• 450 Citations
  • 13 h-Index
20002018
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Research Output 2000 2018

  • 450 Citations
  • 13 h-Index
  • 54 Article
  • 2 Review article
  • 1 Comment/debate
2018

5′-Chloro-2,2′-dihydroxychalcone and related flavanoids as treatments for prostate cancer

Saito, Y., Mizokami, A., Tsurimoto, H., Izumi, K., Goto, M. & Nakagawa-Goto, K., Sep 5 2018, In : European Journal of Medicinal Chemistry. 157, p. 1143-1152 10 p.

Research output: Contribution to journalArticle

Chalcone
Androgen Receptors
Chalcones
Cells
Lead compounds

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species

Takeuchi, M., Saito, Y., Goto, M., Miyake, K., Newman, D. J., O'Keefe, B. R., Lee, K-H. & Nakagawa-Goto, K., Aug 24 2018, In : Journal of Natural Products. 81, 8, p. 1884-1891 8 p.

Research output: Contribution to journalArticle

Alangiaceae
Phytochemicals
Alkaloids
Cells
Tetrahydroisoquinolines
4 Citations

Biologically active quinoline and quinazoline alkaloids part I

Shang, X. F., Morris-Natschke, S. L., Liu, Y. Q., Guo, X., Xu, X. S., Goto, M., Li, J. C., Yang, G. Z. & Lee, K. H., May 1 2018, In : Medicinal Research Reviews. 38, 3, p. 775-828 54 p.

Research output: Contribution to journalReview article

Quinazolines
Alkaloids
Antimalarials
Heterocyclic Compounds
Antiparasitic Agents
2 Citations

Biologically active quinoline and quinazoline alkaloids part II

Shang, X. F., Morris-Natschke, S. L., Yang, G. Z., Liu, Y. Q., Guo, X., Xu, X. S., Goto, M., Li, J. C., Zhang, J. Y. & Lee, K. H., Sep 1 2018, In : Medicinal Research Reviews. 38, 5, p. 1614-1660 47 p.

Research output: Contribution to journalReview article

Quinazolines
Alkaloids
Antitussive Agents
Antiparasitic Agents
Biological Products

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa

Aimaiti, S., Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Jan 19 2018, In : Journal of Organic Chemistry. 83, 2, p. 951-963 13 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Clerodane Diterpenes
Spectroscopic analysis
X ray analysis
Cell proliferation

Four new C19-diterpenoid alkaloids from Delphinium elatum

Yamashita, H., Katoh, M., Kokubun, A., Uchimura, A., Mikami, S., Takeuchi, A., Kaneda, K., Suzuki, Y., Mizukami, M., Goto, M., Lee, K. H. & Wada, K., Apr 1 2018, In : Phytochemistry Letters. 24, p. 6-9 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
1 Citations

Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum

Yamashita, H., Takeda, K., Haraguchi, M., Abe, Y., Kuwahara, N., Suzuki, S., Terui, A., Masaka, T., Munakata, N., Uchida, M., Nunokawa, M., Kaneda, K., Goto, M., Lee, K. H. & Wada, K., Jan 1 2018, In : Journal of Natural Medicines. 72, 1, p. 230-237 8 p.

Research output: Contribution to journalArticle

Chinese Herbal Drugs
Aconitum
Diterpenes
Molecular Structure
Alkaloids

Kleinhospitine e and Cycloartane Triterpenoids from Kleinhovia hospita

Rahim, A., Saito, Y., Miyake, K., Goto, M., Chen, C. H., Alam, G., Morris-Natschke, S., Lee, K. H. & Nakagawa-Goto, K., Jul 27 2018, In : Journal of Natural Products. 81, 7, p. 1619-1627 9 p.

Research output: Contribution to journalArticle

Alkaloids
Cells
Lactams
Isomers
Nuclear magnetic resonance spectroscopy
1 Citations

Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris

Teng, Y. N., Wang, Y., Hsu, P. L., Xin, G., Zhang, Y., Morris-Natschke, S. L., Goto, M. & Lee, K. H., Mar 1 2018, In : Phytomedicine. 41, p. 62-66 5 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Antitumor Drug Screening Assays
Chinese Herbal Drugs
Phenylpropionates
Euphorbia

Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root

Wang, Y. R., Yu, Y., Li, S. M., Liu, W., Li, W., Morris-Natschke, S. L., Goto, M., Lee, K. H. & Huang, X. F., Apr 1 2018, In : Chemistry and Biodiversity. 15, 4, e1800019.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Terpenes
Cell proliferation
lissamine rhodamine B
Molecular structure
3 Citations

Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Zhang, Y., Yuan, Y. X., Goto, M., Guo, L. L., Li, X. N., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J., Mar 23 2018, In : Journal of Natural Products. 81, 3, p. 562-571 10 p.

Research output: Contribution to journalArticle

Alkaloids
P-Glycoprotein
X ray diffraction analysis
Cells
Nuclear magnetic resonance

Total Synthesis of Antiproliferative Parvifloron F

Saito, Y., Goto, M. & Nakagawa-Goto, K., Feb 2 2018, In : Organic Letters. 20, 3, p. 628-631 4 p.

Research output: Contribution to journalArticle

Abietane Diterpenes
synthesis
activity (biology)
musculoskeletal system
cultured cells
2017
2 Citations

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Jan 27 2017, In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Contribution to journalArticle

Cryptocarya
Double-Stranded DNA Breaks
Alkaloids
Tumor Cell Line
Tumors
1 Citations

A novel clerodane diterpene from Vitex cofassus

Rasyid, F. A., Fukuyoshi, S., Ando, H., Miyake, K., Atsumi, T., Fujie, T., Saito, Y., Goto, M., Shinya, T., Mikage, M., Sasaki, Y. & Nakagawa-Goto, K., 2017, In : Chemical and Pharmaceutical Bulletin. 65, 1, p. 116-120 5 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes
Vitex
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cells

Antitubulin effects of aminobenzothiophene-substituted triethylated chromones

Kobayashi, Y., Saito, Y., Goto, M. & Nakagawa-Goto, K., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 12, p. 2731-2735 5 p.

Research output: Contribution to journalArticle

Chromones
Prometaphase
Cells
Derivatives
Depolymerization
4 Citations

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O’Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K., Apr 28 2017, In : Journal of Natural Products. 80, 4, p. 1065-1072 8 p.

Research output: Contribution to journalArticle

Clerodane Diterpenes
Esterification
Skeleton
Cell Line
Neoplasms

Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives

Yang, C. J., Song, Z. L., Goto, M., Hsu, P. L., Zhang, X. S., Yang, Q. R., Liu, Y. Q., Wang, M. J., Morris-Natschke, S. L., Shang, X. F. & Lee, K. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 20, p. 4694-4697 4 p.

Research output: Contribution to journalArticle

Camptothecin
Derivatives
irinotecan
Cells
Cytotoxicity
2 Citations

Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties

Yang, C. J., Song, Z. L., Goto, M., Liu, Y. Q., Hsieh, K. Y., Morris-Natschke, S. L., Zhao, Y. L., Zhang, J. X. & Lee, K. H., Jan 1 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 17, p. 3959-3962 4 p.

Research output: Contribution to journalArticle

Piperazines
Amidines
Camptothecin
irinotecan
Cell proliferation
3 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H., 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxicity
Inhibitory Concentration 50
Derivatives
irinotecan

Design, synthesis and structure-activity relationships of (±)-isochaihulactone derivatives

Zhao, Y., Liu, P. Y., Hsieh, K. Y., Hsu, P. L., Goto, M., Morris-Natschke, S. L., Harn, H. J. & Lee, K. H., Jan 1 2017, In : MedChemComm. 8, 11, p. 2040-2049 10 p.

Research output: Contribution to journalArticle

Tumors
Cells
Derivatives
Bearings (structural)
P-Glycoprotein
Staurosporine
Pharmaceutical Chemistry
Protein-Tyrosine Kinases
Paclitaxel
Publications
2 Citations

In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents

Cui, M. T., Jiang, L., Goto, M., Hsu, P. L., Li, L., Zhang, Q., Wei, L., Yuan, S. J., Hamel, E., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Jul 13 2017, In : Journal of Medicinal Chemistry. 60, 13, p. 5586-5598 13 p.

Research output: Contribution to journalArticle

Tubulin
Blood Vessels
Neoplasms
Vascular Tissue Neoplasms
Quinazolines
5 Citations

Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa

Yuan, Y. X., Zhang, Y., Guo, L. L., Wang, Y. H., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Hao, X. J., Sep 15 2017, In : Organic Letters. 19, 18, p. 4964-4967 4 p.

Research output: Contribution to journalArticle

Phytogenic Antineoplastic Agents
Alkaloids
Molecular structure
Vincristine
Cells
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y., Mar 1 2016, In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
alkaloids
7 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K., Nov 23 2016, In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Contribution to journalArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Monomers
Cells
11 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H., Mar 1 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Contribution to journalArticle

Oxytropis
Alkaloids
Cells
Derivatives
Cell Line
8 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H., Jun 10 2016, In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
irinotecan
Structure-Activity Relationship
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H., Sep 1 2016, In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J., Nov 16 2016, In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Contribution to journalArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction
2 Citations

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria

Suzuki, A., Miyake, K., Saito, Y., Rasyid, F. A., Tokuda, H., Takeuchi, M., Suzuki, N., Ichiishi, E., Fujie, T., Goto, M., Sasaki, Y. & Nakagawa-Goto, K., Jun 15 2016, (Accepted/In press) In : Planta Medica.

Research output: Contribution to journalArticle

Thymelaeaceae
Chromones
Tumor Cell Line
Tumors
Cells
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Jul 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Tumor Cell Line
Tumors
Cells
Quinazolines
4 Citations

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Nakagawa-Goto, K., Taniguchi, Y., Watanabe, Y., Oda, A., Ohkoshi, E., Hamel, E., Lee, K. H. & Goto, M., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 22, p. 6048-6057 10 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Naphthalenes
Chromones
Tubulin
Colchicine
2015
10 Citations

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., Jan 1 2015, In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Endoplasmic Reticulum Stress
Cyclin A2
Growth
Neoplasm Metastasis
18 Citations

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

Song, Z. L., Chen, H. L., Wang, Y. H., Goto, M., Gao, W. J., Cheng, P. L., Morris-Natschke, S. L., Liu, Y. Q., Zhu, G. X., Wang, M. J. & Lee, K. H., May 30 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 13, p. 2690-2693 4 p.

Research output: Contribution to journalArticle

irinotecan
Camptothecin
Tumor Cell Line
Polyethylene glycols
Cells
28 Citations

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

Nakagawa-Goto, K., Oda, A., Hamel, E., Ohkoshi, E., Lee, K. H. & Goto, M., Mar 12 2015, In : Journal of Medicinal Chemistry. 58, 5, p. 2378-2389 12 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Tubulin
Microtubules
Interphase
Hydrogen
9 Citations

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

Wada, K., Ohkoshi, E., Zhao, Y., Goto, M., Morris-Natschke, S. L. & Lee, K. H., Apr 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 7, p. 1525-1531 7 p.

Research output: Contribution to journalArticle

Aconitum
Diterpenes
Alkaloids
Vincristine
Tumors
11 Citations

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H., Apr 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Contribution to journalArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Phosphorylation
Pharmaceutical Preparations
9 Citations

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

Wang, S. B., Wang, X. F., Qin, B., Ohkoshi, E., Hsieh, K. Y., Hamel, E., Cui, M. T., Zhu, D. Q., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Xie, L., Apr 28 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5740-5747 8 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Colchicine
Tubulin
Antineoplastic Agents
Assays
4 Citations

Six new norditerpenoid alkaloids from Delphinium elatum

Wada, K., Chiba, R., Kanazawa, R., Matsuoka, K., Suzuki, M., Ikuta, M., Goto, M., Yamashita, H. & Lee, K. H., Jan 1 2015, In : Phytochemistry Letters. 12, p. 79-83 5 p.

Research output: Contribution to journalArticle

Delphinium elatum
Delphinium
diterpenoid alkaloids
Diterpenes
Alkaloids
2014
33 Citations

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J., Liu, Y. Q., Chang, L. C., Wang, C. Y., Zhao, Y. L., Zhao, X. B., Qian, K., Nan, X., Yang, L., Yang, X. M., Hung, H. Y., Yang, J. S., Kuo, D. H., Goto, M., Morris-Natschke, S. L., Pan, S. L., Teng, C. M., Kuo, S. C., Wu, T. S., Wu, Y. C. & 1 othersLee, K. H., Jul 24 2014, In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
irinotecan
Lethal Dose 50
Antineoplastic Agents
10 Citations

Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Goto, M., Song, Z. L., Morris-Natschke, S. L., Zhao, Y., Wu, D., Yang, L., Li, S. G., Liu, Y. Q., Zhu, G. X., Wu, X. B. & Lee, K. H., Aug 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3850-3853 4 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Topotecan
Derivatives
7 Citations

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Wu, D., Wang, M. J., Goto, M., Morris-Natschke, S. L., Liu, Y. Q., Wu, X. B., Song, Z. L., Zhu, G. X. & Lee, K. H., Nov 15 2014, In : Bioorganic and Medicinal Chemistry. 22, 22, p. 6453-6458 6 p.

Research output: Contribution to journalArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Cells
Cytotoxicity
11 Citations

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

Wang, Y. H., Goto, M., Wang, L. T., Hsieh, K. Y., Morris-Natschke, S. L., Tang, G. H., Long, C. L. & Lee, K. H., Oct 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 20, p. 4818-4821 4 p.

Research output: Contribution to journalArticle

Piper
Multiple Drug Resistance
Alkaloids
Amides
Inhibitory Concentration 50
3 Citations

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

Yang, L., Wang, M. J., Zhang, Z. J., Morris-Natschke, S. L., Goto, M., Tian, J., Liu, Y. Q., Wang, C. Y., Tian, X., Yang, X. M. & Lee, K. H., Jan 1 2014, In : Medicinal Chemistry Research. 23, 7, p. 3269-3273 5 p.

Research output: Contribution to journalArticle

Fluorouracil
Antineoplastic Agents
Lung Neoplasms
Cells
Derivatives
2013
17 Citations

Discovery of novel andrographolide derivatives as cytotoxic agents

Wei, S., Tang, Y. B., Hua, H., Ohkoshi, E., Goto, M., Wang, L. T., Lee, K. H. & Xiao, Z., Jul 15 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 14, p. 4056-4060 5 p.

Research output: Contribution to journalArticle

Cytotoxins
Tumors
Cells
Derivatives
Diterpenes
14 Citations

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

Zhao, Y., Su, J., Goto, M., Morris-Natschke, S. L., Li, Y., Zhao, Q. S., Yao, Z. J. & Lee, K. H., Jun 13 2013, In : Journal of Medicinal Chemistry. 56, 11, p. 4749-4757 9 p.

Research output: Contribution to journalArticle

Taxoids
Tumor Cell Line
Microtubules
Taxus
Antimitotic Agents
2012
1 Citations

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

Hung, H. Y., Ohkoshi, E., Goto, M., Nakagawa-Goto, K. & Lee, K. H., Dec 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7726-7729 4 p.

Research output: Contribution to journalArticle

Ethane
Vincristine
Verapamil
Esters
Chromones
23 Citations
Vincristine
Antineoplastic Agents
P-Glycoprotein
Verapamil
Doxorubicin
19 Citations

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

Shi, Q., Wada, K., Ohkoshi, E., Lin, L., Huang, R., Morris-Natschke, S. L., Goto, M. & Lee, K. H., Jul 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 13, p. 4020-4031 12 p.

Research output: Contribution to journalArticle

Curcumin
Antineoplastic Agents
Androgens
Pseudopodia
Prostatic Neoplasms
2011
17 Citations

Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

Nakagawa-Goto, K., Wu, P. C., Lai, C. Y., Hamel, E., Zhu, H., Zhang, L., Kozaka, T., Ohkoshi, E., Goto, M., Bastow, K. F. & Lee, K. H., Mar 10 2011, In : Journal of Medicinal Chemistry. 54, 5, p. 1244-1255 12 p.

Research output: Contribution to journalArticle

Cytotoxins
Antineoplastic Agents
P-Glycoprotein
Cell Line
Colchicine