Research Output 2000 2017

  • 345 Citations
  • 12 h-Index
  • 37 Article
  • 1 Comment/debate
2017

(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata, induces DNA double-strand breaks

Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H. & Nakagawa-Goto, K. Jan 27 2017 In : Journal of Natural Products. 80, 1, p. 220-224 5 p.

Research output: Research - peer-reviewArticle

Alkaloids
DNA
Cryptocarya
Double-Stranded DNA Breaks
Tumors

A novel clerodane diterpene from Vitex cofassus

Rasyid, F. A., Fukuyoshi, S., Ando, H., Miyake, K., Atsumi, T., Fujie, T., Saito, Y., Goto, M., Shinya, T., Mikage, M., Sasaki, Y. & Nakagawa-Goto, K. 2017 In : Chemical and Pharmaceutical Bulletin. 65, 1, p. 116-120 5 p.

Research output: Research - peer-reviewArticle

Clerodane Diterpenes
Vitex
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Cell Line
1 Citations

Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives

Zhu, G. X., Cheng, P. L., Goto, M., Zhang, N., Morris-Natschke, S. L., Hsieh, K. Y., Yang, G. Z., Yang, Q. R., Liu, Y. Q., Chen, H. L., Zhang, X. S. & Lee, K. H. 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1750-1753 4 p.

Research output: Research - peer-reviewArticle

Camptothecin
Derivatives
Cytotoxicity
Cells
irinotecan
Staurosporine
Pharmaceutical Chemistry
Protein-Tyrosine Kinases
Paclitaxel
Publications
2016
2 Citations

(+)-(14β)-14-Ethylmatridin-15-one, a New Quinolizidine Alkaloid from the Poisonous Plant Oxytropis ochrocephala Bunge

Tan, C. J., Yi, P., Goto, M., Morris-Natschke, S. L., Liu, L. N., Lee, K. H. & Zhao, B. Y. Mar 1 2016 In : Helvetica Chimica Acta. 99, 3, p. 225-227 3 p.

Research output: Research - peer-reviewArticle

Quinolizidines
Alkaloids
Nuclear magnetic resonance
Derivatives
Experiments
1 Citations

Acetophenone Monomers from Acronychia trifoliolata

Miyake, K., Suzuki, A., Morita, C., Goto, M., Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H. & Nakagawa-Goto, K. Nov 23 2016 In : Journal of Natural Products. 79, 11, p. 2883-2889 7 p.

Research output: Research - peer-reviewArticle

Rutaceae
National Cancer Institute (U.S.)
Human Activities
Cell Line
Neoplasms
6 Citations

Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines

Tan, C. J., Zhao, Y., Goto, M., Hsieh, K. Y., Yang, X. M., Morris-Natschke, S. L., Liu, L. N., Zhao, B. Y. & Lee, K. H. Mar 1 2016 In : Bioorganic and Medicinal Chemistry Letters. 26, 5, p. 1495-1497 3 p.

Research output: Research - peer-reviewArticle

Oxytropis
Alkaloids
Cell Line
Neoplasms
matrine
4 Citations

Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives

Song, Z. L., Wang, M. J., Li, L., Wu, D., Wang, Y. H., Yan, L. T., Morris-Natschke, S. L., Liu, Y. Q., Zhao, Y. L., Wang, C. Y., Liu, H., Goto, M., Liu, H., Zhu, G. X. & Lee, K. H. Jun 10 2016 In : European Journal of Medicinal Chemistry. 115, p. 109-120 12 p.

Research output: Research - peer-reviewArticle

Camptothecin
Type I DNA Topoisomerase
Derivatives
Cells
Structure-Activity Relationship
2 Citations

Four new diterpenoid alkaloids from Delphinium elatum

Wada, K., Asakawa, E., Tosho, Y., Nakata, A., Hasegawa, Y., Kaneda, K., Goto, M., Yamashita, H. & Lee, K. H. Sep 1 2016 In : Phytochemistry Letters. 17, p. 190-193 4 p.

Research output: Research - peer-reviewArticle

Delphinium elatum
diterpenoid alkaloids
Delphinium
Diterpenes
Alkaloids
2 Citations

Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge

Liu, L. N., Ran, J. Q., Li, L. J., Zhao, Y., Goto, M., Morris-Natschke, S. L., Lee, K. H., Zhao, B. Y. & Tan, C. J. Nov 16 2016 In : Tetrahedron Letters. 57, 46, p. 5047-5049 3 p.

Research output: Research - peer-reviewArticle

Oxytropis
Quinolizidines
Toxic Plants
Alkaloids
X-Ray Diffraction

Phenylethylchromones with In Vitro Antitumor Promoting Activity from Aquilaria filaria

Suzuki, A., Miyake, K., Saito, Y., Rasyid, F. A., Tokuda, H., Takeuchi, M., Suzuki, N., Ichiishi, E., Fujie, T., Goto, M., Sasaki, Y. & Nakagawa-Goto, K. Jun 15 2016 (Accepted/In press) In : Planta Medica.

Research output: Research - peer-reviewArticle

Thymelaeaceae
Tumor Cell Line
In Vitro Techniques
Tumors
Cells
1 Citations

Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors

Wang, S. B., Cui, M. T., Wang, X. F., Ohkoshi, E., Goto, M., Yang, D. X., Li, L., Yuan, S., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Jul 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 13, p. 3083-3092 10 p.

Research output: Research - peer-reviewArticle

Protein-Tyrosine Kinases
Tumors
Cells
Tumor Cell Line
Quinazolines
2 Citations

Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Nakagawa-Goto, K., Taniguchi, Y., Watanabe, Y., Oda, A., Ohkoshi, E., Hamel, E., Lee, K. H. & Goto, M. Jan 1 2016 In : Bioorganic and Medicinal Chemistry. 24, 22, p. 6048-6057 10 p.

Research output: Research - peer-reviewArticle

Tubulin Modulators
Naphthalenes
Chromones
Tubulin
Tumors
2015
8 Citations

A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J. Jan 1 2015 In : Oncotarget. 6, 15, p. 13671-13687 17 p.

Research output: Research - peer-reviewArticle

Lung Neoplasms
Growth
Neoplasms
betulinic acid
Endoplasmic Reticulum Stress
13 Citations

Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction

Song, Z. L., Chen, H. L., Wang, Y. H., Goto, M., Gao, W. J., Cheng, P. L., Morris-Natschke, S. L., Liu, Y. Q., Zhu, G. X., Wang, M. J. & Lee, K. H. May 30 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 13, p. 2690-2693 4 p.

Research output: Research - peer-reviewArticle

Camptothecin
Polyethylene glycols
Cells
Derivatives
irinotecan
18 Citations

Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring

Nakagawa-Goto, K., Oda, A., Hamel, E., Ohkoshi, E., Lee, K. H. & Goto, M. Mar 12 2015 In : Journal of Medicinal Chemistry. 58, 5, p. 2378-2389 12 p.

Research output: Research - peer-reviewArticle

Tubulin Modulators
Tubulin
Microtubules
Interphase
Hydrogen
6 Citations

Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents

Wada, K., Ohkoshi, E., Zhao, Y., Goto, M., Morris-Natschke, S. L. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry Letters. 25, 7, p. 1525-1531 7 p.

Research output: Research - peer-reviewArticle

Aconitum
Diterpenes
Alkaloids
Vincristine
Tumors
8 Citations

Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects

Wada, K., Lee, J. Y., Hung, H. Y., Shi, Q., Lin, L., Zhao, Y., Goto, M., Yang, P. C., Kuo, S. C., Chen, H. W. & Lee, K. H. Apr 1 2015 In : Bioorganic and Medicinal Chemistry. 23, 7, p. 1507-1514 8 p.

Research output: Research - peer-reviewArticle

Curcumin
Epidermal Growth Factor Receptor
Drug Resistance
Adenocarcinoma of lung
Pharmaceutical Preparations
9 Citations

Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors

Wang, S. B., Wang, X. F., Qin, B., Ohkoshi, E., Hsieh, K. Y., Hamel, E., Cui, M. T., Zhu, D. Q., Goto, M., Morris-Natschke, S. L., Lee, K. H. & Xie, L. Apr 28 2015 In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5740-5747 8 p.

Research output: Research - peer-reviewArticle

Tubulin Modulators
Colchicine
Tubulin
Assays
Pharmaceutical Preparations
3 Citations

Six new norditerpenoid alkaloids from Delphinium elatum

Wada, K., Chiba, R., Kanazawa, R., Matsuoka, K., Suzuki, M., Ikuta, M., Goto, M., Yamashita, H. & Lee, K. H. Jan 1 2015 In : Phytochemistry Letters. 12, p. 79-83 5 p.

Research output: Research - peer-reviewArticle

Delphinium
Diterpenes
Alkaloids
Delphinium elatum
diterpenoid alkaloids
2014
25 Citations

Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents

Wang, M. J. , Liu, Y. Q. , Chang, L. C. , Wang, C. Y. , Zhao, Y. L. , Zhao, X. B. , Qian, K. , Nan, X. , Yang, L. , Yang, X. M. , Hung, H. Y. , Yang, J. S. , Kuo, D. H. , Goto, M. , Morris-Natschke, S. L. , Pan, S. L. , Teng, C. M. , Kuo, S. C. , Wu, T. S. , Wu, Y. C. & 1 others Lee, K. H. Jul 24 2014 In : Journal of Medicinal Chemistry. 57, 14, p. 6008-6018 11 p.

Research output: Research - peer-reviewArticle

Camptothecin
Type I DNA Topoisomerase
Antineoplastic Agents
DNA Damage
irinotecan
7 Citations

Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Goto, M., Song, Z. L., Morris-Natschke, S. L., Zhao, Y., Wu, D., Yang, L., Li, S. G., Liu, Y. Q., Zhu, G. X., Wu, X. B. & Lee, K. H. Aug 15 2014 In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3850-3853 4 p.

Research output: Research - peer-reviewArticle

Camptothecin
Cytotoxins
Tumor Cell Line
In Vitro Techniques
Derivatives
7 Citations

Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents

Zhao, X. B., Wu, D., Wang, M. J., Goto, M., Morris-Natschke, S. L., Liu, Y. Q., Wu, X. B., Song, Z. L., Zhu, G. X. & Lee, K. H. Nov 15 2014 In : Bioorganic and Medicinal Chemistry. 22, 22, p. 6453-6458 6 p.

Research output: Research - peer-reviewArticle

Camptothecin
Cytotoxins
Tumor Cell Line
Cells
Derivatives
9 Citations

Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues

Wang, Y. H., Goto, M., Wang, L. T., Hsieh, K. Y., Morris-Natschke, S. L., Tang, G. H., Long, C. L. & Lee, K. H. Oct 15 2014 In : Bioorganic and Medicinal Chemistry Letters. 24, 20, p. 4818-4821 4 p.

Research output: Research - peer-reviewArticle

Piper
Multiple Drug Resistance
Alkaloids
Amides
Neoplasms
3 Citations

Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents

Yang, L., Wang, M. J., Zhang, Z. J., Morris-Natschke, S. L., Goto, M., Tian, J., Liu, Y. Q., Wang, C. Y., Tian, X., Yang, X. M. & Lee, K. H. Jan 1 2014 In : Medicinal Chemistry Research. 23, 7, p. 3269-3273 5 p.

Research output: Research - peer-reviewArticle

Fluorouracil
Antineoplastic Agents
Lung Neoplasms
Cells
Derivatives
2013
13 Citations

Discovery of novel andrographolide derivatives as cytotoxic agents

Wei, S., Tang, Y. B., Hua, H., Ohkoshi, E., Goto, M., Wang, L. T., Lee, K. H. & Xiao, Z. Jul 15 2013 In : Bioorganic and Medicinal Chemistry Letters. 23, 14, p. 4056-4060 5 p.

Research output: Research - peer-reviewArticle

Cytotoxins
Tumors
Cells
Derivatives
andrographolide
10 Citations

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation

Zhao, Y., Su, J., Goto, M., Morris-Natschke, S. L., Li, Y., Zhao, Q. S., Yao, Z. J. & Lee, K. H. Jun 13 2013 In : Journal of Medicinal Chemistry. 56, 11, p. 4749-4757 9 p.

Research output: Research - peer-reviewArticle

Taxoids
Tumor Cell Line
Microtubules
taxchinin A
taxane
2012
1 Citations

1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity

Hung, H. Y., Ohkoshi, E., Goto, M., Nakagawa-Goto, K. & Lee, K. H. Dec 15 2012 In : Bioorganic and Medicinal Chemistry Letters. 22, 24, p. 7726-7729 4 p.

Research output: Research - peer-reviewArticle

Ethane
Vincristine
Verapamil
Esters
Derivatives
20 Citations
Vincristine
Antineoplastic Agents
Pharmaceutical Preparations
Neoplasms
7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester
19 Citations

Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens

Shi, Q., Wada, K., Ohkoshi, E., Lin, L., Huang, R., Morris-Natschke, S. L., Goto, M. & Lee, K. H. Jul 1 2012 In : Bioorganic and Medicinal Chemistry. 20, 13, p. 4020-4031 12 p.

Research output: Research - peer-reviewArticle

Curcumin
Antineoplastic Agents
Androgens
Pseudopodia
Prostatic Neoplasms
2011
15 Citations

Antitumor agents. 284. new desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents

Nakagawa-Goto, K., Wu, P. C., Lai, C. Y., Hamel, E., Zhu, H., Zhang, L., Kozaka, T., Ohkoshi, E., Goto, M., Bastow, K. F. & Lee, K. H. Mar 10 2011 In : Journal of Medicinal Chemistry. 54, 5, p. 1244-1255 12 p.

Research output: Research - peer-reviewArticle

Cytotoxins
Antineoplastic Agents
In Vitro Techniques
P-Glycoprotein
Cell Line
12 Citations

Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action

Nakagawa-Goto, K., Wu, P. C., Bastow, K. F., Yang, S. C., Yu, S. L., Chen, H. Y., Lin, J. C., Goto, M., Morris-Natschke, S. L., Yang, P. C. & Lee, K. H. Mar 1 2011 In : Bioorganic and Medicinal Chemistry. 19, 5, p. 1816-1822 7 p.

Research output: Research - peer-reviewArticle

M Phase Cell Cycle Checkpoints
Tumor Cell Line
Antineoplastic Agents
desmosdumotin C
Tumors
2010
13 Citations

Antitumor agents. 282. 2′-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent

Usami, Y., Nakagawa-Goto, K., Lang, J. Y., Kim, Y., Lai, C. Y., Goto, M., Sakurai, N., Taniguchi, M., Akiyama, T., Morris-Natschke, S. L., Bastow, K. F., Cragg, G., Newman, D. J., Fujitake, M., Takeya, K., Hung, M. C., Lee, E. Y. H. P. & Lee, K. H. Sep 24 2010 In : Journal of Natural Products. 73, 9, p. 1553-1558 6 p.

Research output: Research - peer-reviewArticle

Quassins
Antineoplastic Agents
Ovarian Neoplasms
Breast
Cell Line
23 Citations

Speriolin is a novel human and mouse sperm centrosome protein

Goto, M., O'Brien, D. A. & Eddy, E. M. Aug 1 2010 In : Human Reproduction. 25, 8, p. 1884-1894 11 p.

Research output: Research - peer-reviewArticle

Centrosome
Spermatozoa
Proteins
Centrioles
Zygote
2005
54 Citations

Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p

Izawa, D., Goto, M., Yamashita, A., Yamano, H. & Yamamoto, M. Mar 24 2005 In : Nature. 434, 7032, p. 529-533 5 p.

Research output: Research - peer-reviewArticle

Cyclins
Schizosaccharomyces
Meiosis
Mitosis
Anaphase-Promoting Complex-Cyclosome
2004
25 Citations

Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20

Goto, M. & Eddy, E. M. Oct 1 2004 In : Journal of Biological Chemistry. 279, 40, p. 42128-42138 11 p.

Research output: Research - peer-reviewArticle

Centrosome
Cytoplasm
Proteins
Cells
Spermatocytes
2001

Arabidopsis cDNA clones isolated by transcomplementation of the fission yeast cAMP phosphodiesterase mutant

Oshitani-Okamoto, S., Kuromori, T., Goto, M. & Yamamoto, M. Jan 1 2001 In : DNA Research. 8, 4, p. 189-192 4 p.

Research output: Research - peer-reviewArticle

2000
3 Citations

Molecular cloning and characterization of mouse testis poly(A) binding protein II encoded by the Pabp3 gene, which transcomplements meiotic mutant sme2 of S. pombe

Okamura, T., Imai, Y., Kon, Y., Goto, M., Yamamoto, M. & Watanabe, T. 2000 In : Biochemical Genetics. 38, 1-2, p. 1-11 11 p.

Research output: Research - peer-reviewArticle

binding proteins
molecular cloning
testes
mutants
mice