic Chemistry. 83, 2, p. 951-963 13 p.

Research output: Contribution to journalArticle

X ray analysis
Esterification
Cytotoxicity
Efflorescence
Cells

Four new C19-diterpenoid alkaloids from Delphinium elatum

Yamashita, H., Katoh, M., Kokubun, A., Uchimura, A., Mikami, S., Takeuchi, A., Kaneda, K., Suzuki, Y., Mizukami, M., Goto, M., Lee, K. H. & Wada, K., Apr 1 2018, In : Phytochemistry Letters. 24, p. 6-9 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
Computer operating procedures
diterpenoid alkaloids
Applicators
1 Citations

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

Yamashita, H., Takeda, K., Haraguchi, M., Abe, Y., Kuwahara, N., Suzuki, S., Terui, A., Masaka, T., Munakata, N., Uchida, M., Nunokawa, M., Kaneda, K., Goto, M., Lee, K. H. & Wada, K., Jan 1 2018, In : Journal of Natural Medicines. 72, 1, p. 230-237 8 p.

Research output: Contribution to journalArticle

Aconitum
Computer operating procedures
Applicators
Diterpenes
Alkaloids

Kleinhospitine e and Cycloartane Triterpenoids from Kleinhovia hospita

Rahim, A., Saito, Y., Miyake, K., Goto, M., Chen, C. H., Alam, G., Morris-Natschke, S., Lee, K. H. & Nakagawa-Goto, K., Jul 27 2018, In : Journal of Natural Products. 81, 7, p. 1619-1627 9 p.

Research output: Contribution to journalArticle

Applicators
Alkaloids
Carry logic
Lactams
Tumor Cell Line
1 Citations

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris

Teng, Y. N., Wang, Y., Hsu, P. L., Xin, G., Zhang, Y., Morris-Natschke, S. L., Goto, M. & Lee, K. H., Mar 1 2018, In : Phytomedicine. 41, p. 62-66 5 p.

Research output: Contribution to journalArticle

Euphorbia
Multiple Drug Resistance
Diterpenes
Seeds
lissamine rhodamine B

Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root

Wang, Y. R., Yu, Y., Li, S. M., Liu, W., Li, W., Morris-Natschke, S. L., Goto, M., Lee, K. H. & Huang, X. F., Apr 1 2018, In : Chemistry and Biodiversity. 15, 4, e1800019

Research output: Contribution to journalArticle

Dietary supplements
Salvia
Terpenes
Accessories
lissamine rhodamine B
1 Citations

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Zhang, Y., Yuan, Y. X., Goto, M., Guo, L. L., Li, X. N., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 562-571 10 p.

Research output: Contribution to journalArticle

Tabernaemontana
Applicators
Alkaloids
KB Cells
P-Glycoprotein

Total Synthesis of Antiproliferative Parvifloron F

Saito, Y., Goto, M. & Nakagawa-Goto, K., Feb 2 2018, In : Organic Letters. 20, 3, p. 628-631 4 p.

Research output: Contribution to journalArticle

Abietane Diterpenes
synthesis
activity (biology)
musculoskeletal system
cultured cells
2017
2 Citations

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Double-Stranded DNA Breaks
Alkaloids
Tumor Cell Line
Tumors
1 Citations

A novel clerodane diterpene from Vitex cofassus

Rasyid, F. A., Fukuyoshi, S., Ando, H., Miyake, K., Atsumi, T., Fujie, T., Saito, Y., Goto, M., Shinya, T., Mikage, M., Sasaki, Y. & Nakagawa-Goto, K., 2017, In : Chemical and Pharmaceutical Bulletin. 65, 1, p. 116-120 5 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes
Vitex
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cells

Antitubulin effects of aminobenzothiophene-substituted triethylated chromones

Kobayashi, Y., Saito, Y., Goto, M. & Nakagawa-Goto, K., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 12, p. 2731-2735 5 p.

Research output: Contribution to journalArticle

4 Citations

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O’Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Apr 28 2017, In : Journal of Natural Products. 80, 4, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Antitumor Drug Screening Assays
Salicaceae
Clerodane Diterpenes
Plant Bark

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives

Yang, C. J., Song, Z. L., Goto, M., Hsu, P. L., Zhang, X. S., Yang, Q. R., Liu, Y. Q., Wang, M. J., Morris-Natschke, S. L., Shang, X. F. & Lee, K. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 20, p. 4694-4697 4 p.

Research output: Contribution to journalArticle

1 Citations

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties

Yang, C. J., Song, Z. L., Goto, M., Liu, Y. Q., Hsieh, K. Y., Morris-Natschke, S. L., Zhao, Y. L., Zhang, J. X. & Lee, K. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 3959-3962 4 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Antitumor Drug Screening Assays
irinotecan
Piperazines
Amidines
3 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxicity
Derivatives
irinotecan
lissamine rhodamine B

Design, synthesis and structure-activity relationships of (±)-isochaihulactone derivatives

Zhao, Y., Liu, P. Y., Hsieh, K. Y., Hsu, P. L., Goto, M., Morris-Natschke, S. L., Harn, H. J. & Lee, K. H., Jan 1 2017, In : MedChemComm. 8, 11, p. 2040-2049 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
KB Cells
G2 Phase
P-Glycoprotein
Cell Cycle Checkpoints
Staurosporine
Pharmaceutical Chemistry
Protein-Tyrosine Kinases
Paclitaxel
Publications
2 Citations

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents

Cui, M. T., Jiang, L., Goto, M., Hsu, P. L., Li, L., Zhang, Q., Wei, L., Yuan, S. J., Hamel, E., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Jul 13 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5586-5598 13 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Molecular Docking Simulation
Quinazolines
Angiogenesis Inhibitors
Tubulin
3 Citations

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Yuan, Y. X., Zhang, Y., Guo, L. L., Wang, Y. H., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J., Sep 15 2017, In : Organic Letters. 19, 18, p. 4964-4967 4 p.

Research output: Contribution to journalArticle

Tabernaemontana
Applicators
alkaloids
Alkaloids
Vincristine
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y., Mar 1 2016, In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
alkaloids
5 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K., Nov 23 2016, In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Contribution to journalArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Monomers
Cells
11 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H., Mar 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Contribution to journalArticle

Oxytropis
Alkaloids
Cells
Derivatives
Cell Line
7 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H., Jun 10 2016, In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
irinotecan
Structure-Activity Relationship
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H., Sep 1 2016, In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J., Nov 16 2016, In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction
2 Citations

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria

Suzuki, A., Miyake, K., Saito, Y., Rasyid, F. A., Tokuda, H., Takeuchi, M., Suzuki, N., Ichiishi, E., Fujie, T., Goto, M., Sasaki, Y. & Nakagawa-Goto, K., Jun 15 2016, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Thymelaeaceae
Chromones
Tumor Cell Line
Tumors
Cells
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Jul 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tumor Cell Line
Tumors
Cells
Quinazolines
4 Citations

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Nakagawa-Goto, K., Taniguchi, Y., Watanabe, Y., Oda, A., Ohkoshi, E., Hamel, E., Lee, K. H. & Goto, M., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 22, p. 6048-6057 10 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Naphthalenes
Chromones
Tubulin
Colchicine
2015
10 Citations

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., Jan 1 2015, In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Endoplasmic Reticulum Stress
Cyclin A2
Growth
Neoplasm Metastasis
18 Citations

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

Song, Z. L., Chen, H. L., Wang, Y. H., Goto, M., Gao, W. J., Cheng, P. L., Morris-Natschke, S. L., Liu, Y. Q., Zhu, G. X., Wang, M. J. & Lee, K. H., May 30 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 13, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

irinotecan
Camptothecin
Tumor Cell Line
Polyethylene glycols
Cells
28 Citations

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

Nakagawa-Goto, K., Oda, A., Hamel, E., Ohkoshi, E., Lee, K. H. & Goto, M., Mar 12 2015, In : Journal of Medicinal Chemistry. 58, 5, p. 2378-2389 12 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Tubulin
Microtubules
Interphase
Hydrogen
9 Citations

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

Wada, K., Ohkoshi, E., Zhao, Y., Goto, M., Morris-Natschke, S. L. & Lee, K. H., Apr 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 7, p. 1525-1531 7 p.

Research output: Contribution to journalArticle

Aconitum
Diterpenes
Alkaloids
Vincristine
Tumors
11 Citations

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H., Apr 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Pharmaceutical Preparations
Phosphorylation
9 Citations

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

Wang, S. B., Wang, X. F., Qin, B., Ohkoshi, E., Hsieh, K. Y., Hamel, E., Cui, M. T., Zhu, D. Q., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Apr 28 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5740-5747 8 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Colchicine
Tubulin
Antineoplastic Agents
Assays
4 Citations

Six new norditerpenoid alkaloids from Delphinium elatum

Wada, K., Chiba, R., Kanazawa, R., Matsuoka, K., Suzuki, M., Ikuta, M., Goto, M., Yamashita, H. & Lee, K. H. Jan 1 2015 In : Phytochemistry Letters. 12, p. 79-83 5 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
2014
32 Citations

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J. , Liu, Y. Q. , Chang, L. C. , Wang, C. Y. , Zhao, Y. L. , Zhao, X. B. , Qian, K. , Nan, X. , Yang, L. , Yang, X. M. , Hung, H. Y. , Yang, J. S. , Kuo, D. H. , Goto, M. , Morris-Natschke, S. L. , Pan, S. L. , Teng, C. M. , Kuo, S. C. , Wu, T. S. , Wu, Y. C. & 1 others Lee, K. H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
irinotecan
Antineoplastic Agents
DNA Damage
9 Citations

Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Goto, M., Song, Z. L., Morris-Natschke, S. L., Zhao, Y., Wu, D., Yang, L., Li, S. G., Liu, Y. Q., Zhu, G. X., Wu, X. B. & Lee, K. H., Aug 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3850-3853 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Topotecan
Derivatives
7 Citations

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Wu, D., Wang, M. J., Goto, M., Morris-Natschke, S. L., Liu, Y. Q., Wu, X. B., Song, Z. L., Zhu, G. X. & Lee, K. H., Nov 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 22, p. 6453-6458 6 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Cells
Cytotoxicity
10 Citations

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

Wang, Y. H., Goto, M., Wang, L. T., Hsieh, K. Y., Morris-Natschke, S. L., Tang, G. H., Long, C. L. & Lee, K. H., Oct 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 20, p. 4818-4821 4 p.

Research output: Contribution to journalArticle

Piper
Multiple Drug Resistance
Alkaloids
Amides
Tumors
3 Citations

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

Yang, L., Wang, M. J., Zhang, Z. J., Morris-Natschke, S. L., Goto, M., Tian, J., Liu, Y. Q., Wang, C. Y., Tian, X., Yang, X. M. & Lee, K. H., Jan 1 2014, In : Medicinal Chemistry Research. 23, 7, p. 3269-3273 5 p.

Research output: Contribution to journalArticle

Fluorouracil
Antineoplastic Agents
Lung Neoplasms
Cells
Derivatives
2013
17 Citations

Discovery of novel andrographolide derivatives as cytotoxic agents

Wei, S., Tang, Y. B., Hua, H., Ohkoshi, E., Goto, M., Wang, L. T., Lee, K. H. & Xiao, Z., Jul 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 14, p. 4056-4060 5 p.

Research output: Contribution to journalArticle

Cytotoxins
Tumors
Cells
Derivatives
Diterpenes
14 Citations

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

Zhao, Y., Su, J., Goto, M., Morris-Natschke, S. L., Li, Y., Zhao, Q. S., Yao, Z. J. & Lee, K. H., Jun 13 2013, In : Journal of Medicinal Chemistry. 56, 11, p. 4749-4757 9 p.

Research output: Contribution to journalArticle

Taxoids
Tumor Cell Line
Microtubules
Taxus
Antimitotic Agents
2012
1 Citations

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

Hung, H. Y., Ohkoshi, E., Goto, M., Nakagawa-Goto, K. & Lee, K. H., Dec 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7726-7729 4 p.

Research output: Contribution to journalArticle

Ethane
Vincristine
Verapamil
Esters
Chromones
23 Citations
Vincristine
Antineoplastic Agents
P-Glycoprotein
Verapamil
Doxorubicin
19 Citations

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

Shi, Q., Wada, K., Ohkoshi, E., Lin, L., Huang, R., Morris-Natschke, S. L., Goto, M. & Lee, K. H., Jul 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 13, p. 4020-4031 12 p.

Research output: Contribution to journalArticle

Curcumin
Antineoplastic Agents
Androgens
Pseudopodia
Prostatic Neoplasms
2011
17 Citations

Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

Nakagawa-Goto, K., Wu, P. C., Lai, C. Y., Hamel, E., Zhu, H., Zhang, L., Kozaka, T., Ohkoshi, E., Goto, M., Bastow, K. F. & Lee, K. H., Mar 10 2011, In : Journal of Medicinal Chemistry. 54, 5, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Cytotoxins
Antineoplastic Agents
P-Glycoprotein
Cell Line
Colchicine
13 Citations

Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action

Nakagawa-Goto, K., Wu, P. C., Bastow, K. F., Yang, S. C., Yu, S. L., Chen, H. Y., Lin, J. C., Goto, M., Morris-Natschke, S. L., Yang, P. C. & Lee, K. H., Mar 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 5, p. 1816-1822 7 p.

Research output: Contribution to journalArticle

M Phase Cell Cycle Checkpoints
Tumor Cell Line
Antineoplastic Agents
Tumors
Chemical activation
2010
15 Citations

Antitumor agents. 282. 2′-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent

Usami, Y., Nakagawa-Goto, K., Lang, J. Y., Kim, Y., Lai, C. Y., Goto, M., Sakurai, N., Taniguchi, M., Akiyama, T., Morris-Natschke, S. L., Bastow, K. F., Cragg, G., Newman, D. J., Fujitake, M., Takeya, K., Hung, M. C., Lee, E. Y. H. P. & Lee, K. H., Sep 24 2010, In : Journal of Natural Products. 73, 9, p. 1553-1558 6 p.

Research output: Contribution to journalArticle

Quassins
Antineoplastic Agents
Ovarian Neoplasms
Quassia
Breast